Systemic sclerosis

Disease description

A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA. Year introduced: 1971

Source: MeSH

References 1

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Journal Year Authors
Increased cysteinyl-leukotrienes and 8-isoprostane in exhaled breath condensate from systemic sclerosis patients. Rheumatology (Oxford) 2010 E. Tufvesson, G. Bozovic, R. Hesselstrand, L. Bjermer, A. Scheja, DM. Wuttge
Rheumatology (Oxford) 2010 Dec;49(12):2322-6. PubMed:20702485

Compounds 1

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8-epi-PGF2alpha PubChem CID: 5282263

MeSH information

MeSH ID D012595
MeSH name Scleroderma, Systemic