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Reduction of immunoreactive prostacyclin metabolite after paralysis in ventilated preterm infants.
JM. Rennie, J. Doyle, RW. Cooke
Early Hum. Dev. 1986 Feb;13(1):75-80.
PubMed: 3754206
Abstract
Levels of the stable metabolite of prostacyclin, 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were measured by radioimmunoassay during the first 48 hours of life in a group of 20 infants ventilated for the respiratory distress syndrome in whom a simultaneous record of respiratory activity was made. 6-Keto-PGF1 alpha was significantly lower when the infants were paralysed (P = 0.0004) than when they were breathing spontaneously. Elimination of the capacity for spontaneous respiration may reduce barotrauma and hence the stimulus for prostacyclin release from the lung.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
6-Keto-prostaglandin F1 alpha | 15 |