Upper and lower airway inflammation in Atopic dermatitis (AD)

Disease description

A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

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References 4

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Journal Year Authors
Noninvasive methods for the detection of upper and lower airway inflammation in atopic children. J. Allergy Clin. Immunol. 2006 M. Profita, S. La Grutta, E. Carpagnano, L. Riccobono, R. Di Giorgi, A. Bonanno, E. Pace, G. Bonsignore, J. Bousquet, AM. Vignola, M. Gjomarkaj
J. Allergy Clin. Immunol. 2006 Nov;118(5):1068-74. PubMed:17088131
Airway inflammation and eotaxin in exhaled breath condensate of patients with severe persistent allergic asthma during omalizumab therapy. Adv Med Sci 2011 Z. Zietkowski, R. Skiepko, MM. Tomasiak-Lozowska, A. Bodzenta-Lukaszyk
Adv Med Sci 2011 ;56(2):318-22. PubMed:21940268
Markers of oxidative stress are increased in exhaled breath condensates of children with atopic dermatitis. Br J Dermatol. 2012 DG. Peroni, A. Bodini, M. Corradi, A. Coghi, AL. Boner, GL. Piacentini
Br J Dermatol. 2012 Apr;166(4):839-43. doi: 10.1111/j.1365-2133.2011.10771.x. PubMed:22175656
Different Patterns in Changes of Exhaled Breath Condensate pH and Exhaled Nitric Oxide After Ozone Exposure. Adv. Exp. Med. Biol. 2015 F. Hoffmeyer, K. Sucker, C. Monsé, H. Berresheim, B. Jettkant, N. Rosenkranz, T. Brüning, J. Bünger
Adv. Exp. Med. Biol. 2015 ;834:39-47. PubMed:25310951

Compounds 4

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Hydrogen peroxide PubChem CID: 784
Nitric oxide PubChem CID: 145068
Leukotriene B4 PubChem CID: 5280492
8-epi-PGF2alpha PubChem CID: 5282263

MeSH information

MeSH ID D003876
MeSH name Dermatitis, Atopic