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An automated exposure system for human inhalation study.
YS. Lin, TJ. Smith, PY. Wang
Arch. Environ. Health 2002 May-Jun;57(3):215-23.
PubMed: 12507174
Abstract
The authors developed a computer-based exposure system for human inhalation research to study the toxicokinetics of gases. The system uses a set of computer-controlled solenoid valves that regulates inhaled gases and collect exhaled breaths from the subject in accordance with a predetermined time schedule. The volunteer's breathing activity is monitored simultaneously with a real-time instrument, calibrated by both internal and external standards. The common air pollutant, 1,3-butadiene, was used for system validation. The results indicated that the errors were less than 3% relative to reference standards, and the error in the timing of the valve operation was negligible. The average difference between breath-monitoring methods was within 10%. The proposed system is an easy-to-use, reliable device for human studies; more than 130 subjects were tested in a companion study.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Buta-1,3-diene | 62 |