Hydrogen peroxide
Description
Description of Hydrogen peroxide with associated disease summary
Inflammatory cells such as macrophages and neutrophils released reactive oxygen species (ROS) like hydrogen peroxide (H2O2) and play a role in the
pathophysiology of childhood asthma. Elevated levels of hydrogen peroxide have been found in a number of respiratory disorders, including cystic fibrosis, chronic obstructive pulmonary disorder and asthma.
Thus, hydrogen peroxide is considered to be a possible biomarker of airway inflammation. ( Respir Res.(2012), J Chromatogr B AnalytTechnol Biomed Life Sci.(2004)). Since the bronchoalveolar extracellular lining fluid contains a large number of mediators of airway inflammation and oxidative damage, exhaled breath condensate (EBC) was
frequently used todetect the hydrogen peroxideconcentration (Br J Dermatol. (2012)).
Hydrogen peroxide was identified through diagnostic studies such as 'study name, citations' and 'another study name, citations'. However, it is a proposed prognostic lipid mediator that can be measured to predict an individual's associative risk of developing the following conditions or diseases: asthma, chronic obstructive pulmonary disease, pneumonectomy, bronchiectasis, breast neoplasms, atopic dermatitis, fever, obstructive lung diseases, obstructive sleep apnea, rhinitis and sleep apnea syndromes.
The commercial kit (e.g. Amplex Red Hydrogen Peroxide Assay Kit) for H2O2 measured in EBC (exhaled breath condensate) was available. Spectrophometer is the most commonly method for H2O2 detection H2O2 concentrations were also
measured by fluorescence and enzyme immunoassay (EIA). Although there are numbers of studies enrolled children, adult patients and healthy volunteers, the patients numbers in each studies was very limited (Inflammation. (2007), Sleep Breath. (2012) and J Cancer Res Clin Oncol. (2010)).
Description of disease(s) related to hydrogen peroxide:
Disease summary
Asthma
The pH and levels of CRP, H2O2 and nitrate were correlated with asthma severity and significantly higher in the mild persistent group than that in the other groups. (Respirology.(2008))Chronic obstructive pulmonary disease (COPD)
The H2O2 levels were elevated and pH was lower in both asthma and COPD compared with control subjects (COPD.(2014)). Pneumonectomy: In both exhaled breath condensate and blood, H2O2 levels significantly and directly correlated with the duration of one-lung ventilation immediately before resuming two-lung ventilation and immediately after resuming two-lung ventilation. (Eur J Cardiothorac Surg. (2015)).Bronchiectasis
H2O2 is elevated in exhaled air condensate of patients with bronchiectasis and is correlated with disease severity (Am J Respir Crit Care Med. (1998)). Breast Neoplasms: The H2O2 concentration was significantly correlated and increased in cases with nodal metastases. Patients with localized breast malignancy was associated with H2O2 increment in EBC in and also related with its clinical severity (J Cancer Res Clin Oncol. (2010)).Atopic Dermatitis (AD)
Patients with AD were analysis their inflammatory mediators in the EBC and they found that exhaled H2O2 concentrations were significantly higher in controls compared with patients affected by AD (Br J Dermatol. (2012)). Obstructive Lung Diseases: H202 levels in EBC was significantly higher in obstructive lung diseases group. The levels of H202 in EBC was also showed a positive and significant correlation with % eosinophils in IS (Inflammation. (2007)).Renal Dialysis (RD)
Chronic RD patients exhale more H2O2 than healthy subjects at baseline. Although no change of breath H2O2 concentration was observed during RD, as H2O2 easily diffuses through the dialyser membrane, EBC H2O2 concentration was 22 times higher in Renal Dialysis patients than in controls (Nephrol Dial Transplant. (2004)).Obstructive Sleep Apnea
H2O2 was shown to be an indirect index of altered redox status in the respiratory tract, since children with moderate-to-severe OSA have increased H2O2 levels in morning EBC (Sleep Breath. (2012)).Summary of extracted biomedical information
Hydrogen peroxide is associated with abnormalities such as Oxygen toxicity. The involved biomedical functions are known as Oxidation, Oxidants, Respiration, enzyme activity and Evolution. Hydrogen peroxide is associated with Hydroxyl Radical, Ozone, Superoxides, Toluene and manganese oxide.Associated references with human 108
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Elevated exhalation of hydrogen peroxide and circulating IL-18 in patients with pulmonary tuberculosis. | Respir Med | 2007 |
S. Kwiatkowska, U. Szkudlarek, M. Luczyńska, D. Nowak, M. Zieba
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N. Omidbakhsh
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Optimising hydrogen peroxide measurement in exhaled breath condensate. | Redox Rep. | 2006 |
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FC. Cheah, BA. Darlow, CC. Winterbourn
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Oxidative stress and antioxidant deficiencies in asthma: potential modification by diet. | Redox Rep. | 2005 |
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Passive smoking does not increase hydrogen peroxide (H2O2) levels in exhaled breath condensate in 9-year-old healthy children. | Pediatr. Pulmonol. | 2005 |
Z. Doniec, D. Nowak, W. Tomalak, K. Pisiewicz, R. Kurzawa
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U. Szkudlarek, L. Maria, M. Kasielski, S. Kaucka, D. Nowak
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Indirect monitoring of lung inflammation. | Nat Rev Drug Discov | 2002 |
P. Montuschi
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P. Montuschi, PJ. Barnes
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An efficient and reproducible method for measuring hydrogen peroxide in exhaled breath condensate. | Respir Med | 2002 |
WJ. van Beurden, GA. Harff, PN. Dekhuijzen, MJ. van den Bosch, JP. Creemers, FW. Smeenk
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Variability of exhaled hydrogen peroxide in stable COPD patients and matched healthy controls. | Respiration | 2002 |
WJ. van Beurden, PN. Dekhuijzen, GA. Harff, FW. Smeenk
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The relationships among hydrogen peroxide in expired breath condensate, airway inflammation, and asthma severity. | Chest | 2002 |
S. Loukides, D. Bouros, G. Papatheodorou, P. Panagou, NM. Siafakas
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Exhaled H(2)O(2) in steady-state bronchiectasis: relationship with cellular composition in induced sputum, spirometry, and extent and severity of disease. | Chest | 2002 |
S. Loukides, D. Bouros, G. Papatheodorou, S. Lachanis, P. Panagou, NM. Siafakas
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A noninvasive method to collect nasally exhaled air condensate in humans of all ages. | Eur. J. Clin. Invest. | 2001 |
M. Griese, P. Latzin, J. Beck
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Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients. | Chest | 2001 |
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Exhalation of H2O2 and thiobarbituric acid reactive substances (TBARs) by healthy subjects. | Free Radic. Biol. Med. | 2001 |
D. Nowak, S. Kalucka, P. Białasiewicz, M. Król
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Hydrogen peroxide in breath condensate during a common cold. | Mediators Inflamm. | 2001 |
RQ. Jöbsis, SL. Schellekens, A. Fakkel-Kroesbergen, RH. Raatgeep, JC. de Jongste
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Exhaled nitric oxide and hydrogen peroxide in patients with chronic obstructive pulmonary disease: effects of inhaled beclomethasone. | Am. J. Respir. Crit. Care Med. | 2001 |
IM. Ferreira, MS. Hazari, C. Gutierrez, N. Zamel, KR. Chapman
Am. J. Respir. Crit. Care Med. 2001 Sep;164(6):1012-5. PubMed:11587988 |
Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease. | Respir Med | 2001 |
M. Kasielski, D. Nowak
Respir Med 2001 Jun;95(6):448-56. PubMed:11421501 |
The concentration of hydrogen peroxide in exhaled air depends on expiratory flow rate. | Eur. Respir. J. | 2000 |
MB. Schleiss, O. Holz, M. Behnke, K. Richter, H. Magnussen, RA. Jörres
Eur. Respir. J. 2000 Dec;16(6):1115-8. PubMed:11292115 |
Hydrogen peroxide in the human body. | FEBS Lett. | 2000 |
B. Halliwell, MV. Clement, LH. Long
FEBS Lett. 2000 Dec;486(1):10-3. PubMed:11108833 |
Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment. | Eur. Respir. J. | 2000 |
Q. Jöbsis, HC. Raatgeep, SL. Schellekens, A. Kroesbergen, WC. Hop, JC. de Jongste
Eur. Respir. J. 2000 Jul;16(1):95-100. PubMed:10933092 |
Increased exhalation of hydrogen peroxide in healthy subjects following cigarette consumption. | Sao Paulo Med J | 2000 |
SB. Guatura, JA. Martinez, PC. Santos Bueno, ML. Santos
Sao Paulo Med J 2000 Jul;118(4):93-8. PubMed:10887384 |
Inhaled glucocorticosteroids decrease hydrogen peroxide level in expired air condensate in asthmatic patients. | Respir Med | 2000 |
A. Antczak, Z. Kurmanowska, M. Kasielski, D. Nowak
Respir Med 2000 May;94(5):416-21. PubMed:10868702 |
Oxidative stress after lung resection therapy: A pilot study. | Chest | 2000 |
EC. Lases, VA. Duurkens, WB. Gerritsen, FJ. Haas
Chest 2000 Apr;117(4):999-1003. PubMed:10767230 |
The influence of liposome-encapsulated prostaglandin E1 on hydrogen peroxide concentrations in the exhaled breath of patients with the acute respiratory distress syndrome. | Anesth. Analg. | 1999 |
SO. Heard, K. Longtine, I. Toth, JC. Puyana, B. Potenza, N. Smyrnios
Anesth. Analg. 1999 Aug;89(2):353-7. PubMed:10439747 |
Expired hydrogen peroxide in breath condensate of cystic fibrosis patients. | Eur. Respir. J. | 1999 |
LP. Ho, J. Faccenda, JA. Innes, AP. Greening
Eur. Respir. J. 1999 Jan;13(1):103-6. PubMed:10836332 |
Hydrogen peroxide and catalase are inversely related in adult patients undergoing cardiopulmonary bypass: implications for antioxidant protection. | Redox Rep. | 1999 |
S. Mumby, R. Block, AJ. Petros, JM. Gutteridge
Redox Rep. 1999 ;4(1-2):49-52. PubMed:10714276 |
Increased content of thiobarbituric acid-reactive substances and hydrogen peroxide in the expired breath condensate of patients with stable chronic obstructive pulmonary disease: no significant effect of cigarette smoking. | Respir Med | 1999 |
D. Nowak, M. Kasielski, A. Antczak, T. Pietras, P. Bialasiewicz
Respir Med 1999 Jun;93(6):389-96. PubMed:10464820 |
Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. | Am. J. Respir. Crit. Care Med. | 1998 |
I. Horváth, LE. Donnelly, A. Kiss, SA. Kharitonov, S. Lim, KF. Chung, PJ. Barnes
Am. J. Respir. Crit. Care Med. 1998 Oct;158(4):1042-6. PubMed:9769258 |
Hydrogen peroxide in exhaled air of healthy children: reference values. | Eur. Respir. J. | 1998 |
Q. Jöbsis, HC. Raatgeep, SL. Schellekens, WC. Hop, PW. Hermans, JC. de Jongste
Eur. Respir. J. 1998 Aug;12(2):483-5. PubMed:9727806 |
Catalase, myeloperoxidase and hydrogen peroxide in cystic fibrosis. | Eur. Respir. J. | 1998 |
D. Worlitzsch, G. Herberth, M. Ulrich, G. Döring
Eur. Respir. J. 1998 Feb;11(2):377-83. PubMed:9551742 |
Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients. | Eur. Respir. J. | 1997 |
A. Antczak, D. Nowak, B. Shariati, M. Król, G. Piasecka, Z. Kurmanowska
Eur. Respir. J. 1997 Jun;10(6):1235-41. PubMed:9192922 |
Hydrogen peroxide in exhaled air is increased in stable asthmatic children. | Eur. Respir. J. | 1997 |
Q. Jöbsis, HC. Raatgeep, PW. Hermans, JC. de Jongste
Eur. Respir. J. 1997 Mar;10(3):519-21. PubMed:9072978 |
Hydrogenase encapsulation into red blood cells and regeneration of electron acceptor. | Biotechnol. Appl. Biochem. | 1996 |
MJ. Axley, LK. Dad, AL. Harabin
Biotechnol. Appl. Biochem. 1996 10;24(2):95-100. PubMed:8865603 |
Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease. | Am. J. Respir. Crit. Care Med. | 1996 |
PN. Dekhuijzen, KK. Aben, I. Dekker, LP. Aarts, PL. Wielders, CL. van Herwaarden, A. Bast
Am. J. Respir. Crit. Care Med. 1996 Sep;154(3 Pt 1):813-6. PubMed:8810624 |
Cellular oxygen toxicity. Oxidant injury without apoptosis. | J. Biol. Chem. | 1996 |
JA. Kazzaz, J. Xu, TA. Palaia, L. Mantell, AM. Fein, S. Horowitz
J. Biol. Chem. 1996 Jun;271(25):15182-6. PubMed:8662947 |
Increased content of hydrogen peroxide in the expired breath of cigarette smokers. | Eur. Respir. J. | 1996 |
D. Nowak, A. Antczak, M. Krol, T. Pietras, B. Shariati, P. Bialasiewicz, K. Jeczkowski, P. Kula
Eur. Respir. J. 1996 Apr;9(4):652-7. PubMed:8726926 |
Reperfusion injury and exhaled hydrogen peroxide. | Anesth. Analg. | 1993 |
WC. Wilson, PR. Laborde, JL. Benumof, R. Taylor, JF. Swetland
Anesth. Analg. 1993 Nov;77(5):963-70. PubMed:8214735 |
Postinsult treatment with N-acetyl-L-cysteine decreases IL-1-induced neutrophil influx and lung leak in rats. | Am. J. Physiol. | 1993 |
JA. Leff, CP. Wilke, BM. Hybertson, PF. Shanley, CJ. Beehler, JE. Repine
Am. J. Physiol. 1993 Nov;265(5 Pt 1):L501-6. PubMed:8238538 |
Expired breath hydrogen peroxide is a marker of acute airway inflammation in pediatric patients with asthma. | Am. Rev. Respir. Dis. | 1993 |
AW. Dohlman, HR. Black, JA. Royall
Am. Rev. Respir. Dis. 1993 Oct;148(4 Pt 1):955-60. PubMed:8214950 |
General anesthesia and exhaled breath hydrogen peroxide. | Anesthesiology | 1992 |
WC. Wilson, JF. Swetland, JL. Benumof, P. Laborde, R. Taylor
Anesthesiology 1992 May;76(5):703-10. PubMed:1575337 |
Increased hydrogen peroxide in the expired breath of patients with acute hypoxemic respiratory failure. | Chest | 1989 |
JI. Sznajder, A. Fraiman, JB. Hall, W. Sanders, G. Schmidt, G. Crawford, A. Nahum, P. Factor, LD. Wood
Chest 1989 Sep;96(3):606-12. PubMed:2766820 |
Expired breath oxidant activity during haemodialysis. | Nephron | 1989 |
ER. Maher, DG. Wickens, JR. Curtis, TL. Dormandy
Nephron 1989 ;52(2):190-1. PubMed:2739857 |
Oxidant activity in expired breath of patients with adult respiratory distress syndrome. | Lancet | 1986 |
SR. Baldwin, RH. Simon, CM. Grum, LH. Ketai, LA. Boxer, LJ. Devall
Lancet 1986 Jan;1(8471):11-4. PubMed:2867261 |
Effects of inhaled corticosteroids with different lung deposition on exhaled hydrogen peroxide in stable COPD patients. | Respiration |
WJ. van Beurden, GA. Harff, PN. Dekhuijzen, SM. van der Poel-Smet, FW. Smeenk
Respiration 2003 May-Jun;70(3):242-8. PubMed:12915742 |
|
Exhaled nitric oxide and hydrogen peroxide concentrations in asthmatic smokers. | Respiration |
I. Horváth, LE. Donnelly, A. Kiss, B. Balint, SA. Kharitonov, PJ. Barnes
Respiration 2004 Sep-Oct;71(5):463-8. PubMed:15467323 |
Associated curated diseases 10
Download diseasesAssociated disease mapping
Mapping of all associated diseases to Hydrogen peroxide is displayed in red.
Disease Name
with link to disease page |
Description of MeSH term
with link to MeSH Database |
Number of references |
---|---|---|
Acute Mountain Sickness |
MeSH:
Altitude Sickness
Multiple symptoms associated with reduced oxygen at high ALTITUDE. Year introduced: 1991(1975)
Link to MeSH Database: D000532
|
2 |
Asthma |
MeSH:
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and
intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of
airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
|
91 |
Primary Breast Cancer |
MeSH:
Breast Neoplasms
Tumors or cancer of the human BREAST.
Link to MeSH Database: D001943
|
1 |
Bronchiectasis |
MeSH:
Bronchiectasis
Persistent abnormal dilatation of the bronchi.
Link to MeSH Database: D001987
|
3 |
Upper And Lower Airway Inflammation In Atopic Dermatitis (Ad) |
MeSH:
Dermatitis, Atopic
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic
rhinitis and asthma, and hereditary disposition to a lowered threshold for
pruritus. It is manifested by lichenification, excoriation, and crusting, mainly
on the flexural surfaces of the elbow and knee. In infants it is known as
infantile eczema.
Link to MeSH Database: D003876
|
4 |
Feverish |
MeSH:
Fever
An abnormal elevation of body temperature, usually as a result of a pathologic process.
Link to MeSH Database: D005334
|
1 |
Obstructive Lung Disease |
MeSH:
Lung Diseases, Obstructive
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
Year introduced: 1972(1971)
Link to MeSH Database: D008173
|
1 |
Allergic Rhinitis With Asthma |
MeSH:
Rhinitis, Allergic, Perennial
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually
air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.
Year introduced: 1980
Link to MeSH Database: D012221
|
5 |
Obstructive Sleep Apnea |
MeSH:
Sleep Apnea, Obstructive
A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory
pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of
systemic and pulmonary arterial pressures may occur. Frequent partial arousals
occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime
tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA;
micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR
DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)
Year introduced: 2000
Link to MeSH Database: D020181
|
7 |
Chronic Obstructive Pulmonary Disease (Copd) |
MeSH:
Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Year introduced: 2002
Link to MeSH Database: D029424
|
31 |
Associated abnormalities 1
Concept Name | External ID | Weighted Score | Hits | References | |
Oxygen toxicity | 1000.0 | 1 |
|
Associated chemicals 14
Associated functions 14
Associated genes 0
No associated genes are detected in current reference collection.
There are 108 associated references with Hydrogen peroxide. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
NCBI Entrez Crosslinks
Chemical Information
Formula | H2O2 |
Mass | 34.014 |
Synonyms | hydrogen peroxide oxydol perhydrol 7722-84-1 Superoxol Inhibine Peroxaan Albone Hioxyl Interox Kastone Hydrogen dioxide Albone 35 Albone DS Dihydrogen dioxide T-Stuff Lensept Elawox Perone Albone 50 |
PubChem CID | 784 |