Introduction of Human Breathomics Database

Human Breathomics Database is a reference database, providing 2766 related references, 913 compounds and 60 diseases associated with human breathomics.

It is so challenging to understand about the breath molecules in related to disease, mechanism, and pathways we identified from our experimental analytical measurements due to the lack of organization of breath molecules and their related literature organization and summarization embedded in the enormous literatures. Thus, we deployed a text-mining pipeline to extract biomedical information from literatures and gathered our researchers in our institutes to manually organize and curated literatures to provide a breath molecules knowledgebase. The Human Breathomics Database (HBDB) collected total of 913 volatile organic compounds in human exhaled breath reported more than 2766 literatures. The number seems to be relative small but it is the most comprehensive knowledge database regarding to volatile organic compounds in human exhaled breath up to date. HBDB is useful for researchers and clinicians who are into investigating potential biomarkers from patients' breath.

Disease mapping in HBDB

(1) Heart Lung (179) Airway (42) (1) Esophagus Kidney (1) Intestine (1)
Related diseases mapping with associated reference counts.

HBDB contains 23 lung-associated diseases with 179 references, 17 airway-associated diseases with 42 references, 1 kidney-associated disease with 1 reference, 1 intestine-associated disease with 1 reference, 1 esophagus-associated disease with 1 reference, and 1 heart-associated disease with 1 reference.

Associated references
Title Journal Year Authors
Influence of air pollution on airway inflammation and disease activity in childhood-systemic lupus erythematosus. Clin. Rheumatol. 2018 AGF. Alves, MF. de Azevedo Giacomin, ALF. Braga, AME. Sallum, LAA. Pereira, LC. Farhat, FL. Strufaldi, AJ. de Faria Coimbra Lichtenfels, T. de Santana Carvalho, NK. Nakagawa, CA. Silva, SCL. Farhat
Translating Asthma: Dissecting the Role of Metabolomics, Genomics and Personalized Medicine. Indian J Pediatr 2018 A. Bush
The Effect of a Dietary Nitrate Supplementation in the Form of a Single Shot of Beetroot Juice on Static and Dynamic Apnea Performance. Int J Sport Nutr Exerc Metab 2018 MJ. Barlow, A. Elia, OM. Shannon, A. Zacharogianni, A. Lodin-Sundstrom
Eradication Rate of Helicobacter pylori on the US-Mexico Border Using the Urea Breath Test. South. Med. J. 2018 RP. Liu, R. Romero, J. Sarosiek, C. Dodoo, AK. Dwivedi, MJ. Zuckerman
Electret filter collects more exhaled albumin than glass condenser: A method comparison based on human study. Medicine (Baltimore) 2018 Z. Jia, H. Liu, W. Li, D. Xie, K. Cheng, X. Pi
Biomonitoring-based exposure assessment of benzene, toluene, ethylbenzene and xylene among workers at petroleum distribution facilities. Ecotoxicol. Environ. Saf. 2018 B. Heibati, KJ. Godri Pollitt, JY. Charati, A. Ducatman, M. Shokrzadeh, A. Karimi, M. Mohammadyan
Solid-phase microextraction of volatile organic compounds in headspace of PM-induced MRC-5 cell lines. Talanta 2018 J. Li, N. Chen, Y. Tian, H. Xu
Blood rheology in children with the S/β+-thalassemia syndrome. Clin. Hemorheol. Microcirc. 2018 C. Renoux, P. Joly, A. Gauthier, V. Pialoux, C. Romanet-Faes, Y. Bertrand, N. Garnier, D. Cuzzubbo, G. Cannas, P. Connes
Cancer breath testing: a patent review. Expert Opin Ther Pat 2018 KMM. Kabir, WA. Donald
Effects of leukotriene D4 and histamine nasal challenge on airway responsiveness and inflammation in persistent allergic rhinitis patients. Clin Respir J 2018 Z. Zhu, Y. Xie, W. Guan, Y. Gao, S. Xia, R. Huang, N. Zhong, J. Zheng
Associated compounds
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Other All
Name Structure Number of references
Urea Imgsrv 1130
Nitric oxide Imgsrv 276
Acetone Imgsrv 275
Hydrogen peroxide Imgsrv 209
Nitrate Imgsrv 183
Ethylbenzene Imgsrv 143
Adenosine triphosphate Imgsrv 134
Octanoic acid Imgsrv 126
2-methylbuta-1,3-diene Imgsrv 121
8-epi-PGF2alpha Imgsrv 120