Back
Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children.
RC. Strunk, SJ. Szefler, BR. Phillips, RS. Zeiger, VM. Chinchilli, G. Larsen, K. Hodgdon, W. Morgan, CA. Sorkness, RF. Lemanske, .
J. Allergy Clin. Immunol. 2003 Nov;112(5):883-92.
PubMed: 14610474
Abstract
Exhaled nitric oxide (eNO) is a noninvasive test that measures airway inflammation. Insufficient information is available concerning correlations between eNO and biologic, physiologic, and clinical characteristics of asthma in children currently not taking controller medications. The aim of this study was to find correlations between eNO and other characteristics of children with mild to moderate asthma currently not taking medications. Children aged 6 to 17 years with mild to moderate persistent asthma, taking only albuterol as needed, were characterized during 2 visits 1 week apart before being randomly assigned into a clinical trial. At the screening visit, online measurements of eNO, spirometry before and after bronchodilator, and biomarkers of peripheral blood eosinophils, serum eosinophil cationic protein, total serum IgE, and urinary leukotriene E4 were obtained. During a week characterization period before randomization, symptoms were recorded on a diary and peak expiratory flows were measured twice daily using an electronic device. At the randomization visit, eNO was repeated followed by a methacholine challenge and aeroallergen skin testing. Correlations and rank regression analyses between eNO and clinical characteristics, pulmonary function, and biomarkers were evaluated. eNO was significantly correlated with peripheral blood eosinophils (r =.51, P
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Leukotriene E4 | 61 |