Leukotriene E4

Description

Description of Leukotriene E4 with associated disease summary

Cysteinyl-leukotrienes (Cys-LTs) including Leukotriene C4, Leukotriene D4, Leukotriene E4 (LTE4) are biosynthesized from arachidonic acids (AA) and may be mediators of airway obstruction, inflammation and fibrosis (Int. J. Occup. Med. Environ Health (2014)). Cys-LTs in EBC (Exhaled breath condensate) is seen as an inflammatory marker to distinguish asthmatic children from healthy children (Pediatr Allergy Immunol. (2008)). Cys-LTs were used to assess the severity of the following conditions or diseases: asthma, sleep apnea syndromes, rhinitis, sarcoidosis, bronchoconstriction, non-small-cell lung carcinoma, pneumoconiosis, chronic obstructive pulmonary disease and respiratory sounds. Cys-LTs are involved in pathogenesis of lung inflammation due to air pollution (BMC Pulm. Med. (2014)). It was suggested that levels of Cys-LTs in EBC may be contributed by saliva contamination. Authors concluded the levels of Cys-LTs in EBC cannot be explained by saliva contamination (J Chromatogr B Analyt Technol Biomed Life Sci. (2011)). Levels of Cys-LTs in EBC were associated with clinical severity of asthma (Respir Med. (2009)). Quantifying Cys-LTs and Prostaglandin D2 in EBC could be useful in monitoring acute asthmatic airway inflammation (J Allergy Clin Immunol. (2008)). Antagonists of leukotriene receptor decreased LTE4 in EBC of atopic children with asthma. The reduction of LTE4 was dependent on the baseline values of LTE4 in EBC (J Allergy Clin. Immunol. (2006)). Cys-LTs in EBC may be useful as a non-invasive marker to assess airway inflammation and hyperreactivity in asthmatic children (Chest (2006)). Cys-LTs in EBC may have associations with reticular basement membrane thickening in asthmatic subjects (Respir. Res. (2006)). LTE4 concentrations were reduced by inhaled corticosteroid treatment in asthmatic children (J Allergy Clin Immunol. (2004)). Levels of Cys-LTs in EBC were reduced by a 5-day course of oral prednisone in children with an asthma exacerbation (Thorax. (2003)). Cys-LTs in EBC were reported undetectable with large variances in EBC. Leukotriene B4 was detected in EBC as a surrogate metabolite (J. Allergy Clin. Immunol. (2014)). Levels of Cys-LTs including Leukotriene C4, Leukotriene D4, Leukotriene E4, were mostly measured by using enzyme immunoassay (EIA) (BMC Pulm. Med. (2014)). A method was developed for identification and quantification of Cys-LTs by immunoaffinity separation and detecting by liquid chromatography combined with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) in EBC (J Chromatogr B Analyt Technol Biomed Life Sci. (2011)). Levels of Cys-LTs were reported varying widely in asthma and healthy subjects in EBC. EBC stands for the airway lining fluid which is diluted by water, so the inability of detection may be due to limits of assay detection. Authors conducted the experiments to compare two methods: lyophylization and solid-phase extraction (SPE). Authors concluded the efficiency and variability of recovery were better by using SPE than using lyophylization (J Allergy Clin Immunol.(2007)). Gas chromatography/mass spectrometry (GC/MS) could be used to detect and quantify leukotrienes in EBC (Thorax. (2004)). Description of disease(s) related to Leukotriene E4:

Asthma

The level of Cys-LTs in EBC (Exhaled Breath Condensate) was higher in children with asthma than healthy children (BMC Pulm. Med. (2014)). LTE4 levels were higher in asthmatic smoker/non-smoker subjects than healthy controls (Clin. Chem. Lab. Med. (2013)). Levels of LTC4, LTD4, LTE4, Cys-LTs were higher in bronchial asthma than in healthy group (J Chromatogr B Analyt Technol Biomed Life Sci. (2011)). Levels of Cys-LTs were higher in asthma group than in healthy group in EBC, saliva and sputum (Clin Respir J. (2010)). Levels of Cys-LTs were significantly higher in severe (p < 0.001) and moderate (p < 0.05) asthma group compared to healthy group (Respir Med. (2009)). Levels of Cys-LTs were significantly higher in EBC in asthmatic children compared to healthy children (p = 0.002) (Pediatr Allergy Immunol. (2008)). Levels of Cys-LTs were significantly higher (p = 0.02) in adults with asthma than in healthy adults. Levels of Cys-LTs were significantly higher (p < 0.001) in hospitalized children with asthma using sample concentration with SPE (J Allergy Clin Immunol. (2007)). Levels of Cys-LTs were significantly higher in steroid-naïve patients with Aspirin-induced asthma compared to steroid-naïve patients with Aspirin-tolerate asthma and healthy controls (Am J Respir Crit Care Med. (2002)).

Sleep Apnea Syndromes

Elevated levels of Cys-LTs have been detected in EBC in children with obstructive apnea-hypopnea index (OAHI) more than 5 episodes/hour (Chest (2009)). Levels of Cys-LTs and LTE4 in EBC were elevated in children with sleep-disordered breathing (SDB; OAHI > 5/h) compared to children with mild SDB (p < 0.01) and controls (p < 0.01).

Rhinitis, Allergic, Perennial

Combining assessment of the change of peak nasal inspiratory flow with measurement of Cys-LTs in EBC, was able to discriminate children with allergic rhinitis and healthy children ( Arch Immunol Ther Exp (Warsz). (2013)).

Rhinitis

Levels of LTB4 and LTE4 in EBC were higher in seasonal allergic rhinitis patients than in healthy subjects. After the pollen season, the levels of LTB4 and LTE4 were decreased compared with levels in the season ( Allergy (2005) ).

Rhinitis, Allergic, Seasonal

Levels of LTB4 and LTE4 in EBC were increased significantly in patients with seasonal and postseasonal allergic rhinitis compared with healthy controls ( Ann Allergy Asthma Immunol. (2009)).

Sarcoidosis

Levels of Cys-LTs and 8-isoprostane in EBC were higher in sarcoidosis patients than in healthy subjects. It may be not recommended to measure the eicosanoids as markers for lacking of correlation with bronchoalveolar lavage fluid (BALF) lymphocyte (Chest (2007)).

Asthma, Aspirin-Induced

Level of LTE4 in EBC was higher in subjects with aspirin-intolerant asthma compared with subjects with aspirin-tolerant asthma and healthy subjects. Eicosanoid profiling in EBC could discriminate alterations in asthma, especially hypersensitivity to aspirin ( J Allergy Clin Immunol. (2011)).

Asthma, Occupational

Cys-LTs in EBC might be marker for quantify the severity of airway inflammation and oxidative stress for occupational asthma (Int J Occup Med Environ Health. (2014)).

Bronchoconstriction

Levels of Cys-LTs in EBC were higher in asthmatic children with exercise-induced bronchoconstriction compared with controls ( J Allergy Clin Immunol. (2005)).

Carcinoma, Non-Small-Cell Lung

Cys-LTs, LTB4 and 8-isoprostane have positive correlation with all measured mediators in BALF and in EBC. It suggested Cys-LTs. LTB4 and 8-isoprostane may be used as non-invasive markers to monitor non-small cell lung cancer ( Dis Markers. (2012)).

Lung Neoplasms

Cys-LTs, LTB4 and 8-isoprostane have positive correlation with all measured mediators in BALF and in EBC. It suggested Cys-LTs. LTB4 and 8-isoprostane may be used as non-invasive markers to monitor non-small cell lung cancer ( Dis Markers. (2012)).

Disease summary

Pneumoconiosis

Levels of LTD4 and LTE4 were higher in both asbestos exposure (p < 0.001) and silica exposure (p < 0.05), compared with controls in pneumoconiosis ( Ind Health. (2012) ).

Pulmonary Disease, Chronic Obstructive

Levels of Cys-LTs in EBC were higher in chronic obstructive pulmonary disease compared with healthy controls (p < 0.02) ( Arch Med Sci. (2012) ).

Respiratory Sounds

Levels of LTB4, LTE4 and nitrite in EBC were higher in children with wheezing episodes compared with healthy controls (p < 0.001; p < 0.001; p < 0.03). Levels of 8-isoprostane and nitrate were no difference between patients and healthy subjects (J Investig Allergol Clin Immunol. (2013)).

Summary of extracted biomedical information

Leukotriene e4 is associated with abnormalities such as Asthma, Atopic, Childhood asthma, Virus Diseases and Asthma aspirin-sensitive. The involved biomedical functions are known as Excretory function, Drug Interactions, Exhalation, Inflammation and attenuation. Leukotriene e4 is associated with Deuterium, ammonium hydroxide and acetonitrile.
Imgsrv

Associated references with human 24

Download references
Reference title

with link to reference page

Journal Year Authors & PubMed Link
Urine cysteinyl leukotriene levels in children with sleep disordered breathing before and after adenotonsillectomy. Int. J. Pediatr. Otorhinolaryngol. 2017 A. Satdhabudha, P. Sritipsukho, S. Manochantr, W. Chanvimalueng, U. Chaumrattanakul, P. Chaumphol
Int. J. Pediatr. Otorhinolaryngol. 2017 Mar;94:112-116. PubMed:28167000
Utility of low-dose oral aspirin challenges for diagnosis of aspirin-exacerbated respiratory disease. Ann. Allergy Asthma Immunol. 2016 E. Jerschow, Z. Ren, G. Hudes, M. Sanak, E. Morales, V. Schuster, SD. Spivack, D. Rosenstreich
Ann. Allergy Asthma Immunol. 2016 Apr;116(4):321-328.e1. PubMed:26822279
Aspirin provocation increases 8-iso-PGE2 in exhaled breath condensate of aspirin-hypersensitive asthmatics. Prostaglandins Other Lipid Mediat. 2015 L. Mastalerz, R. Januszek, M. Kaszuba, K. Wójcik, N. Celejewska-Wójcik, A. Gielicz, H. Plutecka, K. Oleś, P. Stręk, M. Sanak
Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt B):163-9. PubMed:26209241
Low-level environmental tobacco smoke exposure and inflammatory biomarkers in children with asthma. J Asthma 2014 R. Gill, S. Krishnan, AJ. Dozor
J Asthma 2014 May;51(4):355-9. PubMed:24580138
ALOX5 polymorphism associates with increased leukotriene production and reduced lung function and asthma control in children with poorly controlled asthma. Clin. Exp. Allergy 2013 E. Mougey, JE. Lang, H. Allayee, WG. Teague, AJ. Dozor, RA. Wise, JJ. Lima
Clin. Exp. Allergy 2013 May;43(5):512-20. PubMed:23600541
Asthma outcomes: biomarkers. J. Allergy Clin. Immunol. 2012 SJ. Szefler, S. Wenzel, R. Brown, SC. Erzurum, JV. Fahy, RG. Hamilton, JF. Hunt, H. Kita, AH. Liu, RA. Panettieri, RP. Schleimer, M. Minnicozzi
J. Allergy Clin. Immunol. 2012 Mar;129(3 Suppl):S9-23. PubMed:22386512
Airway molecular phenotypes in pediatric asthma. Curr Opin Allergy Clin Immunol 2011 SJ. Aujla, KR. Ross, JF. Chmiel, F. Holguin
Curr Opin Allergy Clin Immunol 2011 Apr;11(2):122-6. PubMed:21358402
Urinary leukotriene E₄ levels identify children with tobacco smoke exposure at risk for asthma exacerbation. J. Allergy Clin. Immunol. 2011 N. Rabinovitch, N. Reisdorph, L. Silveira, EW. Gelfand
J. Allergy Clin. Immunol. 2011 Aug;128(2):323-7. PubMed:21807251
Urinary leukotriene E4, obesity, and adenotonsillar hypertrophy in Chinese children with sleep disordered breathing. Sleep 2011 Y. Shen, Z. Xu, K. Shen
Sleep 2011 Aug;34(8):1135-041. PubMed:21804676
Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma. J. Allergy Clin. Immunol. 2010 N. Rabinovitch, NJ. Graber, VM. Chinchilli, CA. Sorkness, RS. Zeiger, RC. Strunk, LB. Bacharier, FD. Martinez, SJ. Szefler, .
J. Allergy Clin. Immunol. 2010 Sep;126(3):545-51.e1-4. PubMed:20816189
Recent advances in antileukotriene therapy. Curr Opin Allergy Clin Immunol 2010 GW. Scadding, GK. Scadding
Curr Opin Allergy Clin Immunol 2010 Aug;10(4):370-6. PubMed:20585242
Menopausal asthma: a new biological phenotype? Allergy 2010 MP. Foschino Barbaro, VR. Costa, O. Resta, R. Prato, A. Spanevello, GP. Palladino, D. Martinelli, GE. Carpagnano
Allergy 2010 Oct;65(10):1306-12. PubMed:20557302
Biomarkers in asthma. Curr Opin Pulm Med 2009 A. Murugan, C. Prys-Picard, WJ. Calhoun
Curr Opin Pulm Med 2009 Jan;15(1):12-8. PubMed:19077700
Pediatric biomarkers in asthma: exhaled nitric oxide, sputum eosinophils and leukotriene E4. Curr Opin Allergy Clin Immunol 2008 S. Gogate, R. Katial
Curr Opin Allergy Clin Immunol 2008 Apr;8(2):154-7. PubMed:18317025
Exposure to tobacco smoke increases leukotriene E4-related albuterol usage and response to montelukast. J. Allergy Clin. Immunol. 2008 N. Rabinovitch, M. Strand, K. Stuhlman, EW. Gelfand
J. Allergy Clin. Immunol. 2008 Jun;121(6):1365-71. PubMed:18439662
Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate. J. Allergy Clin. Immunol. 2006 P. Gyllfors, SE. Dahlén, M. Kumlin, K. Larsson, B. Dahlén
J. Allergy Clin. Immunol. 2006 Jul;118(1):78-83. PubMed:16815141
How does exercise cause asthma attacks? Curr Opin Allergy Clin Immunol 2006 SD. Anderson
Curr Opin Allergy Clin Immunol 2006 Feb;6(1):37-42. PubMed:16505610
Exhaled eicosanoids following oral aspirin challenge in asthmatic patients. Clin. Exp. Allergy 2004 M. Sanak, B. Kiełbasa, G. Bochenek, A. Szczeklik
Clin. Exp. Allergy 2004 Dec;34(12):1899-904. PubMed:15663565
Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. J. Allergy Clin. Immunol. 2003 RC. Strunk, SJ. Szefler, BR. Phillips, RS. Zeiger, VM. Chinchilli, G. Larsen, K. Hodgdon, W. Morgan, CA. Sorkness, RF. Lemanske, .
J. Allergy Clin. Immunol. 2003 Nov;112(5):883-92. PubMed:14610474
Urinary leukotriene E(4), eosinophil protein X, and nasal eosinophil cationic protein are not associated with respiratory symptoms in 1-year-old children. Allergy 2001 C. Wojnarowski, G. Halmerbauer, E. Mayatepek, C. Gartner, T. Frischer, J. Forster, J. Kuehr, .
Allergy 2001 Sep;56(9):883-8. PubMed:11551254
Exhaled nitric oxide following leukotriene E(4) and methacholine inhalation in patients with asthma. Am. J. Respir. Crit. Care Med. 2000 A. Deykin, O. Belostotsky, C. Hong, AF. Massaro, CM. Lilly, E. Israel
Am. J. Respir. Crit. Care Med. 2000 Nov;162(5):1685-9. PubMed:11069797
Local generation of sulfidopeptide leukotrienes upon nasal provocation with cold, dry air. Am. Rev. Respir. Dis. 1986 AG. Togias, RM. Naclerio, SP. Peters, I. Nimmagadda, D. Proud, A. Kagey-Sobotka, NF. Adkinson, PS. Norman, LM. Lichtenstein
Am. Rev. Respir. Dis. 1986 Jun;133(6):1133-7. PubMed:3013056
Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes. J Pharm Biomed Anal K. Syslová, A. Böhmová, E. Demirbağ, K. Šimková, M. Kuzma, D. Pelclová, V. Sedlák, P. Čáp, P. Martásek, P. Kačer
J Pharm Biomed Anal 2013 Jul-Aug;81-82:108-17. PubMed:23644905
Effect of inhaled corticosteroid treatment on exhaled breath condensate leukotriene E(4) in children with mild asthma. Allergy Asthma Proc JO. Steiss, S. Rudloff, E. Landmann, C. Rückes-Nilges, KP. Zimmer, H. Lindemann
Allergy Asthma Proc 2008 Jul-Aug;29(4):371-5. PubMed:18702883

Associated curated diseases 14

Download diseases

Associated disease mapping

Mapping of all associated diseases to Leukotriene E4 is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
91
Aspirin Sensitive Asthma MeSH: Asthma, Aspirin-Induced
Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use. Year introduced: 2010
Link to MeSH Database: D055963
2
Seasonal Allergic Rhinitis (Sar) MeSH: Rhinitis, Allergic, Seasonal
Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS. Year introduced: 2006 (1963)
Link to MeSH Database: D006255
1
Pneumoconiosis MeSH: Pneumoconiosis
A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population. Year introduced: 1966
Link to MeSH Database: D011009
1
Wheezing MeSH: Respiratory Sounds
Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT. Year introduced: 1980
Link to MeSH Database: D012135
2
Rhinitis MeSH: Rhinitis
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
Link to MeSH Database: D012220
2
Occupational Asthma (Oa) MeSH: Asthma, Occupational
Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE. Year introduced: 2012
Link to MeSH Database: D059366
1
Non Small Cell Lung Cancer, Lung Neoplasms MeSH: Lung Neoplasms
Tumors or cancer of the LUNG.
Link to MeSH Database: D008175
4
Allergic Rhinitis With Asthma MeSH: Rhinitis, Allergic, Perennial
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc. Year introduced: 1980
Link to MeSH Database: D012221
5
Sarcoidosis MeSH: Sarcoidosis
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands. Year introduced: PSEUDOTUBERCULOSIS use SARCOIDOSIS 1963-1992
Link to MeSH Database: D012507
4
Sleep Disordered Breathing (Sdb) MeSH: Sleep Apnea Syndromes
Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types. Year introduced: 1980
Link to MeSH Database: D012891
2
Exercise Induced Bronchoconstriction MeSH: Bronchoconstriction
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention. Year introduced: 1991
Link to MeSH Database: D016084
2
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31
Non Small Cell Lung Cancer, Carcinoma MeSH: Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy. Year introduced: 1994
Link to MeSH Database: D002289
2

Associated abnormalities 4

Concept Name External ID Weighted Score Hits References
Asthma ICD9-CM:493.9 1000.0 3
  1. Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma.
    N. Rabinovitch, NJ. Graber, VM. Chinchilli, CA. Sorkness, RS. Zeiger, RC. Strunk, LB. Bacharier, FD. Martinez, SJ. Szefler, . (2010) J. Allergy Clin. Immunol.
  2. Asthma outcomes: biomarkers.
    SJ. Szefler, S. Wenzel, R. Brown, SC. Erzurum, JV. Fahy, RG. Hamilton, JF. Hunt, H. Kita, AH. Liu, RA. Panettieri, RP. Schleimer, M. Minnicozzi (2012) J. Allergy Clin. Immunol.
  3. Aspirin provocation increases 8-iso-PGE2 in exhaled breath condensate of aspirin-hypersensitive asthmatics.
    L. Mastalerz, R. Januszek, M. Kaszuba, K. Wójcik, N. Celejewska-Wójcik, A. Gielicz, H. Plutecka, K. Oleś, P. Stręk, M. Sanak (2015) Prostaglandins Other Lipid Mediat.
Virus Diseases 630.79 1
  1. Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma.
    N. Rabinovitch, NJ. Graber, VM. Chinchilli, CA. Sorkness, RS. Zeiger, RC. Strunk, LB. Bacharier, FD. Martinez, SJ. Szefler, . (2010) J. Allergy Clin. Immunol.
Asthma aspirin-sensitive 1000.0 1
  1. Asthma outcomes: biomarkers.
    SJ. Szefler, S. Wenzel, R. Brown, SC. Erzurum, JV. Fahy, RG. Hamilton, JF. Hunt, H. Kita, AH. Liu, RA. Panettieri, RP. Schleimer, M. Minnicozzi (2012) J. Allergy Clin. Immunol.
Airway Obstruction 1000.0 1
  1. Asthma outcomes: biomarkers.
    SJ. Szefler, S. Wenzel, R. Brown, SC. Erzurum, JV. Fahy, RG. Hamilton, JF. Hunt, H. Kita, AH. Liu, RA. Panettieri, RP. Schleimer, M. Minnicozzi (2012) J. Allergy Clin. Immunol.

Associated chemicals 1

Concept Name External ID Definition Weighted Score Hits References
ammonium hydroxide 1000.0 1
  1. Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes.
    K. Syslová, A. Böhmová, E. Demirbağ, K. Šimková, M. Kuzma, D. Pelclová, V. Sedlák, P. Čáp, P. Martásek, P. Kačer () J Pharm Biomed Anal

Associated functions 9

Concept Name External ID Definition Weighted Score Hits References
Excretory function 694.0 3
  1. Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticasone propionate.
    P. Gyllfors, SE. Dahlén, M. Kumlin, K. Larsson, B. Dahlén (2006) J. Allergy Clin. Immunol.
  2. Exposure to tobacco smoke increases leukotriene E4-related albuterol usage and response to montelukast.
    N. Rabinovitch, M. Strand, K. Stuhlman, EW. Gelfand (2008) J. Allergy Clin. Immunol.
  3. Aspirin provocation increases 8-iso-PGE2 in exhaled breath condensate of aspirin-hypersensitive asthmatics.
    L. Mastalerz, R. Januszek, M. Kaszuba, K. Wójcik, N. Celejewska-Wójcik, A. Gielicz, H. Plutecka, K. Oleś, P. Stręk, M. Sanak (2015) Prostaglandins Other Lipid Mediat.
Drug Interactions 742.03 2
  1. Exposure to tobacco smoke increases leukotriene E4-related albuterol usage and response to montelukast.
    N. Rabinovitch, M. Strand, K. Stuhlman, EW. Gelfand (2008) J. Allergy Clin. Immunol.
attenuation 944.0 1
  1. Exposure to tobacco smoke increases leukotriene E4-related albuterol usage and response to montelukast.
    N. Rabinovitch, M. Strand, K. Stuhlman, EW. Gelfand (2008) J. Allergy Clin. Immunol.
inhibitors 898.25 1
  1. Asthma outcomes: biomarkers.
    SJ. Szefler, S. Wenzel, R. Brown, SC. Erzurum, JV. Fahy, RG. Hamilton, JF. Hunt, H. Kita, AH. Liu, RA. Panettieri, RP. Schleimer, M. Minnicozzi (2012) J. Allergy Clin. Immunol.
Adjudication 1000.0 1
  1. Exposure to tobacco smoke increases leukotriene E4-related albuterol usage and response to montelukast.
    N. Rabinovitch, M. Strand, K. Stuhlman, EW. Gelfand (2008) J. Allergy Clin. Immunol.
Respiratory physiology 743.95 1
  1. Asthma outcomes: biomarkers.
    SJ. Szefler, S. Wenzel, R. Brown, SC. Erzurum, JV. Fahy, RG. Hamilton, JF. Hunt, H. Kita, AH. Liu, RA. Panettieri, RP. Schleimer, M. Minnicozzi (2012) J. Allergy Clin. Immunol.
Synthesis 950.5 1
  1. Asthma outcomes: biomarkers.
    SJ. Szefler, S. Wenzel, R. Brown, SC. Erzurum, JV. Fahy, RG. Hamilton, JF. Hunt, H. Kita, AH. Liu, RA. Panettieri, RP. Schleimer, M. Minnicozzi (2012) J. Allergy Clin. Immunol.
Inflammatory Response 1000.0 1
  1. Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma.
    N. Rabinovitch, NJ. Graber, VM. Chinchilli, CA. Sorkness, RS. Zeiger, RC. Strunk, LB. Bacharier, FD. Martinez, SJ. Szefler, . (2010) J. Allergy Clin. Immunol.
Inflammation 945.5 1
  1. Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma.
    N. Rabinovitch, NJ. Graber, VM. Chinchilli, CA. Sorkness, RS. Zeiger, RC. Strunk, LB. Bacharier, FD. Martinez, SJ. Szefler, . (2010) J. Allergy Clin. Immunol.

Associated genes 0

No associated genes are detected in current reference collection.

There are 24 associated references with Leukotriene E4. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C23H37NO5S
Mass 439.611
Synonyms leukotriene E4
LTE4
Leukotriene E
75715-89-8
UNII-8EYT8ATL7G
8EYT8ATL7G
CHEMBL509456
CHEBI:15650
5S-hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid
C23H37NO5S
(7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,14-tetraenoate
(7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate
(5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
(5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-6-((2-Amino-2-carboxyethyl)thio)-5-hydroxy-7,9,11,14-eicosatetraenoic acid
AC1NQXPM
LEUKOTRIEN E4
BSPBio_001370
5S-Hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
[3H]LTE4
GTPL3352
PubChem CID 5280879