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Leukotrienes and 8-isoprostane in exhaled breath condensate in bronchoprovocation tests with occupational allergens.
P. Klusackova, J. Lebedova, P. Kacer, M. Kuzma, M. Brabec, D. Pelclova, Z. Fenclova, T. Navratil
Prostaglandins Leukot. Essent. Fatty Acids 2008 Apr-May;78(4-5):281-92.
PubMed: 18513935
Abstract
Exhaled breath condensate (EBC) contains many substances, which could help in diagnosis of occupational asthma. The aim of the study is to monitor leukotrienes (LT) and 8-isoprostane from EBC in bronchoprovocation tests with allergens in 47 patients with suspected occupational asthma. Forty-one patients were tested negative. In negative bronchoprovocation tests, no significant differences (P<0.05) were seen between the five measurements during and after the test. In control measurements (without provocation), significant differences were found among four measurements done within 24h for 8-isoprostane (P=0.0138). The relationship between the log transformed ratios of the EBC parameters and FEV(1) was never significant at the 5% level in control measurements, while in negative tests, statistical significance was recorded for LTB(4) (P=0.0299) before and 5h after the test. Six of 47 patients were tested positive. Such a small number of patients did not allow proper statistical analysis and therefore, the results are described separately for each patient.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
8-epi-PGF2alpha | 120 |