Buta-1,3-diene

Summary of extracted biomedical information

Buta-1,3-diene is associated with abnormalities such as Vegetation. The involved biomedical functions are known as conjugation, Synthesis, Species Differences, Noise and Respiration. The associated genes/proteins with Buta-1,3-diene are CYP2E1 gene and EPO gene. Buta-1,3-diene is associated with Butadiene, Carbon, isoprene, Alkenes and Organic Chemicals.
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Associated references with human 30

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Journal Year Authors & PubMed Link
A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites. Chem. Biol. Interact. 2015 J. Campbell, C. Van Landingham, S. Crowell, R. Gentry, D. Kaden, S. Fiebelkorn, A. Loccisano, H. Clewell
Chem. Biol. Interact. 2015 Aug;238:102-10. PubMed:26079054
Emissions and ambient air monitoring trends of lower olefins across Texas from 2002 to 2012. Chem. Biol. Interact. 2015 JL. Myers, T. Phillips, RL. Grant
Chem. Biol. Interact. 2015 Nov;241:2-9. PubMed:25727265
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
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Emission factors of gaseous pollutants from recent kerosene space heaters and fuels available in France in 2010. Indoor Air 2012 M. Carteret, JF. Pauwels, B. Hanoune
Indoor Air 2012 Aug;22(4):299-308. PubMed:22175715
Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers. Carcinogenesis 2012 JM. Yuan, YT. Gao, R. Wang, M. Chen, SG. Carmella, SS. Hecht
Carcinogenesis 2012 Apr;33(4):804-9. PubMed:22298640
Evaluation of passive samplers for assessment of community exposure to toxic air contaminants and related pollutants. Environ. Sci. Technol. 2011 JB. Mason, EM. Fujita, DE. Campbell, B. Zielinska
Environ. Sci. Technol. 2011 Mar;45(6):2243-9. PubMed:21322547
Health risk assessment of personal inhalation exposure to volatile organic compounds in Tianjin, China. Sci. Total Environ. 2011 J. Zhou, Y. You, Z. Bai, Y. Hu, J. Zhang, N. Zhang
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The effect of Sao Paulo's smoke-free legislation on carbon monoxide concentration in hospitality venues and their workers. Tob Control 2011 JS. Issa, TM. Abe, AC. Pereira, MC. Megid, CE. Shimabukuro, LS. Valentin, MM. Ferreira, MR. Nobre, I. Lancarotte, AC. Barretto
Tob Control 2011 Mar;20(2):156-62. PubMed:21109684
Environmental and biological monitoring of exposures to PAHs and ETS in the general population. Environ Int 2010 NJ. Aquilina, JM. Delgado-Saborit, C. Meddings, S. Baker, RM. Harrison, P. Jacob, M. Wilson, L. Yu, M. Duan, NL. Benowitz
Environ Int 2010 Oct;36(7):763-71. PubMed:20591483
Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home. Cancer Epidemiol. Biomarkers Prev. 2010 SS. Hecht, A. Seow, M. Wang, R. Wang, L. Meng, WP. Koh, SG. Carmella, M. Chen, S. Han, MC. Yu, JM. Yuan
Cancer Epidemiol. Biomarkers Prev. 2010 May;19(5):1185-92. PubMed:20406956
Assessing the distribution of volatile organic compounds using land use regression in Sarnia, "Chemical Valley", Ontario, Canada. Environ Health 2009 DO. Atari, IN. Luginaah
Environ Health 2009 Apr;8:16. PubMed:19371421
Leukaemia incidence in people living close to an oil refinery. Environ. Res. 2009 L. Barregard, E. Holmberg, G. Sallsten
Environ. Res. 2009 Nov;109(8):985-90. PubMed:19781695
The multitude and diversity of environmental carcinogens. Environ. Res. 2007 D. Belpomme, P. Irigaray, L. Hardell, R. Clapp, L. Montagnier, S. Epstein, AJ. Sasco
Environ. Res. 2007 Nov;105(3):414-29. PubMed:17692309
Measurement of acrolein and 1,3-butadiene in a single puff of cigarette smoke using lead-salt tunable diode laser infrared spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc 2007 WD. Thweatt, CN. Harward, ME. Parrish
Spectrochim Acta A Mol Biomol Spectrosc 2007 May;67(1):16-24. PubMed:17141561
Lifestyle-related factors and environmental agents causing cancer: an overview. Biomed. Pharmacother. 2007 P. Irigaray, JA. Newby, R. Clapp, L. Hardell, V. Howard, L. Montagnier, S. Epstein, D. Belpomme
Biomed. Pharmacother. 2007 Dec;61(10):640-58. PubMed:18055160
Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: global sensitivity analysis for experimental design issues. Chem. Biol. Interact. 2007 C. Brochot, TJ. Smith, FY. Bois
Chem. Biol. Interact. 2007 May;167(3):168-83. PubMed:17397815
Experimental wood smoke exposure in humans. Inhal Toxicol 2006 G. Sällsten, P. Gustafson, L. Johansson, S. Johannesson, P. Molnár, B. Strandberg, C. Tullin, L. Barregard
Inhal Toxicol 2006 Oct;18(11):855-64. PubMed:16864403
Inhalation exposure to 1,3-butadiene and styrene in styrene-butadiene copolymer production. Int J Hyg Environ Health 2006 T. Anttinen-Klemetti, R. Vaaranrinta, P. Mutanen, K. Peltonen
Int J Hyg Environ Health 2006 Mar;209(2):151-8. PubMed:16503301
The "Tuebingen desiccator" system, a tool to study oxidative stress in vivo and inhalation toxicokinetics. Drug Metab. Rev. 2004 JG. Filser, W. Kessler, GA. Csanády
Drug Metab. Rev. 2004 Oct;36(3-4):787-803. PubMed:15554247
Biological monitoring in occupational exposure to low levels of 1,3-butadiene. Toxicol. Lett. 2004 S. Fustinoni, L. Perbellini, L. Soleo, M. Manno, V. Foà
Toxicol. Lett. 2004 Apr;149(1-3):353-60. PubMed:15093281
Personal exposure to 1,3-butadiene in a petrochemical plant, assessed by use of diffusive samplers. Int Arch Occup Environ Health 2004 T. Anttinen-Klemetti, R. Vaaranrinta, P. Mutanen, K. Peltonen
Int Arch Occup Environ Health 2004 May;77(4):288-92. PubMed:14999482
Comparison of breath, blood and urine concentrations in the biomonitoring of environmental exposure to 1,3-butadiene, 2,5-dimethylfuran, and benzene. Int Arch Occup Environ Health 2003 L. Perbellini, A. Princivalle, M. Cerpelloni, F. Pasini, F. Brugnone
Int Arch Occup Environ Health 2003 Jul;76(6):461-6. PubMed:12687377
Human physiologic factors in respiratory uptake of 1,3-butadiene. Environ. Health Perspect. 2001 YS. Lin, TJ. Smith, KT. Kelsey, D. Wypij
Environ. Health Perspect. 2001 Sep;109(9):921-6. PubMed:11673121
Genetic and dietary factors affecting human metabolism of 1,3-butadiene. Chem. Biol. Interact. 2001 TJ. Smith, YS. Lin, M. Mezzetti, FY. Bois, K. Kelsey, J. Ibrahim
Chem. Biol. Interact. 2001 Jun;135-136:407-28. PubMed:11397404
Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment. Chem. Biol. Interact. 2001 LM. Sweeney, MW. Himmelstein, ML. Gargas
Chem. Biol. Interact. 2001 Jun;135-136:303-22. PubMed:11397398
Sites and mechanisms for uptake of gases and vapors in the respiratory tract. Toxicology 2001 MA. Medinsky, JA. Bond
Toxicology 2001 Mar;160(1-3):165-72. PubMed:11246136
Human sensitivity to 1,3-butadiene: role of microsomal epoxide hydrolase polymorphisms. Carcinogenesis 2001 SZ. Abdel-Rahman, MM. Ammenheuser, JB. Ward
Carcinogenesis 2001 Mar;22(3):415-23. PubMed:11238181
An analysis of the health benefits associated with the use of MTBE reformulated gasoline and oxygenated fuels in reducing atmospheric concentrations of selected volatile organic compounds. Risk Anal. 1997 HL. Spitzer
Risk Anal. 1997 Dec;17(6):683-91. PubMed:9463925
Biomonitoring of 1,3-butadiene and related compounds. Environ. Health Perspect. 1996 S. Osterman-Golkar, JA. Bond
Environ. Health Perspect. 1996 Oct;104 Suppl 5:907-15. PubMed:8933033
An automated exposure system for human inhalation study. Arch. Environ. Health YS. Lin, TJ. Smith, PY. Wang
Arch. Environ. Health 2002 May-Jun;57(3):215-23. PubMed:12507174

Associated curated diseases 0

No curated diseases are identified in current reference collection.

Associated abnormalities 1

Concept Name External ID Weighted Score Hits References
Vegetation 901.0 1
  1. Emissions and ambient air monitoring trends of lower olefins across Texas from 2002 to 2012.
    JL. Myers, T. Phillips, RL. Grant (2015) Chem. Biol. Interact.

Associated chemicals 26

Concept Name External ID Definition Weighted Score Hits References
Butadiene 933.64 33
  1. Genetic and dietary factors affecting human metabolism of 1,3-butadiene.
    TJ. Smith, YS. Lin, M. Mezzetti, FY. Bois, K. Kelsey, J. Ibrahim (2001) Chem. Biol. Interact.
  2. Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment.
    LM. Sweeney, MW. Himmelstein, ML. Gargas (2001) Chem. Biol. Interact.
  3. Lifestyle-related factors and environmental agents causing cancer: an overview.
    P. Irigaray, JA. Newby, R. Clapp, L. Hardell, V. Howard, L. Montagnier, S. Epstein, D. Belpomme (2007) Biomed. Pharmacother.
  4. The multitude and diversity of environmental carcinogens.
    D. Belpomme, P. Irigaray, L. Hardell, R. Clapp, L. Montagnier, S. Epstein, AJ. Sasco (2007) Environ. Res.
  5. Measurement of acrolein and 1,3-butadiene in a single puff of cigarette smoke using lead-salt tunable diode laser infrared spectroscopy.
    WD. Thweatt, CN. Harward, ME. Parrish (2007) Spectrochim Acta A Mol Biomol Spectrosc
  6. Measurement of 16 volatile organic compounds in restaurant air contaminated with environmental tobacco smoke.
    S. Vainiotalo, V. Väänänen, R. Vaaranrinta (2008) Environ. Res.
  7. Leukaemia incidence in people living close to an oil refinery.
    L. Barregard, E. Holmberg, G. Sallsten (2009) Environ. Res.
  8. Environmental and biological monitoring of exposures to PAHs and ETS in the general population.
    NJ. Aquilina, JM. Delgado-Saborit, C. Meddings, S. Baker, RM. Harrison, P. Jacob, M. Wilson, L. Yu, M. Duan, NL. Benowitz (2010) Environ Int
  9. Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home.
    SS. Hecht, A. Seow, M. Wang, R. Wang, L. Meng, WP. Koh, SG. Carmella, M. Chen, S. Han, MC. Yu, JM. Yuan (2010) Cancer Epidemiol. Biomarkers Prev.
  10. Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS).
    KU. Alwis, BC. Blount, AS. Britt, D. Patel, DL. Ashley (2012) Anal. Chim. Acta
  11. The multielectron ionization dynamics underlying attosecond strong-field spectroscopies.
    AE. Boguslavskiy, J. Mikosch, A. Gijsbertsen, M. Spanner, S. Patchkovskii, N. Gador, MJ. Vrakking, A. Stolow (2012) Science
  12. A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites.
    J. Campbell, C. Van Landingham, S. Crowell, R. Gentry, D. Kaden, S. Fiebelkorn, A. Loccisano, H. Clewell (2015) Chem. Biol. Interact.
  13. Emissions and ambient air monitoring trends of lower olefins across Texas from 2002 to 2012.
    JL. Myers, T. Phillips, RL. Grant (2015) Chem. Biol. Interact.
Carbon CHEBI:33415 944.51 6
  1. Lifestyle-related factors and environmental agents causing cancer: an overview.
    P. Irigaray, JA. Newby, R. Clapp, L. Hardell, V. Howard, L. Montagnier, S. Epstein, D. Belpomme (2007) Biomed. Pharmacother.
  2. The multitude and diversity of environmental carcinogens.
    D. Belpomme, P. Irigaray, L. Hardell, R. Clapp, L. Montagnier, S. Epstein, AJ. Sasco (2007) Environ. Res.
  3. Measurement of acrolein and 1,3-butadiene in a single puff of cigarette smoke using lead-salt tunable diode laser infrared spectroscopy.
    WD. Thweatt, CN. Harward, ME. Parrish (2007) Spectrochim Acta A Mol Biomol Spectrosc
isoprene CHEBI:35194 986.92 5
  1. Measurement of 16 volatile organic compounds in restaurant air contaminated with environmental tobacco smoke.
    S. Vainiotalo, V. Väänänen, R. Vaaranrinta (2008) Environ. Res.
  2. Emissions and ambient air monitoring trends of lower olefins across Texas from 2002 to 2012.
    JL. Myers, T. Phillips, RL. Grant (2015) Chem. Biol. Interact.
Alkenes 913.58 4
  1. Leukaemia incidence in people living close to an oil refinery.
    L. Barregard, E. Holmberg, G. Sallsten (2009) Environ. Res.
  2. Emissions and ambient air monitoring trends of lower olefins across Texas from 2002 to 2012.
    JL. Myers, T. Phillips, RL. Grant (2015) Chem. Biol. Interact.
Acetaldehyde CHEBI:15343 984.0 3
  1. Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home.
    SS. Hecht, A. Seow, M. Wang, R. Wang, L. Meng, WP. Koh, SG. Carmella, M. Chen, S. Han, MC. Yu, JM. Yuan (2010) Cancer Epidemiol. Biomarkers Prev.
Butane CHEBI:37808 1000.0 3
  1. Measurement of acrolein and 1,3-butadiene in a single puff of cigarette smoke using lead-salt tunable diode laser infrared spectroscopy.
    WD. Thweatt, CN. Harward, ME. Parrish (2007) Spectrochim Acta A Mol Biomol Spectrosc
  2. The multielectron ionization dynamics underlying attosecond strong-field spectroscopies.
    AE. Boguslavskiy, J. Mikosch, A. Gijsbertsen, M. Spanner, S. Patchkovskii, N. Gador, MJ. Vrakking, A. Stolow (2012) Science
  3. A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites.
    J. Campbell, C. Van Landingham, S. Crowell, R. Gentry, D. Kaden, S. Fiebelkorn, A. Loccisano, H. Clewell (2015) Chem. Biol. Interact.
propylene oxide CHEBI:38685 1000.0 3
  1. Leukaemia incidence in people living close to an oil refinery.
    L. Barregard, E. Holmberg, G. Sallsten (2009) Environ. Res.
  2. Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS).
    KU. Alwis, BC. Blount, AS. Britt, D. Patel, DL. Ashley (2012) Anal. Chim. Acta
2-butene 1000.0 2
  1. Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home.
    SS. Hecht, A. Seow, M. Wang, R. Wang, L. Meng, WP. Koh, SG. Carmella, M. Chen, S. Han, MC. Yu, JM. Yuan (2010) Cancer Epidemiol. Biomarkers Prev.
  2. A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites.
    J. Campbell, C. Van Landingham, S. Crowell, R. Gentry, D. Kaden, S. Fiebelkorn, A. Loccisano, H. Clewell (2015) Chem. Biol. Interact.
Butene 944.0 2
  1. Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home.
    SS. Hecht, A. Seow, M. Wang, R. Wang, L. Meng, WP. Koh, SG. Carmella, M. Chen, S. Han, MC. Yu, JM. Yuan (2010) Cancer Epidemiol. Biomarkers Prev.
  2. A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites.
    J. Campbell, C. Van Landingham, S. Crowell, R. Gentry, D. Kaden, S. Fiebelkorn, A. Loccisano, H. Clewell (2015) Chem. Biol. Interact.
Aldehydes CHEBI:17478 880.72 2
  1. Measurement of 16 volatile organic compounds in restaurant air contaminated with environmental tobacco smoke.
    S. Vainiotalo, V. Väänänen, R. Vaaranrinta (2008) Environ. Res.
  2. Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home.
    SS. Hecht, A. Seow, M. Wang, R. Wang, L. Meng, WP. Koh, SG. Carmella, M. Chen, S. Han, MC. Yu, JM. Yuan (2010) Cancer Epidemiol. Biomarkers Prev.
phenanthrene CHEBI:28851 1000.0 2
  1. Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home.
    SS. Hecht, A. Seow, M. Wang, R. Wang, L. Meng, WP. Koh, SG. Carmella, M. Chen, S. Han, MC. Yu, JM. Yuan (2010) Cancer Epidemiol. Biomarkers Prev.
Naphthalene CHEBI:16482 1000.0 2
  1. Measurement of 16 volatile organic compounds in restaurant air contaminated with environmental tobacco smoke.
    S. Vainiotalo, V. Väänänen, R. Vaaranrinta (2008) Environ. Res.
  2. Environmental and biological monitoring of exposures to PAHs and ETS in the general population.
    NJ. Aquilina, JM. Delgado-Saborit, C. Meddings, S. Baker, RM. Harrison, P. Jacob, M. Wilson, L. Yu, M. Duan, NL. Benowitz (2010) Environ Int
Polycyclic Hydrocarbons, Aromatic CHEBI:33848 598.24 2
  1. Environmental and biological monitoring of exposures to PAHs and ETS in the general population.
    NJ. Aquilina, JM. Delgado-Saborit, C. Meddings, S. Baker, RM. Harrison, P. Jacob, M. Wilson, L. Yu, M. Duan, NL. Benowitz (2010) Environ Int
  2. Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home.
    SS. Hecht, A. Seow, M. Wang, R. Wang, L. Meng, WP. Koh, SG. Carmella, M. Chen, S. Han, MC. Yu, JM. Yuan (2010) Cancer Epidemiol. Biomarkers Prev.
Glycol 771.16 2
  1. Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS).
    KU. Alwis, BC. Blount, AS. Britt, D. Patel, DL. Ashley (2012) Anal. Chim. Acta
  2. A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites.
    J. Campbell, C. Van Landingham, S. Crowell, R. Gentry, D. Kaden, S. Fiebelkorn, A. Loccisano, H. Clewell (2015) Chem. Biol. Interact.
Toluene CHEBI:17578 1000.0 2
  1. Measurement of 16 volatile organic compounds in restaurant air contaminated with environmental tobacco smoke.
    S. Vainiotalo, V. Väänänen, R. Vaaranrinta (2008) Environ. Res.
  2. Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS).
    KU. Alwis, BC. Blount, AS. Britt, D. Patel, DL. Ashley (2012) Anal. Chim. Acta
styrene-butadiene rubber 1000.0 1
  1. Emissions and ambient air monitoring trends of lower olefins across Texas from 2002 to 2012.
    JL. Myers, T. Phillips, RL. Grant (2015) Chem. Biol. Interact.
hydroxymethylvinyl ketone 1000.0 1
  1. A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites.
    J. Campbell, C. Van Landingham, S. Crowell, R. Gentry, D. Kaden, S. Fiebelkorn, A. Loccisano, H. Clewell (2015) Chem. Biol. Interact.
Lead salt 895.0 1
  1. Measurement of acrolein and 1,3-butadiene in a single puff of cigarette smoke using lead-salt tunable diode laser infrared spectroscopy.
    WD. Thweatt, CN. Harward, ME. Parrish (2007) Spectrochim Acta A Mol Biomol Spectrosc
4-xylene 1000.0 1
  1. Measurement of 16 volatile organic compounds in restaurant air contaminated with environmental tobacco smoke.
    S. Vainiotalo, V. Väänänen, R. Vaaranrinta (2008) Environ. Res.
Phenols CHEBI:33853 928.57 1
  1. Measurement of 16 volatile organic compounds in restaurant air contaminated with environmental tobacco smoke.
    S. Vainiotalo, V. Väänänen, R. Vaaranrinta (2008) Environ. Res.
Picoline 944.0 1
  1. Measurement of 16 volatile organic compounds in restaurant air contaminated with environmental tobacco smoke.
    S. Vainiotalo, V. Väänänen, R. Vaaranrinta (2008) Environ. Res.
Dry Ice 950.5 1
  1. Measurement of acrolein and 1,3-butadiene in a single puff of cigarette smoke using lead-salt tunable diode laser infrared spectroscopy.
    WD. Thweatt, CN. Harward, ME. Parrish (2007) Spectrochim Acta A Mol Biomol Spectrosc
Quartz 887.5 1
  1. Environmental and biological monitoring of exposures to PAHs and ETS in the general population.
    NJ. Aquilina, JM. Delgado-Saborit, C. Meddings, S. Baker, RM. Harrison, P. Jacob, M. Wilson, L. Yu, M. Duan, NL. Benowitz (2010) Environ Int
Hydrocarbons CHEBI:24632 927.67 1
  1. The multielectron ionization dynamics underlying attosecond strong-field spectroscopies.
    AE. Boguslavskiy, J. Mikosch, A. Gijsbertsen, M. Spanner, S. Patchkovskii, N. Gador, MJ. Vrakking, A. Stolow (2012) Science
Cyanides 937.5 1
  1. Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS).
    KU. Alwis, BC. Blount, AS. Britt, D. Patel, DL. Ashley (2012) Anal. Chim. Acta
1-bromopropane 1000.0 1
  1. Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS).
    KU. Alwis, BC. Blount, AS. Britt, D. Patel, DL. Ashley (2012) Anal. Chim. Acta

Associated functions 12

Concept Name External ID Definition Weighted Score Hits References
conjugation 965.25 2
  1. Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS).
    KU. Alwis, BC. Blount, AS. Britt, D. Patel, DL. Ashley (2012) Anal. Chim. Acta
  2. A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites.
    J. Campbell, C. Van Landingham, S. Crowell, R. Gentry, D. Kaden, S. Fiebelkorn, A. Loccisano, H. Clewell (2015) Chem. Biol. Interact.
Synthesis 930.5 1
  1. A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites.
    J. Campbell, C. Van Landingham, S. Crowell, R. Gentry, D. Kaden, S. Fiebelkorn, A. Loccisano, H. Clewell (2015) Chem. Biol. Interact.
Species Differences 950.5 1
  1. Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment.
    LM. Sweeney, MW. Himmelstein, ML. Gargas (2001) Chem. Biol. Interact.
Noise 906.0 1
  1. Measurement of acrolein and 1,3-butadiene in a single puff of cigarette smoke using lead-salt tunable diode laser infrared spectroscopy.
    WD. Thweatt, CN. Harward, ME. Parrish (2007) Spectrochim Acta A Mol Biomol Spectrosc
Respiration 944.0 1
  1. Genetic and dietary factors affecting human metabolism of 1,3-butadiene.
    TJ. Smith, YS. Lin, M. Mezzetti, FY. Bois, K. Kelsey, J. Ibrahim (2001) Chem. Biol. Interact.
Oxidation 944.0 1
  1. Genetic and dietary factors affecting human metabolism of 1,3-butadiene.
    TJ. Smith, YS. Lin, M. Mezzetti, FY. Bois, K. Kelsey, J. Ibrahim (2001) Chem. Biol. Interact.
volatile substances 965.18 1
  1. Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home.
    SS. Hecht, A. Seow, M. Wang, R. Wang, L. Meng, WP. Koh, SG. Carmella, M. Chen, S. Han, MC. Yu, JM. Yuan (2010) Cancer Epidemiol. Biomarkers Prev.
Urinary concentration 1000.0 1
  1. Environmental and biological monitoring of exposures to PAHs and ETS in the general population.
    NJ. Aquilina, JM. Delgado-Saborit, C. Meddings, S. Baker, RM. Harrison, P. Jacob, M. Wilson, L. Yu, M. Duan, NL. Benowitz (2010) Environ Int
Polymorphism, Genetic 725.9 1
  1. Genetic and dietary factors affecting human metabolism of 1,3-butadiene.
    TJ. Smith, YS. Lin, M. Mezzetti, FY. Bois, K. Kelsey, J. Ibrahim (2001) Chem. Biol. Interact.
Drug Interactions 767.53 1
  1. The multielectron ionization dynamics underlying attosecond strong-field spectroscopies.
    AE. Boguslavskiy, J. Mikosch, A. Gijsbertsen, M. Spanner, S. Patchkovskii, N. Gador, MJ. Vrakking, A. Stolow (2012) Science
Laser-generated electromagnetic radiation 504.98 1
  1. The multielectron ionization dynamics underlying attosecond strong-field spectroscopies.
    AE. Boguslavskiy, J. Mikosch, A. Gijsbertsen, M. Spanner, S. Patchkovskii, N. Gador, MJ. Vrakking, A. Stolow (2012) Science
ionization 927.06 1
  1. The multielectron ionization dynamics underlying attosecond strong-field spectroscopies.
    AE. Boguslavskiy, J. Mikosch, A. Gijsbertsen, M. Spanner, S. Patchkovskii, N. Gador, MJ. Vrakking, A. Stolow (2012) Science

Associated genes 2

Concept Name External ID Definition Weighted Score Hits References
CYP2E1 gene EntrezGene:1571 716.73 1
  1. Genetic and dietary factors affecting human metabolism of 1,3-butadiene.
    TJ. Smith, YS. Lin, M. Mezzetti, FY. Bois, K. Kelsey, J. Ibrahim (2001) Chem. Biol. Interact.
EPO gene EntrezGene:2056 694.0 1
  1. Environmental and biological monitoring of exposures to PAHs and ETS in the general population.
    NJ. Aquilina, JM. Delgado-Saborit, C. Meddings, S. Baker, RM. Harrison, P. Jacob, M. Wilson, L. Yu, M. Duan, NL. Benowitz (2010) Environ Int

Chemical Information

Formula C4H6
Mass 54.092
Synonyms 1,3-BUTADIENE
Buta-1,3-diene
BUTADIENE
Divinyl
106-99-0
Vinylethylene
Biethylene
Erythrene
Bivinyl
Pyrrolylene
Butadieen
Butadien
Buta-1,3-dien
Buta-1,3-dieen
alpha,gamma-Butadiene
Butadiene monomer
NCI-C50602
Butadiene-1,3-uninhibited
CCRIS 99
1,3 butadiene
Butadieen [Dutch]
Butadien [Polish]
1,3-butadien
HSDB 181
JSD5FGP5VD
UNII-JSD5FGP5VD
EINECS 203-450-8
CH2=CHCH=CH2
.alpha.,.gamma.-Butadiene
Buta-1,3-dieen [Dutch]
Buta-1,3-dien [German]
CHEBI:39478
KAKZBPTYRLMSJV-UHFFFAOYSA-N
UN 1010
25339-57-5
9003-17-2
130983-70-9
1,3-Butadiene, puriss., >=99.5% (GC)
budiene
Alfine
Hydrocarbons, C4-5 unsatd.
Hydrocarbons, C4-5-unsatd.
vinyl ethylene
Butadiene resin
Hystl
Carboxy-terminated polybutadiene
Poly(butadiene)
Butadiene polymer
Polybutadiene, carboxy-terminated
Butadiene oligomer
Butarez 15
EINECS 271-039-0
Butadiene homopolymer
alpha-gamma-butadiene
Dienite 556
Dienite 643
Polyoil 110
Polyoil 130
Butadiene, 1,3-
Poly-1,3-butadiene
Dienite X 555
Dienite X 644
Diene 35 NF
Budium RK 622
Quintol B 1000
1,3-Butadiene, homopolymer, syndiotactic
1,3-Butadiene polymer, carboxy-terminated
ACMC-1BPVB
Nisso PB 100
Hystl B 300
1,3-Butadiene polymer, carboxyl-terminated
Atactic butadiene polymer
AC1L1POL
Nisso BN 1000
Nisso PB 3000
Nisso PB 4000
Nisso PR 2000
Hystl B 1000
Hystl B 2000
Hystl B 3000
Pbc200
1,3-Butadiene, polymers
Nisso PB-B 4000
Nisso PB-GQ 3000
1,3-Butadiene, homopolymer, carboxy-terminated
2-Butene-1,4-diylradical
AC1Q2A9R
AC1Q2A9S
alpha,<>-Butadiene
FCR 1261pd
CH2=CH-CH=CH2
CH22CH1CH2CH2
1,3-Butadiene, homopolymer
1,3-Butadiene, >=99%
1,3-butadiene, various grades
CHEMBL537970
XPDR-A 288
XRDR-A-288
Jsp000619
DTXSID3020203
CTK0H7242
HSDB 1196
FCR 126
LCB 150
MolPort-001-770-631
1,3-Butadiene, >=99.6%
CB 10
FCR 1261
KS-000017UN
[(E)-2-Butene-1,4-diyl]radical
LS-417
ZINC71775431
1,3-Butadiene, purum, >=98.0%
AKOS007930655
RTR-001370
TRA0025835
1,3-Butadiene (ca. 15% in Toluene)
31567-90-5
68441-48-5
68514-37-4
AN-22457
B 11
1,3-Butadiene 200 ng/microL in Methanol
AB1008356
KB-150117
TR-001370
929-EP2270101A1
929-EP2270113A1
929-EP2272849A1
929-EP2272935A1
929-EP2277945A1
929-EP2284165A1
929-EP2289896A1
929-EP2292586A2
929-EP2295426A1
929-EP2295427A1
929-EP2295438A1
929-EP2298753A1
929-EP2301924A1
929-EP2309584A1
929-EP2374780A1
929-EP2374781A1
B0675
B4358
B4359
FT-0606587
S 820
J3.623.750C
1,3-Butadiene solution, 15 wt. % in hexane
1,3-Butadiene solution, 20 wt. % in toluene
5920-EP0930075A1
5920-EP2292604A2
5920-EP2308843A1
B 3000
C16450
EC 203-450-8
InChI=1/C4H6/c1-3-4-2/h3-4H,1-2H
1,3-Butadiene(ca.13%inTetrahydrofuran,ca.2mol/L)
I14-17825
1026023-28-8
105521-92-4
1213224-27-1
1337929-27-7
150773-71-0
183592-61-2
186263-90-1
191172-06-2
29717-41-7
29717-42-8
37325-15-8
54577-68-3
57829-13-7
57829-18-2
785803-43-2
801291-48-5
874748-74-0
B 7
PubChem CID 7845