Nickel

Description

Description of Nickel with associated disease summary

Nickel (Ni) is one of the metal indicators of interstitial lung diseases (ILD) including idiopathic interstitial pneumonia (IIPs) and sarcoidosis. Higher levels of copper were detected in interstitial lung diseases patients. The higher levels of nickel and other metallic elements (Cr and Si) in ILD patients may be due to their difficulties of metal removal. Structural modification in the pulmonary interstitium reduce gaseous exchange and make lung retain some metals such as Ni, Cr and Si for many years. (J Breath Res. (2009)) Description of disease(s) related to Nickel:

Idiopathic pulmonary fibrosis

One study using inductive coupled plasma mass spectrometry (ICP-MS) to detect nickel and shows that the EBC nickel level in idiopathic pulmonary fibrosis patients are significantly higher than the healthy controls (p < 0.05 versus controls) (J Breath Res. (2009)).

Non-specific interstitial pneumonia

One study using inductive coupled plasma mass spectrometry (ICP-MS) to detect nickel and shows that the EBC nickel level in non-specific interstitial pneumonia patients are higher than the healthy controls (p < 0.05 versus controls) (J Breath Res. (2009)).

Sarcoidosis

One study using inductive coupled plasma mass spectrometry (ICP-MS) to detect copper and shows that the EBC nickel level in sarcoidosis patients are higher than the healthy controls (p < 0.05 versus controls) (J Breath Res. (2009)).

Summary of extracted biomedical information

No extracted biomedical infomation is detected in current reference collection for lack of full text of associated references or no biomedical terms are detected with Nickel in the same sentence by our text-mining approach.
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Associated references with human 21

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Reference title

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Journal Year Authors & PubMed Link
Rare occupational cause of nasal septum perforation: Nickel exposure. Int J Occup Med Environ Health 2017 EC. Bolek, A. Erden, C. Kulekci, U. Kalyoncu, O. Karadag
Int J Occup Med Environ Health 2017 Oct;30(6):963-967. PubMed:28839290
Reduced graphene oxide-nickel nanoparticles/biopolymer composite films for the sub-millimolar detection of glucose. Analyst 2016 R. Krishna, JM. Campiña, PM. Fernandes, J. Ventura, E. Titus, AF. Silva
Analyst 2016 Jun;141(13):4151-61. PubMed:27214596
Manganese in exhaled breath condensate: a new marker of exposure to welding fumes. Toxicol. Lett. 2014 S. Hulo, N. Chérot-Kornobis, M. Howsam, S. Crucq, V. de Broucker, A. Sobaszek, JL. Edme
Toxicol. Lett. 2014 Apr;226(1):63-9. PubMed:24508310
[Urban individual exposure to cadmium and baroreceptor response to posture]. Clin Ter 2014 A. Sancini, F. Sinibaldi, B. Loreti, S. De Sio, T. Casale, C. Sacco, B. Scala, C. Monti, A. Chighine, S. Bonomi, P. Cirelli, R. Massimi, R. Giubilati, F. Tomei, MV. Rosati
Clin Ter 2014 ;165(3):e205-12. PubMed:24999575
Case report of occupational asthma induced by polyvinyl chloride and nickel. J. Korean Med. Sci. 2013 GW. Song, GY. Ban, YH. Nam, HS. Park, YM. Ye
J. Korean Med. Sci. 2013 Oct;28(10):1540-2. PubMed:24133363
Health status within the precincts of a nickel-copper mining and smelting environment. Afr Health Sci 2011 GI. Ekosse
Afr Health Sci 2011 Mar;11(1):90-6. PubMed:21572863
Reconstruction of tracheal wall defect with a mesh patch of nickel-titanium shape-memory alloy. Ann. Otol. Rhinol. Laryngol. 2011 JS. Luo, PC. Cui, PF. Gao, H. Nan, Z. Liu, YZ. Sun
Ann. Otol. Rhinol. Laryngol. 2011 Mar;120(3):198-203. PubMed:21510146
Urinary elimination of nickel and cobalt in relation to airborne nickel and cobalt exposures in a battery plant. Int Arch Occup Environ Health 2007 K. Yokota, Y. Johyama, Y. Kunitani, H. Michitsuji, S. Yamada
Int Arch Occup Environ Health 2007 May;80(6):527-31. PubMed:17136408
[Forty-three tracheal stricture with Ni-Ti shape memory alloy stent]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2005 HJ. Yi, BQ. Zhang, W. Liu, PH. Peng, XZ. Shi, Y. Zhang, L. He, H. Jiang, BJ. Wei, F. Qi, ZD. Jiang, XL. Zhu
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2005 Apr;40(4):261-5. PubMed:16008258
Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells. Physiol. Genomics 2005 A. Vengellur, JM. Phillips, JB. Hogenesch, JJ. LaPres
Physiol. Genomics 2005 Aug;22(3):308-18. PubMed:15942021
Evaluation of the human nickel retention model with workplace data. Regul. Toxicol. Pharmacol. 2001 CP. Yu, TH. Hsieh, AR. Oller, G. Oberdörster
Regul. Toxicol. Pharmacol. 2001 Apr;33(2):165-72. PubMed:11350199
Cloning of differentially expressed sequence tags from nickel-transformed human embryonic lung cells. Cancer Lett. 2000 X. Mao, T. Kashii, R. Hayashi, K. Sassa, T. Fujishita, M. Maruyama, M. Kobayashi, S. Liu
Cancer Lett. 2000 Dec;161(1):57-62. PubMed:11078913
Assessment of historical exposures in a nickel refinery in Norway. Scand J Work Environ Health 2000 TK. Grimsrud, SR. Berge, F. Resmann, T. Norseth, A. Andersen
Scand J Work Environ Health 2000 Aug;26(4):338-45. PubMed:10994800
Occupational exposure to chromium and nickel in the 1980s in Finland. Sci. Total Environ. 1997 M. Kiilunen
Sci. Total Environ. 1997 Jun;199(1-2):91-101. PubMed:9200851
Persistent neurotoxicity from a battery fire: is cadmium the culprit? South. Med. J. 1996 KH. Kilburn, KL. McKinley
South. Med. J. 1996 Jul;89(7):693-8. PubMed:8685756
Relation between various chromium compounds and some other elements in fumes from manual metal arc stainless steel welding. Br J Ind Med 1993 W. Matczak, J. Chmielnicka
Br J Ind Med 1993 Mar;50(3):244-51. PubMed:8457491
Acute nickel carbonyl poisoning. Am J Emerg Med 1993 DL. Kurta, BS. Dean, EP. Krenzelok
Am J Emerg Med 1993 Jan;11(1):64-6. PubMed:8383493
Cross-shift and chronic effects of stainless-steel welding related to internal dosimetry of chromium and nickel. Am. J. Ind. Med. 1990 KH. Kilburn, R. Warshaw, CT. Boylen, JC. Thornton, SM. Hopfer, FW. Sunderman, J. Finklea
Am. J. Ind. Med. 1990 ;17(5):607-15. PubMed:2337084
Acute nickel toxicity in electroplating workers who accidently ingested a solution of nickel sulfate and nickel chloride. Am. J. Ind. Med. 1988 FW. Sunderman, B. Dingle, SM. Hopfer, T. Swift
Am. J. Ind. Med. 1988 ;14(3):257-66. PubMed:3189343
Dust in dental laboratories. Part I: Types and levels in specific operations. J Prosthet Dent 1980 D. Brune, H. Beltesbrekke
J Prosthet Dent 1980 Jun;43(6):687-92. PubMed:6929337
Lactose intolerance in systemic nickel allergy syndrome. Int J Immunopathol Pharmacol IA. Cazzato, E. Vadrucci, G. Cammarota, M. Minelli, A. Gasbarrini
Int J Immunopathol Pharmacol 2011 Apr-Jun;24(2):535-7. PubMed:21658331

Associated curated diseases 3

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Associated disease mapping

Mapping of all associated diseases to Nickel is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

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Number of references
Sarcoidosis MeSH: Sarcoidosis
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands. Year introduced: PSEUDOTUBERCULOSIS use SARCOIDOSIS 1963-1992
Link to MeSH Database: D012507
4
Non Specific Interstitial Pneumonia MeSH: Lung Diseases, Interstitial
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features. Year introduced: 1994
Link to MeSH Database: D017563
1
Idiopathic Pulmonary Fibrosis MeSH: Idiopathic Pulmonary Fibrosis
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change. Year introduced: 2009
Link to MeSH Database: D054990
3

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 21 associated references with Nickel. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 21 associated references with Nickel. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 21 associated references with Nickel. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 21 associated references with Nickel. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula Ni
Mass 58.693
Synonyms NICKEL
7440-02-0
Raney alloy
Fibrex
Nickel catalyst
Fibrex P
Nickel, elemental
Nichel [Italian]
(63ni)nickel
Nickel 207
Nickel, soluble salts
niccolum
niquel
Alcan 756
Metallic nickel
Nickel, ion (Ni1+)
Nickel compounds
NI 0901-S (harshaw)
(59ni)nickel
CCRIS 427
PubChem CID 935