DL-o-Tyrosine

Description

Description of DL-o-Tyrosine with associated disease summary

The measurement of o-tyrosine from exhaled breath condensate (EBC) is a non-invasive method for detecting amino acid oxidation associated with silica- and asbestos-induced diseases. O-tyrosine is an amino acid oxidation marker; it has not been described extensively. A method was developed for the selective and sensitive detection of o-tyrosine using liquid chromatography and electrospray ionization-tandem mass spectrometry. The LC-ESI-MS/MS detection method described here is highly specific for quantifying o-tyrosine in clinical samples from asbestosis/silicosis patients. This method consists of a pre-treatment procedure and lyophilization, intended for concentrating biomarkers from EBC. Enzymatic reactions, temperature fluctuations, and oxidation are all common reasons for degradation of clinical samples. The addition of antioxidant, rapid sample preparation under mild conditions, and storage of sample at −80 ◦C in sealed sample vials could all prolong the storage period of samples without marked deterioration of o-tyrosine biomarker for up to a month. The developed LC-ESI-MS/MS method was used to assess the extent of oxidative stress, by determining o-tyrosine concentration, in EBC of subjects with long-term exposure to asbestos or silica dust, compared to control subjects. These subjects were of similar average age and the same gender. The concentration levels of o-tyrosine were statistically different between asbestosis and silicosis patients compared to healthy control subjects. ( J Breath Res. (2010) ) Description of disease(s) related to o-tyrosine:

Disease summary

Asbestosis | Silicosis

The concentration levels of o-tyrosine were statistically different between asbestosis and silicosis patients compared to healthy control subjects. ( J Breath Res. (2010) )

Summary of extracted biomedical information

Associated references with human 0

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to DL-o-Tyrosine is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Asbestosis	MeSH: Asbestosis A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium. Link to MeSH Database: D001195	4

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with DL-o-Tyrosine. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with DL-o-Tyrosine. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with DL-o-Tyrosine. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with DL-o-Tyrosine. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₉H₁₁NO₃
Mass	181.191
Synonyms	DL-o-Tyrosine 2370-61-8 2-amino-3-(2-hydroxyphenyl)propanoic acid O-Tyrosine 2-Hydroxyphenylalanine 2-hydroxy-DL-Phenylalanine Ortho-tyrosine 2-Tyrosine o-Tyrosine, DL- DL-3-(o-Hydroxyphenyl)alanine 2-Amino-3-(2-hydroxyphenyl)propionic Acid Alanine, 3-(o-hydroxyphenyl)-, DL DL-2-TYROSINE EINECS 219-134-8 NSC 72345 MFCD00021725 DL-3-(2-HYDROXYPHENYL)ALANINE ST50407955 T-9035 709-16-0
PubChem CID	91482