6-Keto-prostaglandin F1 alpha

Description

Description of 6-Keto-prostaglandin F1 alpha with associated disease summary

6-keto-prostaglandin F1a (6-keto-PGF1a) is a downstream product of arachidonic acid and prostaglandins G2 (PGG2) in eicosanoid biosynthetic pathways (Pediatr Pulmonol. (2013)). It can be detected using LC-MS/MS and GC-MS method. The concentrations of EBC 6-keto-PGF1a in asthmatic patients are significantly higher than the healthy control (Pediatr Pulmonol. (2013), J Allergy Clin Immunol. (2011)). Description of disease(s) related to 6-keto-prostaglandin F1a (6-keto-PGF1a):

Disease summary

Asthma

The concentrations of EBC 6-keto-PGF1a in asthmatic patients are significantly higher than the healthy control (Pediatr Pulmonol. (2013), J Allergy Clin Immunol. (2011)).

Summary of extracted biomedical information

Imgsrv

Associated references with human 3

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Reference title

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Journal Year Authors & PubMed Link
Sickle cell vaso-occlusive crisis is associated with abnormalities in the ratio of vasoconstrictor to vasodilator prostanoids. Pediatr. Res. 1995 BN. Setty, D. Chen, MJ. Stuart
Pediatr. Res. 1995 Jul;38(1):95-102. PubMed:7478805
Hyperventilation stimulates the release of prostaglandin I2 and E2 from lung in humans. Prostaglandins 1990 Y. Ishii, S. Kitamura
Prostaglandins 1990 Jun;39(6):685-91. PubMed:2115188
Reduction of immunoreactive prostacyclin metabolite after paralysis in ventilated preterm infants. Early Hum. Dev. 1986 JM. Rennie, J. Doyle, RW. Cooke
Early Hum. Dev. 1986 Feb;13(1):75-80. PubMed:3754206

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to 6-Keto-prostaglandin F1 alpha is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
91
Aspirin Sensitive Asthma MeSH: Asthma, Aspirin-Induced
Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use. Year introduced: 2010
Link to MeSH Database: D055963
2

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 3 associated references with 6-Keto-prostaglandin F1 alpha. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 3 associated references with 6-Keto-prostaglandin F1 alpha. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 3 associated references with 6-Keto-prostaglandin F1 alpha. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 3 associated references with 6-Keto-prostaglandin F1 alpha. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C20H34O6
Mass 370.486
Synonyms 6-Keto-prostaglandin F1alpha
6-Keto-PGF1alpha
6-Oxo-PGF1alpha
6-keto-prostaglandin F1a
6-KETOPROSTAGLANDIN F1alpha
6-Oxoprostaglandin F1alpha
6-oxo-prostaglandin F1alpha
6-Ketoprostaglandin F1 alpha
6-Keto-PGF1a
58962-34-8
UNII-8URB805JJJ
8URB805JJJ
CHEBI:28158
6-oxo-9S,11R,15S-trihydroxy-13E-prostenoic acid
6-Keto-prostaglandin F1-alpha
PGF1 alpha 6-keto
AC1NQXQD
6-Oxo-PGF1a
6-Oxoprostaglandin F1a
BSPBio_001457
PubChem CID 5280888