Chronic obstructive pulmonary disease (COPD)

Disease description

A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002

Source: MeSH

References 31

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Journal Year Authors
Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases. Am J Respir Crit Care Med. 2001 M. Corradi, P. Montuschi, LE. Donnelly, A. Pesci, SA. Kharitonov, PJ. Barnes
Am J Respir Crit Care Med. 2001 Mar;163(4):854-8. PubMed:11282756
Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2003 M. Corradi, I. Rubinstein, R. Andreoli, P. Manini, A. Caglieri, D. Poli, R. Alinovi, A. Mutti
Am. J. Respir. Crit. Care Med. 2003 May;167(10):1380-6. PubMed:12522029
Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD. Thorax 2003 WA. Biernacki, SA. Kharitonov, PJ. Barnes
Thorax 2003 Apr;58(4):294-8. PubMed:12668789
Exhaled leukotrienes and prostaglandins in COPD. Thorax 2003 P. Montuschi, SA. Kharitonov, G. Ciabattoni, PJ. Barnes
Thorax 2003 Jul;58(7):585-8. PubMed:12832671
Supplementary oxygen in healthy subjects and those with COPD increases oxidative stress and airway inflammation. Thorax 2004 GE. Carpagnano, SA. Kharitonov, MP. Foschino-Barbaro, O. Resta, E. Gramiccioni, PJ. Barnes
Thorax 2004 Dec;59(12):1016-9. PubMed:15563698
Leukotriene B4 in exhaled breath condensate and sputum supernatant in patients with COPD and asthma. Chest 2005 K. Kostikas, M. Gaga, G. Papatheodorou, T. Karamanis, D. Orphanidou, S. Loukides
Chest 2005 May;127(5):1553-9. PubMed:15888827
Validation of a new method to measure hydrogen peroxide in exhaled breath condensate. Respir Med. 2005 WB. Gerritsen, P. Zanen, AA. Bauwens, JM. van den Bosch, FJ. Haas
Respir Med. 2005 Sep;99(9):1132-7. Epub 2005 Apr 15. PubMed:16085214
Exhaled breath condensate levels of 8-isoprostane, growth related oncogene alpha and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary disease. Respir Med 2006 FW. Ko, CY. Lau, TF. Leung, GW. Wong, CW. Lam, DS. Hui
Respir Med 2006 Apr;100(4):630-8. PubMed:16213701
The effects of volatile salivary acids and bases on exhaled breath condensate pH. Am. J. Respir. Crit. Care Med. 2006 RM. Effros, R. Casaburi, J. Su, M. Dunning, J. Torday, J. Biller, R. Shaker
Am. J. Respir. Crit. Care Med. 2006 Feb;173(4):386-92. PubMed:16284109
Exhaled breath condensate 8-isoprostane, clinical parameters, radiological indices and airway inflammation in COPD. Respiration 2008 D. Makris, E. Paraskakis, P. Korakas, E. Karagiannakis, G. Sourvinos, NM. Siafakas, N. Tzanakis
Respiration 2008 ;75(2):138-44. PubMed:17641539
Clinical use of exhaled biomarkers in COPD. Int J Chron Obstruct Pulmon Dis 2007 P. O'Reilly, W. Bailey
Int J Chron Obstruct Pulmon Dis 2007 ;2(4):403-8. PubMed:18268915
Leukotriene B4 contributes to exhaled breath condensate and sputum neutrophil chemotaxis in COPD. Chest 2009 JL. Corhay, M. Henket, D. Nguyen, B. Duysinx, J. Sele, R. Louis
Chest 2009 Oct;136(4):1047-1054. PubMed:19429719
Expression of functional leukotriene B4 receptors on human airway smooth muscle cells. J. Allergy Clin. Immunol. 2009 S. Watanabe, A. Yamasaki, K. Hashimoto, Y. Shigeoka, H. Chikumi, Y. Hasegawa, T. Sumikawa, M. Takata, R. Okazaki, M. Watanabe, T. Yokogawa, M. Yamamura, T. Hayabuchi, WT. Gerthoffer, AJ. Halayko, E. Shimizu
J. Allergy Clin. Immunol. 2009 Jul;124(1):59-65.e1-3. PubMed:19477492
Daily physical activity in patients with chronic obstructive pulmonary disease is mainly associated with dynamic hyperinflation. Am. J. Respir. Crit. Care Med. 2009 F. Garcia-Rio, V. Lores, O. Mediano, B. Rojo, A. Hernanz, E. López-Collazo, R. Alvarez-Sala
Am. J. Respir. Crit. Care Med. 2009 Sep;180(6):506-12. PubMed:19542481
Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients. Respir. Res. 2009 R. Koczulla, S. Dragonieri, R. Schot, R. Bals, SA. Gauw, C. Vogelmeier, KF. Rabe, PJ. Sterk, PS. Hiemstra
Respir. Res. 2009 Aug;10:78. PubMed:19703285
Ambient temperature impacts on pH of exhaled breath condensate. Respirology 2010 AR. Koczulla, S. Noeske, C. Herr, F. Dette, O. Pinkenburg, S. Schmid, RA. Jörres, C. Vogelmeier, R. Bals
Respirology 2010 Jan;15(1):155-9. PubMed:19947991
Nitrite in exhaled breath condensate as a marker of nitrossative stress in the airways of patients with asthma, COPD, and idiopathic pulmonary fibrosis. J Clin Lab Anal. 2010 V. Rihák, P. Zatloukal, J. Chládková, A. Zimulová, Z. Havlínová, J. Chládek
J Clin Lab Anal. 2010;24(5):317-22. doi: 10.1002/jcla.20408. PubMed:20872566
Dynamic hyperinflation, arterial blood oxygen, and airway oxidative stress in stable patients with COPD. Chest 2011 F. García-Rio, D. Romero, V. Lores, R. Casitas, A. Hernanz, R. Galera, R. Alvarez-Sala, I. Torres
Chest 2011 Oct;140(4):961-969. PubMed:21436248
Exhaled breath condensate pH as a biomarker of COPD severity in ex-smokers. Respir. Res. 2011 AI. Papaioannou, S. Loukides, M. Minas, K. Kontogianni, P. Bakakos, KI. Gourgoulianis, M. Alchanatis, S. Papiris, K. Kostikas
Respir. Res. 2011 May;12:67. PubMed:21600044
Malondialdehyde in exhaled breath condensate as a marker of oxidative stress in different pulmonary diseases. Mediators Inflamm. 2011 ML. Bartoli, F. Novelli, F. Costa, L. Malagrinò, L. Melosini, E. Bacci, S. Cianchetti, FL. Dente, A. Di Franco, B. Vagaggini, PL. Paggiaro
Mediators Inflamm. 2011 ;2011:891752. PubMed:21772668
Exhaled eicosanoids and biomarkers of oxidative stress in exacerbation of chronic obstructive pulmonary disease. Arch Med Sci 2012 A. Antczak, M. Ciebiada, T. Pietras, WJ. Piotrowski, Z. Kurmanowska, P. Górski
Arch Med Sci 2012 May;8(2):277-85. PubMed:22662001
Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate. J. Proteome Res. 2013 G. de Laurentiis, D. Paris, D. Melck, P. Montuschi, M. Maniscalco, A. Bianco, M. Sofia, A. Motta
J. Proteome Res. 2013 Mar;12(3):1502-11. PubMed:23360153
Non-invasive biomarkers in exacerbations of obstructive lung disease. Respirology. 2013 G. Warwick, PS. Thomas, DH. Yates
Respirology. 2013 Jul;18(5):874-84. doi: 10.1111/resp.12089. PubMed:23521049
Monitoring oxidative stress during chronic obstructive pulmonary disease exacerbations using malondialdehyde. Respirology. 2014 B. Antus, G. Harnasi, O. Drozdovszky, I. Barta
Respirology. 2014 Jan;19(1):74-9. doi: 10.1111/resp.12155. PubMed:23834671
Hydrogen peroxide content and pH of expired breath condensate from patients with asthma and COPD. COPD 2014 K. Murata, K. Fujimoto, Y. Kitaguchi, T. Horiuchi, K. Kubo, T. Honda
COPD 2014 Feb;11(1):81-7. PubMed:24111595
Malondialdehyde and 3-nitrotyrosine in exhaled breath condensate in retired elderly coal miners with chronic obstructive pulmonary disease. Saf Health Work 2014 JS. Lee, JH. Shin, JH. Hwang, JE. Baek, BS. Choi
Saf Health Work 2014 Jun;5(2):91-6. PubMed:25180140
Biomarkers of progression of chronic obstructive pulmonary disease (COPD). J Thorac Dis 2014 JG. Shaw, A. Vaughan, AG. Dent, PE. O'Hare, F. Goh, RV. Bowman, KM. Fong, IA. Yang
J Thorac Dis 2014 Nov;6(11):1532-47. PubMed:25478195
Evaluation of Markers of Inflammation and Oxidative Stress in COPD Patients with or without Cardiovascular Comorbidities. Heart Lung Circ 2015 M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, A. Nielepkowicz-Goździńska, A. Antczak
Heart Lung Circ 2015 Aug;24(8):817-23. PubMed:25797323
Patients with chronic obstructive pulmonary disease and chronically colonized with Haemophilus influenzae during stable disease phase have increased airway inflammation. Int J Chron Obstruct Pulmon Dis 2015 E. Tufvesson, L. Bjermer, M. Ekberg
Int J Chron Obstruct Pulmon Dis 2015 ;10:881-9. PubMed:26005341
Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages. Am. J. Physiol. Lung Cell Mol. Physiol. 2015 A. Croasdell, TH. Thatcher, RM. Kottmann, RA. Colas, J. Dalli, CN. Serhan, PJ. Sime, RP. Phipps
Am. J. Physiol. Lung Cell Mol. Physiol. 2015 Oct;309(8):L888-901. PubMed:26301452
Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation. Eur Respir J. 2004 M. Corradi, P. Pignatti, P. Manini, R. Andreoli, M. Goldoni, M. Poppa, G. Moscato, B. Balbi, A. Mutti
Eur Respir J. 2004 Dec;24(6):1011-7. PubMed:15572547

Compounds 127

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Acetate PubChem CID: 175
Formate PubChem CID: 283
Ethanol PubChem CID: 702
Hydrogen peroxide PubChem CID: 784
Nitrite PubChem CID: 946
1-methylimidazole PubChem CID: 1390
Isopropanol PubChem CID: 3776
Neopterin PubChem CID: 4455
Hexaldehyde PubChem CID: 6184
Isobutyric acid PubChem CID: 6590
Heptanal PubChem CID: 8130
Malondialdehyde PubChem CID: 10964
Propanoate PubChem CID: 104745
3-Nitrotyrosine PubChem CID: 235719
Docosahexaenoic acid PubChem CID: 445580
Prostaglandin E2 PubChem CID: 5280360
Leukotriene B4 PubChem CID: 5280492
8-epi-PGF2alpha PubChem CID: 5282263
12-HETE PubChem CID: 5312983
12-Hydroxyeicosapentaenoate PubChem CID: 10041593
Thionitrous acid PubChem CID: 11389353
Methanol PubChem CID: 101954077
Leukotriene E4 PubChem CID: 5280879
Acetic acid, (aminooxy)- PubChem CID: 286
Silane, (2-methoxyphenyl)trimethyl- PubChem CID: 10969113
Oxime-, methoxy-phenyl-_ PubChem CID: 9602988
2-butoxyethanol PubChem CID: 8133
4-Trimethylsilyloxybenzoic anhydride PubChem CID: 91731726
1-ethyl-4-methylbenzene PubChem CID: 12160
Benzaldehyde PubChem CID: 240
Arsenous acid, tris(trimethylsilyl) ester PubChem CID: 180508
N-Vinylimidazole PubChem CID: 66171
2-pentylfuran PubChem CID: 19602
1-ethyl-3-methylbenzene PubChem CID: 12100
Decane PubChem CID: 15600
Cyclotetrasiloxane, octamethyl- PubChem CID: 11169
Ethanol, 2-[2-(2-propenyloxy)ethoxy]- PubChem CID: 84777
Cyclohexanol, 1-ethyl- PubChem CID: 16021
Cumene PubChem CID: 7406
2-ethylhexan-1-ol PubChem CID: 7720
Phenylmethanol PubChem CID: 244
Sulfurous acid, nonyl pentyl ester PubChem CID: 6421048
Benzeneacetaldehyde PubChem CID: 998
Nonane, 2-methyl-5-propyl- PubChem CID: 545954
Heptane, 4-ethyl- PubChem CID: 16663
2,6-dimethylnonane PubChem CID: 28457
Benzenemethanol, .alpha.-methyl-, (R)- PubChem CID: 637516
Heptadecane, 2,6-dimethyl- PubChem CID: 545603
1-phenylethanone PubChem CID: 7410
2-methoxyphenol PubChem CID: 460
Benzenemethanol, .alpha.,.alpha.-dimethyl- PubChem CID: 12053
2,4-Dihydroxybenzaldehyde, 2TMS derivative PubChem CID: 622439
N-Methyl-N-[2-(methylamino)ethyl]benzamide PubChem CID: 13544681
Undecane PubChem CID: 14257
1,2-Benzenediol, O-acetoxyacetyl-O'-(3-fluorobenzoyl)- PubChem CID: 91711798
1-Octene, 3,3-dimethyl- PubChem CID: 549578
P-Trimethylsilyloxyphenyl-bis(trimethylsilyloxy)ethane PubChem CID: 622436
Benzenemethanol, .alpha.-ethyl- PubChem CID: 7147
Benzoic acid, ethyl ester PubChem CID: 7165
1,4-Pentadiene, 2,3,3-trimethyl- PubChem CID: 136569
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1S-(1.alpha.,2.alpha.,5.beta.)]- PubChem CID: 1254
Terpinen-4-ol PubChem CID: 11230
Azulene PubChem CID: 9231
Methyl salicylate PubChem CID: 4133
2-(4-methylcyclohex-3-en-1-yl)propan-2-ol PubChem CID: 17100
Decanal PubChem CID: 8175
Benzaldehyde, 3,5-dimethyl- PubChem CID: 34225
2-phenoxyethanol PubChem CID: 31236
1,3-Benzothiazole PubChem CID: 7222
4-Methyl-2-oxovaleric acid PubChem CID: 70
Atrolactic acid PubChem CID: 1303
Hexadecane PubChem CID: 11006
2-Hydroxy-iso-butyrophenone PubChem CID: 81984
3-(4-Ethoxybenzyl)-2,6-piperidinedione PubChem CID: 137353
Tridecane PubChem CID: 12388
5H-1-Pyrindine PubChem CID: 575987
1-Hexanamine, N-propyl- PubChem CID: 29996
2,4'-Dimethoxy-2'-(trimethylsilyl)oxychalcone PubChem CID: 6041429
Dodecane, 1-iodo- PubChem CID: 20282
Heptadecane, 2,6,10,14-tetramethyl- PubChem CID: 29036
Methyl 5-cyclopropyl-1-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-3-carboxylate PubChem CID: 91704350
2,2,4-Trimethyl-1,3-pentanediol diisobutyrate PubChem CID: 23284
Benzene, 1,3,5-triethyl- PubChem CID: 7602
Propyl butanoate PubChem CID: 7770
1,7-Di(3-ethylphenyl)-2,2,4,4,6,6-hexamethyl-1,3,5,7-tetraoxa-2,4,6-trisilaheptane PubChem CID: 146102
Ethanol, 2-phenoxy-, acetate PubChem CID: 22568
2-Propenal, 3-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl)- PubChem CID: 5370158
Dodecanal PubChem CID: 8194
Ethanone, 1,1'-(1,3-phenylene)bis- PubChem CID: 23229
2,6-Di-tert-butyl-4-hydroxy-4-methylcyclohexa-2,5-dien-1-one PubChem CID: 91742720
Acetic acid, 2,6,6-trimethyl-3-methylene-7-(3-oxobutylidene)oxepan-2-yl ester PubChem CID: 5363907
Cyclododecane PubChem CID: 9268
Cycloheptasiloxane, tetradecamethyl- PubChem CID: 7874
Benzamide, 4-ethyl-N-methyl-N-ethyl- PubChem CID: 67583415
Phenol, 2,5-bis(1,1-dimethylethyl)- PubChem CID: 79983
Triisobutyl phosphate PubChem CID: 31355
3,5-Bis(4-hydroxybenzoyl)-1,2,4-oxadiazolidine-4-oxide PubChem CID: 102123396
Benzoic acid, 4-ethoxy-, ethyl ester PubChem CID: 90232
5-Chloro-3-(1H-indol-1-yl)-1-(4-methoxybenzyl)indolin-2-one PubChem CID: 71728917
Propanoic acid, 2-methyl-, 2-propenyl ester PubChem CID: 85071
Cyclooctasiloxane, hexadecamethyl- PubChem CID: 11170
Benzophenone PubChem CID: 3102
Succinic acid, 2-(2-chlorophenoxy)ethyl ethyl ester PubChem CID: 91726212
Isocitronellol PubChem CID: 557859
3,5-Dinitrobenzoic acid, tetrahydrofuran-2-on-5-ylmethyl ester PubChem CID: 558880
Adipic acid, butyl 2-propyl ester PubChem CID: 91713521
2,4,2',4'-Tetramethyl-biphenyl PubChem CID: 520958
Dodecyl acrylate PubChem CID: 75084
Heptacosane PubChem CID: 11636
Phenol, 4-(1,1,3,3-tetramethylbutyl)- PubChem CID: 8814
Benzoic acid, 2-methylbutyl ester PubChem CID: 103653
Heptadecane, 2,6,10,15-tetramethyl- PubChem CID: 41209
Hexestrol, O-heptafluorobutyryl- PubChem CID: 91715001
3,5-di-tert-Butyl-4-hydroxybenzaldehyde PubChem CID: 73219
Cyclononasiloxane, octadecamethyl- PubChem CID: 11172
Carbonic acid, bis(2-ethylhexyl) ester PubChem CID: 85781
2-((But-3-enyloxy)carbonyl)benzoic acid PubChem CID: 13596727
2-Morpholinomethyl-1,3-diphenyl-2-propanol PubChem CID: 567717
Pentadecanoic acid, 14-methyl-, methyl ester PubChem CID: 21205
2-(2',4',4',6',6',8',8'-Heptamethyltetrasiloxan-2'-yloxy)-2,4,4,6,6,8,8,10,10-nonamethylcyclopentasiloxane PubChem CID: 551986
Palmitic acid PubChem CID: 985
1,2-Benzenedicarboxylic acid, butyl 2-ethylhexyl ester PubChem CID: 6818
.gamma.-Dodecalactone PubChem CID: 16821
2-Butenedioic acid (E)-, bis(2-ethylhexyl) ester PubChem CID: 5370325
2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl ester PubChem CID: 21630
Bis(2-ethylhexyl) phthalate PubChem CID: 8343

MeSH information

MeSH ID D029424
MeSH name Pulmonary Disease, Chronic Obstructive