Isobutyric acid

Description

Description of Isobutyric acid with associated disease summary

Isobutyrate arises from valine catabolism. Nuclear magnetic resonance (NMR)-based metabolomics has the ability to separate exhaled breath condensate (EBC) profiles of patients affected by pulmonary diseases from those of healthy subjects. EBC has been used to study the influence of smoking on changes in smoking-related airways diseases, but data on metabolic variation in different diseases sharing a common risk factor: smoking, hasn't been established. In a study, 50 duplicated EBC samples from smokers (without COPD, with COPD, or with pulmonary Langerhans cell histiocytosis (PLCH)) were analyzed by means of NMR spectroscopy followed by principal component analysis (PCA) and projection to latent structures discriminant analysis (PLSDA). The result shows clusterization of EBC spectra was disease-specific; COPD and PLCH samples present a profile different from that of HS (smokes without COPD). Smokers with COPD correlate with low isobutyrate, whereas smokers with PLCH correlate with high isobutyrate. Isobutyrate level is different in COPD and PLCH, the relationship is not clear, but the NMR approach could favor a noninvasive monitoring of both pathologies (J Proteome Res. (2013)). Description of disease(s) related to Isobutyrate:

Disease summary

Pulmonary Langerhans cell histiocytosis (PLCH)

One study shows clusterization of EBC spectra was disease-specific; COPD and PLCH samples present a profile different from that of HS (smokes without COPD). Smokers with PLCH correlate with high isobutyrate (J Proteome Res. (2013) ).

Pulmonary Disease, Chronic Obstructive (COPD)

One study shows clusterization of EBC spectra was disease-specific; COPD and PLCH samples present a profile different from that of HS (smokes without COPD). Smokers with COPD correlate with low isobutyrate (J Proteome Res. (2013) ).

Summary of extracted biomedical information

Isobutyric acid is associated with isobutyric acid and tert-amyl alcohol.
Imgsrv

Associated references with human 3

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Reference title

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Journal Year Authors & PubMed Link
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate. J. Proteome Res. 2013 G. de Laurentiis, D. Paris, D. Melck, P. Montuschi, M. Maniscalco, A. Bianco, M. Sofia, A. Motta
J. Proteome Res. 2013 Mar;12(3):1502-11. PubMed:23360153
The analytical utility of thermally desorbed polydimethylsilicone membranes for in-vivo sampling of volatile organic compounds in and on human skin. Analyst 2008 S. Riazanskaia, G. Blackburn, M. Harker, D. Taylor, CL. Thomas
Analyst 2008 Aug;133(8):1020-7. PubMed:18645643

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to Isobutyric acid is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Pulmonary Langerhans Cell Histiocytosis MeSH: Histiocytosis, Langerhans-Cell
A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder. Year introduced: 1990(1975)
Link to MeSH Database: D006646
1
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 3 associated references with Isobutyric acid. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 3 associated references with Isobutyric acid. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 3 associated references with Isobutyric acid. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 3 associated references with Isobutyric acid. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C4H8O2
Mass 88.106
Synonyms ISOBUTYRIC ACID
2-Methylpropanoic acid
Isobutanoic acid
79-31-2
2-Methylpropionic acid
Dimethylacetic acid
Propanoic acid, 2-methyl-
Isopropylformic acid
Iso-butyric acid
Isobutyrate
Cenex RP b2
Acetic acid, dimethyl-
Isobutanoate
alpha-Methylpropanoic acid
alpha-Methylpropionic acid
Propionic acid, 2-methyl-
Isobutyric acid (natural)
Tenox IBP-2
2-METHYL-PROPIONIC ACID
Kyselina isomaselna
PubChem CID 6590