Copper

Description

Description of Copper with associated disease summary

Copper is one of the metal indicators of interstitial lung diseases including idiopathic interstitial pneumonia (IIPs) and sarcoidosis. Lower levels of copper were detected in interstitial lung diseases patients. The depletion of copper involved in the oxidant/anti-oxidant balance may be linked to the oxidative stress and chronic inflammation (J Breath Res. (2009)) Description of disease(s) related to Copper:

Idiopathic pulmonary fibrosis

One study using inductive coupled plasma mass spectrometry (ICP-MS) to detect copper and shows that the EBC copper level in idiopathic pulmonary fibrosis patients are significantly lower than the healthy controls (p < 0.05 versus controls) (J Breath Res. (2009)) .

Non-specific interstitial pneumonia

One study using inductive coupled plasma mass spectrometry (ICP-MS) to detect copper and shows that the EBC copper level in non-specific interstitial pneumonia patients are lower than the healthy controls (p < 0.05 versus controls) (J Breath Res. (2009)) .

Sarcoidosis

One study using inductive coupled plasma mass spectrometry (ICP-MS) to detect copper and shows that the EBC copper level in sarcoidosis patients are lower than the healthy controls (p < 0.05 versus controls) (J Breath Res. (2009)) .

Summary of extracted biomedical information

Associated references with human 0

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link

Associated curated diseases 3

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Associated disease mapping

Mapping of all associated diseases to Copper is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Sarcoidosis	MeSH: Sarcoidosis An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands. Year introduced: PSEUDOTUBERCULOSIS use SARCOIDOSIS 1963-1992 Link to MeSH Database: D012507	4
Non Specific Interstitial Pneumonia	MeSH: Lung Diseases, Interstitial A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features. Year introduced: 1994 Link to MeSH Database: D017563	1
Idiopathic Pulmonary Fibrosis	MeSH: Idiopathic Pulmonary Fibrosis A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change. Year introduced: 2009 Link to MeSH Database: D054990	3

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with Copper. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with Copper. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with Copper. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with Copper. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	Cu
Mass	63.546
Synonyms	COPPER 7440-50-8 cuprum Blister copper Cathode copper Copper powder Anode copper Copper precipitates cobre cuivre Copper-airborne Rame Arwood copper Copper bronze Copper dust Copper-milled Gold bronze Kafar copper Raney copper Copper, elemental
PubChem CID	23978