Iron

Description

Description of Iron with associated disease summary

Iron (Fe) is a transition element that plays an important role in the oxidant/anti-oxidant balance and a co-factor of various enzymes. According to epidemiological data, environmental and occupational agents play a critical role in the development of interstitial lung diseases (ILDs), such as idiopathic interstitial pneumonia (IIPs), non-specific interstitial pneumonia (NSIP) and sarcoidosis. A study investigated the exhaled breath condensate (EBC) of 33 healthy subjects, 22 patients with sarcoidosis, 15 patients with NSIP and 19 with IIPs to determine the role of Fe metal in the pathogenesis of ILDs. Fe traces were measured by inductively coupled plasma-mass spectrometry (ICP-MS). The report indicates Fe levels were higher in the control subjects than in the IPF and NSIP patients. There was a positive correlation between EBC Fe levels and diffusing lung capacity for carbon monoxide (DLCO) in the patients with sarcoidosis, and between EBC Fe levels and total lung capacity (TLC) in the IPF patients. COPD patients showed lower levels of Fe, and patients with asthma had lower levels of Fe than healthy non-smokers. Chronic inflammation and oxidative stress are important mechanisms in the pathogenesis of ILDs. ILD patients have lower Fe levels, compared to controls. This reduction in Fe was possibly due to pulmonary depletion as a result of chronic oxidative stress and inflammation. Assessing the elemental composition of EBC in ILD patients seems to provide useful information, although further studies are required to confirm the robustness of this approach, and to better understand the underlying pathophysiological processes of ILDs ( J Breath Res. (2009) ). Description of disease(s) related to Iron:

Disease summary

Idiopathic Pulmonary Fibrosis (IPF)

The report indicates iron (Fe) levels were higher in the control subjects than in the IPF and NSIP patients ( J Breath Res. (2009) ).

Non-specific interstitial pneumonia (NSIP)

The report indicates iron (Fe) levels were higher in the control subjects than in the IPF and NSIP patients ( J Breath Res. (2009) ).

Sarcoidosis

No significant difference of iron level between sarcoidosis patients and healthy control (J Breath Res. (2009) ) .

Summary of extracted biomedical information

Associated references with human 0

Download references

Reference title with link to reference page	Journal	Year	Authors & PubMed Link

Associated curated diseases 2

Download diseases

Associated disease mapping

Mapping of all associated diseases to Iron is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Non Specific Interstitial Pneumonia	MeSH: Lung Diseases, Interstitial A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features. Year introduced: 1994 Link to MeSH Database: D017563	1
Idiopathic Pulmonary Fibrosis	MeSH: Idiopathic Pulmonary Fibrosis A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change. Year introduced: 2009 Link to MeSH Database: D054990	3

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with Iron. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with Iron. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with Iron. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with Iron. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	Fe
Mass	55.845
Synonyms	IRON 7439-89-6 Ferrum ferrous iron Remko Carbonyl iron Armco iron Iron, elemental Ferrovac E Hoeganaes EH Ancor B Atomiron 5M PZhO Atomiron 44MR Atomiron AFP 5 Atomiron AFP 25 hierro Atomel 28 Atomel 95 HQ (metal)
PubChem CID	23925