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Reduced graphene oxide-nickel nanoparticles/biopolymer composite films for the sub-millimolar detection of glucose.
R. Krishna, JM. Campiña, PM. Fernandes, J. Ventura, E. Titus, AF. Silva
Analyst 2016 Jun;141(13):4151-61.
PubMed: 27214596
Abstract
Hybrid conjugates of graphene with metallic/semiconducting nanostructures can improve the sensitivity of electrochemical sensors due to their combination of well-balanced electrical/electrocatalytic properties and superior surface-to-volume ratio. In this study, the synthesis and physical characterization of a hybrid conjugate of reduced graphene oxide and nickel nanoparticles (rGO-Ni NPs) is presented. The conjugate was further deposited onto a glassy carbon electrode as a nanocomposite film of chitosan and glucose oxidase. The electrochemical response and morphology of the films were investigated using SEM, CV, and EIS, and their applications as a glucose biosensor explored for the first time in proof-of-concept tests. The low operating potential along with the good linearity and sensitivity (up to 129 μA cm(-2) mM(-1)) found in the sub-millimolar range suggest potential applications in the self-management of hypoglycemia from blood samples or in the development of non-invasive assays for body fluids such as saliva, tears or breath.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Nickel | 36 |