8-epi-PGF2alpha

Description

Description of 8-epi-PGF2alpha with associated disease summary

8-isoprostane is a known biomarker of oxidative stress. It is synthesized in vivo, it is a stable metabolite, and biologically active, which makes it a favorable biomarker. These characteristics make 8-isoprostane a promising marker of oxidative stress in inflammatory respiratory diseases (Pediatr Crit Care Med. (2011)). 8-isoprostane elevation is most notably reported in individuals with asthma, COPD, obstructive sleep apnea, airway inflammation, and related pulmonary diseases, but the increased concentration of 8-isoprostane may not directly correlate to the increase or decrease of other markers, such as superoxide anion from BALF cells (Inflamm Res. (2010)), or pH (Br J Dermatol. (2012)). 8-isoprostane is a proposed prognostic lipid mediator that can be measured to predict an individual's associative risk of developing the following conditions or diseases: allergic rhinitis, asbestosis, asthma, atopic dermatitis, chronic cough, COPD, cystic fibrosis, heart failure, obstructive sleep apnea, primary ciliary dyskinesia, sarcoidosis, status asthmaticus, steroid-naïve atopic asthmatic, systemic sclerosis. 8-isoprostane is most commonly identified through enzyme immunoassays (EIA), although many forms of tests (including breath tests, bronchodilation tests, 6-minute walking test, incremental exercise test etc.) have been performed to assess the pathophysiologic role of 8-isoprostane in patients. It is worth mentioning that most studies are limited by the number of patients enrolled, and although there are a number of studies conducted with adult healthy volunteers and patients, the number of studies conducted with children (age 7-18) are far less in number (Pediatr Crit Care Med. (2012)). Most of the studies use EIA kit to identify 8-isoprostane, and validate using mass spectrometry; this method is common used and has acceptable repeatability. To increase reproducibility of these results, it is recommended that a condenser system with a silicon or glass coating be used in the collection and measurement of EBC (Eur Respir J. (2008)). Description of disease(s) related to 8-isoprostane:

Asbestosis

Significant increase in the concentration of 8-isoprostane was found in EBC of subjects with asbestosis, compared to normal subjects.

Asthma

Airway oxidative stress may be involved in asthma-associated cough, and the increase in 8-isoprostane concentration may be associated with the clinical severity of cough. The direct correlation between 8-isoprostane concentrations and cough severity is unclear, and more studies need to be conducted to understand the mechanism behind asthma associated cough, however, the EBC levels of 8-isoprostane could be used as a marker for post-treatment studies as well. For example, before and after anti-inflammatory drug treatment (inhaled corticosteroids etc.) in childhood asthma.

Atopic dermatitis

It was indicated that 1mL of EBC condensate is sufficient for analysis, and the level of 8-isoprostane was noted as doubled in mild asthma and greater in moderate-severe asthma, reflecting small airway inflammation. Study suggests 8-isoprostane could be a sensitive marker for assessing progressive atopic march or lung inflammation too.

Chronic cough

While mechanisms of chronic cough are unclear, there is a correlation between significantly higher 8-isoprostane level and chronic cough. This increase is also associated with higher Leicester Cough Questionnaire total score.

COPD

Significantly higher concentrations of 8-isoprostane was observed in COPD patients, especially in patients with exacerbated COPD. However, the link between 8-isoprostane increase in COPD patients with other conditions is unclear, for example the level of 8-isoprostane in COPD patients with chronically colonized with H. influenza during stable phase or dynamic hyperinflation is elevated, but interestingly not more so in COPD patients with cardiovascular diseases (CVD).

Cystic Fibrosis

Significantly higher 8-isoprostane level was observed in stable CF patients compared to controls, and even higher level of exhaled 8-isoprostane was noted for patients with unstable CF.

Heart Failure

Higher 8-isoprostane level was noted for patients with chronic HF compared to healthy control subjects, and even higher 8-isoprostane level was observed for patients with acute HF.

Obstructive Sleep Apnoea

8-isoprostane concentration is positively correlated with apnea/hypopnea index, or the overall disease severity of OSA.

Primary Ciliary Dyskinesia

8-isoprostane concentrations in EBC of children with stable PCD were significantly increased compared to normal controls.

Sarcoidosis

8-isoprostane is increased in sarcoidosis patients, but there was no correlation between 8-isoprostane and spontaneous or stimulated superoxide anion release from BALF cells.

Status Asthmaticus

Elevated level of 8-isoprostane was observed in the EBC of children recovering from status asthmaticus. The measurements of 8-isoprostane from EBC could assist in the study of and provide insight into the biochemical changes of oxidative stress in children.

Steroid-naïve atopic asthmatic

Asthmatic children have higher concentrations of 8-isoprostane in EBC.

Systemic Sclerosis

8-isoprostane levels were increased in patients with systemic sclerosis. This study indicates that collection of EBC is a possible non-invasive assessment method for disease progression and therapy evaluation.

Summary of extracted biomedical information

8-epi-pgf2alpha is associated with abnormalities such as Asthma, Chronic Obstructive Airway Disease, Cystic Fibrosis, Obesity and Lung Diseases, Interstitial. The involved biomedical functions are known as Exhalation, Inflammation, Lipid Peroxidation, Respiration and Respiratory physiology. The associated genes/proteins with 8-epi-PGF2alpha are CYP1A1 gene, ANP32B gene, UCP2 gene, LTA gene and NR3C1 gene. 8-epi-pgf2alpha is associated with Carbon, Ozone, Aluminum, Malondialdehyde and Superoxides.
Imgsrv

Associated references with human 66

Download references
Reference title

with link to reference page

Journal Year Authors & PubMed Link
Concentration of 8-isoprostanes in the exhaled breath condensate as a marker of oxidative stress in patients with type 1 diabetes. Adv Respir Med 2018 A. Pękala-Wojciechowska, M. Poznański, K. Szyszow, A. Antczak
Adv Respir Med 2018 ;86(1):3-6. PubMed:29490415
Global DNA methylation and oxidative stress biomarkers in workers exposed to metal oxide nanoparticles. J. Hazard. Mater. 2017 SH. Liou, WT. Wu, HY. Liao, CY. Chen, CY. Tsai, WT. Jung, HL. Lee
J. Hazard. Mater. 2017 Jun;331:329-335. PubMed:28273583
Biomarkers in adult asthma: a systematic review of 8-isoprostane in exhaled breath condensate. J Breath Res 2017 AM. Peel, CJ. Crossman-Barnes, J. Tang, SJ. Fowler, GA. Davies, AM. Wilson, YK. Loke
J Breath Res 2017 02;11(1):016011. PubMed:28102831
Cardio-Respiratory Effects of Air Pollution in a Panel Study of Outdoor Physical Activity and Health in Rural Older Adults. J. Occup. Environ. Med. 2017 DM. Stieb, R. Shutt, L. Kauri, S. Mason, L. Chen, M. Szyszkowicz, NA. Dobbin, M. Rigden, B. Jovic, M. Mulholland, MS. Green, L. Liu, G. Pelletier, SA. Weichenthal, RE. Dales, I. Luginaah
J. Occup. Environ. Med. 2017 04;59(4):356-364. PubMed:28628045
Post-prandial systemic 8-isoprostane increases after consumption of moderate and high-fat meals in insufficiently active males. Nutr Res 2017 SP. Kurti, SR. Emerson, SK. Rosenkranz, CS. Teeman, EM. Emerson, BJ. Cull, JR. Smith, CA. Harms
Nutr Res 2017 Mar;39:61-68. PubMed:28385290
8-isoprostane as Oxidative Stress Marker in Coal Mine Workers. Biomed. Environ. Sci. 2016 Z. Zimet, M. Bilban, M. Marc Malovrh, P. Korošec, B. Poljšak, J. Osredkar, M. Šilar
Biomed. Environ. Sci. 2016 Aug;29(8):589-593. PubMed:27660223
[Airway oxidative stress and inflammation markers in chronic obstructive pulmonary diseases(COPD) patients are linked with exposure to traffic-related air pollution: a panel study]. Zhonghua Yu Fang Yi Xue Za Zhi 2016 J. Chen, Q. Zhao, BB. Liu, J. Wang, HB. Xu, Y. Zhang, XM. Song, B. He, W. Huang
Zhonghua Yu Fang Yi Xue Za Zhi 2016 May;50(5):411-7. PubMed:27141896
Snoring as a Determinant Factor of Oxidative Stress in the Airway of Patients with Obstructive Sleep Apnea. Lung 2016 R. Fernandez Alvarez, G. Rubinos Cuadrado, R. Alonso Arias, JA. Cascon Hernandez, B. Palomo Antequera, M. Iscar Urrutia, P. Casan Clara
Lung 2016 06;194(3):469-73. PubMed:27048175
Exhaled and non-exhaled non-invasive markers for assessment of respiratory inflammation in patients with stable COPD and healthy smokers. J Breath Res 2016 G. Santini, N. Mores, R. Shohreh, S. Valente, M. Dabrowska, A. Trové, G. Zini, P. Cattani, L. Fuso, A. Mautone, C. Mondino, G. Pagliari, A. Sala, G. Folco, M. Aiello, R. Pisi, A. Chetta, M. Losi, E. Clini, G. Ciabattoni, P. Montuschi
J Breath Res 2016 Jan;10(1):017102. PubMed:26814886
Increased exhaled breath condensate 8-isoprostane after a swimming session in competitive swimmers. Eur J Sport Sci 2016 MC. Morissette, N. Murray, J. Turmel, J. Milot, LP. Boulet, V. Bougault
Eur J Sport Sci 2016 Aug;16(5):569-76. PubMed:26279287
Systemic inflammation and oxidative stress post-lung resection: Effect of pretreatment with N-acetylcysteine. Respirology 2016 AJ. Bastin, N. Davies, E. Lim, GJ. Quinlan, MJ. Griffiths
Respirology 2016 Jan;21(1):180-7. PubMed:26503312
Endothelial dysfunction and oxidative stress in children with sleep disordered breathing: role of NADPH oxidase. Atherosclerosis 2015 L. Loffredo, AM. Zicari, F. Occasi, L. Perri, R. Carnevale, F. Angelico, M. Del Ben, F. Martino, C. Nocella, V. Savastano, A. Cesoni Marcelli, M. Duse, F. Violi
Atherosclerosis 2015 May;240(1):222-7. PubMed:25805361
Domestic airborne black carbon levels and 8-isoprostane in exhaled breath condensate among children in New York City. Environ. Res. 2014 MJ. Rosa, B. Yan, SN. Chillrud, LM. Acosta, A. Divjan, JS. Jacobson, RL. Miller, IF. Goldstein, MS. Perzanowski
Environ. Res. 2014 Nov;135:105-10. PubMed:25262082
Airway oxidative stress and inflammation markers in exhaled breath from children are linked with exposure to black carbon. Environ Int 2014 S. De Prins, E. Dons, M. Van Poppel, L. Int Panis, E. Van de Mieroop, V. Nelen, B. Cox, TS. Nawrot, C. Teughels, G. Schoeters, G. Koppen
Environ Int 2014 Dec;73:440-6. PubMed:25244707
8-Isoprostane in exhaled breath condensate of patients with non-small cell lung cancer: the effect of chemotherapy. Anticancer Res. 2014 D. Stathopoulos, S. Loukides, K. Syrigos
Anticancer Res. 2014 Sep;34(9):5143-5. PubMed:25202105
Oxidative stress in cystic fibrosis patients with Burkholderia cenocepacia airway colonization: relation of 8-isoprostane concentration in exhaled breath condensate to lung function decline. Folia Microbiol. (Praha) 2014 L. Fila, A. Grandcourtová, J. Chládek, J. Musil
Folia Microbiol. (Praha) 2014 May;59(3):217-22. PubMed:24132725
Influence of CPAP treatment on airway and systemic inflammation in OSAS patients. Sleep Breath 2014 H. Karamanlı, D. Özol, KS. Ugur, Z. Yıldırım, F. Armutçu, B. Bozkurt, R. Yigitoglu
Sleep Breath 2014 May;18(2):251-6. PubMed:22945540
Urinary concentration of 8-isoprostane as marker of severity of pediatric OSAS. Sleep Breath 2014 MP. Villa, MC. Supino, S. Fedeli, J. Rabasco, O. Vitelli, M. Del Pozzo, G. Gentile, L. Lionetto, M. Barreto, M. Simmaco
Sleep Breath 2014 Dec;18(4):723-9. PubMed:24436094
Oxidative stress in adolescent passive smokers living in urban and rural environments. Int J Hyg Environ Health 2014 R. Bono, V. Bellisario, V. Romanazzi, V. Pirro, P. Piccioni, M. Pazzi, M. Bugiani, M. Vincenti
Int J Hyg Environ Health 2014 Mar;217(2-3):287-93. PubMed:23890683
Cysteinyl leukotriene levels correlate with 8-isoprostane levels in exhaled breath condensates of atopic and healthy children. Pediatr. Res. 2013 GH. Wan, DC. Yan, HY. Tseng, TH. Tung, SJ. Lin, YW. Lin
Pediatr. Res. 2013 Nov;74(5):584-91. PubMed:24153334
Evaluation of oxidative status with exhaled breath 8-isoprostane levels in patients with hyperthyroidism. Endocr Metab Immune Disord Drug Targets 2013 E. Bastug, T. Tasliyurt, F. Kutluturk, S. Sahin, A. Yilmaz, H. Sivgin, BM. Yelken, B. Ozturk, A. Yilmaz, S. Sahin
Endocr Metab Immune Disord Drug Targets 2013 Dec;13(4):306-10. PubMed:24107071
Effect of allergen inhalation on airway oxidant stress, using exhaled breath condensate 8-isoprostane, in mild asthma. J Asthma 2013 A. Sood, C. Qualls, J. Seagrave, J. McDonald, R. Shohreh, A. Chiavaroli, M. Schuyler
J Asthma 2013 Jun;50(5):449-56. PubMed:23461590
Traffic-related air pollutants and exhaled markers of airway inflammation and oxidative stress in New York City adolescents. Environ. Res. 2013 MM. Patel, SN. Chillrud, KC. Deepti, JM. Ross, PL. Kinney
Environ. Res. 2013 Feb;121:71-8. PubMed:23177171
Sex-specific differences in hyperoxic lung injury in mice: implications for acute and chronic lung disease in humans. Toxicol. Appl. Pharmacol. 2013 K. Lingappan, W. Jiang, L. Wang, XI. Couroucli, R. Barrios, B. Moorthy
Toxicol. Appl. Pharmacol. 2013 Oct;272(2):281-90. PubMed:23792423
Obesity and asthma: a coincidence or a causal relationship? A systematic review. Respir Med 2013 Z. Ali, CS. Ulrik
Respir Med 2013 Sep;107(9):1287-300. PubMed:23642708
15-F₂t isoprostane as biomarker of oxidative stress induced by tobacco smoke and occupational exposure to formaldehyde in workers of plastic laminates. Sci. Total Environ. 2013 V. Romanazzi, V. Pirro, V. Bellisario, G. Mengozzi, M. Peluso, M. Pazzi, M. Bugiani, G. Verlato, R. Bono
Sci. Total Environ. 2013 Jan;442:20-5. PubMed:23178760
Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled study. J. Pineal Res. 2012 AG. de Matos Cavalcante, PF. de Bruin, VM. de Bruin, DM. Nunes, ED. Pereira, MM. Cavalcante, GM. Andrade
J. Pineal Res. 2012 Oct;53(3):238-44. PubMed:22507631
Somatostatin receptor scintigraphy in sarcoidosis: relation to selected clinical and laboratory markers. Pol. Arch. Med. Wewn. 2012 WJ. Piotrowski, M. Bieńkiewicz, I. Frieske, J. Marczak, A. Antczak, P. Górski, J. Kuśmierek, A. Płachcińska
Pol. Arch. Med. Wewn. 2012 ;122(3):98-106. PubMed:22249433
Exhaled breath condensate: a breathalyzer for lung inflammation. Pediatr Crit Care Med 2012 JJ. Zimmerman
Pediatr Crit Care Med 2012 Mar;13(2):212-4. PubMed:22391827
Correlation between eicosanoids in bronchoalveolar lavage fluid and in exhaled breath condensate. Dis. Markers 2011 A. Antczak, W. Piotrowski, J. Marczak, M. Ciebiada, P. Gorski, PJ. Barnes
Dis. Markers 2011 ;30(5):213-20. PubMed:21734340
Short-term changes in respiratory biomarkers after swimming in a chlorinated pool. Environ. Health Perspect. 2010 L. Font-Ribera, M. Kogevinas, JP. Zock, FP. Gómez, E. Barreiro, MJ. Nieuwenhuijsen, P. Fernandez, C. Lourencetti, M. Pérez-Olabarría, M. Bustamante, R. Marcos, JO. Grimalt, CM. Villanueva
Environ. Health Perspect. 2010 Nov;118(11):1538-44. PubMed:20833607
Oxidative stress and airway inflammation after allergen challenge evaluated by exhaled breath condensate analysis. Clin. Exp. Allergy 2010 L. Brussino, I. Badiu, S. Sciascia, M. Bugiani, E. Heffler, G. Guida, A. Malinovschi, C. Bucca, G. Rolla
Clin. Exp. Allergy 2010 Nov;40(11):1642-7. PubMed:20726860
Health changes in fishermen 2 years after clean-up of the Prestige oil spill. Ann. Intern. Med. 2010 G. Rodríguez-Trigo, JP. Zock, F. Pozo-Rodríguez, FP. Gómez, G. Monyarch, L. Bouso, MD. Coll, H. Verea, JM. Antó, C. Fuster, JA. Barberà, .
Ann. Intern. Med. 2010 Oct;153(8):489-98. PubMed:20733177
Assessment of airway inflammation by exhaled breath condensate and impedance due to gastroesophageal reflux disease (GERD). Inflamm Allergy Drug Targets 2009 Y. Shimizu, K. Dobashi, A. Nagoshi, O. Kawamura, M. Mori
Inflamm Allergy Drug Targets 2009 Sep;8(4):292-6. PubMed:19754413
Measurement of nitric oxide and 8-isoprostane in exhaled breath of children with atopic eczema. Clin. Exp. Dermatol. 2009 C. Zinelli, C. Caffarelli, J. Strid, A. Jaffe, DJ. Atherton
Clin. Exp. Dermatol. 2009 Jul;34(5):607-12. PubMed:19508477
Reduced exhaled breath condensate pH in asthmatic smokers using inhaled corticosteroids. Respirology 2009 B. Kane, Z. Borrill, T. Southworth, A. Woodcock, D. Singh
Respirology 2009 Apr;14(3):419-23. PubMed:19353777
Comparison of 8-isoprostane and interleukin-8 in induced sputum and exhaled breath condensate from asymptomatic and symptomatic smokers. Respiration 2009 W. Mazur, H. Stark, A. Sovijärvi, M. Myllärniemi, VL. Kinnula
Respiration 2009 ;78(2):209-16. PubMed:19252398
Impact of age on pH, 8-isoprostane, and nitrogen oxides in exhaled breath condensate. Chest 2009 MJ. Cruz, S. Sánchez-Vidaurre, PV. Romero, F. Morell, X. Muñoz
Chest 2009 Feb;135(2):462-467. PubMed:19017879
VEGF, TNF-alpha and 8-isoprostane levels in exhaled breath condensate and serum of patients with lung cancer. Lung Cancer 2009 E. Dalaveris, T. Kerenidi, A. Katsabeki-Katsafli, T. Kiropoulos, K. Tanou, KI. Gourgoulianis, K. Kostikas
Lung Cancer 2009 May;64(2):219-25. PubMed:18845357
8-Isoprostane in exhaled breath condensate and exercise-induced bronchoconstriction in asthmatic children and adolescents. Chest 2009 M. Barreto, MP. Villa, C. Olita, S. Martella, G. Ciabattoni, P. Montuschi
Chest 2009 Jan;135(1):66-73. PubMed:18753466
Exhaled breath condensate cytokine level as a diagnostic tool for obstructive sleep apnea syndrome. Sleep Med. 2009 Y. Li, V. Chongsuvivatwong, A. Geater, A. Liu
Sleep Med. 2009 Jan;10(1):95-103. PubMed:18207457
Persistence of oxidant and protease burden in the airways after smoking cessation. BMC Pulm Med 2009 N. Louhelainen, P. Rytilä, T. Haahtela, VL. Kinnula, R. Djukanović
BMC Pulm Med 2009 May;9:25. PubMed:19473482
Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure. Ind Health 2008 D. Pelclová, Z. Fenclová, P. Kacer, M. Kuzma, T. Navrátil, J. Lebedová
Ind Health 2008 Oct;46(5):484-9. PubMed:18840939
Leukotrienes and 8-isoprostane in exhaled breath condensate in bronchoprovocation tests with occupational allergens. Prostaglandins Leukot. Essent. Fatty Acids 2008 P. Klusackova, J. Lebedova, P. Kacer, M. Kuzma, M. Brabec, D. Pelclova, Z. Fenclova, T. Navratil
Prostaglandins Leukot. Essent. Fatty Acids 2008 Apr-May;78(4-5):281-92. PubMed:18513935
Chronic obstructive pulmonary disease phenotyping: a possible role for 8-isoprostane measurement in exhaled breath condensate? Respiration 2008 P. Montuschi
Respiration 2008 ;75(2):134-5. PubMed:18332620
Are biomarker levels a good follow-up tool for evaluating obstructive sleep apnea syndrome treatments? Respiration 2008 Y. Li, V. Chongsuvivatwong, A. Geater, A. Liu
Respiration 2008 ;76(3):317-23. PubMed:18311073
The value of sputum 8-isoprostane in detecting oxidative stress in mild asthma. J Asthma 2008 N. Louhelainen, P. Rytilä, Y. Obase, M. Mäkelä, T. Haahtela, VL. Kinnula, A. Pelkonen
J Asthma 2008 Mar;45(2):149-54. PubMed:18350407
Collection devices influence the constituents of exhaled breath condensate. Eur. Respir. J. 2007 J. Liu, DH. Conrad, S. Chow, VH. Tran, DH. Yates, PS. Thomas
Eur. Respir. J. 2007 Oct;30(4):807-8. PubMed:17906090
Proton pump inhibitor improves breath marker in moderate asthma with gastroesophageal reflux disease. Respiration 2007 Y. Shimizu, K. Dobashi, JJ. Zhao, T. Kawata, A. Ono, N. Yanagitani, K. Kaira, M. Utsugi, T. Hisada, T. Ishizuka, M. Mori
Respiration 2007 ;74(5):558-64. PubMed:17389779
Inflammatory proteins in patients with obstructive sleep apnea with and without daytime sleepiness. Sleep Breath 2007 Mde L. Bravo, LD. Serpero, A. Barceló, F. Barbé, A. Agustí, D. Gozal
Sleep Breath 2007 Sep;11(3):177-85. PubMed:17279423
Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate. Eur. Respir. J. 2006 PP. Rosias, CM. Robroeks, HJ. Niemarkt, AD. Kester, JH. Vernooy, J. Suykerbuyk, J. Teunissen, J. Heynens, HJ. Hendriks, Q. Jöbsis, E. Dompeling
Eur. Respir. J. 2006 Nov;28(5):1036-41. PubMed:16870660
Safety and feasibility of exhaled breath condensate collection in ventilated infants and children. Eur. Respir. J. 2006 WG. Muller, F. Morini, S. Eaton, M. Peters, A. Jaffe
Eur. Respir. J. 2006 Sep;28(3):479-85. PubMed:16641124
Effects of short-term isocapnic hyperoxia and hypoxia on cardiovascular function. J. Appl. Physiol. 2006 AJ. Thomson, GB. Drummond, WS. Waring, DJ. Webb, SR. Maxwell
J. Appl. Physiol. 2006 Sep;101(3):809-16. PubMed:16902069
Airway inflammation in subjects with gastro-oesophageal reflux and gastro-oesophageal reflux-related asthma. J. Intern. Med. 2006 GE. Carpagnano, O. Resta, MT. Ventura, AC. Amoruso, G. Di Gioia, T. Giliberti, L. Refolo, MP. Foschino-Barbaro
J. Intern. Med. 2006 Mar;259(3):323-31. PubMed:16476110
Inflammatory mediators in exhaled breath, induced sputum and saliva. Clin. Exp. Allergy 2005 JL. Simpson, LG. Wood, PG. Gibson
Clin. Exp. Allergy 2005 Sep;35(9):1180-5. PubMed:16164445
Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: effect of carbocysteine lysine salt monohydrate (SCMC-Lys). Eur. J. Pharmacol. 2004 GE. Carpagnano, O. Resta, MP. Foschino-Barbaro, A. Spanevello, A. Stefano, G. Di Gioia, G. Serviddio, E. Gramiccioni
Eur. J. Pharmacol. 2004 Nov;505(1-3):169-75. PubMed:15556150
8-Isoprostane, a marker of oxidative stress, is increased in the expired breath condensate of patients with pulmonary sarcoidosis. Chest 2004 K. Psathakis, G. Papatheodorou, M. Plataki, P. Panagou, S. Loukides, NM. Siafakas, D. Bouros
Chest 2004 Mar;125(3):1005-11. PubMed:15006961
8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy. Chest 2003 GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes
Chest 2003 Oct;124(4):1386-92. PubMed:14555570
Increased exhaled 8-isoprostane in childhood asthma. Chest 2003 E. Baraldi, L. Ghiro, V. Piovan, S. Carraro, G. Ciabattoni, PJ. Barnes, P. Montuschi
Chest 2003 Jul;124(1):25-31. PubMed:12853498
Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide. Free Radic. Biol. Med. 2002 P. Montuschi, JA. Nightingale, SA. Kharitonov, PJ. Barnes
Free Radic. Biol. Med. 2002 Nov;33(10):1403-8. PubMed:12419472
Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am. J. Respir. Crit. Care Med. 2000 P. Montuschi, JV. Collins, G. Ciabattoni, N. Lazzeri, M. Corradi, SA. Kharitonov, PJ. Barnes
Am. J. Respir. Crit. Care Med. 2000 Sep;162(3 Pt 1):1175-7. PubMed:10988150
Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis. Thorax 2000 P. Montuschi, SA. Kharitonov, G. Ciabattoni, M. Corradi, L. van Rensen, DM. Geddes, ME. Hodson, PJ. Barnes
Thorax 2000 Mar;55(3):205-9. PubMed:10679539
Exhaled breath condensate isoprostanes are elevated in patients with acute lung injury or ARDS. Chest 1998 CT. Carpenter, PV. Price, BW. Christman
Chest 1998 Dec;114(6):1653-9. PubMed:9872202
The efficacy of single-high dose inhaled corticosteroid versus oral prednisone treatment on exhaled leukotriene and 8-isoprostane levels in mild to moderate asthmatic children with asthma exacerbation. Allergol Immunopathol (Madr) O. Keskin, U. Uluca, M. Keskin, B. Gogebakan, E. Kucukosmanoglu, MY. Ozkars, S. Kul, H. Bayram, Y. Coskun
Allergol Immunopathol (Madr) 2016 Mar-Apr;44(2):138-48. PubMed:26318413
Evaluation of oxidative stress using exhaled breath 8-isoprostane levels on chronic kidney disease. Niger J Clin Pract BS. Tiryaki, T. Tasliyurt, BM. Yelken, S. Sahin, F. Kutluturk, HI. Koseoglu, B. Ozturk, A. Yilmaz, S. Sahin
Niger J Clin Pract 2014 May-Jun;17(3):356-60. PubMed:24714017
ROCK activation in lung of idiopathic pulmonary fibrosis with oxidative stress. Int J Immunopathol Pharmacol Y. Shimizu, K. Dobashi, T. Sano, M. Yamada
Int J Immunopathol Pharmacol 2014 Jan-Mar;27(1):37-44. PubMed:24674677

Associated curated diseases 18

Download diseases

Associated disease mapping

Mapping of all associated diseases to 8-epi-PGF2alpha is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Asbestosis MeSH: Asbestosis
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
Link to MeSH Database: D001195
4
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
91
Occupational Asthma (Oa) MeSH: Asthma, Occupational
Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE. Year introduced: 2012
Link to MeSH Database: D059366
1
Status Asthmaticus MeSH: Status Asthmaticus
A sudden intense and continuous aggravation of a state of asthma, marked by dyspnea to the point of exhaustion and collapse and not responding to the usual therapeutic efforts. Year introduced: 1991(1985)
Link to MeSH Database: D013224
2
Chronic Cough MeSH: Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Link to MeSH Database: D002908
2
Cystic Fibrosis MeSH: Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967
Link to MeSH Database: D003550
20
Upper And Lower Airway Inflammation In Atopic Dermatitis (Ad) MeSH: Dermatitis, Atopic
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
Link to MeSH Database: D003876
4
Heart Failure MeSH: Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. Year introduced: 2008 (1966)
Link to MeSH Database: D006333
1
Primary Ciliary Dyskinesia MeSH: Kartagener Syndrome
An autosomal recessive disorder characterized by a triad of DEXTROCARDIA; INFERTILITY; and SINUSITIS. The syndrome is caused by mutations of DYNEIN genes encoding motility proteins which are components of sperm tails, and CILIA in the respiratory and the reproductive tracts. Year introduced: 2002 (1963)
Link to MeSH Database: D007619
2
Cough MeSH: Cough
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
Link to MeSH Database: D003371
2
Non Small Cell Lung Cancer, Lung Neoplasms MeSH: Lung Neoplasms
Tumors or cancer of the LUNG.
Link to MeSH Database: D008175
4
Occupational Respiratory Diseases MeSH: Respiration Disorders
Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available. Year introduced: 1977
Link to MeSH Database: D012120
1
Allergic Rhinitis With Asthma MeSH: Rhinitis, Allergic, Perennial
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc. Year introduced: 1980
Link to MeSH Database: D012221
5
Sarcoidosis MeSH: Sarcoidosis
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands. Year introduced: PSEUDOTUBERCULOSIS use SARCOIDOSIS 1963-1992
Link to MeSH Database: D012507
4
Systemic Sclerosis MeSH: Scleroderma, Systemic
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA. Year introduced: 1971
Link to MeSH Database: D012595
1
Obstructive Sleep Apnea MeSH: Sleep Apnea, Obstructive
A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395) Year introduced: 2000
Link to MeSH Database: D020181
7
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31
Non Small Cell Lung Cancer, Carcinoma MeSH: Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy. Year introduced: 1994
Link to MeSH Database: D002289
2

Associated abnormalities 14

Concept Name External ID Weighted Score Hits References
Asthma ICD9-CM:493.9 1000.0 11
  1. Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis.
    P. Montuschi, SA. Kharitonov, G. Ciabattoni, M. Corradi, L. van Rensen, DM. Geddes, ME. Hodson, PJ. Barnes (2000) Thorax
  2. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide.
    P. Montuschi, JA. Nightingale, SA. Kharitonov, PJ. Barnes (2002) Free Radic. Biol. Med.
  3. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
  4. Increased exhaled 8-isoprostane in childhood asthma.
    E. Baraldi, L. Ghiro, V. Piovan, S. Carraro, G. Ciabattoni, PJ. Barnes, P. Montuschi (2003) Chest
  5. Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate.
    PP. Rosias, CM. Robroeks, HJ. Niemarkt, AD. Kester, JH. Vernooy, J. Suykerbuyk, J. Teunissen, J. Heynens, HJ. Hendriks, Q. Jöbsis, E. Dompeling (2006) Eur. Respir. J.
  6. Impact of age on pH, 8-isoprostane, and nitrogen oxides in exhaled breath condensate.
    MJ. Cruz, S. Sánchez-Vidaurre, PV. Romero, F. Morell, X. Muñoz (2009) Chest
  7. Traffic-related air pollutants and exhaled markers of airway inflammation and oxidative stress in New York City adolescents.
    MM. Patel, SN. Chillrud, KC. Deepti, JM. Ross, PL. Kinney (2013) Environ. Res.
  8. Domestic airborne black carbon levels and 8-isoprostane in exhaled breath condensate among children in New York City.
    MJ. Rosa, B. Yan, SN. Chillrud, LM. Acosta, A. Divjan, JS. Jacobson, RL. Miller, IF. Goldstein, MS. Perzanowski (2014) Environ. Res.
  9. Airway oxidative stress and inflammation markers in exhaled breath from children are linked with exposure to black carbon.
    S. De Prins, E. Dons, M. Van Poppel, L. Int Panis, E. Van de Mieroop, V. Nelen, B. Cox, TS. Nawrot, C. Teughels, G. Schoeters, G. Koppen (2014) Environ Int
Chronic Obstructive Airway Disease 739.04 5
  1. Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis.
    P. Montuschi, SA. Kharitonov, G. Ciabattoni, M. Corradi, L. van Rensen, DM. Geddes, ME. Hodson, PJ. Barnes (2000) Thorax
  2. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
  3. Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: effect of carbocysteine lysine salt monohydrate (SCMC-Lys).
    GE. Carpagnano, O. Resta, MP. Foschino-Barbaro, A. Spanevello, A. Stefano, G. Di Gioia, G. Serviddio, E. Gramiccioni (2004) Eur. J. Pharmacol.
  4. Impact of age on pH, 8-isoprostane, and nitrogen oxides in exhaled breath condensate.
    MJ. Cruz, S. Sánchez-Vidaurre, PV. Romero, F. Morell, X. Muñoz (2009) Chest
Cystic Fibrosis ICD9-CM:277.0 1000.0 5
  1. Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis.
    P. Montuschi, SA. Kharitonov, G. Ciabattoni, M. Corradi, L. van Rensen, DM. Geddes, ME. Hodson, PJ. Barnes (2000) Thorax
  2. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
  3. Impact of age on pH, 8-isoprostane, and nitrogen oxides in exhaled breath condensate.
    MJ. Cruz, S. Sánchez-Vidaurre, PV. Romero, F. Morell, X. Muñoz (2009) Chest
Respiratory Distress Syndrome, Adult 523.36 2
  1. Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis.
    P. Montuschi, SA. Kharitonov, G. Ciabattoni, M. Corradi, L. van Rensen, DM. Geddes, ME. Hodson, PJ. Barnes (2000) Thorax
Lung Diseases, Interstitial 972.22 2
  1. Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis.
    P. Montuschi, SA. Kharitonov, G. Ciabattoni, M. Corradi, L. van Rensen, DM. Geddes, ME. Hodson, PJ. Barnes (2000) Thorax
  2. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
Obesity 777.14 2
  1. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
  2. Obesity and asthma: a coincidence or a causal relationship? A systematic review.
    Z. Ali, CS. Ulrik (2013) Respir Med
Rhinitis 1000.0 2
  1. Leukotrienes and 8-isoprostane in exhaled breath condensate in bronchoprovocation tests with occupational allergens.
    P. Klusackova, J. Lebedova, P. Kacer, M. Kuzma, M. Brabec, D. Pelclova, Z. Fenclova, T. Navratil (2008) Prostaglandins Leukot. Essent. Fatty Acids
  2. Oxidative stress in adolescent passive smokers living in urban and rural environments.
    R. Bono, V. Bellisario, V. Romanazzi, V. Pirro, P. Piccioni, M. Pazzi, M. Bugiani, M. Vincenti (2014) Int J Hyg Environ Health
Bronchitis ICD9-CM:490 1000.0 1
  1. Oxidative stress in adolescent passive smokers living in urban and rural environments.
    R. Bono, V. Bellisario, V. Romanazzi, V. Pirro, P. Piccioni, M. Pazzi, M. Bugiani, M. Vincenti (2014) Int J Hyg Environ Health
Cardiovascular Diseases ICD9-CM:429.2 975.25 1
  1. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
Sleep Apnea Syndromes 696.73 1
  1. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
Lung diseases 1000.0 1
  1. Oxidative stress in adolescent passive smokers living in urban and rural environments.
    R. Bono, V. Bellisario, V. Romanazzi, V. Pirro, P. Piccioni, M. Pazzi, M. Bugiani, M. Vincenti (2014) Int J Hyg Environ Health
Respiratory morbidity 1000.0 1
  1. Traffic-related air pollutants and exhaled markers of airway inflammation and oxidative stress in New York City adolescents.
    MM. Patel, SN. Chillrud, KC. Deepti, JM. Ross, PL. Kinney (2013) Environ. Res.
Respiration Disorders ICD9-CM:519.9 951.44 1
  1. Impact of age on pH, 8-isoprostane, and nitrogen oxides in exhaled breath condensate.
    MJ. Cruz, S. Sánchez-Vidaurre, PV. Romero, F. Morell, X. Muñoz (2009) Chest
Childhood asthma 987.63 1
  1. Increased exhaled 8-isoprostane in childhood asthma.
    E. Baraldi, L. Ghiro, V. Piovan, S. Carraro, G. Ciabattoni, PJ. Barnes, P. Montuschi (2003) Chest

Associated chemicals 5

Concept Name External ID Definition Weighted Score Hits References
Aluminum CHEBI:28984 1000.0 2
  1. Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate.
    PP. Rosias, CM. Robroeks, HJ. Niemarkt, AD. Kester, JH. Vernooy, J. Suykerbuyk, J. Teunissen, J. Heynens, HJ. Hendriks, Q. Jöbsis, E. Dompeling (2006) Eur. Respir. J.
Saline 1000.0 1
  1. Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate.
    PP. Rosias, CM. Robroeks, HJ. Niemarkt, AD. Kester, JH. Vernooy, J. Suykerbuyk, J. Teunissen, J. Heynens, HJ. Hendriks, Q. Jöbsis, E. Dompeling (2006) Eur. Respir. J.
Nitrate 956.75 1
  1. Impact of age on pH, 8-isoprostane, and nitrogen oxides in exhaled breath condensate.
    MJ. Cruz, S. Sánchez-Vidaurre, PV. Romero, F. Morell, X. Muñoz (2009) Chest
Deuterium 848.25 1
  1. Leukotrienes and 8-isoprostane in exhaled breath condensate in bronchoprovocation tests with occupational allergens.
    P. Klusackova, J. Lebedova, P. Kacer, M. Kuzma, M. Brabec, D. Pelclova, Z. Fenclova, T. Navratil (2008) Prostaglandins Leukot. Essent. Fatty Acids
Carbon CHEBI:33415 914.75 1
  1. Traffic-related air pollutants and exhaled markers of airway inflammation and oxidative stress in New York City adolescents.
    MM. Patel, SN. Chillrud, KC. Deepti, JM. Ross, PL. Kinney (2013) Environ. Res.

Associated functions 24

Concept Name External ID Definition Weighted Score Hits References
Exhalation 715.91 11
  1. Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis.
    P. Montuschi, SA. Kharitonov, G. Ciabattoni, M. Corradi, L. van Rensen, DM. Geddes, ME. Hodson, PJ. Barnes (2000) Thorax
  2. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide.
    P. Montuschi, JA. Nightingale, SA. Kharitonov, PJ. Barnes (2002) Free Radic. Biol. Med.
  3. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
  4. Increased exhaled 8-isoprostane in childhood asthma.
    E. Baraldi, L. Ghiro, V. Piovan, S. Carraro, G. Ciabattoni, PJ. Barnes, P. Montuschi (2003) Chest
  5. Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: effect of carbocysteine lysine salt monohydrate (SCMC-Lys).
    GE. Carpagnano, O. Resta, MP. Foschino-Barbaro, A. Spanevello, A. Stefano, G. Di Gioia, G. Serviddio, E. Gramiccioni (2004) Eur. J. Pharmacol.
  6. Obesity and asthma: a coincidence or a causal relationship? A systematic review.
    Z. Ali, CS. Ulrik (2013) Respir Med
  7. Traffic-related air pollutants and exhaled markers of airway inflammation and oxidative stress in New York City adolescents.
    MM. Patel, SN. Chillrud, KC. Deepti, JM. Ross, PL. Kinney (2013) Environ. Res.
  8. Post-prandial systemic 8-isoprostane increases after consumption of moderate and high-fat meals in insufficiently active males.
    SP. Kurti, SR. Emerson, SK. Rosenkranz, CS. Teeman, EM. Emerson, BJ. Cull, JR. Smith, CA. Harms (2017) Nutr Res
Respiratory physiology 775.65 3
  1. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide.
    P. Montuschi, JA. Nightingale, SA. Kharitonov, PJ. Barnes (2002) Free Radic. Biol. Med.
  2. Increased exhaled 8-isoprostane in childhood asthma.
    E. Baraldi, L. Ghiro, V. Piovan, S. Carraro, G. Ciabattoni, PJ. Barnes, P. Montuschi (2003) Chest
  3. Oxidative stress in adolescent passive smokers living in urban and rural environments.
    R. Bono, V. Bellisario, V. Romanazzi, V. Pirro, P. Piccioni, M. Pazzi, M. Bugiani, M. Vincenti (2014) Int J Hyg Environ Health
cross reactivity 982.0 2
  1. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide.
    P. Montuschi, JA. Nightingale, SA. Kharitonov, PJ. Barnes (2002) Free Radic. Biol. Med.
  2. Increased exhaled 8-isoprostane in childhood asthma.
    E. Baraldi, L. Ghiro, V. Piovan, S. Carraro, G. Ciabattoni, PJ. Barnes, P. Montuschi (2003) Chest
Oxidants 877.7 2
  1. Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis.
    P. Montuschi, SA. Kharitonov, G. Ciabattoni, M. Corradi, L. van Rensen, DM. Geddes, ME. Hodson, PJ. Barnes (2000) Thorax
  2. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
Lipid Peroxidation 964.59 2
  1. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
  2. 8-Isoprostane in exhaled breath condensate of patients with non-small cell lung cancer: the effect of chemotherapy.
    D. Stathopoulos, S. Loukides, K. Syrigos (2014) Anticancer Res.
synergism 1000.0 1
  1. Obesity and asthma: a coincidence or a causal relationship? A systematic review.
    Z. Ali, CS. Ulrik (2013) Respir Med
Anabolism 1000.0 1
  1. Oxidative stress in adolescent passive smokers living in urban and rural environments.
    R. Bono, V. Bellisario, V. Romanazzi, V. Pirro, P. Piccioni, M. Pazzi, M. Bugiani, M. Vincenti (2014) Int J Hyg Environ Health
Synthesis 945.5 1
  1. Oxidative stress in adolescent passive smokers living in urban and rural environments.
    R. Bono, V. Bellisario, V. Romanazzi, V. Pirro, P. Piccioni, M. Pazzi, M. Bugiani, M. Vincenti (2014) Int J Hyg Environ Health
Protective Agents 724.62 1
  1. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide.
    P. Montuschi, JA. Nightingale, SA. Kharitonov, PJ. Barnes (2002) Free Radic. Biol. Med.
Atherogenesis 1000.0 1
  1. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
Complication 950.67 1
  1. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
Hypoxia 986.0 1
  1. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
Waking 1000.0 1
  1. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
Apnea HP:0002104 978.38 1
  1. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
Obstruction 927.88 1
  1. 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy.
    GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes (2003) Chest
Stimulus 851.5 1
  1. Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: effect of carbocysteine lysine salt monohydrate (SCMC-Lys).
    GE. Carpagnano, O. Resta, MP. Foschino-Barbaro, A. Spanevello, A. Stefano, G. Di Gioia, G. Serviddio, E. Gramiccioni (2004) Eur. J. Pharmacol.
Respiration 826.32 1
  1. Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate.
    PP. Rosias, CM. Robroeks, HJ. Niemarkt, AD. Kester, JH. Vernooy, J. Suykerbuyk, J. Teunissen, J. Heynens, HJ. Hendriks, Q. Jöbsis, E. Dompeling (2006) Eur. Respir. J.
Inspiration function 654.21 1
  1. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide.
    P. Montuschi, JA. Nightingale, SA. Kharitonov, PJ. Barnes (2002) Free Radic. Biol. Med.
pulmonary function 953.25 1
  1. Domestic airborne black carbon levels and 8-isoprostane in exhaled breath condensate among children in New York City.
    MJ. Rosa, B. Yan, SN. Chillrud, LM. Acosta, A. Divjan, JS. Jacobson, RL. Miller, IF. Goldstein, MS. Perzanowski (2014) Environ. Res.
Drug Interactions 743.53 1
  1. Post-prandial systemic 8-isoprostane increases after consumption of moderate and high-fat meals in insufficiently active males.
    SP. Kurti, SR. Emerson, SK. Rosenkranz, CS. Teeman, EM. Emerson, BJ. Cull, JR. Smith, CA. Harms (2017) Nutr Res
Hypersensitivity 704.1 1
  1. Oxidative stress in adolescent passive smokers living in urban and rural environments.
    R. Bono, V. Bellisario, V. Romanazzi, V. Pirro, P. Piccioni, M. Pazzi, M. Bugiani, M. Vincenti (2014) Int J Hyg Environ Health
Adjudication 985.67 1
  1. Global DNA methylation and oxidative stress biomarkers in workers exposed to metal oxide nanoparticles.
    SH. Liou, WT. Wu, HY. Liao, CY. Chen, CY. Tsai, WT. Jung, HL. Lee (2017) J. Hazard. Mater.
peroxidation 926.83 1
  1. Increased exhaled 8-isoprostane in childhood asthma.
    E. Baraldi, L. Ghiro, V. Piovan, S. Carraro, G. Ciabattoni, PJ. Barnes, P. Montuschi (2003) Chest
DNA Methylation 954.58 1
  1. Global DNA methylation and oxidative stress biomarkers in workers exposed to metal oxide nanoparticles.
    SH. Liou, WT. Wu, HY. Liao, CY. Chen, CY. Tsai, WT. Jung, HL. Lee (2017) J. Hazard. Mater.

Associated genes 0

No associated genes are detected in current reference collection.

There are 66 associated references with 8-epi-PGF2alpha. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C20H34O5
Mass 354.487
Synonyms 8-epi-PGF2alpha
8-isoprostane
8-Epi-prostaglandin F2alpha
8-iso-PGF2alpha
8-Epiprostaglandin F2alpha
8-Isoprostaglandin F2alpha
15-F2t-IsoP
27415-26-5
8-Epi PGF-2alpha
CHEBI:34505
9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid-cyclo[8S,12R]
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,8beta,9alpha,11alpha,13E,15S)-
C20H34O5
15(S)-8-Iso-PGF2|A
(5Z,13E,15S)-9alpha,11alpha,15-trihydroxy-8beta-prosta-5,13-dien-1-oic acid
8-Iso prostaglandin F2beta
15-F2t-Isoprostane
8-iso-PGF2a
AC1NQZQY
(5Z,13E,15S)-9alpha,11alpha,15-trihydroxy-8beta-prosta-5,13-dien-1-oate
PubChem CID 5282263