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Secondhand smoke exposure induces acutely airway acidification and oxidative stress.
K. Kostikas, M. Minas, E. Nikolaou, AI. Papaioannou, P. Liakos, S. Gougoura, KI. Gourgoulianis, PC. Dinas, GS. Metsios, AZ. Jamurtas, AD. Flouris, Y. Koutedakis
Respir Med 2013 Feb;107(2):172-9.
PubMed: 23218453
Abstract
Previous studies have shown that secondhand smoke induces lung function impairment and increases proinflammatory cytokines. The aim of the present study was to evaluate the acute effects of secondhand smoke on airway acidification and airway oxidative stress in never-smokers. In a randomized controlled cross-over trial, 18 young healthy never-smokers were assessed at baseline and 0, 30, 60, 120, 180 and 240 min after one-hour secondhand smoke exposure at bar/restaurant levels. Exhaled NO and CO measurements, exhaled breath condensate collection (for pH, H(2)O(2) and NO(2)(-)/NO(3)(-) measurements) and spirometry were performed at all time-points. Secondhand smoke exposure induced increases in serum cotinine and exhaled CO that persisted until 240 min. Exhaled breath condensate pH decreased immediately after exposure (p
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Hydrogen peroxide | 209 |