Leukotriene C4
Description
Description of Leukotriene C4 with associated disease summary
Asthma
Asthma is an inflammatory respiratory disease. Cys-LTs have been detected in EBC of patients with asthma. EBC Cys-LTs concentration was significantly higher in patients with asthma than in healthy subjects. The level of Cys-LTs would gradually increase according to the severity of asthma. Cys-LTs were involved in the pathogenesis of asthma. Cys-LTs may be a potential biomarker of bronchial asthma.Sleep Apnea Syndromes
In adenotonsillar tissue and EBC of children with sleep apnea, the concentration of Cys-LTs was elevated. In urine, Cys-LTs concentration was significantly related to the severity of sleep-disordered breathing (SDB). Cys-LTs might be the cause of pathogenesis of obstructive sleep apnea (OSA), or the consequence of upper airway obstruction during sleep. Detection of Cys-LTs concentration in EBC or urine could be a non-invasive method to estimate the status of SDB.Rhinitis, Allergic, Perennial
Basal level of Cys-LTs in EBC of allergic rhinitis (AR) patients was significantly higher than that in healthy subjects. Therefore, the measurement of Cys-LTs in EBC could be a fast and effective screening method to early detect the possibility of suffering AR. After the treatment of intranasal corticosteroid fluticasone propionate (FP), basal Cys-LTs level was significantly reduced in AR patients with and without asthma.Sarcoidosis
The mean concentration of Cys-LTs was higher in EBC in sarcoidosis subjects as compared to healthy subjects.Asthma, Aspirin-Induced
Subjects with asthma had significant increased level of LTC4 in EBC as compared to healthy control subjects. Following aspirin challenge, Cys-LTs level was lower in subjects with aspirin-induced asthma/aspirin-intolerant asthma (AIA) as compared to subjects with aspirin-tolerant asthma (ATA).Asthma, Occupational
Total Cys-LTs and LTC4 in EBC were higher in patients with occupational asthma (OA). The level of Cys-LTs in EBC could be used to estimate the status of inflammation and oxidative stress, and reflect the severity of OA.Bronchoconstriction
Asthmatic children with exercise-induced bronchoconstriction (EIB) had higher concentration of Cys-LTs than subjects without exercise-induced bronchoconstriction (non-EIB) and control subjects.Carcinoma, Non-Small-Cell Lung
Cys-LTs were found in exhaled breath condensate (EBC) and bronchoalveolar lavage fluid (BALf) of studied patients with diagnosed non-small cell lung cancer (NSCLC). Compared with healthy controls, patients had significantly higher concentration of Cys-LTs in EBC. In patients, although Cys-LTs concentration in BALf was significantly higher than in EBC, there was a significant and positive correlation between Cys-LTs concentration in EBC and in BALf, which makes the non-invasive, breath-based detection method become feasible to monitor and diagnose lung cancer disease.Lung Neoplasms
It had been demonstrated that lung carcinogenesis could induce local inflammation and enhance oxidative stress. Cys-LTs were increased in lung cancer microenvironment. Since factors unrelated to lung neoplasms, such as age and smoking status, were excluded, the difference of Cys-LTs concentration between patients and healthy control groups was mainly related to the studied neoplasmatic disease.Pneumoconiosis
Patients with pneumoconiosis were divided into asbestos exposure and silica exposure groups. Cys-LTs were elevated in EBC of asbestos exposure subjects.Pulmonary Disease, Chronic Obstructive
The level of Cys-LTs in EBC of patients with exacerbated chronic obstructive pulmonary disease (COPD) was different at different therapeutic stages (including outpatient clinic or hospital visit (visit 1), antibiotic therapy visit (visit 2), post-therapy visit (visit 3), and follow-up visit). Cys-LTs level at visit 1 stage was significantly greater than other stages, and the level had a decreasing trend during treatment. High Cys-LTs level might be derived from the increased 5-lipoxygenase enzyme activity in COPD patients.Summary of extracted biomedical information
Associated references with human 0
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Reference title
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Journal | Year | Authors & PubMed Link |
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Associated curated diseases 2
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Disease Name
with link to disease page |
Description of MeSH term
with link to MeSH Database |
Number of references |
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Asthma |
MeSH:
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and
intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of
airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
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91 |
Aspirin Sensitive Asthma |
MeSH:
Asthma, Aspirin-Induced
Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use.
Year introduced: 2010
Link to MeSH Database: D055963
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2 |
Associated abnormalities 0
No associated abnormalities are detected in current reference collection.
There are 0 associated references with Leukotriene C4. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.
Associated chemicals 0
No associated chemicals are detected in current reference collection.
There are 0 associated references with Leukotriene C4. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.
Associated functions 0
No associated functions are detected in current reference collection.
There are 0 associated references with Leukotriene C4. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.
Associated genes 0
No associated genes are detected in current reference collection.
There are 0 associated references with Leukotriene C4. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
NCBI Entrez Crosslinks
Chemical Information
Formula | C30H47N3O9S |
Mass | 625.778 |
Synonyms | leukotriene C4 LTC4 Leukotriene C Leukotriene C1 LTC (sub 4) Leucotriene C4 5S,6R-Ltc(sub 4) UNII-2CU6TT9V48 72025-60-6 2CU6TT9V48 CHEBI:16978 5S-hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid Leukotriene C(sub 1) Leukotriene C(sub 4) C30H47N3O9S (5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-[[(4S)-4-amino-5-hydroxy-5-oxopentanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid (5~{s},6~{r},7~{e},9~{e},11~{z},14~{z})-6-[(2~{r})-2-[[(4~{s})-4-Azanyl-5-Oxidanyl-5-Oxidanylidene-Pentanoyl]amino]-3-(2-Hydroxy-2-Oxoethylamino)-3-Oxidanylidene-Propyl]sulfanyl-5-Oxidanyl-Icosa-7,9,11,14-Tetraenoic Acid Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))- LTX AC1NQX3P |
PubChem CID | 5280493 |