Uric acid
Description
Description of uric acid with associated disease summary
Urates is a strong reducing agent which can binds prooxidant metals
such as iron and copper and prevent them involved in reactions with hydrogen
peroxide which can produce hydroxyl radical. In addition, urates can reacts
with reactive oxygen species (ROS) and inhibits lipid peroxidation. Increase plasma
urate concentration may be linked to oxidative stress (Biochem Med (Zagreb). (2011)).
EBC urates can be detected using enzymatic color test with uricase. Both
the EBC and serum urates in Obstructive sleep apnea (OSA) children is
significantly higher than the healthy control (Biochem Med (Zagreb). (2011)).
However, the exact anatomical site produce urates remains unknown and further
investigations should be done to link between urates and other biomarkers of
oxidative stress (Biochem
Med (Zagreb). (2011)).
Description of disease(s) related to urates:
Disease summary
Obstructive sleep apnea (OSA)
EBC urates can be detected using enzymatic color test with uricase. Both the EBC and serum urates in OSA children is significantly higher than the healthy control (Biochem Med (Zagreb). (2011)).Summary of extracted biomedical information
Uric acid is associated with abnormalities such as Metabolic syndrome, Hypertensive disease, Kidney Diseases, Hyperuricemia and Primary pulmonary hypertension. The involved biomedical functions are known as Protective Agents, arterial stiffness and accredited.
Associated references with human 21
Download references|
Reference title
with link to reference page |
Journal | Year | Authors & PubMed Link |
|---|---|---|---|
| Oral fructose absorption in obese children with non-alcoholic fatty liver disease. | Pediatr Obes | 2015 |
JS. Sullivan, MT. Le, Z. Pan, C. Rivard, K. Love-Osborne, K. Robbins, RJ. Johnson, RJ. Sokol, SS. Sundaram
Pediatr Obes 2015 Jun;10(3):188-95. PubMed:24961681 |
| Diagnostic and prognostic role of biomarkers for pulmonary hypertension in interstitial lung disease. | Respir Med | 2012 |
CU. Andersen, S. Mellemkjær, JE. Nielsen-Kudsk, E. Bendstrup, U. Simonsen, O. Hilberg
Respir Med 2012 Dec;106(12):1749-55. PubMed:23034317 |
| Weight loss and sleep-disordered breathing in childhood obesity: effects on inflammation and uric acid. | Obesity (Silver Spring) | 2012 |
K. Van Hoorenbeeck, H. Franckx, P. Debode, P. Aerts, K. Wouters, J. Ramet, LF. Van Gaal, KN. Desager, WA. De Backer, SL. Verhulst
Obesity (Silver Spring) 2012 Jan;20(1):172-7. PubMed:21938074 |
| Targeted dual-energy single-source CT for characterisation of urinary calculi: experimental and clinical experience. | Eur Radiol | 2012 |
M. Eiber, K. Holzapfel, M. Frimberger, M. Straub, H. Schneider, EJ. Rummeny, M. Dobritz, A. Huber
Eur Radiol 2012 Jan;22(1):251-8. PubMed:21847542 |
| Comparison of acute effects of red wine, beer and vodka against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans. | Atherosclerosis | 2011 |
M. Krnic, D. Modun, D. Budimir, G. Gunjaca, I. Jajic, J. Vukovic, I. Salamunic, D. Sutlovic, B. Kozina, M. Boban
Atherosclerosis 2011 Oct;218(2):530-5. PubMed:21803358 |
| Altered oxidative state in schoolchildren with asthma and allergic rhinitis. | Pediatr Allergy Immunol | 2011 |
E. Bakkeheim, P. Mowinckel, KH. Carlsen, P. Burney, KC. Carlsen
Pediatr Allergy Immunol 2011 Mar;22(2):178-85. PubMed:20633237 |
| Inflammatory markers and exposure to occupational air pollutants. | Inhal Toxicol | 2010 |
CG. Ohlson, P. Berg, IL. Bryngelsson, K. Elihn, Y. Ngo, H. Westberg, B. Sjögren
Inhal Toxicol 2010 Nov;22(13):1083-90. PubMed:21029032 |
| Antioxidant airway responses following experimental exposure to wood smoke in man. | Part Fibre Toxicol | 2010 |
M. Sehlstedt, R. Dove, C. Boman, J. Pagels, E. Swietlicki, J. Löndahl, R. Westerholm, J. Bosson, S. Barath, AF. Behndig, J. Pourazar, T. Sandström, IS. Mudway, A. Blomberg
Part Fibre Toxicol 2010 Aug;7:21. PubMed:20727160 |
| Experimental exposure to 1,1,1,3,3-pentafluoropropane (HFC-245fa): uptake and disposition in humans. | Toxicol. Sci. | 2010 |
L. Ernstgård, M. Andersen, W. Dekant, B. Sjögren, G. Johanson
Toxicol. Sci. 2010 Feb;113(2):326-36. PubMed:19915083 |
| Uric acid excretion in North American and Southeast European children with obstructive sleep apnea. | Sleep Med. | 2010 |
A. Kaditis, D. Gozal, AB. Snow, L. Kheirandish-Gozal, E. Alexopoulos, V. Varlami, AA. Papathanasiou, OS. Capdevila, R. Bhattacharjee, J. Kim, K. Gourgoulianis, E. Zintzaras
Sleep Med. 2010 May;11(5):489-93. PubMed:20181522 |
| Acute effects of exposure to vapours of standard and dearomatized white spirits in humans. 2. Irritation and inflammation. | J Appl Toxicol | 2009 |
L. Ernstgård, A. Iregren, S. Juran, B. Sjögren, C. van Thriel, G. Johanson
J Appl Toxicol 2009 Apr;29(3):263-74. PubMed:19086013 |
| Acute, food-induced moderate elevation of plasma uric acid protects against hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy humans. | Atherosclerosis | 2009 |
J. Vukovic, D. Modun, D. Budimir, D. Sutlovic, I. Salamunic, I. Zaja, M. Boban
Atherosclerosis 2009 Nov;207(1):255-60. PubMed:19457484 |
| Sleep-disordered breathing and uric acid in overweight and obese children and adolescents. | Chest | 2007 |
SL. Verhulst, K. Van Hoeck, N. Schrauwen, D. Haentjens, R. Rooman, L. Van Gaal, WA. De Backer, KN. Desager
Chest 2007 Jul;132(1):76-80. PubMed:17505038 |
| [Blood uric acid levels in patients with sleep-disordered breathing]. | Arch. Bronconeumol. | 2006 |
A. Ruiz García, A. Sánchez Armengol, E. Luque Crespo, D. García Aguilar, A. Romero Falcón, C. Carmona Bernal, F. Capote
Arch. Bronconeumol. 2006 Oct;42(10):492-500. PubMed:17067515 |
| Toxicokinetics of 1,1,1,2-tetrafluoroethane (HFC-134a) in male volunteers after experimental exposure. | Toxicol. Lett. | 2006 |
S. Gunnare, L. Ernstgård, B. Sjögren, G. Johanson
Toxicol. Lett. 2006 Nov;167(1):54-65. PubMed:17030466 |
| The effect of sulphurous air pollutant exposures on symptoms, lung function, exhaled nitric oxide, and nasal epithelial lining fluid antioxidant concentrations in normal and asthmatic adults. | Occup Environ Med | 2003 |
WS. Tunnicliffe, RM. Harrison, FJ. Kelly, C. Dunster, JG. Ayres
Occup Environ Med 2003 Nov;60(11):e15. PubMed:14573726 |
| Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction. | Clin. Pharmacol. Ther. | 2002 |
K. Abraham, A. Geusau, Y. Tosun, H. Helge, S. Bauer, J. Brockmöller
Clin. Pharmacol. Ther. 2002 Aug;72(2):163-74. PubMed:12189363 |
| Hounsfield unit density in the determination of urinary stone composition. | Urology | 2001 |
G. Motley, N. Dalrymple, C. Keesling, J. Fischer, W. Harmon
Urology 2001 Aug;58(2):170-3. PubMed:11489691 |
| Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test. | Clin. Pharmacol. Ther. | 1994 |
KL. Rost, I. Roots
Clin. Pharmacol. Ther. 1994 Apr;55(4):402-11. PubMed:8162667 |
| Allopurinol influences aminophenazone elimination. | Clin Pharmacokinet | 1990 |
M. Barry, J. Feely
Clin Pharmacokinet 1990 Aug;19(2):167-9. PubMed:2379382 |
| Changes after quitting cigarette smoking. | Circulation | 1980 |
GD. Friedman, AB. Siegelaub
Circulation 1980 Apr;61(4):716-23. PubMed:7357713 |
Associated curated diseases 1
Download diseasesAssociated disease mapping
Mapping of all associated diseases to uric acid is displayed in red.
|
Disease Name
with link to disease page |
Description of MeSH term
with link to MeSH Database |
Number of references |
|---|---|---|
| Obstructive Sleep Apnea |
MeSH:
Sleep Apnea, Obstructive
A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory
pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of
systemic and pulmonary arterial pressures may occur. Frequent partial arousals
occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime
tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA;
micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR
DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)
Year introduced: 2000
Link to MeSH Database: D020181
|
7 |
Associated abnormalities 6
Associated chemicals 0
No associated chemicals are detected in current reference collection.
There are 21 associated references with uric acid. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.
Associated functions 0
No associated functions are detected in current reference collection.
There are 21 associated references with uric acid. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.
Associated genes 0
No associated genes are detected in current reference collection.
There are 21 associated references with uric acid. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
NCBI Entrez Crosslinks
Chemical Information
| Formula | C5H4N4O3 |
| Mass | 168.112 |
| Synonyms | uric acid 69-93-2 urate 2,6,8-trioxypurine Lithic acid 2,6,8-trihydroxypurine 2,6,8-Trioxopurine 1H-Purine-2,6,8-triol 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro- 8-hydroxyxanthine 7,9-Dihydro-1H-purine-2,6,8(3H)-trione Purine-2,6,8(1H,3H,9H)-trione AI3-15432 NSC 3975 7,9-dihydro-3H-purine-2,6,8-trione UNII-268B43MJ25 EINECS 200-720-7 CHEMBL792 9H-purine-2,6,8-triol CHEBI:17775 |
| PubChem CID | 1175 |