Malondialdehyde

Description

Description of Malondialdehyde with associated disease summary

Malondialdehyde (MDA) is one of the most prominent indicators of oxidative stress. It is generated as an end product of fatty acid peroxidation in the cell membrane. Therefore, the measurement of MDA is commonly used to evaluate lipid peroxides in biological fluids. Compared to healthy controls, concentrations of MDA in EBC are elevated in subjects with inflammatory lung diseases including asthma (Am J Respir Crit Care Med. (2003) ), chronic obstructive pulmonary disease (COPD), bronchiectasis (BE) ( Mediators Inflamm. (2011) ), cystic fibrosis (CF) (Lung. (2015) ), occupational asthma (OA) (Int J Occup Med Environ Health. (2014) ) and occupational respiratory diseases (J Chromatogr B Analyt Technol Biomed Life Sci. (2009)). MDA values positively correlated to forced expiratory volume in one second (FEV1) reduction and severity of the disease in COPD ( Eur Respir J. (2004) ) and CF subjects (Lung. (2015)), but not in asthma subjects ( Mediators Inflamm. (2011) ). Elevated MDA levels are observed in smokers among asthma subjects. However, there is no difference regarding smoking status among COPD subjects (Am J Respir Crit Care Med. (2003)). After inhaled corticosteroids therapy, MDA values of asthma subjects drop significantly to the same level as healthy controls (Am J Respir Crit Care Med. (2003) ). When asthma subjects are grouped with their airway responsiveness to ozone (O3) exposure in reduction of FEV1 values, elevated concentrations of EBC MDA in non-responders are observed immediately after O3 exposure ( Respir Res. (2010) ). The concentration of MDA and reduced glutathione in EBC correlates negatively ( Am J Respir Crit Care Med. (2003) ). This correlation is also confirmed in children with asthma ( Allergy. (2008) ). In a study of retired male miners, patients with severe COPD show higher concentration of MDA than ones with moderate COPD (Saf Health Work. (2014)). However, another study shows that EBC MDA levels were comparable between controls, stable COPD patients and acute exacerbation of COPD (AECOPD) patients. This may be explained with the high between-day variability of EBC MDA readings ( Respirology. (2014)). In studies mentioned above, MDA in EBC is identified using either LC-MS/MS or a HPLC with fluorescence detector. Detection of MDA in EBC shows promise as a noninvasive method to investigate the oxidative stress for inflammatory lung diseases in clinical practice. It is sensitive to changes induced by therapeutic intervention in the case of asthma. Therefor may contribute in prediction of the usefulness of antioxidant drugs. Description of disease(s) related to Malondialdehyde (MDA)

Asthma

EBC MDA levels increase in asthma subjects compared to healthy controls regardless of severity of asthma. After treatment with corticosteroids, MDA levels in EBC lowers and are no longer different from healthy controls.

COPD

Elevated concentrations of EBC MDA are observed in patients with COPD. MDA levels increase with the COPD severity.

Bronchiectasis (BE)

Levels of MDA in EBC are higher in BE subjects versus healthy controls.

Cystic fibrosis (CF)

Increased EBC MDA values are shown in patients with CF versus healthy controls.

Occupational asthma

MDA values in EBC are higher in patients with occupational asthma than ones in healthy controls.

Occupational respiratory diseases

Higher concentrations of EBC MDA are detected in subjects with occupational respiratory diseases.

Summary of extracted biomedical information

Malondialdehyde is associated with abnormalities such as Asthma. The involved biomedical functions are known as Respiratory physiology, Accident caused by unspecified fire, Lipid Peroxidation, Exocytosis and Vital capacity. Malondialdehyde is associated with Ozone, Malondialdehyde, Nitrate, Nitrite and Tungsten.

Associated references with human 41

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Journal Year Authors & PubMed Link
Poly arginine-graphene quantum dots as a biocompatible and non-toxic nanocomposite: Layer-by-layer electrochemical preparation, characterization and non-invasive malondialdehyde sensory application in exhaled breath condensate. Mater Sci Eng C Mater Biol Appl 2017 M. Hasanzadeh, F. Mokhtari, N. Shadjou, A. Eftekhari, A. Mokhtarzadeh, V. Jouyban-Gharamaleki, S. Mahboob
Mater Sci Eng C Mater Biol Appl 2017 Jun;75:247-258. PubMed:28415460
Sensitive determination of malondialdehyde in exhaled breath condensate and biological fluids by capillary electrophoresis with laser induced fluorescence detection. Talanta 2017 J. Lačná, F. Foret, P. Kubáň
Talanta 2017 Jul;169:85-90. PubMed:28411827
Markers of lipid oxidative damage in the exhaled breath condensate of nano TiO2 production workers. Nanotoxicology 2017 D. Pelclova, V. Zdimal, P. Kacer, N. Zikova, M. Komarc, Z. Fenclova, S. Vlckova, J. Schwarz, O. Makeš, K. Syslova, T. Navratil, F. Turci, I. Corazzari, S. Zakharov, D. Bello
Nanotoxicology 2017 02;11(1):52-63. PubMed:27855548
Exhaled breath malondialdehyde, spirometric results and dust exposure assessment in ceramics production workers. Int J Occup Med Environ Health 2015 MJ. Sakhvidi, J. Biabani Ardekani, A. Firoozichahak, J. Zavarreza, M. Hajaghazade, M. Mostaghaci, A. Mehrparvar, A. Barkhordari
Int J Occup Med Environ Health 2015 ;28(1):81-9. PubMed:26159950
Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry. Rapid Commun. Mass Spectrom. 2015 V. Shestivska, SS. Antonowicz, K. Dryahina, J. Kubišta, D. Smith, P. Španěl
Rapid Commun. Mass Spectrom. 2015 Jun;29(11):1069-79. PubMed:26044275
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Hyperbaric oxygen diving affects exhaled molecular profiles in men. Respir Physiol Neurobiol 2014 PJ. van Ooij, RA. van Hulst, W. Kulik, P. Brinkman, A. Houtkooper, PJ. Sterk
Respir Physiol Neurobiol 2014 Jul;198:20-4. PubMed:24703972
Urinary benzene metabolite and insulin resistance in elderly adults. Sci. Total Environ. 2014 YH. Choi, JH. Kim, BE. Lee, YC. Hong
Sci. Total Environ. 2014 Jun;482-483:260-8. PubMed:24657371
Residential proximity to a major roadway is associated with features of asthma control in children. PLoS ONE 2012 MS. Brown, SE. Sarnat, KA. DeMuth, LA. Brown, DR. Whitlock, SW. Brown, PE. Tolbert, AM. Fitzpatrick
PLoS ONE 2012 ;7(5):e37044. PubMed:22615884
Oxidative stress in the airways of children with asthma and allergic rhinitis. Pediatr Allergy Immunol 2012 M. Celik, A. Tuncer, OU. Soyer, C. Saçkesen, H. Tanju Besler, O. Kalayci
Pediatr Allergy Immunol 2012 Sep;23(6):556-61. PubMed:22435922
Inflammatory markers in exhaled breath condensate in patients with asthma and rhinitis. Tuberk Toraks 2012 K. Aksu, H. Kurt, E. Gündüz, I. Değirmenci, E. Kurt
Tuberk Toraks 2012 ;60(4):321-6. PubMed:23289461
Burnt sugarcane harvesting: particulate matter exposure and the effects on lung function, oxidative stress, and urinary 1-hydroxypyrene. Sci. Total Environ. 2012 GF. Prado, DM. Zanetta, MA. Arbex, AL. Braga, LA. Pereira, MR. de Marchi, AP. de Melo Loureiro, T. Marcourakis, LE. Sugauara, GJ. Gattás, FT. Gonçalves, JM. Salge, M. Terra-Filho, U. de Paula Santos
Sci. Total Environ. 2012 Oct;437:200-8. PubMed:22940481
Diaphragmatic breathing exercise as a therapeutic intervention for control of oxidative stress in type 2 diabetes mellitus. Complement Ther Clin Pract 2012 SV. Hegde, P. Adhikari, NK. Subbalakshmi, M. Nandini, GM. Rao, V. D'Souza
Complement Ther Clin Pract 2012 Aug;18(3):151-3. PubMed:22789789
Effects on airways of short-term exposure to two kinds of wood smoke in a chamber study of healthy humans. Inhal Toxicol 2012 L. Stockfelt, G. Sallsten, AC. Olin, P. Almerud, L. Samuelsson, S. Johannesson, P. Molnar, B. Strandberg, AC. Almstrand, K. Bergemalm-Rynell, L. Barregard
Inhal Toxicol 2012 Jan;24(1):47-59. PubMed:22220980
Oxidative stress markers in exhaled breath condensate in lung fibroses are not significantly affected by systemic diseases. Ind Health 2011 D. Pelclová, Z. Fenclová, K. Syslová, S. Vlčková, J. Lebedová, O. Pecha, J. Běláček, T. Navrátil, M. Kuzma, P. Kačer
Ind Health 2011 ;49(6):746-54. PubMed:22020018
Oxidative status in the lungs associated with tobacco smoke exposure. Clin. Chem. Lab. Med. 2011 S. Doruk, H. Ozyurt, H. Inonu, U. Erkorkmaz, O. Saylan, Z. Seyfikli
Clin. Chem. Lab. Med. 2011 Sep;49(12):2007-12. PubMed:21913795
Pulmonary function and oxidative stress in workers exposed to styrene in plastic factory: occupational hazards in styrene-exposed plastic factory workers. Hum Exp Toxicol 2011 PC. Sati, F. Khaliq, N. Vaney, T. Ahmed, AK. Tripathi, BD. Banerjee
Hum Exp Toxicol 2011 Nov;30(11):1743-50. PubMed:21382913
Changes in oxidative stress biomarker and gene expression levels in workers exposed to volatile organic compounds. Ind Health 2011 JH. Kim, JY. Moon, EY. Park, KH. Lee, YC. Hong
Ind Health 2011 ;49(1):8-14. PubMed:20823639
Activities of antioxidant enzymes in relation to oxidative and nitrosative challenges in childhood asthma. J Asthma 2011 E. Fabian, P. Pölöskey, L. Kósa, I. Elmadfa, LA. Réthy
J Asthma 2011 May;48(4):351-7. PubMed:21401389
Polycyclic aromatic hydrocarbon-induced oxidative stress and lipid peroxidation in relation to immunological alteration. Occup Environ Med 2011 HA. Jeng, CH. Pan, N. Diawara, GP. Chang-Chien, WY. Lin, CT. Huang, CK. Ho, MT. Wu
Occup Environ Med 2011 Sep;68(9):653-8. PubMed:21126960
Exposure to volatile organic compounds and loss of pulmonary function in the elderly. Eur. Respir. J. 2010 HI. Yoon, YC. Hong, SH. Cho, H. Kim, YH. Kim, JR. Sohn, M. Kwon, SH. Park, MH. Cho, HK. Cheong
Eur. Respir. J. 2010 Dec;36(6):1270-6. PubMed:20351028
Evaluation of Alternate Isotope-Coded Derivatization Assay (AIDA) in the LC-MS/MS analysis of aldehydes in exhaled breath condensate. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2010 P. Manini, R. Andreoli, S. Sforza, C. Dall'Asta, G. Galaverna, A. Mutti, WM. Niessen
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2010 Oct;878(27):2616-22. PubMed:20207205
Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock. Crit Care 2010 MO. Maybauer, DM. Maybauer, JF. Fraser, C. Szabo, M. Westphal, L. Kiss, EM. Horvath, Y. Nakano, DN. Herndon, LD. Traber, DL. Traber
Crit Care 2010 ;14(6):R217. PubMed:21110850
Effect of t'ai chi exercise on biochemical profiles and oxidative stress indicators in obese patients with type 2 diabetes. J Altern Complement Med 2010 SC. Chen, KC. Ueng, SH. Lee, KT. Sun, MC. Lee
J Altern Complement Med 2010 Nov;16(11):1153-9. PubMed:20973735
Genotoxicity in filling station attendants exposed to petroleum hydrocarbons. Ann Occup Hyg 2010 PV. Rekhadevi, MF. Rahman, M. Mahboob, P. Grover
Ann Occup Hyg 2010 Nov;54(8):944-54. PubMed:20956619
Acute effects of motor vehicle traffic-related air pollution exposures on measures of oxidative stress in human airways. Ann. N. Y. Acad. Sci. 2010 RJ. Laumbach, HM. Kipen
Ann. N. Y. Acad. Sci. 2010 Aug;1203:107-12. PubMed:20716291
Early incidence of occupational asthma among young bakers, pastry-makers and hairdressers: design of a retrospective cohort study. BMC Public Health 2010 T. Rémen, V. Coevoet, DS. Acouetey, JL. Guéant, RM. Guéant-Rodriguez, C. Paris, D. Zmirou-Navier
BMC Public Health 2010 Apr;10:206. PubMed:20420675
Systemic and pulmonary oxidative stress after single-leg exercise in COPD. Chest 2009 EM. Mercken, HR. Gosker, EP. Rutten, EF. Wouters, A. Bast, GJ. Hageman, AM. Schols
Chest 2009 Nov;136(5):1291-1300. PubMed:19696125
Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children. Environ. Health Perspect. 2009 L. Liu, R. Poon, L. Chen, AM. Frescura, P. Montuschi, G. Ciabattoni, A. Wheeler, R. Dales
Environ. Health Perspect. 2009 Apr;117(4):668-74. PubMed:19440509
How volatile organic compounds affect free radical and antioxidant enzyme activity in textile workers. Arh Hig Rada Toksikol 2008 S. Bayil, H. Cicek, IG. Cimenci, M. Hazar
Arh Hig Rada Toksikol 2008 Dec;59(4):283-7. PubMed:19064366
A comparison of oxidative stress in smokers and non-smokers: an in vivo human quantitative study of n-3 lipid peroxidation. BMC Psychiatry 2008 BK. Puri, IH. Treasaden, M. Cocchi, S. Tsaluchidu, L. Tonello, BM. Ross
BMC Psychiatry 2008 Apr;8 Suppl 1:S4. PubMed:18433514
Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma. J. Allergy Clin. Immunol. 2008 I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin
J. Allergy Clin. Immunol. 2008 Apr;121(4):903-9.e6. PubMed:18234317
Experimental exposure to wood smoke: effects on airway inflammation and oxidative stress. Occup Environ Med 2008 L. Barregard, G. Sällsten, L. Andersson, AC. Almstrand, P. Gustafson, M. Andersson, AC. Olin
Occup Environ Med 2008 May;65(5):319-24. PubMed:17704195
Short-term heart variability and oxidative stress in newly diagnosed essential hypertension. Clin. Exp. Hypertens. 2008 P. Pavithran, H. Nandeesha, V. Sathiyapriya, Z. Bobby, T. Madanmohan
Clin. Exp. Hypertens. 2008 Oct;30(7):486-96. PubMed:18855253
Evidence from in vivo 31-phosphorus magnetic resonance spectroscopy phosphodiesters that exhaled ethane is a biomarker of cerebral n-3 polyunsaturated fatty acid peroxidation in humans. BMC Psychiatry 2008 BK. Puri, SJ. Counsell, BM. Ross, G. Hamilton, MG. Bustos, IH. Treasaden
BMC Psychiatry 2008 Apr;8 Suppl 1:S2. PubMed:18433512
Daily supplementation with iron increases lipid peroxidation in young women with low iron stores. Exp. Biol. Med. (Maywood) 2008 SM. King, CM. Donangelo, MD. Knutson, PB. Walter, BN. Ames, FE. Viteri, JC. King
Exp. Biol. Med. (Maywood) 2008 Jun;233(6):701-7. PubMed:18408148
Airway biomarkers of the oxidant burden in asthma and chronic obstructive pulmonary disease: current and future perspectives. Int J Chron Obstruct Pulmon Dis 2008 N. Louhelainen, M. Myllärniemi, I. Rahman, VL. Kinnula
Int J Chron Obstruct Pulmon Dis 2008 ;3(4):585-603. PubMed:19281076
Hypoxia-related lipid peroxidation: evidences, implications and approaches. Respir Physiol Neurobiol 2007 C. Behn, OF. Araneda, AJ. Llanos, G. Celedón, G. González
Respir Physiol Neurobiol 2007 Sep;158(2-3):143-50. PubMed:17662674
Exhaled breath condensate as a suitable matrix to assess lung dose and effects in workers exposed to cobalt and tungsten. Environ. Health Perspect. 2004 M. Goldoni, S. Catalani, G. De Palma, P. Manini, O. Acampa, M. Corradi, R. Bergonzi, P. Apostoli, A. Mutti
Environ. Health Perspect. 2004 Sep;112(13):1293-8. PubMed:15345342
Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress. J Expo Sci Environ Epidemiol J. Gong, T. Zhu, H. Kipen, G. Wang, M. Hu, P. Ohman-Strickland, SE. Lu, L. Zhang, Y. Wang, P. Zhu, DQ. Rich, SR. Diehl, W. Huang, JJ. Zhang
J Expo Sci Environ Epidemiol 2013 May-Jun;23(3):322-7. PubMed:23321859
Effect of vitamin E supplementation on carbogen-induced amelioration of noise induced hearing loss in man. Noise Health N. Kapoor, KV. Mani, R. Shyam, RK. Sharma, AP. Singh, W. Selvamurthy
Noise Health 2011 Nov-Dec;13(55):452-8. PubMed:22122962

Associated curated diseases 7

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Associated disease mapping

Mapping of all associated diseases to Malondialdehyde is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Acute Mountain Sickness MeSH: Altitude Sickness
Multiple symptoms associated with reduced oxygen at high ALTITUDE. Year introduced: 1991(1975)
Link to MeSH Database: D000532
2
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
91
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31
Bronchiectasis MeSH: Bronchiectasis
Persistent abnormal dilatation of the bronchi.
Link to MeSH Database: D001987
3
Cystic Fibrosis MeSH: Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967
Link to MeSH Database: D003550
20
Occupational Respiratory Diseases MeSH: Respiration Disorders
Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available. Year introduced: 1977
Link to MeSH Database: D012120
1
Occupational Asthma (Oa) MeSH: Asthma, Occupational
Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE. Year introduced: 2012
Link to MeSH Database: D059366
1

Associated abnormalities 1

Concept Name External ID Weighted Score Hits References
Asthma ICD9-CM:493.9 1000.0 1
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.

Associated chemicals 5

Concept Name External ID Definition Weighted Score Hits References
Ozone 968.63 3
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.
Malondialdehyde CHEBI:566274 963.88 3
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.
Nitrate 925.5 1
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.
Nitrite 925.5 1
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.
Tungsten 1000.0 1
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.

Associated functions 7

Concept Name External ID Definition Weighted Score Hits References
Accident caused by unspecified fire 525.5 1
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.
Lipid Peroxidation 975.25 1
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.
Exocytosis GO:0006887 894.0 1
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.
Respiratory physiology 758.05 1
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.
Vital capacity 735.71 1
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.
pulmonary function 1000.0 1
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.
Exhalation 786.0 1
  1. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma.
    I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin (2008) J. Allergy Clin. Immunol.

Associated genes 0

No associated genes are detected in current reference collection.

There are 41 associated references with Malondialdehyde. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C3H4O2
Mass 72.063
Synonyms Malondialdehyde
Propanedial
MALONALDEHYDE
Malonyldialdehyde
Malonodialdehyde
Malonic aldehyde
Malonic dialdehyde
1,3-Propanedial
1,3-Propanedione
1,3-Propanedialdehyde
542-78-9
UNII-4Y8F71G49Q
CCRIS 5168
HSDB 4353
CHEBI:566274
NCI-C54842
BRN 1209262
MDD
Propanedial (9CI)
beta-ketopropionaldehyde
PubChem CID 10964