Nitrite
Summary of extracted biomedical information
Nitrite is associated with abnormalities such as Chronic Obstructive Airway Disease, Hyperdistention, Cystic Fibrosis, Pneumonia and Acute asthma. The involved biomedical functions are known as Inflammation, Pathological Dilatation, Hypoxia, Pathogenesis and protonation. The associated genes/proteins with Nitrite are Glucagon-Like Peptide 1. Nitrite is associated with Nitrate, Nitrite, Sulfuric Acid Esters, 18-crown-6 and Anions.
Associated references with human 36
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Reference title
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Journal | Year | Authors & PubMed Link |
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Z. Vucinovic, D. Duplancic, A. Seselja-Perisin, L. Kukoc-Modun, G. Gunjaca, M. Radman, J. Vukovic, D. Tsikas, K. Poljak, D. Modun
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JA. Castro-Rodriguez, RO. Molina, M. Cáceres, A. Recabarren
Pediatr. Pulmonol. 2014 Mar;49(3):214-20. PubMed:23843321 |
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MH. Fens, SK. Larkin, B. Oronsky, J. Scicinski, CR. Morris, FA. Kuypers
PLoS ONE 2014 ;9(7):e101626. PubMed:25007272 |
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K. Preece, R. Bhatia, J. Belcher, K. Patchett, P. McElduff, A. Collison, J. Mattes
Clin. Exp. Allergy 2014 Mar;44(3):371-80. PubMed:24345088 |
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CW. Jones, KD. Culbreath, A. Mehrotra, PH. Gilligan
J Emerg Med 2014 Jan;46(1):71-6. PubMed:24140018 |
| Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma. | J. Occup. Environ. Med. | 2012 |
S. Hussain, R. Laumbach, J. Coleman, H. Youssef, K. Kelly-McNeil, P. Ohman-Strickland, J. Zhang, H. Kipen
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P. Kubáň, EG. Kobrin, M. Kaljurand
J Chromatogr A 2012 Dec;1267:239-45. PubMed:22796027 |
| Plasma nitrite concentration decreases after hyperoxia-induced oxidative stress in healthy humans. | Clin Physiol Funct Imaging | 2012 |
D. Modun, M. Krnic, J. Vukovic, V. Kokic, L. Kukoc-Modun, D. Tsikas, Z. Dujic
Clin Physiol Funct Imaging 2012 Sep;32(5):404-8. PubMed:22856349 |
| The fraction of NO in exhaled air and estimates of alveolar NO in adolescents with asthma: methodological aspects. | Pediatr. Pulmonol. | 2012 |
C. Heijkenskjöld-Rentzhog, K. Alving, P. Kalm-Stephens, JO. Lundberg, L. Nordvall, A. Malinovschi
Pediatr. Pulmonol. 2012 Oct;47(10):941-9. PubMed:22467536 |
| Effects of successive air and nitrox dives on human vascular function. | Eur. J. Appl. Physiol. | 2012 |
J. Marinovic, M. Ljubkovic, T. Breskovic, G. Gunjaca, A. Obad, D. Modun, N. Bilopavlovic, D. Tsikas, Z. Dujic
Eur. J. Appl. Physiol. 2012 Jun;112(6):2131-7. PubMed:21964910 |
| The biochemistry of asthma. | Biochim. Biophys. Acta | 2011 |
B. Gaston
Biochim. Biophys. Acta 2011 Nov;1810(11):1017-24. PubMed:21718756 |
| Melatonin improves sleep and reduces nitrite in the exhaled breath condensate in cystic fibrosis--a randomized, double-blind placebo-controlled study. | J. Pineal Res. | 2010 |
C. de Castro-Silva, VM. de Bruin, GM. Cunha, DM. Nunes, CA. Medeiros, PF. de Bruin
J. Pineal Res. 2010 Jan;48(1):65-71. PubMed:20025642 |
| Mediators in exhaled breath condensate after hypertonic saline challenge. | J Asthma | 2009 |
. Ratnawati, J. Morton, RL. Henry, PS. Thomas
J Asthma 2009 Dec;46(10):1045-51. PubMed:19995145 |
| Cerebral blood flow and oxygen metabolism measured with the Kety-Schmidt method using nitrous oxide. | Acta Anaesthesiol Scand | 2009 |
S. Taudorf, RM. Berg, DM. Bailey, K. Møller
Acta Anaesthesiol Scand 2009 Feb;53(2):159-67. PubMed:19076112 |
| Exhaled breath condensate nitrite--methodological problems of sample collection. | Med. Sci. Monit. | 2008 |
C. Vogelberg, A. Kahlert, C. Würfel, K. Marx, A. Böhm, U. Range, V. Neumeister, W. Leupold
Med. Sci. Monit. 2008 Aug;14(8):CR416-22. PubMed:18667999 |
| Use of polyurethane foam and 3-hydroxy-7,8-benzo-1,2,3,4-tetrahydroquinoline for determination of nitrite by diffuse reflectance spectroscopy and colorimetry. | Anal Bioanal Chem | 2008 |
VV. Apyari, SG. Dmitrienko, VM. Ostrovskaya, EK. Anaev, YA. Zolotov
Anal Bioanal Chem 2008 Jul;391(5):1977-82. PubMed:18431561 |
| Breath condensate nitrite correlates with hyperinflation in chronic obstructive pulmonary disease. | Respir Med | 2007 |
C. Gessner, S. Hammerschmidt, H. Kuhn, G. Hoheisel, A. Gillissen, U. Sack, H. Wirtz
Respir Med 2007 Nov;101(11):2271-8. PubMed:17693071 |
| Activated protein C suppresses adrenomedullin and ameliorates lipopolysaccharide-induced hypotension. | Shock | 2007 |
A. Gupta, DT. Berg, B. Gerlitz, MA. Richardson, E. Galbreath, S. Syed, AC. Sharma, SF. Lowry, BW. Grinnell
Shock 2007 Oct;28(4):468-76. PubMed:17558353 |
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V. Cardile, L. Lombardo, E. Belluso, A. Panico, S. Capella, M. Balazy
Int J Environ Res Public Health 2007 Mar;4(1):1-9. PubMed:17431308 |
| The exhaled biomarker puzzle: bacteria play their card in the exhaled nitric oxide-exhaled breath condensate nitrite game. | Thorax | 2005 |
I. Horvath
Thorax 2005 Mar;60(3):179-80. PubMed:15741429 |
| Effects of breathing pattern and inspired air conditions on breath condensate volume, pH, nitrite, and protein concentrations. | Thorax | 2004 |
JB. McCafferty, TA. Bradshaw, S. Tate, AP. Greening, JA. Innes
Thorax 2004 Aug;59(8):694-8. PubMed:15282391 |
| Correlation of nitrites in breath condensates and lung function in asthmatic children. | Pediatr Allergy Immunol | 2004 |
DA. Straub, R. Ehmann, GL. Hall, A. Moeller, J. Hamacher, U. Frey, FH. Sennhauser, JH. Wildhaber
Pediatr Allergy Immunol 2004 Feb;15(1):20-5. PubMed:14998378 |
| Markers of inflammation in exhaled breath condensate of young healthy smokers. | Chest | 2004 |
KW. Garey, MM. Neuhauser, RA. Robbins, LH. Danziger, I. Rubinstein
Chest 2004 Jan;125(1):22-6. PubMed:14718416 |
| Exhaled breath condensate nitrite and its relation to tidal volume in acute lung injury. | Chest | 2003 |
C. Gessner, S. Hammerschmidt, H. Kuhn, T. Lange, L. Engelmann, J. Schauer, H. Wirtz
Chest 2003 Sep;124(3):1046-52. PubMed:12970036 |
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RJ. Stewart, EW. Askew, CM. McDonald, J. Metos, WD. Jackson, TW. Balon, RL. Prior
J Am Diet Assoc 2002 Nov;102(11):1652-7. PubMed:12449290 |
| Elevated nitrite in breath condensates of children with respiratory disease. | Eur. Respir. J. | 2002 |
W. Formanek, D. Inci, RP. Lauener, JH. Wildhaber, U. Frey, GL. Hall
Eur. Respir. J. 2002 Mar;19(3):487-91. PubMed:11936527 |
| Expression and regulation of inducible nitric oxide synthase from human primary airway epithelial cells. | Am. J. Respir. Cell Mol. Biol. | 2002 |
LE. Donnelly, PJ. Barnes
Am. J. Respir. Cell Mol. Biol. 2002 Jan;26(1):144-51. PubMed:11751214 |
| Measurement of inflammatory markers in the breath condensate of children with cystic fibrosis. | Eur. Respir. J. | 2000 |
S. Cunningham, JR. McColm, LP. Ho, AP. Greening, TG. Marshall
Eur. Respir. J. 2000 May;15(5):955-7. PubMed:10853865 |
| Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide. | Thorax | 1998 |
LP. Ho, JA. Innes, AP. Greening
Thorax 1998 Aug;53(8):680-4. PubMed:9828856 |
| Expression of inducible nitric oxide in human lung epithelial cells. | Biochem. Biophys. Res. Commun. | 1994 |
RA. Robbins, PJ. Barnes, DR. Springall, JB. Warren, OJ. Kwon, LD. Buttery, AJ. Wilson, DA. Geller, JM. Polak
Biochem. Biophys. Res. Commun. 1994 Aug;203(1):209-18. PubMed:7521161 |
| Exhaled and plasma nitrite: a comparative study among healthy, cirrhotic and liver transplant patients. | Arq Gastroenterol |
VS. Augusto, AJ. Rodrigues, AP. C Silveira, O. de Castro E Silva, ED. Mente, PR. Evora
Arq Gastroenterol 2014 Jan-Mar;51(1):16-20. PubMed:24760058 |
Associated curated diseases 5
Download diseasesAssociated disease mapping
Mapping of all associated diseases to Nitrite is displayed in red.
|
Disease Name
with link to disease page |
Description of MeSH term
with link to MeSH Database |
Number of references |
|---|---|---|
| Asthma |
MeSH:
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and
intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of
airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
|
91 |
| Cystic Fibrosis |
MeSH:
Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE
REGULATOR expressed in several organs including the LUNG, the PANCREAS, the
BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by
epithelial secretory dysfunction associated with ductal obstruction resulting in
AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY;
maldigestion; salt depletion; and HEAT PROSTRATION.
Year introduced: 1967
Link to MeSH Database: D003550
|
20 |
| Wheezing |
MeSH:
Respiratory Sounds
Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.
Year introduced: 1980
Link to MeSH Database: D012135
|
2 |
| Chronic Obstructive Pulmonary Disease (Copd) |
MeSH:
Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Year introduced: 2002
Link to MeSH Database: D029424
|
31 |
| Idiopathic Pulmonary Fibrosis |
MeSH:
Idiopathic Pulmonary Fibrosis
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of
breathlessness with exertion and a nonproductive cough, leading to progressive
DYSPNEA. Pathological features show scant interstitial inflammation, patchy
collagen fibrosis, prominent fibroblast proliferation foci, and microscopic
honeycomb change.
Year introduced: 2009
Link to MeSH Database: D054990
|
3 |
Associated abnormalities 7
| Concept Name | External ID | Weighted Score | Hits | References | |
| Chronic Obstructive Airway Disease | 512.91 | 5 |
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| Hyperdistention | 927.09 | 3 |
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| Cystic Fibrosis | ICD9-CM:277.0 | 1000.0 | 2 |
|
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| Pneumonia | 1000.0 | 2 |
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| Acute asthma | 950.5 | 1 |
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| Spastic syndrome | 697.25 | 1 |
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| Lung diseases | 961.54 | 1 |
|
Associated chemicals 9
Associated functions 17
| Concept Name | External ID | Definition | Weighted Score | Hits | References | |
| Pathological Dilatation | 664.89 | 4 |
|
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| Inflammation | 968.64 | 3 |
|
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| Hypoxia | 925.86 | 2 |
|
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| Pathogenesis | 963.25 | 2 |
|
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| protonation | 944.0 | 1 |
|
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| Lung volume | 950.5 | 1 |
|
|||
| Vital capacity | 928.57 | 1 |
|
|||
| Inspiration function | 685.5 | 1 |
|
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| Respiration | 853.09 | 1 |
|
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| Exhalation | 711.5 | 1 |
|
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| Biological function, NOS | 895.83 | 1 |
|
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| Sterility | 819.39 | 1 |
|
|||
| Gastric Emptying | 1000.0 | 1 |
|
|||
| muscle metabolism | 1000.0 | 1 |
|
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| Apoptosis | GO:0012501 | 1000.0 | 1 |
|
||
| Regulation | 1000.0 | 1 |
|
|||
| nitric oxide metabolism | 1000.0 | 1 |
|
Associated genes 1
| Concept Name | External ID | Definition | Weighted Score | Hits | References | |
| Glucagon-Like Peptide 1 | 598.77 | 1 |
|
NCBI Entrez Crosslinks
Chemical Information
| Formula | NO2 |
| Mass | 46.005 |
| Synonyms | nitrite Nitrite Ion Nitrite anion 14797-65-0 Nitrous acid, ion(1-) Nitrite(1-) NO2- NO2 Nitrite ion (NO2-) Nitrogen dioxide ion(1-) Nitrogen peroxide ion(1-) Nitrit dioxonitrate(1-) dioxonitrate(III) UNII-J39976L608 dioxidonitrate(1-) Nitrogen dioxide ion Nitrogen peroxide ion Nitrite (8CI,9CI) AC1L1ADT |
| PubChem CID | 946 |