Obstructive sleep apnea

Disease description

A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395) Year introduced: 2000

Source: MeSH

References 7

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Journal Year Authors
Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest 2002 GE. Carpagnano, SA. Kharitonov, O. Resta, MP. Foschino-Barbaro, E. Gramiccioni, PJ. Barnes
Chest 2002 Oct;122(4):1162-7. PubMed:12377837
Exhaled pH, exhaled nitric oxide, and induced sputum cellularity in obese patients with obstructive sleep apnea syndrome. Transl Res 2008 GE. Carpagnano, A. Spanevello, R. Sabato, A. Depalo, V. Turchiarelli, MP. Foschino Barbaro
Transl Res 2008 Jan;151(1):45-50. PubMed:18061127
Exhaled breath markers in patients with obstructive sleep apnoea. Sleep Breath 2008 M. Petrosyan, E. Perraki, D. Simoes, I. Koutsourelakis, E. Vagiakis, C. Roussos, C. Gratziou
Sleep Breath 2008 Aug;12(3):207-15. PubMed:18074162
Airway inflammation in obstructive sleep apnea: is leptin the missing link? Respir Med 2008 S. Antonopoulou, S. Loukides, G. Papatheodorou, C. Roussos, M. Alchanatis
Respir Med 2008 Oct;102(10):1399-405. PubMed:18606530
Correlation of 8-isoprostane, interleukin-6 and cardiac functions with clinical score in childhood obstructive sleep apnoea. Acta Paediatr. 2008 MA. Biltagi, MA. Maguid, MA. Ghafar, E. Farid
Acta Paediatr. 2008 Oct;97(10):1397-405. PubMed:18631340
Oxidative stress and inflammatory markers in the exhaled breath condensate of children with OSA. Sleep Breath. 2012 G. Malakasioti, E. Alexopoulos, C. Befani, K. Tanou, V. Varlami, D. Ziogas, P. Liakos, K. Gourgoulianis, AG. Kaditis
Sleep Breath. 2012 Sep;16(3):703-8. doi: 10.1007/s11325-011-0560-7. Epub 2011 Aug 3. PubMed:21811879
Urates in exhaled breath condensate of children with obstructive sleep apnea. Biochem Med (Zagreb). 2011 V. Vlasic, J. Trifunovic, I. Cepelak, P. Nimac, RZ. Topic, S. Dodig
Biochem Med (Zagreb). 2011;21(2):139-44. PubMed:22135853

Compounds 4

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Hydrogen peroxide PubChem CID: 784
Uric acid PubChem CID: 1175
Nitric oxide PubChem CID: 145068
8-epi-PGF2alpha PubChem CID: 5282263

MeSH information

MeSH ID D020181
MeSH name Sleep Apnea, Obstructive