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Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly.
M. Vandal, E. Freemantle, J. Tremblay-Mercier, M. Plourde, M. Fortier, J. Bruneau, J. Gagnon, M. Bégin, SC. Cunnane
Lipids 2008 Nov;43(11):1085-9.
PubMed: 18795357
Abstract
Little information is available concerning whether incorporation of dietary omega-3 fatty acids into plasma lipids changes during healthy aging. Elderly (74 +/- 4 years old) and young (24 +/- 2 years old) adults were given a fish oil supplement for 3 weeks that provided 680 mg/day of docosahexaenoic acid and 320 mg/day of eicosapentaenoic acid, followed by a 2 week wash-out period. Compliance was monitored by spiking the capsules with carbon-13 glucose, the excretion of which was measured in breath CO2. In response to the supplement, plasma docosahexaenoic acid rose 42% more in the elderly but eicosapentaenoic responded similarly in both groups. Despite raising docosahexaenoic acid intake by five to tenfold, the supplement did not raise plasma free docosahexaenoic acid (% or mg/dL) in either group. We conclude that healthy aging is accompanied by subtle but significant changes in DHA incorporation into plasma lipids.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Docosahexaenoic acid | 18 |