Description of Leukotriene E4 with associated disease summary
AsthmaThe level of Cys-LTs in EBC (Exhaled Breath Condensate) was higher in children with asthma than healthy children (BMC Pulm. Med. (2014)). LTE4 levels were higher in asthmatic smoker/non-smoker subjects than healthy controls (Clin. Chem. Lab. Med. (2013)). Levels of LTC4, LTD4, LTE4, Cys-LTs were higher in bronchial asthma than in healthy group (J Chromatogr B Analyt Technol Biomed Life Sci. (2011)). Levels of Cys-LTs were higher in asthma group than in healthy group in EBC, saliva and sputum (Clin Respir J. (2010)). Levels of Cys-LTs were significantly higher in severe (p < 0.001) and moderate (p < 0.05) asthma group compared to healthy group (Respir Med. (2009)). Levels of Cys-LTs were significantly higher in EBC in asthmatic children compared to healthy children (p = 0.002) (Pediatr Allergy Immunol. (2008)). Levels of Cys-LTs were significantly higher (p = 0.02) in adults with asthma than in healthy adults. Levels of Cys-LTs were significantly higher (p < 0.001) in hospitalized children with asthma using sample concentration with SPE (J Allergy Clin Immunol. (2007)). Levels of Cys-LTs were significantly higher in steroid-naïve patients with Aspirin-induced asthma compared to steroid-naïve patients with Aspirin-tolerate asthma and healthy controls (Am J Respir Crit Care Med. (2002)).
Sleep Apnea SyndromesElevated levels of Cys-LTs have been detected in EBC in children with obstructive apnea-hypopnea index (OAHI) more than 5 episodes/hour (Chest (2009)). Levels of Cys-LTs and LTE4 in EBC were elevated in children with sleep-disordered breathing (SDB; OAHI > 5/h) compared to children with mild SDB (p < 0.01) and controls (p < 0.01).
Rhinitis, Allergic, PerennialCombining assessment of the change of peak nasal inspiratory flow with measurement of Cys-LTs in EBC, was able to discriminate children with allergic rhinitis and healthy children ( Arch Immunol Ther Exp (Warsz). (2013)).
RhinitisLevels of LTB4 and LTE4 in EBC were higher in seasonal allergic rhinitis patients than in healthy subjects. After the pollen season, the levels of LTB4 and LTE4 were decreased compared with levels in the season ( Allergy (2005) ).
Rhinitis, Allergic, SeasonalLevels of LTB4 and LTE4 in EBC were increased significantly in patients with seasonal and postseasonal allergic rhinitis compared with healthy controls ( Ann Allergy Asthma Immunol. (2009)).
SarcoidosisLevels of Cys-LTs and 8-isoprostane in EBC were higher in sarcoidosis patients than in healthy subjects. It may be not recommended to measure the eicosanoids as markers for lacking of correlation with bronchoalveolar lavage fluid (BALF) lymphocyte (Chest (2007)).
Asthma, Aspirin-InducedLevel of LTE4 in EBC was higher in subjects with aspirin-intolerant asthma compared with subjects with aspirin-tolerant asthma and healthy subjects. Eicosanoid profiling in EBC could discriminate alterations in asthma, especially hypersensitivity to aspirin ( J Allergy Clin Immunol. (2011)).
Asthma, OccupationalCys-LTs in EBC might be marker for quantify the severity of airway inflammation and oxidative stress for occupational asthma (Int J Occup Med Environ Health. (2014)).
BronchoconstrictionLevels of Cys-LTs in EBC were higher in asthmatic children with exercise-induced bronchoconstriction compared with controls ( J Allergy Clin Immunol. (2005)).
Carcinoma, Non-Small-Cell LungCys-LTs, LTB4 and 8-isoprostane have positive correlation with all measured mediators in BALF and in EBC. It suggested Cys-LTs. LTB4 and 8-isoprostane may be used as non-invasive markers to monitor non-small cell lung cancer ( Dis Markers. (2012)).
Lung NeoplasmsCys-LTs, LTB4 and 8-isoprostane have positive correlation with all measured mediators in BALF and in EBC. It suggested Cys-LTs. LTB4 and 8-isoprostane may be used as non-invasive markers to monitor non-small cell lung cancer ( Dis Markers. (2012)).
PneumoconiosisLevels of LTD4 and LTE4 were higher in both asbestos exposure (p < 0.001) and silica exposure (p < 0.05), compared with controls in pneumoconiosis ( Ind Health. (2012) ).
Pulmonary Disease, Chronic ObstructiveLevels of Cys-LTs in EBC were higher in chronic obstructive pulmonary disease compared with healthy controls (p < 0.02) ( Arch Med Sci. (2012) ).
Respiratory SoundsLevels of LTB4, LTE4 and nitrite in EBC were higher in children with wheezing episodes compared with healthy controls (p < 0.001; p < 0.001; p < 0.03). Levels of 8-isoprostane and nitrate were no difference between patients and healthy subjects (J Investig Allergol Clin Immunol. (2013)).
Summary of extracted biomedical informationLeukotriene e4 is associated with abnormalities such as Asthma, Atopic, Childhood asthma, Virus Diseases and Asthma aspirin-sensitive. The involved biomedical functions are known as Excretory function, Drug Interactions, Exhalation, Inflammation and attenuation. Leukotriene e4 is associated with Deuterium, ammonium hydroxide and acetonitrile.
Associated references with human 24Download references
with link to reference page
|Journal||Year||Authors & PubMed Link|
|Urine cysteinyl leukotriene levels in children with sleep disordered breathing before and after adenotonsillectomy.||Int. J. Pediatr. Otorhinolaryngol.||2017||
A. Satdhabudha, P. Sritipsukho, S. Manochantr, W. Chanvimalueng, U. Chaumrattanakul, P. Chaumphol
Int. J. Pediatr. Otorhinolaryngol. 2017 Mar;94:112-116. PubMed:28167000
|Utility of low-dose oral aspirin challenges for diagnosis of aspirin-exacerbated respiratory disease.||Ann. Allergy Asthma Immunol.||2016||
E. Jerschow, Z. Ren, G. Hudes, M. Sanak, E. Morales, V. Schuster, SD. Spivack, D. Rosenstreich
Ann. Allergy Asthma Immunol. 2016 Apr;116(4):321-328.e1. PubMed:26822279
|Aspirin provocation increases 8-iso-PGE2 in exhaled breath condensate of aspirin-hypersensitive asthmatics.||Prostaglandins Other Lipid Mediat.||2015||
L. Mastalerz, R. Januszek, M. Kaszuba, K. Wójcik, N. Celejewska-Wójcik, A. Gielicz, H. Plutecka, K. Oleś, P. Stręk, M. Sanak
Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt B):163-9. PubMed:26209241
|Low-level environmental tobacco smoke exposure and inflammatory biomarkers in children with asthma.||J Asthma||2014||
R. Gill, S. Krishnan, AJ. Dozor
J Asthma 2014 May;51(4):355-9. PubMed:24580138
|ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma.||Clin. Exp. Allergy||2013||
E. Mougey, JE. Lang, H. Allayee, WG. Teague, AJ. Dozor, RA. Wise, JJ. Lima
Clin. Exp. Allergy 2013 May;43(5):512-20. PubMed:23600541
|Asthma outcomes: biomarkers.||J. Allergy Clin. Immunol.||2012||
SJ. Szefler, S. Wenzel, R. Brown, SC. Erzurum, JV. Fahy, RG. Hamilton, JF. Hunt, H. Kita, AH. Liu, RA. Panettieri, RP. Schleimer, M. Minnicozzi
J. Allergy Clin. Immunol. 2012 Mar;129(3 Suppl):S9-23. PubMed:22386512
|Airway molecular phenotypes in pediatric asthma.||Curr Opin Allergy Clin Immunol||2011||
SJ. Aujla, KR. Ross, JF. Chmiel, F. Holguin
Curr Opin Allergy Clin Immunol 2011 Apr;11(2):122-6. PubMed:21358402
|Urinary leukotriene E₄ levels identify children with tobacco smoke exposure at risk for asthma exacerbation.||J. Allergy Clin. Immunol.||2011||
N. Rabinovitch, N. Reisdorph, L. Silveira, EW. Gelfand
J. Allergy Clin. Immunol. 2011 Aug;128(2):323-7. PubMed:21807251
|Urinary leukotriene E4, obesity, and adenotonsillar hypertrophy in Chinese children with sleep disordered breathing.||Sleep||2011||
Y. Shen, Z. Xu, K. Shen
Sleep 2011 Aug;34(8):1135-041. PubMed:21804676
|Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma.||J. Allergy Clin. Immunol.||2010||
N. Rabinovitch, NJ. Graber, VM. Chinchilli, CA. Sorkness, RS. Zeiger, RC. Strunk, LB. Bacharier, FD. Martinez, SJ. Szefler, .
J. Allergy Clin. Immunol. 2010 Sep;126(3):545-51.e1-4. PubMed:20816189
|Recent advances in antileukotriene therapy.||Curr Opin Allergy Clin Immunol||2010||
GW. Scadding, GK. Scadding
Curr Opin Allergy Clin Immunol 2010 Aug;10(4):370-6. PubMed:20585242
|Menopausal asthma: a new biological phenotype?||Allergy||2010||
MP. Foschino Barbaro, VR. Costa, O. Resta, R. Prato, A. Spanevello, GP. Palladino, D. Martinelli, GE. Carpagnano
Allergy 2010 Oct;65(10):1306-12. PubMed:20557302
|Biomarkers in asthma.||Curr Opin Pulm Med||2009||
A. Murugan, C. Prys-Picard, WJ. Calhoun
Curr Opin Pulm Med 2009 Jan;15(1):12-8. PubMed:19077700
|Pediatric biomarkers in asthma: exhaled nitric oxide, sputum eosinophils and leukotriene E4.||Curr Opin Allergy Clin Immunol||2008||
S. Gogate, R. Katial
Curr Opin Allergy Clin Immunol 2008 Apr;8(2):154-7. PubMed:18317025
|Exposure to tobacco smoke increases leukotriene E4-related albuterol usage and response to montelukast.||J. Allergy Clin. Immunol.||2008||
N. Rabinovitch, M. Strand, K. Stuhlman, EW. Gelfand
J. Allergy Clin. Immunol. 2008 Jun;121(6):1365-71. PubMed:18439662
|Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate.||J. Allergy Clin. Immunol.||2006||
P. Gyllfors, SE. Dahlén, M. Kumlin, K. Larsson, B. Dahlén
J. Allergy Clin. Immunol. 2006 Jul;118(1):78-83. PubMed:16815141
|How does exercise cause asthma attacks?||Curr Opin Allergy Clin Immunol||2006||
Curr Opin Allergy Clin Immunol 2006 Feb;6(1):37-42. PubMed:16505610
|Exhaled eicosanoids following oral aspirin challenge in asthmatic patients.||Clin. Exp. Allergy||2004||
M. Sanak, B. Kiełbasa, G. Bochenek, A. Szczeklik
Clin. Exp. Allergy 2004 Dec;34(12):1899-904. PubMed:15663565
|Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children.||J. Allergy Clin. Immunol.||2003||
RC. Strunk, SJ. Szefler, BR. Phillips, RS. Zeiger, VM. Chinchilli, G. Larsen, K. Hodgdon, W. Morgan, CA. Sorkness, RF. Lemanske, .
J. Allergy Clin. Immunol. 2003 Nov;112(5):883-92. PubMed:14610474
|Urinary leukotriene E(4), eosinophil protein X, and nasal eosinophil cationic protein are not associated with respiratory symptoms in 1-year-old children.||Allergy||2001||
C. Wojnarowski, G. Halmerbauer, E. Mayatepek, C. Gartner, T. Frischer, J. Forster, J. Kuehr, .
Allergy 2001 Sep;56(9):883-8. PubMed:11551254
|Exhaled nitric oxide following leukotriene E(4) and methacholine inhalation in patients with asthma.||Am. J. Respir. Crit. Care Med.||2000||
A. Deykin, O. Belostotsky, C. Hong, AF. Massaro, CM. Lilly, E. Israel
Am. J. Respir. Crit. Care Med. 2000 Nov;162(5):1685-9. PubMed:11069797
|Local generation of sulfidopeptide leukotrienes upon nasal provocation with cold, dry air.||Am. Rev. Respir. Dis.||1986||
AG. Togias, RM. Naclerio, SP. Peters, I. Nimmagadda, D. Proud, A. Kagey-Sobotka, NF. Adkinson, PS. Norman, LM. Lichtenstein
Am. Rev. Respir. Dis. 1986 Jun;133(6):1133-7. PubMed:3013056
|Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes.||J Pharm Biomed Anal||
K. Syslová, A. Böhmová, E. Demirbağ, K. Šimková, M. Kuzma, D. Pelclová, V. Sedlák, P. Čáp, P. Martásek, P. Kačer
J Pharm Biomed Anal 2013 Jul-Aug;81-82:108-17. PubMed:23644905
|Effect of inhaled corticosteroid treatment on exhaled breath condensate leukotriene E(4) in children with mild asthma.||Allergy Asthma Proc||
JO. Steiss, S. Rudloff, E. Landmann, C. Rückes-Nilges, KP. Zimmer, H. Lindemann
Allergy Asthma Proc 2008 Jul-Aug;29(4):371-5. PubMed:18702883
Associated curated diseases 14Download diseases
Associated disease mapping
Mapping of all associated diseases to Leukotriene E4 is displayed in red.
with link to disease page
Description of MeSH term
with link to MeSH Database
|Number of references|
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Link to MeSH Database: D001249
|Aspirin Sensitive Asthma||
Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use. Year introduced: 2010Link to MeSH Database: D055963
|Seasonal Allergic Rhinitis (Sar)||
Rhinitis, Allergic, Seasonal
Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS. Year introduced: 2006 (1963)Link to MeSH Database: D006255
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population. Year introduced: 1966Link to MeSH Database: D011009
Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT. Year introduced: 1980Link to MeSH Database: D012135
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.Link to MeSH Database: D012220
|Occupational Asthma (Oa)||
Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE. Year introduced: 2012Link to MeSH Database: D059366
|Non Small Cell Lung Cancer, Lung Neoplasms||
Tumors or cancer of the LUNG.Link to MeSH Database: D008175
|Allergic Rhinitis With Asthma||
Rhinitis, Allergic, Perennial
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc. Year introduced: 1980Link to MeSH Database: D012221
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands. Year introduced: PSEUDOTUBERCULOSIS use SARCOIDOSIS 1963-1992Link to MeSH Database: D012507
|Sleep Disordered Breathing (Sdb)||
Sleep Apnea Syndromes
Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types. Year introduced: 1980Link to MeSH Database: D012891
|Exercise Induced Bronchoconstriction||
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention. Year introduced: 1991Link to MeSH Database: D016084
|Chronic Obstructive Pulmonary Disease (Copd)||
Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002Link to MeSH Database: D029424
|Non Small Cell Lung Cancer, Carcinoma||
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy. Year introduced: 1994Link to MeSH Database: D002289
Associated abnormalities 4
|Concept Name||External ID||Weighted Score||Hits||References|
Associated chemicals 1
|Concept Name||External ID||Definition||Weighted Score||Hits||References|
Associated functions 9
|Concept Name||External ID||Definition||Weighted Score||Hits||References|
Associated genes 0
No associated genes are detected in current reference collection.
There are 24 associated references with Leukotriene E4. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
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