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Leukotrienes and 8-isoprostane in exhaled breath condensate of children with stable and unstable asthma.
S. Zanconato, S. Carraro, M. Corradi, R. Alinovi, MF. Pasquale, G. Piacentini, F. Zacchello, E. Baraldi
J. Allergy Clin. Immunol. 2004 Feb;113(2):257-63.
PubMed: 14767439
Abstract
Cysteinyl-leukotrienes (cys-LTs) and 8-isoprostane are biomarkers of airway inflammation and oxidative stress. The aim of this study was to evaluate cys-LT and 8-isoprostane levels in exhaled breath condensate (EBC) of children with different degrees of asthma severity. EBC was collected from 14 steroid-naive children with mild persistent asthma, 13 children with stable mild- to-moderate persistent asthma treated with inhaled corticosteroids (ICS), 9 ICS-treated children with unstable asthma, and 19 healthy children. In the three groups of asthmatic children, EBC concentrations of cys-LTs and 8-isoprostane were significantly higher than in control children (steroid-naive asthmatic children: cys-LTs median, 10.8 pg/mL, P
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
8-epi-PGF2alpha | 120 | |
Leukotriene E4 | 61 | |
Leukotriene D4 | 37 | |
Leukotriene C4 | 30 |