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Elevated exhalation of hydrogen peroxide in patients with non-small cell lung cancer is not affected by chemotherapy.
A. Krawczyk, D. Nowak, PJ. Nowak, G. Padula, S. Kwiatkowska
Redox Rep. 2017 Nov;22(6):308-314.
PubMed: 27611345
Abstract
Reactive oxygen species, which are implicated in the process of carcinogenesis, are also responsible for cell death during chemotherapy (CHT). Therefore, the aim of the study was to evaluate exhaled H2O2 levels in non-small cell lung cancer (NSCLC) patients before and after CHT. Thirty patients (age 61.3 ± 9.3 years) with advanced NSCLC (stage IIIB-IV) and 15 age-matched healthy cigarette smokers were enrolled into the study. Patients received four cycles of cisplatin or carboplatin with vinorelbine every three weeks. Before and after the first, second, and fourth cycle, the concentration of H2O2 in exhaled breath condensate was measured with respect to treatment response. At the baseline, NSCLC patients exhaled 3.8 times more H2O2 than the control group (0.49 ± 0.14 vs. 0.13 ± 0.03 µmol/L, P
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Hydrogen peroxide | 209 |