Heptanal

Description

Description of Heptanal with associated disease summary

Aldehydes resulting from lipid peroxidation can be measured in exhaled breath condensate (EBC) of humans. These aldehydes could be potential biomarkers for monitoring diseases and response to therapy; heptanal is one of such aldehydes. ( Am J Respir Crit Care Med. (2003) ) Heptanal is a known breakdown product of oxidized linoleic and arachidonic, palmitoleic, and oleic acid, respectively. ( Am J Respir Crit Care Med. (2003) ) In one study, researchers compared the levels of heptanal in patients of chronic obstructive pulmonary diseases (COPD) with those of smoking/nonsmoking control subjects by LC-MS/MS method. The result shows heptanal level increased in the EBC of patients with COPD compared with nonsmoking control subjects (p=0.002). Heptanal level also increased in the EBC of smoking control subjects compared with nonsmoking control subjects. ( Am J Respir Crit Care Med. (2003) ) Another study reported that under optimum conditions, heptanal levels in EBC of lung cancer patients were higher than those of healthy subjects. ( J Chromatogr A. (2015)) In a third study, a MSPE-HPLC method was applied to determine the heptanal levels in EBC samples of healthy controls and lung cancer patients. Interestingly, heptanal level was found in most healthy subject's EBC, but not in lung cancer patient's EBC. ( J Chromatogr A. (2014)) These methods were proposed for quantifying aldehyde metabolites in complex biological samples. Description of disease(s) related to Heptanal:

Disease summary

Lung Neoplasms

Another study reported that under optimum conditions, heptanal levels in EBC of lung cancer patients were higher than those of healthy subjects ( J Chromatogr A. (2015) ). In another study, a MSPE-HPLC method was applied to determine the heptanal levels in EBC samples of healthy controls and lung cancer patients. Interestingly, heptanal level was found in most healthy subject's EBC, but not in lung cancer patient's EBC. ( J Chromatogr A. (2014))

Pulmonary Disease, Chronic Obstructive (COPD)

In one study, researchers compared the levels of heptanal in patients of chronic obstructive pulmonary diseases (COPD) with those of smoking/nonsmoking control subjects by LC-MS/MS method. The result shows heptanal level increased in the EBC of patients with COPD compared with nonsmoking control subjects (p=0.002) ( Am J Respir Crit Care Med. (2003) ).

Summary of extracted biomedical information

Imgsrv

Associated references with human 3

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Reference title

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Journal Year Authors & PubMed Link
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
First observation of a potential non-invasive breath gas biomarker for kidney function. J Breath Res 2013 I. Kohl, J. Beauchamp, F. Cakar-Beck, J. Herbig, J. Dunkl, O. Tietje, M. Tiefenthaler, C. Boesmueller, A. Wisthaler, M. Breitenlechner, S. Langebner, A. Zabernigg, F. Reinstaller, K. Winkler, R. Gutmann, A. Hansel
J Breath Res 2013 Mar;7(1):017110. PubMed:23446042
[Measurement of exhaled volatile organic compounds in lung cancer patients]. Zhonghua Jie He He Hu Xi Za Zhi 2010 CR. Lu, YJ. Hu, EG. Chen, YH. Qiu, KJ. Ying
Zhonghua Jie He He Hu Xi Za Zhi 2010 Feb;33(2):104-8. PubMed:20367949

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to Heptanal is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Non Small Cell Lung Cancer, Lung Neoplasms MeSH: Lung Neoplasms
Tumors or cancer of the LUNG.
Link to MeSH Database: D008175
4
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 3 associated references with Heptanal. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 3 associated references with Heptanal. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 3 associated references with Heptanal. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 3 associated references with Heptanal. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C7H14O
Mass 114.188
Synonyms Heptanal
Heptaldehyde
Enanthaldehyde
111-71-7
n-Heptaldehyde
Enanthal
Heptyl aldehyde
Heptanaldehyde
N-HEPTANAL
Oenanthaldehyde
Enanthole
Oenanthal
Oenanthol
n-Heptylaldehyde
Enanthic aldehyde
Oenanthic aldehyde
Aldehyde C-7
Heptylaldehyde
1-Heptanal
Heptanal (natural)
PubChem CID 8130