Docosahexaenoic acid
Description
Description of Docosahexaenoic acid with associated disease summary
Docosahexaenoic acid (DHA) is a precursors of specialized
proresolving mediators (SPM) which can modulate inflammatory signaling pathway
including mitogen-activated protein kinase (MAPK) and nuclear factor-k-lightchain
enhancer of activated B cells (NF-kB) families (Am J Physiol Lung Cell Mol
Physiol. (2015)). Chronic obstructive pulmonary disease (COPD) patients who
cannot resolve inflammation have dysregulated lipid mediator levels and the EBC
DHA concentrations in COPD patients are higher than the healthy control (Am J Physiol Lung Cell Mol
Physiol. (2015)).
Description of disease(s) related to Docosahexaenoic acid (DHA):
Disease summary
Chronic obstructive pulmonary disease (COPD)
The EBC DHA concentrations in chronic obstructive pulmonary disease (COPD) patients are higher than the healthy control (Am J Physiol Lung Cell Mol Physiol. (2015)).Summary of extracted biomedical information
Docosahexaenoic acid is associated with abnormalities such as Asthma. The involved biomedical functions are known as Morbidity, infant, Immunologic function, enzyme pathway, Anabolism and Inflammation, allergic.
Associated references with human 15
Download references|
Reference title
with link to reference page |
Journal | Year | Authors & PubMed Link |
|---|---|---|---|
| Metabolism of uniformly labeled 13C-eicosapentaenoic acid and 13C-arachidonic acid in young and old men. | Am. J. Clin. Nutr. | 2017 |
P. Léveillé, R. Chouinard-Watkins, A. Windust, P. Lawrence, SC. Cunnane, JT. Brenna, M. Plourde
Am. J. Clin. Nutr. 2017 Aug;106(2):467-474. PubMed:28659301 |
| Elevated prostaglandin E metabolites and abnormal plasma fatty acids at baseline in pediatric cystic fibrosis patients: a pilot study. | Prostaglandins Leukot. Essent. Fatty Acids | 2016 |
MG. O'Connor, K. Thomsen, RF. Brown, M. Laposata, A. Seegmiller
Prostaglandins Leukot. Essent. Fatty Acids 2016 10;113:46-49. PubMed:27720040 |
| Kinetics of 13C-DHA before and during fish-oil supplementation in healthy older individuals. | Am. J. Clin. Nutr. | 2014 |
M. Plourde, R. Chouinard-Watkins, C. Rioux-Perreault, M. Fortier, MT. Dang, MJ. Allard, J. Tremblay-Mercier, Y. Zhang, P. Lawrence, MC. Vohl, P. Perron, D. Lorrain, JT. Brenna, SC. Cunnane
Am. J. Clin. Nutr. 2014 Jul;100(1):105-12. PubMed:24829492 |
| Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele. | Br. J. Nutr. | 2013 |
R. Chouinard-Watkins, C. Rioux-Perreault, M. Fortier, J. Tremblay-Mercier, Y. Zhang, P. Lawrence, MC. Vohl, P. Perron, D. Lorrain, JT. Brenna, SC. Cunnane, M. Plourde
Br. J. Nutr. 2013 Nov;110(10):1751-9. PubMed:23631810 |
| The role of docosahexaenoic and the marine food web as determinants of evolution and hominid brain development: the challenge for human sustainability. | Nutr Health | 2012 |
MA. Crawford, CL. Broadhurst
Nutr Health 2012 Jan;21(1):17-39. PubMed:22544773 |
| Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. | Pediatrics | 2011 |
B. Imhoff-Kunsch, AD. Stein, R. Martorell, S. Parra-Cabrera, I. Romieu, U. Ramakrishnan
Pediatrics 2011 Sep;128(3):e505-12. PubMed:21807696 |
| Impact of a novel nutritional formula on asthma control and biomarkers of allergic airway inflammation in children. | Clin. Exp. Allergy | 2010 |
R. Covar, M. Gleason, B. Macomber, L. Stewart, P. Szefler, K. Engelhardt, J. Murphy, A. Liu, S. Wood, S. DeMichele, EW. Gelfand, SJ. Szefler
Clin. Exp. Allergy 2010 Aug;40(8):1163-74. PubMed:20545703 |
| Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly. | Lipids | 2008 |
M. Vandal, E. Freemantle, J. Tremblay-Mercier, M. Plourde, M. Fortier, J. Bruneau, J. Gagnon, M. Bégin, SC. Cunnane
Lipids 2008 Nov;43(11):1085-9. PubMed:18795357 |
| Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. | J. Immunol. | 2007 |
BD. Levy, P. Kohli, K. Gotlinger, O. Haworth, S. Hong, S. Kazani, E. Israel, KJ. Haley, CN. Serhan
J. Immunol. 2007 Jan;178(1):496-502. PubMed:17182589 |
| Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. | Pediatr. Res. | 2006 |
C. Mayes, GC. Burdge, A. Bingham, JL. Murphy, R. Tubman, SA. Wootton
Pediatr. Res. 2006 Feb;59(2):271-5. PubMed:16439591 |
| [Hydroa vacciniforme: dietary fish oil]. | Ann Dermatol Venereol | 2001 |
AB. Modeste, N. Cordel, X. Balguerie, D. Leroy, P. Lauret, P. Joly
Ann Dermatol Venereol 2001 Mar;128(3 Pt 1):247-9. PubMed:11319390 |
| Effects of dietary alpha-linolenic acid on the conversion and oxidation of 13C-alpha-linolenic acid. | Lipids | 2000 |
SH. Vermunt, RP. Mensink, MM. Simonis, G. Hornstra
Lipids 2000 Feb;35(2):137-42. PubMed:10757543 |
| Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. | Ann. Nutr. Metab. | 1999 |
N. Fidler, T. Sauerwald, H. Demmelmair, A. Pohl, B. Koletzko
Ann. Nutr. Metab. 1999 ;43(6):339-45. PubMed:10725767 |
| Lipid peroxidation during n-3 fatty acid and vitamin E supplementation in humans. | Lipids | 1997 |
JP. Allard, R. Kurian, E. Aghdassi, R. Muggli, D. Royall
Lipids 1997 May;32(5):535-41. PubMed:9168460 |
| Combinations of distinct long-chain polyunsaturated fatty acid species for improved dietary treatment against allergic bronchial asthma. | Nutrition |
C. Beermann, S. Neumann, D. Fußbroich, S. Zielen, R. Schubert
Nutrition 2016 Nov-Dec;32(11-12):1165-70. PubMed:27297719 |
Associated curated diseases 1
Download diseasesAssociated disease mapping
Mapping of all associated diseases to Docosahexaenoic acid is displayed in red.
|
Disease Name
with link to disease page |
Description of MeSH term
with link to MeSH Database |
Number of references |
|---|---|---|
| Chronic Obstructive Pulmonary Disease (Copd) |
MeSH:
Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Year introduced: 2002
Link to MeSH Database: D029424
|
31 |
Associated abnormalities 1
| Concept Name | External ID | Weighted Score | Hits | References | |
| Asthma | ICD9-CM:493.9 | 944.0 | 1 |
|
Associated chemicals 0
No associated chemicals are detected in current reference collection.
There are 15 associated references with Docosahexaenoic acid. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.
Associated functions 0
No associated functions are detected in current reference collection.
There are 15 associated references with Docosahexaenoic acid. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.
Associated genes 0
No associated genes are detected in current reference collection.
There are 15 associated references with Docosahexaenoic acid. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
NCBI Entrez Crosslinks
Chemical Information
| Formula | C22H32O2 |
| Mass | 328.496 |
| Synonyms | Docosahexaenoic acid Doconexent Cervonic acid 6217-54-5 Doconexento Doconexentum Doxonexent AquaGrow Advantage all-Z-Docosahexaenoic acid Martek DHA HM Ropufa 60 cis-4,7,10,13,16,19-Docosahexaenoic acid Docosahexaenoate UNII-ZAD9OKH9JC docosahexaenoic acid(DHA) (4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid all-cis-DHA Docosahexaenoic acid (all-Z) CCRIS 7670 (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid |
| PubChem CID | 445580 |