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Demonstration of a mid-infrared cavity enhanced absorption spectrometer for breath acetone detection.
L. Ciaffoni, G. Hancock, JJ. Harrison, JP. van Helden, CE. Langley, R. Peverall, GA. Ritchie, S. Wood
Anal. Chem. 2013 Jan;85(2):846-50.
PubMed: 23231744
Abstract
A high-resolution absorption spectrum of gaseous acetone near 8.2 μm has been taken using both Fourier transform and quantum cascade laser (QCL)-based infrared spectrometers. Absolute absorption cross sections within the 1215-1222 cm(-1) range have been determined, and the spectral window around 1216.5 cm(-1) (σ = 3.4 × 10(-19) cm(2) molecule(-1)) has been chosen for monitoring trace acetone in exhaled breath. Acetone at sub parts-per-million (ppm) levels has been measured in a breath sample with a precision of 0.17 ppm (1σ) by utilizing a cavity enhanced absorption spectrometer constructed from the QCL source and a linear, low-volume, optical cavity. The use of a water vapor trap ensured the accuracy of the results, which have been corroborated by mass spectrometric measurements.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Acetone | 275 |