Malondialdehyde
Description
Description of Malondialdehyde with associated disease summary
Malondialdehyde (MDA)
is one of the most prominent indicators of oxidative stress. It is generated as
an end product of fatty acid peroxidation in the cell
membrane. Therefore, the measurement of MDA
is commonly used to evaluate lipid peroxides in biological fluids.
Compared to healthy controls, concentrations of MDA in EBC are elevated in subjects with inflammatory lung diseases including asthma (Am J Respir Crit Care Med.
(2003) ), chronic obstructive pulmonary disease (COPD), bronchiectasis (BE) ( Mediators Inflamm. (2011)
), cystic fibrosis (CF) (Lung. (2015)
), occupational asthma (OA) (Int J Occup Med Environ
Health. (2014) ) and occupational respiratory
diseases (J Chromatogr B Analyt Technol Biomed Life Sci. (2009)).
MDA values positively correlated to forced expiratory volume in one second (FEV1) reduction and severity of the disease in COPD (
Eur Respir J.
(2004) ) and CF subjects (Lung. (2015)), but not in asthma subjects (
Mediators
Inflamm. (2011) ). Elevated MDA levels are observed in smokers among asthma subjects. However, there is no difference regarding smoking status among COPD subjects (Am J Respir Crit Care Med. (2003)).
After inhaled corticosteroids therapy, MDA values of asthma subjects drop significantly to
the same level as healthy controls (Am J Respir
Crit Care Med. (2003) ). When asthma subjects are grouped with their airway responsiveness to ozone (O3)
exposure in reduction of FEV1 values, elevated
concentrations of EBC MDA in non-responders are observed immediately after O3
exposure ( Respir Res. (2010)
). The concentration of MDA and reduced glutathione in EBC correlates negatively (
Am J Respir
Crit Care Med. (2003) ). This
correlation is also confirmed in children with asthma (
Allergy.
(2008) ).
In a study of retired male miners, patients
with severe COPD show higher concentration of MDA than ones with moderate COPD
(Saf Health Work. (2014)). However, another study
shows that EBC MDA levels were comparable between controls, stable COPD
patients and acute exacerbation of COPD (AECOPD) patients. This may be
explained with the high between-day variability of EBC MDA readings (
Respirology.
(2014)).
In studies mentioned above, MDA in EBC is identified
using either LC-MS/MS or a HPLC with fluorescence
detector. Detection of MDA in EBC shows promise as a noninvasive method to investigate
the oxidative stress for inflammatory lung diseases in clinical practice. It is
sensitive to changes induced by therapeutic intervention in the case of asthma.
Therefor may contribute in prediction of the usefulness of antioxidant drugs.
Description of disease(s) related to Malondialdehyde (MDA)
Asthma
EBC MDA levels increase in asthma subjects compared to healthy controls regardless of severity of asthma. After treatment with corticosteroids, MDA levels in EBC lowers and are no longer different from healthy controls.COPD
Elevated concentrations of EBC MDA are observed in patients with COPD. MDA levels increase with the COPD severity.Bronchiectasis (BE)
Levels of MDA in EBC are higher in BE subjects versus healthy controls.Cystic fibrosis (CF)
Increased EBC MDA values are shown in patients with CF versus healthy controls.Occupational asthma
MDA values in EBC are higher in patients with occupational asthma than ones in healthy controls.Occupational respiratory diseases
Higher concentrations of EBC MDA are detected in subjects with occupational respiratory diseases.Summary of extracted biomedical information
Malondialdehyde is associated with abnormalities such as Asthma. The involved biomedical functions are known as Respiratory physiology, Accident caused by unspecified fire, Lipid Peroxidation, Exocytosis and Vital capacity. Malondialdehyde is associated with Ozone, Malondialdehyde, Nitrate, Nitrite and Tungsten.Associated references with human 41
Download references
Reference title
with link to reference page |
Journal | Year | Authors & PubMed Link |
---|---|---|---|
Poly arginine-graphene quantum dots as a biocompatible and non-toxic nanocomposite: Layer-by-layer electrochemical preparation, characterization and non-invasive malondialdehyde sensory application in exhaled breath condensate. | Mater Sci Eng C Mater Biol Appl | 2017 |
M. Hasanzadeh, F. Mokhtari, N. Shadjou, A. Eftekhari, A. Mokhtarzadeh, V. Jouyban-Gharamaleki, S. Mahboob
Mater Sci Eng C Mater Biol Appl 2017 Jun;75:247-258. PubMed:28415460 |
Sensitive determination of malondialdehyde in exhaled breath condensate and biological fluids by capillary electrophoresis with laser induced fluorescence detection. | Talanta | 2017 |
J. Lačná, F. Foret, P. Kubáň
Talanta 2017 Jul;169:85-90. PubMed:28411827 |
Markers of lipid oxidative damage in the exhaled breath condensate of nano TiO2 production workers. | Nanotoxicology | 2017 |
D. Pelclova, V. Zdimal, P. Kacer, N. Zikova, M. Komarc, Z. Fenclova, S. Vlckova, J. Schwarz, O. Makeš, K. Syslova, T. Navratil, F. Turci, I. Corazzari, S. Zakharov, D. Bello
Nanotoxicology 2017 02;11(1):52-63. PubMed:27855548 |
Exhaled breath malondialdehyde, spirometric results and dust exposure assessment in ceramics production workers. | Int J Occup Med Environ Health | 2015 |
MJ. Sakhvidi, J. Biabani Ardekani, A. Firoozichahak, J. Zavarreza, M. Hajaghazade, M. Mostaghaci, A. Mehrparvar, A. Barkhordari
Int J Occup Med Environ Health 2015 ;28(1):81-9. PubMed:26159950 |
Direct detection and quantification of malondialdehyde vapour in humid air using selected ion flow tube mass spectrometry supported by gas chromatography/mass spectrometry. | Rapid Commun. Mass Spectrom. | 2015 |
V. Shestivska, SS. Antonowicz, K. Dryahina, J. Kubišta, D. Smith, P. Španěl
Rapid Commun. Mass Spectrom. 2015 Jun;29(11):1069-79. PubMed:26044275 |
A review of the volatiles from the healthy human body. | J Breath Res | 2014 |
B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258 |
Hyperbaric oxygen diving affects exhaled molecular profiles in men. | Respir Physiol Neurobiol | 2014 |
PJ. van Ooij, RA. van Hulst, W. Kulik, P. Brinkman, A. Houtkooper, PJ. Sterk
Respir Physiol Neurobiol 2014 Jul;198:20-4. PubMed:24703972 |
Urinary benzene metabolite and insulin resistance in elderly adults. | Sci. Total Environ. | 2014 |
YH. Choi, JH. Kim, BE. Lee, YC. Hong
Sci. Total Environ. 2014 Jun;482-483:260-8. PubMed:24657371 |
Residential proximity to a major roadway is associated with features of asthma control in children. | PLoS ONE | 2012 |
MS. Brown, SE. Sarnat, KA. DeMuth, LA. Brown, DR. Whitlock, SW. Brown, PE. Tolbert, AM. Fitzpatrick
PLoS ONE 2012 ;7(5):e37044. PubMed:22615884 |
Oxidative stress in the airways of children with asthma and allergic rhinitis. | Pediatr Allergy Immunol | 2012 |
M. Celik, A. Tuncer, OU. Soyer, C. Saçkesen, H. Tanju Besler, O. Kalayci
Pediatr Allergy Immunol 2012 Sep;23(6):556-61. PubMed:22435922 |
Inflammatory markers in exhaled breath condensate in patients with asthma and rhinitis. | Tuberk Toraks | 2012 |
K. Aksu, H. Kurt, E. Gündüz, I. Değirmenci, E. Kurt
Tuberk Toraks 2012 ;60(4):321-6. PubMed:23289461 |
Burnt sugarcane harvesting: particulate matter exposure and the effects on lung function, oxidative stress, and urinary 1-hydroxypyrene. | Sci. Total Environ. | 2012 |
GF. Prado, DM. Zanetta, MA. Arbex, AL. Braga, LA. Pereira, MR. de Marchi, AP. de Melo Loureiro, T. Marcourakis, LE. Sugauara, GJ. Gattás, FT. Gonçalves, JM. Salge, M. Terra-Filho, U. de Paula Santos
Sci. Total Environ. 2012 Oct;437:200-8. PubMed:22940481 |
Diaphragmatic breathing exercise as a therapeutic intervention for control of oxidative stress in type 2 diabetes mellitus. | Complement Ther Clin Pract | 2012 |
SV. Hegde, P. Adhikari, NK. Subbalakshmi, M. Nandini, GM. Rao, V. D'Souza
Complement Ther Clin Pract 2012 Aug;18(3):151-3. PubMed:22789789 |
Effects on airways of short-term exposure to two kinds of wood smoke in a chamber study of healthy humans. | Inhal Toxicol | 2012 |
L. Stockfelt, G. Sallsten, AC. Olin, P. Almerud, L. Samuelsson, S. Johannesson, P. Molnar, B. Strandberg, AC. Almstrand, K. Bergemalm-Rynell, L. Barregard
Inhal Toxicol 2012 Jan;24(1):47-59. PubMed:22220980 |
Oxidative stress markers in exhaled breath condensate in lung fibroses are not significantly affected by systemic diseases. | Ind Health | 2011 |
D. Pelclová, Z. Fenclová, K. Syslová, S. Vlčková, J. Lebedová, O. Pecha, J. Běláček, T. Navrátil, M. Kuzma, P. Kačer
Ind Health 2011 ;49(6):746-54. PubMed:22020018 |
Oxidative status in the lungs associated with tobacco smoke exposure. | Clin. Chem. Lab. Med. | 2011 |
S. Doruk, H. Ozyurt, H. Inonu, U. Erkorkmaz, O. Saylan, Z. Seyfikli
Clin. Chem. Lab. Med. 2011 Sep;49(12):2007-12. PubMed:21913795 |
Pulmonary function and oxidative stress in workers exposed to styrene in plastic factory: occupational hazards in styrene-exposed plastic factory workers. | Hum Exp Toxicol | 2011 |
PC. Sati, F. Khaliq, N. Vaney, T. Ahmed, AK. Tripathi, BD. Banerjee
Hum Exp Toxicol 2011 Nov;30(11):1743-50. PubMed:21382913 |
Changes in oxidative stress biomarker and gene expression levels in workers exposed to volatile organic compounds. | Ind Health | 2011 |
JH. Kim, JY. Moon, EY. Park, KH. Lee, YC. Hong
Ind Health 2011 ;49(1):8-14. PubMed:20823639 |
Activities of antioxidant enzymes in relation to oxidative and nitrosative challenges in childhood asthma. | J Asthma | 2011 |
E. Fabian, P. Pölöskey, L. Kósa, I. Elmadfa, LA. Réthy
J Asthma 2011 May;48(4):351-7. PubMed:21401389 |
Polycyclic aromatic hydrocarbon-induced oxidative stress and lipid peroxidation in relation to immunological alteration. | Occup Environ Med | 2011 |
HA. Jeng, CH. Pan, N. Diawara, GP. Chang-Chien, WY. Lin, CT. Huang, CK. Ho, MT. Wu
Occup Environ Med 2011 Sep;68(9):653-8. PubMed:21126960 |
Exposure to volatile organic compounds and loss of pulmonary function in the elderly. | Eur. Respir. J. | 2010 |
HI. Yoon, YC. Hong, SH. Cho, H. Kim, YH. Kim, JR. Sohn, M. Kwon, SH. Park, MH. Cho, HK. Cheong
Eur. Respir. J. 2010 Dec;36(6):1270-6. PubMed:20351028 |
Evaluation of Alternate Isotope-Coded Derivatization Assay (AIDA) in the LC-MS/MS analysis of aldehydes in exhaled breath condensate. | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | 2010 |
P. Manini, R. Andreoli, S. Sforza, C. Dall'Asta, G. Galaverna, A. Mutti, WM. Niessen
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2010 Oct;878(27):2616-22. PubMed:20207205 |
Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock. | Crit Care | 2010 |
MO. Maybauer, DM. Maybauer, JF. Fraser, C. Szabo, M. Westphal, L. Kiss, EM. Horvath, Y. Nakano, DN. Herndon, LD. Traber, DL. Traber
Crit Care 2010 ;14(6):R217. PubMed:21110850 |
Effect of t'ai chi exercise on biochemical profiles and oxidative stress indicators in obese patients with type 2 diabetes. | J Altern Complement Med | 2010 |
SC. Chen, KC. Ueng, SH. Lee, KT. Sun, MC. Lee
J Altern Complement Med 2010 Nov;16(11):1153-9. PubMed:20973735 |
Genotoxicity in filling station attendants exposed to petroleum hydrocarbons. | Ann Occup Hyg | 2010 |
PV. Rekhadevi, MF. Rahman, M. Mahboob, P. Grover
Ann Occup Hyg 2010 Nov;54(8):944-54. PubMed:20956619 |
Acute effects of motor vehicle traffic-related air pollution exposures on measures of oxidative stress in human airways. | Ann. N. Y. Acad. Sci. | 2010 |
RJ. Laumbach, HM. Kipen
Ann. N. Y. Acad. Sci. 2010 Aug;1203:107-12. PubMed:20716291 |
Early incidence of occupational asthma among young bakers, pastry-makers and hairdressers: design of a retrospective cohort study. | BMC Public Health | 2010 |
T. Rémen, V. Coevoet, DS. Acouetey, JL. Guéant, RM. Guéant-Rodriguez, C. Paris, D. Zmirou-Navier
BMC Public Health 2010 Apr;10:206. PubMed:20420675 |
Systemic and pulmonary oxidative stress after single-leg exercise in COPD. | Chest | 2009 |
EM. Mercken, HR. Gosker, EP. Rutten, EF. Wouters, A. Bast, GJ. Hageman, AM. Schols
Chest 2009 Nov;136(5):1291-1300. PubMed:19696125 |
Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children. | Environ. Health Perspect. | 2009 |
L. Liu, R. Poon, L. Chen, AM. Frescura, P. Montuschi, G. Ciabattoni, A. Wheeler, R. Dales
Environ. Health Perspect. 2009 Apr;117(4):668-74. PubMed:19440509 |
How volatile organic compounds affect free radical and antioxidant enzyme activity in textile workers. | Arh Hig Rada Toksikol | 2008 |
S. Bayil, H. Cicek, IG. Cimenci, M. Hazar
Arh Hig Rada Toksikol 2008 Dec;59(4):283-7. PubMed:19064366 |
A comparison of oxidative stress in smokers and non-smokers: an in vivo human quantitative study of n-3 lipid peroxidation. | BMC Psychiatry | 2008 |
BK. Puri, IH. Treasaden, M. Cocchi, S. Tsaluchidu, L. Tonello, BM. Ross
BMC Psychiatry 2008 Apr;8 Suppl 1:S4. PubMed:18433514 |
Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma. | J. Allergy Clin. Immunol. | 2008 |
I. Romieu, A. Barraza-Villarreal, C. Escamilla-Nuñez, AC. Almstrand, D. Diaz-Sanchez, PD. Sly, AC. Olin
J. Allergy Clin. Immunol. 2008 Apr;121(4):903-9.e6. PubMed:18234317 |
Experimental exposure to wood smoke: effects on airway inflammation and oxidative stress. | Occup Environ Med | 2008 |
L. Barregard, G. Sällsten, L. Andersson, AC. Almstrand, P. Gustafson, M. Andersson, AC. Olin
Occup Environ Med 2008 May;65(5):319-24. PubMed:17704195 |
Short-term heart variability and oxidative stress in newly diagnosed essential hypertension. | Clin. Exp. Hypertens. | 2008 |
P. Pavithran, H. Nandeesha, V. Sathiyapriya, Z. Bobby, T. Madanmohan
Clin. Exp. Hypertens. 2008 Oct;30(7):486-96. PubMed:18855253 |
Evidence from in vivo 31-phosphorus magnetic resonance spectroscopy phosphodiesters that exhaled ethane is a biomarker of cerebral n-3 polyunsaturated fatty acid peroxidation in humans. | BMC Psychiatry | 2008 |
BK. Puri, SJ. Counsell, BM. Ross, G. Hamilton, MG. Bustos, IH. Treasaden
BMC Psychiatry 2008 Apr;8 Suppl 1:S2. PubMed:18433512 |
Daily supplementation with iron increases lipid peroxidation in young women with low iron stores. | Exp. Biol. Med. (Maywood) | 2008 |
SM. King, CM. Donangelo, MD. Knutson, PB. Walter, BN. Ames, FE. Viteri, JC. King
Exp. Biol. Med. (Maywood) 2008 Jun;233(6):701-7. PubMed:18408148 |
Airway biomarkers of the oxidant burden in asthma and chronic obstructive pulmonary disease: current and future perspectives. | Int J Chron Obstruct Pulmon Dis | 2008 |
N. Louhelainen, M. Myllärniemi, I. Rahman, VL. Kinnula
Int J Chron Obstruct Pulmon Dis 2008 ;3(4):585-603. PubMed:19281076 |
Hypoxia-related lipid peroxidation: evidences, implications and approaches. | Respir Physiol Neurobiol | 2007 |
C. Behn, OF. Araneda, AJ. Llanos, G. Celedón, G. González
Respir Physiol Neurobiol 2007 Sep;158(2-3):143-50. PubMed:17662674 |
Exhaled breath condensate as a suitable matrix to assess lung dose and effects in workers exposed to cobalt and tungsten. | Environ. Health Perspect. | 2004 |
M. Goldoni, S. Catalani, G. De Palma, P. Manini, O. Acampa, M. Corradi, R. Bergonzi, P. Apostoli, A. Mutti
Environ. Health Perspect. 2004 Sep;112(13):1293-8. PubMed:15345342 |
Malondialdehyde in exhaled breath condensate and urine as a biomarker of air pollution induced oxidative stress. | J Expo Sci Environ Epidemiol |
J. Gong, T. Zhu, H. Kipen, G. Wang, M. Hu, P. Ohman-Strickland, SE. Lu, L. Zhang, Y. Wang, P. Zhu, DQ. Rich, SR. Diehl, W. Huang, JJ. Zhang
J Expo Sci Environ Epidemiol 2013 May-Jun;23(3):322-7. PubMed:23321859 |
|
Effect of vitamin E supplementation on carbogen-induced amelioration of noise induced hearing loss in man. | Noise Health |
N. Kapoor, KV. Mani, R. Shyam, RK. Sharma, AP. Singh, W. Selvamurthy
Noise Health 2011 Nov-Dec;13(55):452-8. PubMed:22122962 |
Associated curated diseases 7
Download diseasesAssociated disease mapping
Mapping of all associated diseases to Malondialdehyde is displayed in red.
Disease Name
with link to disease page |
Description of MeSH term
with link to MeSH Database |
Number of references |
---|---|---|
Acute Mountain Sickness |
MeSH:
Altitude Sickness
Multiple symptoms associated with reduced oxygen at high ALTITUDE. Year introduced: 1991(1975)
Link to MeSH Database: D000532
|
2 |
Asthma |
MeSH:
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and
intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of
airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
|
91 |
Chronic Obstructive Pulmonary Disease (Copd) |
MeSH:
Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Year introduced: 2002
Link to MeSH Database: D029424
|
31 |
Bronchiectasis |
MeSH:
Bronchiectasis
Persistent abnormal dilatation of the bronchi.
Link to MeSH Database: D001987
|
3 |
Cystic Fibrosis |
MeSH:
Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE
REGULATOR expressed in several organs including the LUNG, the PANCREAS, the
BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by
epithelial secretory dysfunction associated with ductal obstruction resulting in
AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY;
maldigestion; salt depletion; and HEAT PROSTRATION.
Year introduced: 1967
Link to MeSH Database: D003550
|
20 |
Occupational Respiratory Diseases |
MeSH:
Respiration Disorders
Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available.
Year introduced: 1977
Link to MeSH Database: D012120
|
1 |
Occupational Asthma (Oa) |
MeSH:
Asthma, Occupational
Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE. Year introduced: 2012
Link to MeSH Database: D059366
|
1 |
Associated abnormalities 1
Concept Name | External ID | Weighted Score | Hits | References | |
Asthma | ICD9-CM:493.9 | 1000.0 | 1 |
|
Associated chemicals 5
Concept Name | External ID | Definition | Weighted Score | Hits | References | |
Ozone | 968.63 | 3 |
|
|||
Malondialdehyde | CHEBI:566274 | 963.88 | 3 |
|
||
Nitrate | 925.5 | 1 |
|
|||
Nitrite | 925.5 | 1 |
|
|||
Tungsten | 1000.0 | 1 |
|
Associated functions 7
Concept Name | External ID | Definition | Weighted Score | Hits | References | |
Accident caused by unspecified fire | 525.5 | 1 |
|
|||
Lipid Peroxidation | 975.25 | 1 |
|
|||
Exocytosis | GO:0006887 | 894.0 | 1 |
|
||
Respiratory physiology | 758.05 | 1 |
|
|||
Vital capacity | 735.71 | 1 |
|
|||
pulmonary function | 1000.0 | 1 |
|
|||
Exhalation | 786.0 | 1 |
|
Associated genes 0
No associated genes are detected in current reference collection.
There are 41 associated references with Malondialdehyde. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
NCBI Entrez Crosslinks
Chemical Information
Formula | C3H4O2 |
Mass | 72.063 |
Synonyms | Malondialdehyde Propanedial MALONALDEHYDE Malonyldialdehyde Malonodialdehyde Malonic aldehyde Malonic dialdehyde 1,3-Propanedial 1,3-Propanedione 1,3-Propanedialdehyde 542-78-9 UNII-4Y8F71G49Q CCRIS 5168 HSDB 4353 CHEBI:566274 NCI-C54842 BRN 1209262 MDD Propanedial (9CI) beta-ketopropionaldehyde |
PubChem CID | 10964 |