Acetone
Description
Description of acetone with associated disease summary
Acetone is one of ketone bodies, which are synthesized in the mitochondria of hepatocytes for energy generation when glycogen storage is depleted. Ketone bodies are exhaled and
excreted in the urine when levels of ketone bodies are high.
In a study of EBC metabolomes in patients with cystic fibrosis (CF), acetone and other
metabolites are identified using high resolution 2D-NMR spectroscopy. Elevated
concentrations of acetone, acetate, ethanol and 2-propanol are observed in
patients with CF compared to healthy controls. Within CF patients, ethanol and
2-propanol levels are higher whereas acetate and methanol levels are lower in
stable CF subjects versus unstable CF subjects. (Thorax. (2012))
The analysis of specific molecules containing acetone may provide further insights into the detection and pathophysiology of CF.
Description ofdisease(s) related to Acetone:
Cystic fibrosis (CF)
Acetone level in EBC is higher in CF patients than in healthy subjects. (Thorax. (2012))Summary of extracted biomedical information
Acetone is associated with abnormalities such as Diabetes, Diabetes Mellitus, Sweet's Syndrome, Diabetes Mellitus, Non-Insulin-Dependent and Diabetes Mellitus, Insulin-Dependent. The involved biomedical functions are known as Exhalation, Analyte, Noise, Drug Interactions and Adjudication. Acetone is associated with Toluene, 4-xylene, Ketones, Acetaldehyde and Acetoacetates.Associated references with human 92
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Journal | Year | Authors & PubMed Link |
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Environ. Health Perspect. 2003 Apr;111(4):647-56. PubMed:12676630 |
Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vapors. | Toxicol. Appl. Pharmacol. | 2002 |
CB. Frederick, LG. Lomax, KA. Black, L. Finch, HE. Scribner, JS. Kimbell, KT. Morgan, RP. Subramaniam, JB. Morris
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Exhalation behavior of four organic substrates and water absorbed by human skin. | Biol. Pharm. Bull. | 2002 |
K. Naitoh, Y. Inai, T. Hirabayashi, T. Tsuda
Biol. Pharm. Bull. 2002 Jul;25(7):867-71. PubMed:12132659 |
Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection. | J. Heart Lung Transplant. | 2001 |
SM. Studer, JB. Orens, I. Rosas, JA. Krishnan, KA. Cope, S. Yang, JV. Conte, PB. Becker, TH. Risby
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Atmospheric volatile organic compound measurements during the 1996 Paso del Norte Ozone Study. | Sci. Total Environ. | 2001 |
RL. Seila, HH. Main, JL. Arriaga, G. Martínez, AB. Ramadan
Sci. Total Environ. 2001 Aug;276(1-3):153-69. PubMed:11523535 |
Elevated concentrations of acetone and unidentified compounds in the breath of alcohol abusers. | Alcohol. Clin. Exp. Res. | 1989 |
M. Phillips, J. Greenberg, V. Martinez
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|
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Associated curated diseases 1
Download diseasesAssociated disease mapping
Mapping of all associated diseases to acetone is displayed in red.
Disease Name
with link to disease page |
Description of MeSH term
with link to MeSH Database |
Number of references |
---|---|---|
Cystic Fibrosis |
MeSH:
Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE
REGULATOR expressed in several organs including the LUNG, the PANCREAS, the
BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by
epithelial secretory dysfunction associated with ductal obstruction resulting in
AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY;
maldigestion; salt depletion; and HEAT PROSTRATION.
Year introduced: 1967
Link to MeSH Database: D003550
|
20 |
Associated abnormalities 7
Concept Name | External ID | Weighted Score | Hits | References | |
Diabetes | 1000.0 | 4 |
|
||
Diabetes Mellitus | ICD9-CM:250 | 987.63 | 3 |
|
|
Sweet's Syndrome | 503.25 | 1 |
|
||
Diabetes Mellitus, Non-Insulin-Dependent | 625.0 | 1 |
|
||
Diabetes Mellitus, Insulin-Dependent | 861.11 | 1 |
|
||
Ketosis | 947.5 | 1 |
|
||
ADHF | 1000.0 | 1 |
|
Associated chemicals 47
Associated functions 27
Concept Name | External ID | Definition | Weighted Score | Hits | References | |
Exhalation | 795.85 | 5 |
|
|||
Noise | 874.33 | 4 |
|
|||
Drug Interactions | 795.53 | 3 |
|
|||
Adjudication | 1000.0 | 3 |
|
|||
Signal Transduction | GO:0007165 | 532.89 | 3 |
|
||
Urinary concentration | 1000.0 | 2 |
|
|||
Obstruction | 641.68 | 2 |
|
|||
Evolution | 925.5 | 2 |
|
|||
enzyme activity | 1000.0 | 2 |
|
|||
volatile substances | 960.92 | 2 |
|
|||
Biological function, NOS | 908.17 | 1 |
|
|||
Summation | 952.06 | 1 |
|
|||
Lipid Mobilization | 1000.0 | 1 |
|
|||
dehydrogenation | 1000.0 | 1 |
|
|||
Blood Circulation | GO:0008015 | 823.53 | 1 |
|
||
chemical bond | 1000.0 | 1 |
|
|||
Extravasation | 694.73 | 1 |
|
|||
physiological aspects | 682.1 | 1 |
|
|||
Vapour pressure | 917.17 | 1 |
|
|||
catalyst | 979.3 | 1 |
|
|||
Exocytosis | GO:0006887 | 950.0 | 1 |
|
||
Shock | 1000.0 | 1 |
|
|||
Adverse effects | 1000.0 | 1 |
|
|||
Physiologic pulse | 620.47 | 1 |
|
|||
Analyte | 949.21 | 1 |
|
|||
Pressure- physical agent | 598.34 | 1 |
|
|||
Synthesis | 1000.0 | 1 |
|
Associated genes 0
No associated genes are detected in current reference collection.
There are 92 associated references with acetone. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
NCBI Entrez Crosslinks
Chemical Information
Formula | C3H6O |
Mass | 58.08 |
Synonyms | acetone 2-propanone propanone Dimethyl ketone Methyl ketone 67-64-1 Dimethylformaldehyde Pyroacetic ether beta-Ketopropane Dimethylketal propan-2-one Chevron acetone Ketone propane Aceton Pyroacetic acid Ketone, dimethyl dimethylketone Acetone (natural) RCRA waste number U002 Dimethyl formaldehyde |
PubChem CID | 180 |