Leukotriene B4

Description

Description of Leukotriene B4 with associated disease summary

Leukotriene B4 (LTB4) is a downstream product of arachidonic acid in eicosanoid biosynthetic pathways (Pediatr Pulmonol. (2013)). It is very import compound which can be linked to more than 10 diseases and can be detected by many methods including Enzyme Immunoassay (EIA), GC-MS and LC-MS/MS. Description of disease(s) related to Leukotriene B4 (LTB4):

Asthma

GC-MS can be used to accurately quantify and measured EBC of leukotrienes in asthmatic adults and children. Higher concentrations of leukotriene B4 in EBC of asthmatic patients in comparison with healthy control subjects increase asthma severity in adults. LTB4 concentrations were also increased in asthmatic children compared to healthy subjects, with differences detected for 2 degrees of asthma severity. The direct effects of LTB4 on human airway smooth muscle (ASM) have also been studied and suggested a role for a LTB4-BLT1 signaling in ASM responses contributing to the pathogenesis of airway remodeling in asthma. LTB4 concentrations in EBC were also increased in COPD patients and asthmatic patients compared to healthy controls. The difference might be contributed from the presence of reversibility in airway obstruction, and be part of a inflammatory process.

Pulmonary Disease, Chronic Obstructive

The LTB4 was detected in nasal lavage, sputum and BAL fluid in patients with stable COPD. The concentration of LTB4 in sputum and BAL also associated with other biomarkers of inflammation such as myeloperoxidase and elastase activity. The patients with acute exacerbations of COPD were found to have significantly increased level of LTB4 but the concentration of LTB4 will decrease during treatment although they remain in higher levels in COPD patients than healthy controls. An increased neutrophil chemotactic activity to which LTB4 contributes were also studied in EBC from COPD patients. The reciprocal interactions between chronic obstructive pulmonary disease (COPD) and cardiovascular diseases (CVD) were studied. EBC concentrations of LTB4, and serum levels of LTB4 were all significantly higher in patients with COPD than in healthy subjects while COPD patients with CVD were not found to have higher concentrations of LTB4.

Cystic Fibrosis

Chronic neutrophilic airway inflammation is a key symptom of cystic fibrosis (CF). Noninvasive inflammatory markers may be useful in monitoring CF. Leukotriene B4 (LTB4) is a noninvasive inflammatory biomarker that may be elevated in EBC levels of CF patients during exacerbation.

Sarcoidosis

The differences in levels of CysLT, LTB4, and 8-isoprostane in EBC of patients with sarcoidosis and healthy controls were analyzed. A positive correlations between BALF and EBC eicosanoids has been found.

Asthma, Aspirin-Induced

A significant increase in patients with aspirin-Induced asthma in 5-HETE, 12-HETE, and 15-HETE levels of EBC was associated by an increase in level of LTC4, LTD4, and LTE4, but not in LTB4.

Carcinoma, Non-Small-Cell Lung

LTB4 can be recognized in EBC collected from lung cancer, and their concentrations found to be significantly lower than those in BALf patients using diagnosed NSCLC. The EBC level of LTB4 and cys-LTs in lung cancer patients was higher than those measured in healthy, age-matched smokers and healthy nonsmokers.

Community-Acquired Infections, Pneumonia

LTB is a strong EBC biomarkers for community acquired pneumonia (CAP). The EBC of LTB4 increased in CAP and return to normal after 1 week when 18 children with CAP and 17 healthy children were recruited. EBC collection is a feasible way to monitor in children with CAP.

Dermatitis, Atopic

pH, LTB4 and 8-isoprostane in EBC are sensitive markers of airway inflammation in children with AD. These EBC could be used to predict the development of asthma later in life in children with AD.

Lung Neoplasms

Compared with both healthy subjects, patients with lung cancer achieved higher concentrations of cys-LTs (p< 0.05) and LTB4 (p < 0.05) in EBC. The levels of cys-LT, LTB4 and 8-isoprostane in EBC from lung cancer patients showed their concentrations in BALf. They can be used to monitor the disease and to assess the effectiveness of therapy.

Pneumoconiosis

The possible impact on extra-pulmonary disorders in EBC markers was analyzed. Both level of LTB4 and cysteinyl LTs were increase in asbestos-exposed subjects (p<0.05).

Respiratory Sounds

21 healthy nonatopic children and 25 patients with wheezing episodes were recruited for analyzing their EBC profiling. LTB4 concentrations were found to be higher in children with wheezing episodes than in healthy controls.

Rhinitis

EBC of LTB4 and LTE4 achieved higher concentrations in seasonal allergic rhinitis patients than in healthy subjects and reduced the concentrations after the pollen season as compared with levels in season.

Rhinitis, Allergic, Seasonal

The seasonal and postseasonal elevated in both EBC of LTB4 and LTE4 concentrations for the patients with seasonal allergic rhinitis significantly associated with the later increase in bronchial responsiveness to methacholine (BRM). The relationship can be used to monitor early inflammatory processes in the lower airways of patients with allergic rhinitis.

Sleep Apnea Syndromes

Obstructive sleep apnea (OSA) syndrome is an upper airway inflammation recognized in adults. LTB4 concentrations of EBC significant increased in children compared to control subjects.

Summary of extracted biomedical information

Leukotriene b4 is associated with abnormalities such as Asthma, Lung diseases, Inflammatory disorder, Septicemia and Atopic. The involved biomedical functions are known as Inflammation, Exhalation, inhibitors, Synthesis and amylase activity. The associated genes/proteins with Leukotriene B4 are CCL2 gene, LTB4R gene, interleukin-12 subunit p40, MAPK3 gene and TLR4 gene. Leukotriene b4 is associated with lipid mediator, Hydrocarbons, hydroxyl group, carboxylate and Anions.
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Associated references with human 50

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Journal Year Authors & PubMed Link
Acute respiratory effects and biomarkers of inflammation due to welding-derived nanoparticle aggregates. Int Arch Occup Environ Health 2017 K. Dierschke, C. Isaxon, UBK. Andersson, E. Assarsson, A. Axmon, L. Stockfelt, A. Gudmundsson, BAG. Jönsson, M. Kåredal, J. Löndahl, J. Pagels, A. Wierzbicka, M. Bohgard, J. Nielsen
Int Arch Occup Environ Health 2017 Jul;90(5):451-463. PubMed:28258373
[Determination of biomarkers in exhaled breath condensation of acute exacerbation of chronic obstructive pulmonary disease and its clinical implications]. Zhonghua Jie He He Hu Xi Za Zhi 2017 XQ. Dong, Q. Shen, YN. Yao, JJ. Chen, GH. Lu, JY. Zhou
Zhonghua Jie He He Hu Xi Za Zhi 2017 Feb;40(2):114-117. PubMed:28209042
A novel monoclonal antibody suitable for the detection of leukotriene B4. Biochem. Biophys. Res. Commun. 2017 S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack
Biochem. Biophys. Res. Commun. 2017 Jan;482(4):1054-1059. PubMed:27913298
A novel biomarker associated with distress in humans: calcium-binding protein, spermatid-specific 1 (CABS1). Am. J. Physiol. Regul. Integr. Comp. Physiol. 2017 T. Ritz, D. Rosenfield, CD. St Laurent, AF. Trueba, CA. Werchan, PD. Vogel, RJ. Auchus, E. Reyes-Serratos, AD. Befus
Am. J. Physiol. Regul. Integr. Comp. Physiol. 2017 06;312(6):R1004-R1016. PubMed:28381457
Effects of academic exam stress on nasal leukotriene B4 and vascular endothelial growth factor in asthma and health. Biol Psychol 2016 A. Trueba, MW. Ryan, PD. Vogel, T. Ritz
Biol Psychol 2016 07;118:44-51. PubMed:27143192
Biomarkers of inflammation in persons with chronic tetraplegia. J Breath Res 2015 M. Radulovic, WA. Bauman, JM. Wecht, M. LaFountaine, N. Kahn, J. Hobson, K. Singh, C. Renzi, C. Yen, GJ. Schilero
J Breath Res 2015 May;9(3):036001. PubMed:25971935
Evaluation of Airway Inflammation in Compost Workers Exposed to Bioaerosols Using Exhaled Breath Condensate and Fractional Exhaled Nitric Oxide. Adv. Exp. Med. Biol. 2015 F. Hoffmeyer, V. van Kampen, A. Deckert, HD. Neumann, M. Buxtrup, E. Willer, C. Felten, T. Brüning, M. Raulf, J. Bünger
Adv. Exp. Med. Biol. 2015 ;858:57-67. PubMed:25786401
Elevated exhaled leukotriene B₄ in the small airway compartment in children with asthma. Ann. Allergy Asthma Immunol. 2015 J. Trischler, CM. Müller, S. Könitzer, E. Prell, I. Korten, S. Unverzagt, C. Lex
Ann. Allergy Asthma Immunol. 2015 Feb;114(2):111-6. PubMed:25624130
Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD. Respir Care 2015 J. Zhang, X. Wang, Y. Chen, W. Yao
Respir Care 2015 Feb;60(2):251-8. PubMed:25336529
[Determining asthma treatment in children by monitoring fractional exhaled nitric oxide, sputum eosinophils and leukotriene B₄]. An Pediatr (Barc) 2015 G. Vizmanos-Lamotte, MJ. Cruz, S. Gómez-Ollés, X. Muñoz, I. de Mir Messa, A. Moreno-Galdó
An Pediatr (Barc) 2015 Jan;82(1):e21-5. PubMed:24857428
Serum leukotrienes, circulating neutrophils, and high sensitivity C-reactive protein in Chinese children with sleep-disordered breathing. Int. Immunopharmacol. 2014 Y. Shen, Q. Qin, Z. Xu, K. Shen
Int. Immunopharmacol. 2014 Sep;22(1):120-5. PubMed:24975656
Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases. Pol. Arch. Med. Wewn. 2014 M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak
Pol. Arch. Med. Wewn. 2014 ;124(6):290-7. PubMed:24824617
Using high-performance liquid chromatography with UV detector to quantify exhaled leukotriene B4 level in nonatopic adults. J. Formos. Med. Assoc. 2014 GH. Wan, DC. Yan, HY. Tseng, JT. Lee, YW. Lin
J. Formos. Med. Assoc. 2014 Aug;113(8):566-8. PubMed:24491995
The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma. BMC Pulm Med 2014 BR. Leaker, D. Singh, FY. Ali, PJ. Barnes, B. O'Connor
BMC Pulm Med 2014 Oct;14:166. PubMed:25351474
Inflammatory biomarkers in sputum predict COPD exacerbations. Lung 2013 E. Tufvesson, M. Ekberg, L. Bjermer
Lung 2013 Aug;191(4):413-6. PubMed:23689877
Comparison of different non-invasive methods for detection of allergic asthma. Adv. Exp. Med. Biol. 2013 M. Raulf-Heimsoth, V. van Kampen, E. Heinze, S. Bernard, G. Borowitzki, S. Freundt, K. Sucker, C. Eliakopoulos, A. Nienhaus, T. Brüning, R. Merget
Adv. Exp. Med. Biol. 2013 ;755:55-63. PubMed:22826049
Impact of different welding techniques on biological effect markers in exhaled breath condensate of 58 mild steel welders. J. Toxicol. Environ. Health Part A 2012 F. Hoffmeyer, M. Raulf-Heimsoth, M. Lehnert, B. Kendzia, S. Bernard, H. Berresheim, M. Düser, J. Henry, T. Weiss, HM. Koch, B. Pesch, T. Brüning, .
J. Toxicol. Environ. Health Part A 2012 ;75(8-10):525-32. PubMed:22686312
The cough receptor TRPV1 agonists 15(S)-HETE and LTB4 in the cough response to hypertonicity. Inflamm Allergy Drug Targets 2012 H. Koskela, M. Purokivi, R. Nieminen, E. Moilanen
Inflamm Allergy Drug Targets 2012 Apr;11(2):102-8. PubMed:22280233
Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8. BMC Cancer 2011 GE. Carpagnano, GP. Palladino, D. Lacedonia, A. Koutelou, S. Orlando, MP. Foschino-Barbaro
BMC Cancer 2011 Jun;11:226. PubMed:21649887
Effects of inhalation of thermal water on exhaled breath condensate in chronic obstructive pulmonary disease. Respiration 2010 G. Guarnieri, S. Ferrazzoni, MC. Scarpa, A. Lalli, P. Maestrelli
Respiration 2010 ;79(3):216-21. PubMed:19590158
Leukotriene B4, 8-iso-prostaglandin F2 alpha, and pH in exhaled breath condensate from asymptomatic smokers. J. Physiol. Pharmacol. 2009 F. Hoffmeyer, V. Harth, J. Bunger, T. Bruning, M. Raulf-Heimsoth
J. Physiol. Pharmacol. 2009 Nov;60 Suppl 5:57-60. PubMed:20134040
Measurement of tumor necrosis factor-alpha, leukotriene B4, and interleukin 8 in the exhaled breath condensate in patients with acute exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2009 FW. Ko, TF. Leung, GW. Wong, J. Ngai, KW. To, S. Ng, DS. Hui
Int J Chron Obstruct Pulmon Dis 2009 ;4:79-86. PubMed:19436689
LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2009 P. Montuschi
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2009 May;877(13):1272-80. PubMed:19233745
Inflammatory and oxidative stress biomarkers in allergic rhinitis: the effect of smoking. Clin. Exp. Allergy 2009 K. Tanou, A. Koutsokera, TS. Kiropoulos, M. Maniati, AI. Papaioannou, K. Georga, S. Zarogiannis, KI. Gourgoulianis, K. Kostikas
Clin. Exp. Allergy 2009 Mar;39(3):345-53. PubMed:19187324
[Determination and clinical implication of leukotriene B(4) and tumor necrosis factor-alpha in condensate of exhaled breath of chronic obstructive pulmonary disease patients]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2008 JL. Chen, JR. Chen, YJ. Tao, YY. Cai, GH. Tao
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2008 Jun;20(6):357-60. PubMed:18549718
Influence of condensing equipment and temperature on exhaled breath condensate pH, total protein and leukotriene concentrations. Respir Med 2008 K. Czebe, I. Barta, B. Antus, M. Valyon, I. Horváth, T. Kullmann
Respir Med 2008 May;102(5):720-5. PubMed:18249106
Increased levels of cysteinyl-leukotrienes in saliva, induced sputum, urine and blood from patients with aspirin-intolerant asthma. Thorax 2008 F. Gaber, K. Daham, A. Higashi, N. Higashi, A. Gülich, I. Delin, A. James, M. Skedinger, P. Gyllfors, M. Nord, SE. Dahlén, M. Kumlin, B. Dahlén
Thorax 2008 Dec;63(12):1076-82. PubMed:18757457
Exhaled breath condensate analysis: evaluation of a methodological setting for epidemiological field studies. J. Physiol. Pharmacol. 2007 F. Hoffmeyer, V. Harth, R. Merget, N. Goldscheid, E. Hainze, P. Degens, B. Pesch, J. Bünger, T. Brüning, M. Raulf-Heimsoth
J. Physiol. Pharmacol. 2007 Nov;58 Suppl 5(Pt 1):289-98. PubMed:18204138
Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients. Int J Chron Obstruct Pulmon Dis 2007 ZL. Borrill, RC. Starkey, SD. Singh
Int J Chron Obstruct Pulmon Dis 2007 ;2(1):71-6. PubMed:18044068
Reproducibility of exhaled biomarkers in COPD--the road less traveled. Int J Chron Obstruct Pulmon Dis 2007 I. Horvath
Int J Chron Obstruct Pulmon Dis 2007 ;2(1):2-3. PubMed:18044058
Saliva is one likely source of leukotriene B4 in exhaled breath condensate. Eur. Respir. J. 2006 F. Gaber, F. Acevedo, I. Delin, BM. Sundblad, L. Palmberg, K. Larsson, M. Kumlin, SE. Dahlén
Eur. Respir. J. 2006 Dec;28(6):1229-35. PubMed:16971403
[Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease]. Arch. Bronconeumol. 2006 JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez
Arch. Bronconeumol. 2006 Jul;42(7):332-7. PubMed:16945263
Clinical and technical factors affecting pH and other biomarkers in exhaled breath condensate. Pediatr. Pulmonol. 2006 TF. Leung, CY. Li, E. Yung, EK. Liu, CW. Lam, GW. Wong
Pediatr. Pulmonol. 2006 Jan;41(1):87-94. PubMed:16292777
Biomarkers of neutrophilic inflammation in exhaled air of cystic fibrosis children with bacterial airway infections. Pediatr. Pulmonol. 2005 A. Bodini, C. D'Orazio, D. Peroni, M. Corradi, G. Folesani, E. Baraldi, BM. Assael, A. Boner, GL. Piacentini
Pediatr. Pulmonol. 2005 Dec;40(6):494-9. PubMed:16229003
Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD. Thorax 2005 P. Montuschi, F. Macagno, P. Parente, S. Valente, L. Lauriola, G. Ciappi, SA. Kharitonov, PJ. Barnes, G. Ciabattoni
Thorax 2005 Oct;60(10):827-33. PubMed:16192367
Clinical and atopic parameters and airway inflammatory markers in childhood asthma: a factor analysis. Thorax 2005 TF. Leung, GW. Wong, FW. Ko, CW. Lam, TF. Fok
Thorax 2005 Oct;60(10):822-6. PubMed:16055623
Inverse association between Chlamydia pneumoniae respiratory tract infection and initiation of asthma or allergic rhinitis in children. Pediatr Allergy Immunol 2005 SM. Schmidt, CE. Müller, SK. Wiersbitzky
Pediatr Allergy Immunol 2005 Mar;16(2):137-44. PubMed:15787871
The relation between obesity and asthmatic airway inflammation. Pediatr Allergy Immunol 2004 TF. Leung, CY. Li, CW. Lam, CS. Au, E. Yung, IH. Chan, GW. Wong, TF. Fok
Pediatr Allergy Immunol 2004 Aug;15(4):344-50. PubMed:15305944
Exhaled breath condensate eicosanoids and sputum eosinophils in asthmatic children: a pilot study. Pediatr Allergy Immunol 2004 A. Bodini, D. Peroni, L. Vicentini, A. Loiacono, E. Baraldi, L. Ghiro, M. Corradi, R. Alinovi, AL. Boner, GL. Piacentini
Pediatr Allergy Immunol 2004 Feb;15(1):26-31. PubMed:14998379
Suppression of leukotriene B4 generation by ex-vivo neutrophils isolated from asthma patients on dietary supplementation with gammalinolenic acid-containing borage oil: possible implication in asthma. Clin. Dev. Immunol. 2004 VA. Ziboh, S. Naguwa, K. Vang, J. Wineinger, BM. Morrissey, M. Watnik, ME. Gershwin
Clin. Dev. Immunol. 2004 Mar;11(1):13-21. PubMed:15154607
Increased inflammatory markers in the exhaled breath condensate of cigarette smokers. Eur. Respir. J. 2003 GE. Carpagnano, SA. Kharitonov, MP. Foschino-Barbaro, O. Resta, E. Gramiccioni, PJ. Barnes
Eur. Respir. J. 2003 Apr;21(4):589-93. PubMed:12762340
Validation of leukotriene B4 measurements in exhaled breath condensate. Inflamm. Res. 2003 P. Montuschi, E. Ragazzoni, S. Valente, G. Corbo, C. Mondino, G. Ciappi, PJ. Barnes, G. Ciabattoni
Inflamm. Res. 2003 Feb;52(2):69-73. PubMed:12665124
Exhaled nitric oxide correlated with induced sputum findings in COPD. Chest 2001 PE. Silkoff, D. Martin, J. Pak, JY. Westcott, RJ. Martin
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Protective effects of nedocromil sodium on cellular and biohumoral components present in the bronchial alveolar lavage fluid and in peripheral blood in atopic asthmatics. Respiration 1994 G. Mazzarella, E. Grella, L. Romano, A. Perna, C. Marzo, C. Guarino, A. Cammarata, A. Bianco, G. Liccardo
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Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic obstructive pulmonary disease. Chest 1993 D. Piperno, Y. Pacheco, R. Hosni, P. Moliere, C. Gharib, M. Lagarde, M. Perrin-Fayolle
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Hyperoxic exposure in humans. Effects of 50 percent oxygen on alveolar macrophage leukotriene B4 synthesis. Chest 1992 DE. Griffith, JG. Garcia, HL. James, KS. Callahan, S. Iriana, D. Holiday
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Novel perspectives in the detection of oral and nasal oxidative stress and inflammation in pediatric united airway diseases. Int J Immunopathol Pharmacol M. Profita, P. Montuschi, A. Bonanno, L. Riccobono, AM. Montalbano, G. Ciabattoni, GD. Albano, G. Liotta, J. Bousquet, M. Gjomarkaj, S. La Grutta
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Breath markers of oxidative stress and airway inflammation in Seasonal Allergic Rhinitis. Int J Immunopathol Pharmacol C. Gratziou, N. Rovina, M. Makris, DC. Simoes, A. Papapetropoulos, C. Roussos
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The respiratory effects of volatile organic compounds. Int J Occup Environ Health GP. Pappas, RJ. Herbert, W. Henderson, J. Koenig, B. Stover, S. Barnhart
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Associated curated diseases 15

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Associated disease mapping

Mapping of all associated diseases to Leukotriene B4 is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
91
Cystic Fibrosis MeSH: Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967
Link to MeSH Database: D003550
20
Upper And Lower Airway Inflammation In Atopic Dermatitis (Ad) MeSH: Dermatitis, Atopic
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
Link to MeSH Database: D003876
4
Seasonal Allergic Rhinitis (Sar) MeSH: Rhinitis, Allergic, Seasonal
Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS. Year introduced: 2006 (1963)
Link to MeSH Database: D006255
1
Aspirin Sensitive Asthma MeSH: Asthma, Aspirin-Induced
Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use. Year introduced: 2010
Link to MeSH Database: D055963
2
Non Small Cell Lung Cancer, Lung Neoplasms MeSH: Lung Neoplasms
Tumors or cancer of the LUNG.
Link to MeSH Database: D008175
4
Pneumoconiosis MeSH: Pneumoconiosis
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population. Year introduced: 1966
Link to MeSH Database: D011009
1
Non Small Cell Lung Cancer, Carcinoma MeSH: Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy. Year introduced: 1994
Link to MeSH Database: D002289
2
Community Acquired Pneumonia MeSH: Pneumonia
Infection of the lung often accompanied by inflammation. Year introduced: 1963
Link to MeSH Database: D011014
2
Wheezing MeSH: Respiratory Sounds
Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT. Year introduced: 1980
Link to MeSH Database: D012135
2
Rhinitis MeSH: Rhinitis
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
Link to MeSH Database: D012220
2
Sarcoidosis MeSH: Sarcoidosis
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands. Year introduced: PSEUDOTUBERCULOSIS use SARCOIDOSIS 1963-1992
Link to MeSH Database: D012507
4
Sleep Disordered Breathing (Sdb) MeSH: Sleep Apnea Syndromes
Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types. Year introduced: 1980
Link to MeSH Database: D012891
2
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31
Community Acquired Pneumonia MeSH: Community-Acquired Infections
Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility. Year introduced: 1994
Link to MeSH Database: D017714
2

Associated abnormalities 16

Concept Name External ID Weighted Score Hits References
Asthma ICD9-CM:493.9 1000.0 7
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
  2. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  3. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Lung diseases 1000.0 4
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
  2. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  3. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Inflammatory disorder 1000.0 4
  1. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
  2. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  3. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
  4. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Atopic 901.61 3
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Chronic Obstructive Airway Disease 801.47 3
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
  2. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Cystic Fibrosis ICD9-CM:277.0 1000.0 3
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
  2. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Respiration Disorders ICD9-CM:519.9 951.44 2
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
  2. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Helminthiasis ICD9-CM:128.9 692.31 2
  1. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
Rhinitis 1000.0 1
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
Septicemia ICD9-CM:038 787.63 1
  1. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
Mixed infectious disease 954.42 1
  1. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
Extrinsic asthma NOS ICD9-CM:493.0 825.0 1
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Arthritis 1000.0 1
  1. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
Respiratory Distress Syndrome, Adult 986.11 1
  1. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Psoriasis 1000.0 1
  1. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Bronchitis, Chronic ICD9-CM:491 973.68 1
  1. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.

Associated chemicals 17

Concept Name External ID Definition Weighted Score Hits References
Hydrocarbons CHEBI:24632 814.0 2
  1. The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.
    BR. Leaker, D. Singh, FY. Ali, PJ. Barnes, B. O'Connor (2014) BMC Pulm Med
hydroxyl group CHEBI:43176 990.36 2
  1. The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.
    BR. Leaker, D. Singh, FY. Ali, PJ. Barnes, B. O'Connor (2014) BMC Pulm Med
carboxylate 958.0 2
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Anions 869.38 2
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
lipid mediator 966.23 2
  1. Serum leukotrienes, circulating neutrophils, and high sensitivity C-reactive protein in Chinese children with sleep-disordered breathing.
    Y. Shen, Q. Qin, Z. Xu, K. Shen (2014) Int. Immunopharmacol.
  2. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Sulfhydryl Compounds 570.0 1
  1. Hyperoxic exposure in humans. Effects of 50 percent oxygen on alveolar macrophage leukotriene B4 synthesis.
    DE. Griffith, JG. Garcia, HL. James, KS. Callahan, S. Iriana, D. Holiday (1992) Chest
Amines CHEBI:32952 1000.0 1
  1. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
Carbodiimides 944.54 1
  1. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
Protons CHEBI:24636 829.57 1
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
diene 944.0 1
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Nitrogen CHEBI:17997 925.5 1
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
acetonitrile 1000.0 1
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
ammonium hydroxide 1000.0 1
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Carbon CHEBI:33415 901.0 1
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Ligands CHEBI:52214 868.0 1
  1. Inverse association between Chlamydia pneumoniae respiratory tract infection and initiation of asthma or allergic rhinitis in children.
    SM. Schmidt, CE. Müller, SK. Wiersbitzky (2005) Pediatr Allergy Immunol
amino group 930.5 1
  1. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Carbon compound 1000.0 1
  1. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.

Associated functions 43

Concept Name External ID Definition Weighted Score Hits References
Exhalation 704.41 6
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
  2. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  3. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Inflammation 988.0 5
  1. Breath markers of oxidative stress and airway inflammation in Seasonal Allergic Rhinitis.
    C. Gratziou, N. Rovina, M. Makris, DC. Simoes, A. Papapetropoulos, C. Roussos () Int J Immunopathol Pharmacol
  2. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
  3. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
  4. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  5. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
inhibitors 926.0 4
  1. Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic obstructive pulmonary disease.
    D. Piperno, Y. Pacheco, R. Hosni, P. Moliere, C. Gharib, M. Lagarde, M. Perrin-Fayolle (1993) Chest
  2. Inverse association between Chlamydia pneumoniae respiratory tract infection and initiation of asthma or allergic rhinitis in children.
    SM. Schmidt, CE. Müller, SK. Wiersbitzky (2005) Pediatr Allergy Immunol
  3. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
  4. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Synthesis 953.24 4
  1. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
  2. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
amylase activity 1000.0 3
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
Immunoreactivity 952.25 3
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
Docking 933.18 2
  1. The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.
    BR. Leaker, D. Singh, FY. Ali, PJ. Barnes, B. O'Connor (2014) BMC Pulm Med
Neutrophil Infiltration 978.26 2
  1. Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic obstructive pulmonary disease.
    D. Piperno, Y. Pacheco, R. Hosni, P. Moliere, C. Gharib, M. Lagarde, M. Perrin-Fayolle (1993) Chest
  2. Evaluation of leukotriene B4 in the canine exhaled breath: standardization of a technique of sample collection.
    M. Pietra, A. Diana, M. Forni, M. Jöchler, S. Cinotti (2003) Vet. Res. Commun.
Binding (Molecular Function) 457.14 2
  1. The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.
    BR. Leaker, D. Singh, FY. Ali, PJ. Barnes, B. O'Connor (2014) BMC Pulm Med
Provocation 944.0 2
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
Collision 892.71 2
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Inspiration function 602.83 2
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
Stimulus 878.75 2
  1. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
  2. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
Drug Interactions 823.53 2
  1. The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.
    BR. Leaker, D. Singh, FY. Ali, PJ. Barnes, B. O'Connor (2014) BMC Pulm Med
Signal Transduction GO:0007165 687.3 2
  1. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
  2. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
Increased Leukotriene Production 989.38 1
  1. Hyperoxic exposure in humans. Effects of 50 percent oxygen on alveolar macrophage leukotriene B4 synthesis.
    DE. Griffith, JG. Garcia, HL. James, KS. Callahan, S. Iriana, D. Holiday (1992) Chest
Chronic eosinophilic inflammation 803.31 1
  1. Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic obstructive pulmonary disease.
    D. Piperno, Y. Pacheco, R. Hosni, P. Moliere, C. Gharib, M. Lagarde, M. Perrin-Fayolle (1993) Chest
Cell Degranulation 950.5 1
  1. Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic obstructive pulmonary disease.
    D. Piperno, Y. Pacheco, R. Hosni, P. Moliere, C. Gharib, M. Lagarde, M. Perrin-Fayolle (1993) Chest
Infiltration 960.0 1
  1. Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic obstructive pulmonary disease.
    D. Piperno, Y. Pacheco, R. Hosni, P. Moliere, C. Gharib, M. Lagarde, M. Perrin-Fayolle (1993) Chest
Mutation 1000.0 1
  1. The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.
    BR. Leaker, D. Singh, FY. Ali, PJ. Barnes, B. O'Connor (2014) BMC Pulm Med
targeting 897.0 1
  1. The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.
    BR. Leaker, D. Singh, FY. Ali, PJ. Barnes, B. O'Connor (2014) BMC Pulm Med
Regulation 913.5 1
  1. The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.
    BR. Leaker, D. Singh, FY. Ali, PJ. Barnes, B. O'Connor (2014) BMC Pulm Med
Lymphocytic migration 958.19 1
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
Permeability, Microvascular 911.98 1
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
Chemotaxis 851.5 1
  1. Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic obstructive pulmonary disease.
    D. Piperno, Y. Pacheco, R. Hosni, P. Moliere, C. Gharib, M. Lagarde, M. Perrin-Fayolle (1993) Chest
Physiologic Organization 750.0 1
  1. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
Respiratory physiology 795.45 1
  1. LC/MS/MS analysis of leukotriene B4 and other eicosanoids in exhaled breath condensate for assessing lung inflammation.
    P. Montuschi (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
antagonists 922.5 1
  1. Increased plasma levels of atrial natriuretic factor, renin activity, and leukotriene C4 in chronic obstructive pulmonary disease.
    D. Piperno, Y. Pacheco, R. Hosni, P. Moliere, C. Gharib, M. Lagarde, M. Perrin-Fayolle (1993) Chest
Eosinophil production 1000.0 1
  1. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
paracrine 925.5 1
  1. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
Paracrine Communication 1000.0 1
  1. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
Neutrophil migration, function 833.33 1
  1. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
Cell Adhesion 950.5 1
  1. Serum leukotrienes, circulating neutrophils, and high sensitivity C-reactive protein in Chinese children with sleep-disordered breathing.
    Y. Shen, Q. Qin, Z. Xu, K. Shen (2014) Int. Immunopharmacol.
Feedback 887.5 1
  1. Serum leukotrienes, circulating neutrophils, and high sensitivity C-reactive protein in Chinese children with sleep-disordered breathing.
    Y. Shen, Q. Qin, Z. Xu, K. Shen (2014) Int. Immunopharmacol.
Apoptosis GO:0012501 1000.0 1
  1. Serum leukotrienes, circulating neutrophils, and high sensitivity C-reactive protein in Chinese children with sleep-disordered breathing.
    Y. Shen, Q. Qin, Z. Xu, K. Shen (2014) Int. Immunopharmacol.
Hypoxia 849.5 1
  1. Serum leukotrienes, circulating neutrophils, and high sensitivity C-reactive protein in Chinese children with sleep-disordered breathing.
    Y. Shen, Q. Qin, Z. Xu, K. Shen (2014) Int. Immunopharmacol.
NEUTROPHILIC 895.0 1
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
Inflammatory Response 986.45 1
  1. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
smooth muscle contraction 937.0 1
  1. The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma.
    BR. Leaker, D. Singh, FY. Ali, PJ. Barnes, B. O'Connor (2014) BMC Pulm Med
Respiration 839.59 1
  1. [Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease].
    JL. Izquierdo, C. Almonacid, T. Parra, J. Pérez (2006) Arch. Bronconeumol.
Amplification 925.5 1
  1. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
cross reactivity 1000.0 1
  1. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
cell activation 944.0 1
  1. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.

Associated genes 4

Concept Name External ID Definition Weighted Score Hits References
LTB4R gene EntrezGene:1241 738.9 3
  1. Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases.
    M. Kaźmierczak, M. Ciebiada, A. Pękala-Wojciechowska, M. Pawłowski, T. Pietras, A. Antczak (2014) Pol. Arch. Med. Wewn.
  2. A novel monoclonal antibody suitable for the detection of leukotriene B4.
    S. Lütkecosmann, A. Warsinke, W. Tschöpe, R. Eichler, K. Hanack (2017) Biochem. Biophys. Res. Commun.
interleukin-12 subunit p40 653.85 1
  1. Evaluation of leukotriene B4 in the canine exhaled breath: standardization of a technique of sample collection.
    M. Pietra, A. Diana, M. Forni, M. Jöchler, S. Cinotti (2003) Vet. Res. Commun.
CCL2 gene EntrezGene:6347 719.85 1
  1. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis
TLR4 gene EntrezGene:7099 647.72 1
  1. Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients.
    ZL. Borrill, RC. Starkey, SD. Singh (2007) Int J Chron Obstruct Pulmon Dis

Chemical Information

Formula C20H32O4
Mass 336.472
Synonyms LEUKOTRIENE B4
LTB4
5,12-Dihete
5,12-Hete
71160-24-2
5S,12R-diHETE
(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
CHEMBL65061
5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid
CHEBI:15647
VNYSSYRCGWBHLG-AMOLWHMGSA-N
[5S,12R]-Dihydroxy-[6Z,8E,10E,14Z]-eicosatetraenoic acid
(6z,8e,10e,14z)-(5s,12r)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
(S-(R*,S*-(E,Z,E,Z)))-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid
5(S),12(R)-Dihydroxy-6-cis-8-trans-10-trans-14-cis-eicosatetraenoic Acid
6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12R,14Z)-
6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-, (S-(R*,S*-(E,E,Z,Z)))-
UNII-1HGW4DR56D
LEUKOTRIENEB4
LEUKOTRIENE_B4
PubChem CID 5280492