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Markers of oxidative stress are increased in exhaled breath condensates of children with atopic dermatitis.
DG. Peroni, A. Bodini, M. Corradi, A. Coghi, AL. Boner, GL. Piacentini
Br J Dermatol. 2012 Apr;166(4):839-43. doi: 10.1111/j.1365-2133.2011.10771.x.
PubMed: 22175656
Abstract
Airway inflammation may be present in subjects affected by atopic dermatitis (AD) but still without asthma symptoms. Exhaled breath condensate (EBC) reflects the composition of bronchoalveolar extracellular lining fluid that contains a large number of mediators of airway inflammation and oxidative damage. We assessed inflammatory markers in the EBC of patients with AD. Fifty-six children (34 girls and 22 boys) were enrolled: 33 affected by AD and 23 healthy controls. EBC was collected using a condenser device. We measured EBC pH and concentrations of leukotriene B4 (LTB4), 8-isoprostane, H(2) O(2) , malondialdehyde and 4-hydroxynoneal. Respiratory resistance was also evaluated. EBC pH in patients with AD was significantly lower than in healthy children, median (range) being 8·02 (7·94-8·12) in AD vs. 8·11 (8·05-8·16) (P = 0·02). The values of exhaled 8-isoprostane and LTB4 were significantly increased in subjects with AD compared with normal controls (P
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Hydrogen peroxide | 209 | |
8-epi-PGF2alpha | 120 | |
Leukotriene B4 | 88 |