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Evaluation of the human nickel retention model with workplace data.
CP. Yu, TH. Hsieh, AR. Oller, G. Oberdörster
Regul. Toxicol. Pharmacol. 2001 Apr;33(2):165-72.
PubMed: 11350199
Abstract
A previously developed dosimetry model of inhaled Ni compounds in the human lung has been expanded by incorporating three additional factors: (1) inhalability, (2) mixed breathing mode, and (3) clearance rate coefficient of a Ni compounds' mixture. Predicted lung burdens of Ni compounds from the expanded model for workers at different departments in a Ni refinery plant compared favorably with the reported data. Although many uncertainties remain, the present model represents a first step toward developing a more meaningful risk assessment tool that will allow for more accurate extrapolation of animal data to humans.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Nickel | 36 |