Adenosine triphosphate

Description

Description of Adenosine triphosphate with associated disease summary

Extracellular adenosine triphosphate (ATP) and its metabolites in airway surface liquid are important agonists for purinergic signaling pathways. They regulate airway defense mechanisms, including mucociliary clearance, airway inflammation and smooth muscle reactivity. ATP in exhaled breath condensate has been studied among middle-aged COPD patients, adult asthma patients and children with cystic fibrosis to aid diagnosis and disease follow-ups. EBC ATP levels were reported to be increased in CF patients relative to healthy controls, and they decreased after treatment. The improvement of lung function after antibiotic treatment was associated with a three-fold fall in EBC ATP levels. (Eur Respir (2008)) But no significant differences in EBC ATP levels were found either between COPD patients with severe exacerbation and healthy controls (Inflamm. Res. (2008)). Nor were there significant differences found between non-exacerbating asthma patients and their healthy counterparts (Lazar et al., Chest 2010). In these studies, EBC ATP were detected through luminometry (luciferin-luciferase assay). In a pilot study by Esther Jr. et al., analyses using etheno-derivatisation and HPLC revealed that EBC purine concentrations were below the detection threshold in most individuals. When optimal separation and detection of adenosine and AMP were achieved, ATP-specific signal was not detected in 20-fold concentrated EBC samples. In another study by Lazar et al., using HPLC was not able to detect ATP in EBC, even in 10-fold concentrated samples from COPD patients and controls. EBC may be a better source of sampling for ATP measurement in comparison to broncho-alveolar or nasal lavage fluids. It exerts negligible mechanical stress that stimulates airway ATP release; the low protein content implies low ATPase activity, while the low cellular components prevents cellular leakage. Nonetheless, salivary contamination may be confounding, since ATP level in human saliva is 105-6 Description of disease(s) related to Adenosine triphosphate (ATP):

Disease summary

Cystic Fibrosis (CF)

EBC ATP levels were reported to be increased in CF patients relative to healthy controls, and they decreased after treatment. The improvement of lung function after antibiotic treatment was associated with a three-fold fall in EBC ATP levels (Eur Respir (2008)).

Summary of extracted biomedical information

Adenosine triphosphate is associated with abnormalities such as Ischemia, Spastic syndrome, Septicemia and Sphincter. The involved biomedical functions are known as Signal Transduction, Phosphorylation, ATP binding, inhibitors and Oxidative Phosphorylation. The associated genes/proteins with Adenosine triphosphate are PDPK1 gene, CD28 gene, IL2 gene, Mutant Proteins and PANX1 gene. Adenosine triphosphate is associated with Succinates, Purines, Neurotransmitters, Protons and cofactor.
Imgsrv

Associated references with human 52

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Reference title

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Journal Year Authors & PubMed Link
Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors. BMC Cancer 2017 E. Leung, RA. Cairns, N. Chaudary, RN. Vellanki, T. Kalliomaki, EH. Moriyama, H. Mujcic, BC. Wilson, BG. Wouters, R. Hill, M. Milosevic
BMC Cancer 2017 Jun;17(1):418. PubMed:28619042
Why do premature newborn infants display elevated blood adenosine levels? Med. Hypotheses 2016 I. Panfoli, M. Cassanello, M. Bruschettini, M. Colella, R. Cerone, S. Ravera, D. Calzia, G. Candiano, L. Ramenghi
Med. Hypotheses 2016 May;90:53-6. PubMed:27063086
Unifying the DNA end-processing roles of the artemis nuclease: Ku-dependent artemis resection at blunt DNA ends. J. Biol. Chem. 2015 HH. Chang, G. Watanabe, MR. Lieber
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Elite female athletes' ventilatory compensation to decreased inspired O2 during the wingate test. Res Q Exerc Sport 2015 S. Fallon, A. Belcoe, C. Shawcross, A. May, C. Monteverde, D. McCann
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Design and synthesis of 3,3'-biscoumarin-based c-Met inhibitors. Org. Biomol. Chem. 2014 J. Xu, J. Ai, S. Liu, X. Peng, L. Yu, M. Geng, F. Nan
Org. Biomol. Chem. 2014 Jun;12(22):3721-34. PubMed:24781551
Effects of ATP release on mucin5AC secretion in airway epithelial cells by mechanical stretching. Ann. Clin. Lab. Sci. 2014 T. Zhang, C. Liu, X. Zhou, VP. Kolosov, JM. Perelman
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Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study. Biomed Res Int 2014 SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath
Biomed Res Int 2014 ;2014:483136. PubMed:25054141
Chronic hypoxia increases arterial blood pressure and reduces adenosine and ATP induced vasodilatation in skeletal muscle in healthy humans. Acta Physiol (Oxf) 2014 JA. Calbet, R. Boushel, P. Robach, Y. Hellsten, B. Saltin, C. Lundby
Acta Physiol (Oxf) 2014 Aug;211(4):574-84. PubMed:24920313
Effect of epithelium ATP release on cyclic pressure-induced airway mucus secretion. Biosci. Rep. 2014 J. Tong, XD. Zhou, JM. Perelman, VP. Kolosov
Biosci. Rep. 2014 02;34(1):. PubMed:27919041
Role of ATP and adenosine on carotid body function during development. Respir Physiol Neurobiol 2013 A. Bairam, LM. Niane, V. Joseph
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Astrocyte-neuron communication: functional consequences. Neurochem. Res. 2012 S. Ben Achour, O. Pascual
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Regulation of airway nucleotides in chronic lung diseases. Subcell. Biochem. 2011 CR. Esther, NE. Alexis, M. Picher
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Computational model for the regulation of extracellular ATP and adenosine in airway epithelia. Subcell. Biochem. 2011 GJ. Garcia, M. Picher, P. Zuo, SF. Okada, ER. Lazarowski, B. Button, RC. Boucher, TC. Elston
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Adenosine triphosphate concentration of exhaled breath condensate in asthma. Chest 2010 Z. Lázár, L. Cervenak, M. Orosz, G. Gálffy, ZI. Komlósi, A. Bikov, G. Losonczy, I. Horváth
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Control of breathing by "nerve glue". Sci Signal 2010 K. Ballanyi, B. Panaitescu, A. Ruangkittisakul
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Current ideas on central chemoreception by neurons and glial cells in the retrotrapezoid nucleus. J. Appl. Physiol. 2010 DK. Mulkey, IC. Wenker, O. Kréneisz
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[Sudden infant death syndrome (SIDS) caused by ATP-depletion following hyperventilation, tissue-hypoxia and hypermetabolism--a hypothesis]. Z Geburtshilfe Neonatol 2009 E. Deixler
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Purinergic signalling in autonomic control. Trends Neurosci. 2009 AV. Gourine, JD. Wood, G. Burnstock
Trends Neurosci. 2009 May;32(5):241-8. PubMed:19359051
Effects of a prior high-intensity knee-extension exercise on muscle recruitment and energy cost: a combined local and global investigation in humans. Exp. Physiol. 2009 G. Layec, A. Bringard, Y. Le Fur, C. Vilmen, JP. Micallef, S. Perrey, PJ. Cozzone, D. Bendahan
Exp. Physiol. 2009 Jun;94(6):704-19. PubMed:19151077
Adenosine triphosphate in exhaled breath condensate of healthy subjects and patients with chronic obstructive pulmonary disease. Inflamm. Res. 2008 Z. Lázár, E. Huszár, T. Kullmann, I. Barta, B. Antus, A. Bikov, M. Kollai, I. Horváth
Inflamm. Res. 2008 Aug;57(8):367-73. PubMed:18787775
Physiological and pathophysiological roles of extracellular ATP in chemosensory control of breathing. Biochem. Soc. Trans. 2007 GL. Ackland, V. Kasymov, AV. Gourine
Biochem. Soc. Trans. 2007 Nov;35(Pt 5):1264-8. PubMed:17956326
Intravenous ATP infusions can be safely administered in the home setting: a study in pre-terminal cancer patients. Invest New Drugs 2007 S. Beijer, EA. Gielisse, PS. Hupperets, BE. van den Borne, M. van den Beuken-van Everdingen, MR. Nijziel, AM. van Henten, PC. Dagnelie
Invest New Drugs 2007 Dec;25(6):571-9. PubMed:17786387
Bupivacaine induced cardiac toxicity mimicking an acute non-ST segment elevation myocardial infarction. Yonsei Med. J. 2007 HY. Ryu, JY. Kim, HK. Lim, J. Yoon, BS. Yoo, KH. Choe, SH. Lee
Yonsei Med. J. 2007 Apr;48(2):331-6. PubMed:17461537
Differential effects of cyclic and constant stress on ATP release and mucociliary transport by human airway epithelia. J. Physiol. (Lond.) 2007 B. Button, M. Picher, RC. Boucher
J. Physiol. (Lond.) 2007 Apr;580(Pt. 2):577-92. PubMed:17317749
Supplemental oxygen and muscle metabolism in mitochondrial myopathy patients. Eur. J. Appl. Physiol. 2007 MI. Trenell, CM. Sue, CH. Thompson, GJ. Kemp
Eur. J. Appl. Physiol. 2007 Mar;99(5):541-7. PubMed:17219172
Assessing the efficacy of HME filters at preventing contamination of breathing systems. Anaesthesia 2007 LM. Rees, TE. Sheraton, C. Modestini, AR. Wilkes, JE. Hall
Anaesthesia 2007 Jan;62(1):67-71. PubMed:17156229
The relationship between the VO2 slow component, muscle metabolites and performance during very-heavy exhaustive exercise. J Sci Med Sport 2007 R. Duffield, J. Edge, D. Bishop, C. Goodman
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Effect of aging on respiratory system physiology and immunology. Clin Interv Aging 2006 G. Sharma, J. Goodwin
Clin Interv Aging 2006 ;1(3):253-60. PubMed:18046878
Gene expression profile of human airway epithelium induced by hyperoxia in vivo. Am. J. Respir. Cell Mol. Biol. 2006 A. Chambellan, PJ. Cruickshank, P. McKenzie, SB. Cannady, K. Szabo, SA. Comhair, SC. Erzurum
Am. J. Respir. Cell Mol. Biol. 2006 Oct;35(4):424-35. PubMed:16690988
On the peripheral and central chemoreception and control of breathing: an emerging role of ATP. J. Physiol. (Lond.) 2005 AV. Gourine
J. Physiol. (Lond.) 2005 Nov;568(Pt 3):715-24. PubMed:16141266
Molecular motions of human cyclin-dependent kinase 2. J. Biol. Chem. 2005 CP. Barrett, ME. Noble
J. Biol. Chem. 2005 Apr;280(14):13993-4005. PubMed:15695825
Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans. J. Appl. Physiol. 2003 HB. Rossiter, SA. Ward, FA. Howe, DM. Wood, JM. Kowalchuk, JR. Griffiths, BJ. Whipp
J. Appl. Physiol. 2003 Sep;95(3):1105-15. PubMed:12754181
Effects of respiratory alkalosis on human skeletal muscle metabolism at the onset of submaximal exercise. J. Physiol. (Lond.) 2002 PJ. LeBlanc, ML. Parolin, NL. Jones, GJ. Heigenhauser
J. Physiol. (Lond.) 2002 Oct;544(Pt 1):303-13. PubMed:12356901
Longevity: don't hold your breath. Nature 2002 SS. Lee, G. Ruvkun
Nature 2002 Jul;418(6895):287-8. PubMed:12124610
Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise. Am. J. Physiol. Endocrinol. Metab. 2002 I. Savasi, MK. Evans, GJ. Heigenhauser, LL. Spriet
Am. J. Physiol. Endocrinol. Metab. 2002 Jul;283(1):E108-15. PubMed:12067850
Augmentation of death ligand-induced apoptosis by aminopeptidase inhibitors in human solid tumor cell lines. Int. J. Cancer 2001 K. Sekine, H. Fujii, F. Abe, K. Nishikawa
Int. J. Cancer 2001 Nov;94(4):485-91. PubMed:11745433
Pharmacology of airway afferent nerve activity. Respir. Res. 2001 BJ. Undem, MJ. Carr
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Signaling takes a breath--new quantitative perspectives on bioenergetics and signal transduction. Immunity 2001 S. Krauss, MD. Brand, F. Buttgereit
Immunity 2001 Oct;15(4):497-502. PubMed:11672532
Perturbed equilibria of myosin binding in airway smooth muscle: bond-length distributions, mechanics, and ATP metabolism. Biophys. J. 2000 SM. Mijailovich, JP. Butler, JJ. Fredberg
Biophys. J. 2000 Nov;79(5):2667-81. PubMed:11053139
Intersample fluctuations in phosphocreatine concentration determined by 31P-magnetic resonance spectroscopy and parameter estimation of metabolic responses to exercise in humans. J. Physiol. (Lond.) 2000 HB. Rossiter, FA. Howe, SA. Ward, JM. Kowalchuk, JR. Griffiths, BJ. Whipp
J. Physiol. (Lond.) 2000 Oct;528 Pt 2:359-69. PubMed:11034625
Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia. Am. J. Physiol. Endocrinol. Metab. 2000 ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser
Am. J. Physiol. Endocrinol. Metab. 2000 Oct;279(4):E752-61. PubMed:11001755
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Regulation of glycogen phosphorylase and PDH during exercise in human skeletal muscle during hypoxia. Am. J. Physiol. Endocrinol. Metab. 2000 ML. Parolin, LL. Spriet, E. Hultman, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser
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Inferences from pulmonary O2 uptake with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans. J. Physiol. (Lond.) 1999 HB. Rossiter, SA. Ward, VL. Doyle, FA. Howe, JR. Griffiths, BJ. Whipp
J. Physiol. (Lond.) 1999 Aug;518 ( Pt 3):921-32. PubMed:10421675
Simultaneous determination of muscle 31P and O2 uptake kinetics during whole body NMR spectroscopy. J. Appl. Physiol. 1999 BJ. Whipp, HB. Rossiter, SA. Ward, D. Avery, VL. Doyle, FA. Howe, JR. Griffiths
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Muscle energetics and pulmonary oxygen uptake kinetics during moderate exercise. J. Appl. Physiol. 1994 TJ. Barstow, S. Buchthal, S. Zanconato, DM. Cooper
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Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to Adenosine triphosphate is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

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Number of references
Cystic Fibrosis MeSH: Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967
Link to MeSH Database: D003550
20

Associated abnormalities 3

Concept Name External ID Weighted Score Hits References
Ischemia 1000.0 1
  1. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser (2000) Am. J. Physiol. Endocrinol. Metab.
Spastic syndrome 605.25 1
  1. Perturbed equilibria of myosin binding in airway smooth muscle: bond-length distributions, mechanics, and ATP metabolism.
    SM. Mijailovich, JP. Butler, JJ. Fredberg (2000) Biophys. J.
Septicemia ICD9-CM:038 744.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int

Associated chemicals 19

Concept Name External ID Definition Weighted Score Hits References
Purines 929.54 2
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
  2. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
carboxyatractyloside 1000.0 1
  1. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser (2000) Am. J. Physiol. Endocrinol. Metab.
second messenger 1000.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Heavy Ions 817.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
latrunculin B 1000.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
carbonyl 3-chlorophenylhydrazone 1000.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Polyphosphates 900.29 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Liquid nitrogen 1000.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Bicarbonates 610.67 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Anions 847.17 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Pyrimidines CHEBI:16898 1000.0 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Neurotransmitters CHEBI:25512 939.84 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Protons CHEBI:24636 899.86 1
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
triphosphate 913.5 1
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
Sulfuric Acid Esters 619.0 1
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
cofactor 996.5 1
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
Hydroxide Ion 694.73 1
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
Signaling Molecule CHEBI:62488 1000.0 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Ligands CHEBI:52214 930.5 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.

Associated functions 52

Concept Name External ID Definition Weighted Score Hits References
Signal Transduction GO:0007165 671.92 8
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
  2. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Phosphorylation 952.0 7
  1. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser (2000) Am. J. Physiol. Endocrinol. Metab.
  2. Perturbed equilibria of myosin binding in airway smooth muscle: bond-length distributions, mechanics, and ATP metabolism.
    SM. Mijailovich, JP. Butler, JJ. Fredberg (2000) Biophys. J.
  3. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
  4. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Oxidative Phosphorylation 988.06 5
  1. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser (2000) Am. J. Physiol. Endocrinol. Metab.
  2. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
ATP binding 968.88 5
  1. Perturbed equilibria of myosin binding in airway smooth muscle: bond-length distributions, mechanics, and ATP metabolism.
    SM. Mijailovich, JP. Butler, JJ. Fredberg (2000) Biophys. J.
  2. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
Synthesis 911.88 4
  1. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser (2000) Am. J. Physiol. Endocrinol. Metab.
  2. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Glycolysis GO:0006096 987.75 3
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
T-Cell Activation 998.17 3
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Cell physiology 1000.0 3
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Feedback 923.17 3
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Respiration 963.64 3
  1. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser (2000) Am. J. Physiol. Endocrinol. Metab.
  2. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Hypoxia 981.33 3
  1. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser (2000) Am. J. Physiol. Endocrinol. Metab.
  2. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Stimulus 893.67 3
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Macromolecular alteration 931.5 3
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
inhibitors 950.2 3
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
  2. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
  3. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
adenosinetriphosphatase activity GO:0016887 741.96 2
  1. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser (2000) Am. J. Physiol. Endocrinol. Metab.
  2. Perturbed equilibria of myosin binding in airway smooth muscle: bond-length distributions, mechanics, and ATP metabolism.
    SM. Mijailovich, JP. Butler, JJ. Fredberg (2000) Biophys. J.
Bioluminescence 884.33 2
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Citric Acid Cycle 735.38 2
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
purinergic nucleotide receptor activity 658.17 2
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Chromosome Pairing 644.47 2
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
  2. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Exocytosis GO:0006887 1000.0 2
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Neuronal Transmission 951.92 2
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Force 965.25 2
  1. Perturbed equilibria of myosin binding in airway smooth muscle: bond-length distributions, mechanics, and ATP metabolism.
    SM. Mijailovich, JP. Butler, JJ. Fredberg (2000) Biophys. J.
Regulation 1000.0 2
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
  2. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Adjudication 1000.0 2
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
  2. Adenosine triphosphate concentration of exhaled breath condensate in asthma.
    Z. Lázár, L. Cervenak, M. Orosz, G. Gálffy, ZI. Komlósi, A. Bikov, G. Losonczy, I. Horváth (2010) Chest
Binding (Molecular Function) 520.84 2
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
Cell Survival 1000.0 1
  1. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser (2000) Am. J. Physiol. Endocrinol. Metab.
Anoxia 926.5 1
  1. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser (2000) Am. J. Physiol. Endocrinol. Metab.
ATP Hydrolysis 959.8 1
  1. Intersample fluctuations in phosphocreatine concentration determined by 31P-magnetic resonance spectroscopy and parameter estimation of metabolic responses to exercise in humans.
    HB. Rossiter, FA. Howe, SA. Ward, JM. Kowalchuk, JR. Griffiths, BJ. Whipp (2000) J. Physiol. (Lond.)
T-Cell Proliferation GO:0042098 1000.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Mitochondrion in division 812.5 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Anabolism 1000.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
depolarization 944.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Polymerization 944.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Electron Transport 911.33 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
synaptogenesis 1000.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Autocrine Communication 1000.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Transcription, Genetic 745.95 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Membrane Potentials 924.18 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
uptake 891.25 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Inflammation 944.0 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Physiological action 1000.0 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
respiratory reflex 1000.0 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Excitatory Postsynaptic Potentials 495.53 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Inspiration function 644.0 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
sensory transduction 1000.0 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Synaptic Potentials 888.0 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
paracrine 847.0 1
  1. Purinergic signalling in autonomic control.
    AV. Gourine, JD. Wood, G. Burnstock (2009) Trends Neurosci.
Summation 1000.0 1
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
Physiologic pulse 676.47 1
  1. Effects of PDH activation by dichloroacetate in human skeletal muscle during exercise in hypoxia.
    ML. Parolin, LL. Spriet, E. Hultman, MP. Matsos, MG. Hollidge-Horvat, NL. Jones, GJ. Heigenhauser (2000) Am. J. Physiol. Endocrinol. Metab.
Transferring 1000.0 1
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
Entropy 1000.0 1
  1. Distinct Ca(2+) signalling mechanisms induced by ATP and sphingosylphosphorylcholine in porcine aortic smooth muscle cells.
    TY. Chin, SH. Chueh (2000) Br. J. Pharmacol.
Mutation 996.0 1
  1. Intersample fluctuations in phosphocreatine concentration determined by 31P-magnetic resonance spectroscopy and parameter estimation of metabolic responses to exercise in humans.
    HB. Rossiter, FA. Howe, SA. Ward, JM. Kowalchuk, JR. Griffiths, BJ. Whipp (2000) J. Physiol. (Lond.)

Associated genes 5

Concept Name External ID Definition Weighted Score Hits References
CD28 gene EntrezGene:940 647.09 3
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
IL2 gene EntrezGene:3558 700.5 2
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
PDPK1 gene EntrezGene:5170 606.76 2
  1. Adenosine triphosphate concentration of exhaled breath condensate in asthma.
    Z. Lázár, L. Cervenak, M. Orosz, G. Gálffy, ZI. Komlósi, A. Bikov, G. Losonczy, I. Horváth (2010) Chest
PANX1 gene EntrezGene:24145 881.0 1
  1. Helicobacter pylori is not eradicated after triple therapy: a nested PCR based study.
    SK. Patel, GN. Mishra, CB. Pratap, AK. Jain, G. Nath (2014) Biomed Res Int
Heavy Meromyosin 1000.0 1
  1. Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise.
    I. Savasi, MK. Evans, GJ. Heigenhauser, LL. Spriet (2002) Am. J. Physiol. Endocrinol. Metab.

Chemical Information

Formula C10H16N5O13P3
Mass 507.181
Synonyms Adenosine triphosphate
Adenosine 5'-triphosphate
Atriphos
Striadyne
Triphosphaden
Myotriphos
Triadenyl
Glucobasin
56-65-5
Adephos
Adetol
Adynol
Atipi
ATP
Triphosaden
5'-Atp
adenosine-5'-triphosphate
Adenylpyrophosphoric acid
Adenosine 5'-(tetrahydrogen triphosphate)
Triphosphoric acid adenosine ester
PubChem CID 5957