Uric acid

Description

Description of uric acid with associated disease summary

Urates is a strong reducing agent which can binds prooxidant metals such as iron and copper and prevent them involved in reactions with hydrogen peroxide which can produce hydroxyl radical. In addition, urates can reacts with reactive oxygen species (ROS) and inhibits lipid peroxidation. Increase plasma urate concentration may be linked to oxidative stress (Biochem Med (Zagreb). (2011)). EBC urates can be detected using enzymatic color test with uricase. Both the EBC and serum urates in Obstructive sleep apnea (OSA) children is significantly higher than the healthy control (Biochem Med (Zagreb). (2011)). However, the exact anatomical site produce urates remains unknown and further investigations should be done to link between urates and other biomarkers of oxidative stress (Biochem Med (Zagreb). (2011)). Description of disease(s) related to urates:

Disease summary

Obstructive sleep apnea (OSA)

EBC urates can be detected using enzymatic color test with uricase. Both the EBC and serum urates in OSA children is significantly higher than the healthy control (Biochem Med (Zagreb). (2011)).

Summary of extracted biomedical information

Uric acid is associated with abnormalities such as Metabolic syndrome, Hypertensive disease, Kidney Diseases, Hyperuricemia and Primary pulmonary hypertension. The involved biomedical functions are known as Protective Agents, arterial stiffness and accredited.
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Associated references with human 21

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Journal Year Authors & PubMed Link
Oral fructose absorption in obese children with non-alcoholic fatty liver disease. Pediatr Obes 2015 JS. Sullivan, MT. Le, Z. Pan, C. Rivard, K. Love-Osborne, K. Robbins, RJ. Johnson, RJ. Sokol, SS. Sundaram
Pediatr Obes 2015 Jun;10(3):188-95. PubMed:24961681
Diagnostic and prognostic role of biomarkers for pulmonary hypertension in interstitial lung disease. Respir Med 2012 CU. Andersen, S. Mellemkjær, JE. Nielsen-Kudsk, E. Bendstrup, U. Simonsen, O. Hilberg
Respir Med 2012 Dec;106(12):1749-55. PubMed:23034317
Weight loss and sleep-disordered breathing in childhood obesity: effects on inflammation and uric acid. Obesity (Silver Spring) 2012 K. Van Hoorenbeeck, H. Franckx, P. Debode, P. Aerts, K. Wouters, J. Ramet, LF. Van Gaal, KN. Desager, WA. De Backer, SL. Verhulst
Obesity (Silver Spring) 2012 Jan;20(1):172-7. PubMed:21938074
Targeted dual-energy single-source CT for characterisation of urinary calculi: experimental and clinical experience. Eur Radiol 2012 M. Eiber, K. Holzapfel, M. Frimberger, M. Straub, H. Schneider, EJ. Rummeny, M. Dobritz, A. Huber
Eur Radiol 2012 Jan;22(1):251-8. PubMed:21847542
Comparison of acute effects of red wine, beer and vodka against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans. Atherosclerosis 2011 M. Krnic, D. Modun, D. Budimir, G. Gunjaca, I. Jajic, J. Vukovic, I. Salamunic, D. Sutlovic, B. Kozina, M. Boban
Atherosclerosis 2011 Oct;218(2):530-5. PubMed:21803358
Altered oxidative state in schoolchildren with asthma and allergic rhinitis. Pediatr Allergy Immunol 2011 E. Bakkeheim, P. Mowinckel, KH. Carlsen, P. Burney, KC. Carlsen
Pediatr Allergy Immunol 2011 Mar;22(2):178-85. PubMed:20633237
Inflammatory markers and exposure to occupational air pollutants. Inhal Toxicol 2010 CG. Ohlson, P. Berg, IL. Bryngelsson, K. Elihn, Y. Ngo, H. Westberg, B. Sjögren
Inhal Toxicol 2010 Nov;22(13):1083-90. PubMed:21029032
Antioxidant airway responses following experimental exposure to wood smoke in man. Part Fibre Toxicol 2010 M. Sehlstedt, R. Dove, C. Boman, J. Pagels, E. Swietlicki, J. Löndahl, R. Westerholm, J. Bosson, S. Barath, AF. Behndig, J. Pourazar, T. Sandström, IS. Mudway, A. Blomberg
Part Fibre Toxicol 2010 Aug;7:21. PubMed:20727160
Experimental exposure to 1,1,1,3,3-pentafluoropropane (HFC-245fa): uptake and disposition in humans. Toxicol. Sci. 2010 L. Ernstgård, M. Andersen, W. Dekant, B. Sjögren, G. Johanson
Toxicol. Sci. 2010 Feb;113(2):326-36. PubMed:19915083
Uric acid excretion in North American and Southeast European children with obstructive sleep apnea. Sleep Med. 2010 A. Kaditis, D. Gozal, AB. Snow, L. Kheirandish-Gozal, E. Alexopoulos, V. Varlami, AA. Papathanasiou, OS. Capdevila, R. Bhattacharjee, J. Kim, K. Gourgoulianis, E. Zintzaras
Sleep Med. 2010 May;11(5):489-93. PubMed:20181522
Acute effects of exposure to vapours of standard and dearomatized white spirits in humans. 2. Irritation and inflammation. J Appl Toxicol 2009 L. Ernstgård, A. Iregren, S. Juran, B. Sjögren, C. van Thriel, G. Johanson
J Appl Toxicol 2009 Apr;29(3):263-74. PubMed:19086013
Acute, food-induced moderate elevation of plasma uric acid protects against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans. Atherosclerosis 2009 J. Vukovic, D. Modun, D. Budimir, D. Sutlovic, I. Salamunic, I. Zaja, M. Boban
Atherosclerosis 2009 Nov;207(1):255-60. PubMed:19457484
Sleep-disordered breathing and uric acid in overweight and obese children and adolescents. Chest 2007 SL. Verhulst, K. Van Hoeck, N. Schrauwen, D. Haentjens, R. Rooman, L. Van Gaal, WA. De Backer, KN. Desager
Chest 2007 Jul;132(1):76-80. PubMed:17505038
[Blood uric acid levels in patients with sleep-disordered breathing]. Arch. Bronconeumol. 2006 A. Ruiz García, A. Sánchez Armengol, E. Luque Crespo, D. García Aguilar, A. Romero Falcón, C. Carmona Bernal, F. Capote
Arch. Bronconeumol. 2006 Oct;42(10):492-500. PubMed:17067515
Toxicokinetics of 1,1,1,2-tetrafluoroethane (HFC-134a) in male volunteers after experimental exposure. Toxicol. Lett. 2006 S. Gunnare, L. Ernstgård, B. Sjögren, G. Johanson
Toxicol. Lett. 2006 Nov;167(1):54-65. PubMed:17030466
The effect of sulphurous air pollutant exposures on symptoms, lung function, exhaled nitric oxide, and nasal epithelial lining fluid antioxidant concentrations in normal and asthmatic adults. Occup Environ Med 2003 WS. Tunnicliffe, RM. Harrison, FJ. Kelly, C. Dunster, JG. Ayres
Occup Environ Med 2003 Nov;60(11):e15. PubMed:14573726
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction. Clin. Pharmacol. Ther. 2002 K. Abraham, A. Geusau, Y. Tosun, H. Helge, S. Bauer, J. Brockmöller
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Hounsfield unit density in the determination of urinary stone composition. Urology 2001 G. Motley, N. Dalrymple, C. Keesling, J. Fischer, W. Harmon
Urology 2001 Aug;58(2):170-3. PubMed:11489691
Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test. Clin. Pharmacol. Ther. 1994 KL. Rost, I. Roots
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Circulation 1980 Apr;61(4):716-23. PubMed:7357713

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to uric acid is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

with link to MeSH Database

Number of references
Obstructive Sleep Apnea MeSH: Sleep Apnea, Obstructive
A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395) Year introduced: 2000
Link to MeSH Database: D020181
7

Associated abnormalities 6

Concept Name External ID Weighted Score Hits References
Metabolic syndrome 1000.0 1
  1. Acute, food-induced moderate elevation of plasma uric acid protects against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans.
    J. Vukovic, D. Modun, D. Budimir, D. Sutlovic, I. Salamunic, I. Zaja, M. Boban (2009) Atherosclerosis
Hypertensive disease ICD9-CM:997.91 800.0 1
  1. Acute, food-induced moderate elevation of plasma uric acid protects against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans.
    J. Vukovic, D. Modun, D. Budimir, D. Sutlovic, I. Salamunic, I. Zaja, M. Boban (2009) Atherosclerosis
Kidney Diseases 933.33 1
  1. Acute, food-induced moderate elevation of plasma uric acid protects against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans.
    J. Vukovic, D. Modun, D. Budimir, D. Sutlovic, I. Salamunic, I. Zaja, M. Boban (2009) Atherosclerosis
Hyperuricemia 944.0 1
  1. Acute, food-induced moderate elevation of plasma uric acid protects against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans.
    J. Vukovic, D. Modun, D. Budimir, D. Sutlovic, I. Salamunic, I. Zaja, M. Boban (2009) Atherosclerosis
Primary pulmonary hypertension ICD9-CM:416.0 1000.0 1
  1. Diagnostic and prognostic role of biomarkers for pulmonary hypertension in interstitial lung disease.
    CU. Andersen, S. Mellemkjær, JE. Nielsen-Kudsk, E. Bendstrup, U. Simonsen, O. Hilberg (2012) Respir Med
Scleroderma 944.0 1
  1. Diagnostic and prognostic role of biomarkers for pulmonary hypertension in interstitial lung disease.
    CU. Andersen, S. Mellemkjær, JE. Nielsen-Kudsk, E. Bendstrup, U. Simonsen, O. Hilberg (2012) Respir Med

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 21 associated references with uric acid. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 21 associated references with uric acid. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 21 associated references with uric acid. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C5H4N4O3
Mass 168.112
Synonyms uric acid
69-93-2
urate
2,6,8-trioxypurine
Lithic acid
2,6,8-trihydroxypurine
2,6,8-Trioxopurine
1H-Purine-2,6,8-triol
1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-
8-hydroxyxanthine
7,9-Dihydro-1H-purine-2,6,8(3H)-trione
Purine-2,6,8(1H,3H,9H)-trione
AI3-15432
NSC 3975
7,9-dihydro-3H-purine-2,6,8-trione
UNII-268B43MJ25
EINECS 200-720-7
CHEMBL792
9H-purine-2,6,8-triol
CHEBI:17775
PubChem CID 1175