Adenosine 5'-monophosphate
Description
Description of adenosine 5'-monophosphate with associated disease summary
Adenosine monophosphate (AMP) mediates
multiple inflammatory cell responses. AMP has been demonstrated to be a
potential biomarker of neutrophilic airway inflammation in older children/adults
with cystic fibrosis (CF). Although the correlations between purines and airway bronchitis in older children/adults are
known, the feasibility and utility of AMP as exhaled breath condensate (EBC)
biomarker in young children has not been established.
Previous studies have demonstrated that
LC-MS/MS method is suitable for quantitative
analysis of AMP in the EBC of older population. The EBC samples collected from
children <3 years old with CF or other lung diseases
during clinically indicated infant pulmonary function tests (iPFTs)
were analyzed using the same method.
It was demonstrated that EBC from young
children undergoing iPFTs can be safely collected. The feasibility of analyzing
EBC biomarker AMP was also demonstrated. While promising, additional
investigations are needed to validate the association of AMP and lung functions
or diseases in infants and preschoolers ( Pediatr Pulmonol. (2013)
).
Description of disease(s) related to Adenosine
monophosphate (AMP):
Cystic Fibrosis
No significant difference of AMP/adenosine ratio between CF and non-CF groups (P = 0.769) ( Pediatr Pulmonol. (2013) ).Summary of extracted biomedical information
Adenosine 5'-monophosphate is associated with abnormalities such as Pneumonia, Hyperostosis Frontalis Interna and Intestinal Diseases. The involved biomedical functions are known as inhibitors, adenylate cyclase activity, reverse transcription polymerase chain reaction, adenylate kinase activity and Exocytosis. The associated genes/proteins with adenosine 5'-monophosphate are MAPK3 gene, ADCY6 gene, ADCY9 gene, ADCY5 gene and GLI3 gene. Adenosine 5'-monophosphate is associated with Amines, quinoxaline, 3-methylquercetin, Chlorides and kaempferol.
Associated references with human 73
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Journal | Year | Authors & PubMed Link |
|---|---|---|---|
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L. Prieto, J. Palop, R. Llusar, S. Herrera, C. Perez-Frances, A. Lanuza, D. Aguilar
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SA. Comhair, J. McDunn, C. Bennett, J. Fettig, SC. Erzurum, SC. Kalhan
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MS. Perzanowski, Y. Yoo
Int. Arch. Allergy Immunol. 2015 ;166(2):107-13. PubMed:25792296 |
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M. Arga, A. Bakirtas, E. Topal, I. Turktas
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AJ. Lexmond, E. van der Wiel, P. Hagedoorn, W. Bult, HW. Frijlink, NH. ten Hacken, AH. de Boer
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AJ. Lexmond, P. Hagedoorn, HW. Frijlink, AH. de Boer
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M. Baraket, BG. Oliver, JK. Burgess, S. Lim, GG. King, JL. Black
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V. Lopez, L. Prieto, C. Perez-Frances, D. Barato, J. Marin
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BJ. Koos
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A. Michils, Y. Elkrim, A. Haccuria, A. Van Muylem
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| Prolonged protection of the new inhaled corticosteroid fluticasone furoate against AMP hyperresponsiveness in patients with asthma. | Allergy | 2010 |
M. van den Berge, B. Luijk, P. Bareille, N. Dallow, DS. Postma, JW. Lammers
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MM. Farnham, PM. Pilowsky
Respir Physiol Neurobiol 2010 Nov;174(1-2):65-75. PubMed:20470908 |
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L. Prieto, S. Esnal, V. Lopez, D. Barato, R. Rojas, J. Marín
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L. Prieto, A. Ferrer, S. Ponce, J. Palop, J. Marín
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S. Godfrey
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J. Cohen, WR. Douma, NH. Ten Hacken, M. Oudkerk, DS. Postma
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| Pituitary adenylate cyclase-activating polypeptide is vital for neonatal survival and the neuronal control of breathing. | Respir Physiol Neurobiol | 2008 |
RJ. Wilson, KJ. Cumming
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MC. Michel, S. Parra
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J. Cohen, WR. Douma, NH. ten Hacken, JM. Vonk, M. Oudkerk, DS. Postma
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MC. Clark, DJ. Baro
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L. Spicuzza, G. Di Maria, R. Polosa
Eur. J. Pharmacol. 2006 Mar;533(1-3):77-88. PubMed:16458886 |
| The effect of challenge method on sensitivity and reactivity to adenosine 5'-monophosphate in subjects with suspected asthma. | Chest | 2006 |
L. Prieto, I. Reig, R. Rojas, A. Ferrer, J. Domenech
Chest 2006 Nov;130(5):1448-53. PubMed:17099023 |
| AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil. | Eur. J. Clin. Invest. | 2006 |
CT. Bruce, D. Zhao, DH. Yates, PS. Thomas
Eur. J. Clin. Invest. 2006 Dec;36(12):899-905. PubMed:17087785 |
| Markers of exacerbation severity in chronic obstructive pulmonary disease. | Respir. Res. | 2006 |
LG. Franciosi, CP. Page, BR. Celli, M. Cazzola, MJ. Walker, M. Danhof, KF. Rabe, OE. Della Pasqua
Respir. Res. 2006 May;7:74. PubMed:16686949 |
| Anti-inflammatory effects of once daily low dose inhaled ciclesonide in mild to moderate asthmatic patients. | Allergy | 2006 |
AM. Wilson, M. Duong, B. Pratt, M. Dolovich, PM. O'Byrne
Allergy 2006 May;61(5):537-42. PubMed:16629781 |
| Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice. | Respir. Res. | 2006 |
R. Ten Broeke, R. De Crom, R. Van Haperen, V. Verweij, T. Leusink-Muis, I. Van Ark, F. De Clerck, FP. Nijkamp, G. Folkerts
Respir. Res. 2006 Apr;7:58. PubMed:16597326 |
| Early rise in exhaled nitric oxide and mast cell activation in repeated low-dose allergen challenge. | Eur. Respir. J. | 2006 |
E. Ihre, P. Gyllfors, LE. Gustafsson, M. Kumlin, B. Dahlén
Eur. Respir. J. 2006 Jun;27(6):1152-9. PubMed:16510451 |
| Effect of fluticasone propionate-salmeterol therapy on seasonal changes in airway responsiveness and exhaled nitric oxide levels in patients with pollen-induced asthma. | Ann. Allergy Asthma Immunol. | 2005 |
L. Prieto, V. Gutiérrez, C. Pérez-Francés, C. Badiola, A. Lanuza, L. Bruno, A. Ferrer
Ann. Allergy Asthma Immunol. 2005 Nov;95(5):452-61. PubMed:16312168 |
| Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge. | Ann. Allergy Asthma Immunol. | 2005 |
BJ. Lipworth, EJ. Sims, SK. Das, H. Buck, M. Paterson
Ann. Allergy Asthma Immunol. 2005 Jun;94(6):675-81. PubMed:15984601 |
| Benefit from anti-inflammatory treatment during clinical remission of atopic asthma. | Respir Med | 2005 |
LM. van den Toorn, JB. Prins, JC. de Jongste, K. Leman, PG. Mulder, HC. Hoogsteden, SE. Overbeek
Respir Med 2005 Jun;99(6):779-87. PubMed:15878496 |
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N. Berkman, A. Avital, R. Breuer, E. Bardach, C. Springer, S. Godfrey
Thorax 2005 May;60(5):383-8. PubMed:15860713 |
| Timing and nature of wheezing at the endpoint of a bronchial challenge in preschool children. | Pediatr. Pulmonol. | 2005 |
S. Godfrey, S. Cohen, A. Avital, C. Springer
Pediatr. Pulmonol. 2005 Mar;39(3):262-7. PubMed:15668938 |
| Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma. | Respir Med | 2004 |
E. Bucchioni, Z. Csoma, L. Allegra, KF. Chung, PJ. Barnes, SA. Kharitonov
Respir Med 2004 Jul;98(7):651-5. PubMed:15250231 |
| Exhaled nitric oxide levels and airway responsiveness to adenosine 5'-monophosphate in subjects with nasal polyposis. | Int. Arch. Allergy Immunol. | 2004 |
L. Prieto, T. Seijas, V. Gutiérrez, S. Uixera, L. Bruno, R. López
Int. Arch. Allergy Immunol. 2004 Aug;134(4):303-9. PubMed:15205562 |
| Duration of effect of single-dose inhaled fluticasone propionate on AMP-induced bronchoconstriction. | Eur. Respir. J. | 2004 |
B. Luijk, RD. Kempsford, AM. Wright, P. Zanen, JW. Lammers
Eur. Respir. J. 2004 Apr;23(4):559-64. PubMed:15083754 |
| Repeated dosing effects of mediator antagonists in inhaled corticosteroid-treated atopic asthmatic patients. | Chest | 2004 |
DK. Lee, CM. Jackson, K. Haggart, BJ. Lipworth
Chest 2004 Apr;125(4):1372-7. PubMed:15078748 |
| Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids. | Clin. Exp. Allergy | 2004 |
DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth
Clin. Exp. Allergy 2004 Jan;34(1):110-4. PubMed:14720270 |
| A synthetic VIP peptide analogue inhibits neutrophil recruitment in rat airways in vivo. | Regul. Pept. | 2004 |
S. Sergejeva, H. Hoshino, S. Yoshihara, K. Kashimoto, J. Lötvall, A. Lindén
Regul. Pept. 2004 Feb;117(2):149-54. PubMed:14700751 |
| The effect of montelukast on bronchial provocation tests and exhaled nitric oxide levels in asthmatic patients. | Isr. Med. Assoc. J. | 2003 |
N. Berkman, A. Avital, E. Bardach, C. Springer, R. Breuer, S. Godfrey
Isr. Med. Assoc. J. 2003 Nov;5(11):778-81. PubMed:14650101 |
| Airway responsiveness to adenosine 5'-monophosphate and exhaled nitric oxide measurements: predictive value as markers for reducing the dose of inhaled corticosteroids in asthmatic subjects. | Chest | 2003 |
L. Prieto, L. Bruno, V. Gutiérrez, S. Uixera, C. Pérez-Francés, A. Lanuza, A. Ferrer
Chest 2003 Oct;124(4):1325-33. PubMed:14555562 |
| Exhaled nitric oxide is age-dependent in asthma. | Pediatr. Pulmonol. | 2003 |
A. Avital, K. Uwyyed, N. Berkman, E. Bar-Yishay, S. Godfrey, C. Springer
Pediatr. Pulmonol. 2003 Nov;36(5):433-8. PubMed:14520727 |
| [New techniques in the study of asthma]. | An Sist Sanit Navar | 2003 |
JM. Olaguíbel, MJ. Alvarez, P. Uribe, BE. García, AI. Tabar
An Sist Sanit Navar 2003 ;26 Suppl 2:57-63. PubMed:13679964 |
| Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma. | Br J Clin Pharmacol | 2003 |
GP. Currie, JJ. Lima, JE. Sylvester, DK. Lee, WJ. Cockburn, BJ. Lipworth
Br J Clin Pharmacol 2003 Oct;56(4):422-6. PubMed:12968987 |
| Effects of fluticasone plus salmeterol versus twice the dose of fluticasone in asthmatic patients. | Eur. J. Clin. Pharmacol. | 2003 |
GP. Currie, CE. Bates, DK. Lee, CM. Jackson, BJ. Lipworth
Eur. J. Clin. Pharmacol. 2003 May;59(1):11-5. PubMed:12743669 |
| The skin vasoconstrictor assay does not correlate significantly to airway or systemic responsiveness to inhaled budesonide in asthmatic patients. | Eur. J. Clin. Pharmacol. | 2003 |
AM. Wilson, WJ. Coutie, EJ. Sims, BJ. Lipworth
Eur. J. Clin. Pharmacol. 2003 Feb;58(10):643-7. PubMed:12610738 |
| Effects of montelukast on surrogate inflammatory markers in corticosteroid-treated patients with asthma. | Am. J. Respir. Crit. Care Med. | 2003 |
GP. Currie, DK. Lee, K. Haggart, CE. Bates, BJ. Lipworth
Am. J. Respir. Crit. Care Med. 2003 May;167(9):1232-8. PubMed:12456382 |
| Concentrations of exhaled nitric oxide in asthmatics and subjects with allergic rhinitis sensitized to the same pollen allergen. | Clin. Exp. Allergy | 2002 |
L. Prieto, V. Gutiérrez, S. Uixera, L. Bruno
Clin. Exp. Allergy 2002 Dec;32(12):1728-33. PubMed:12653163 |
| Modifications of airway responsiveness to adenosine 5'-monophosphate and exhaled nitric oxide concentrations after the pollen season in subjects with pollen-induced rhinitis. | Chest | 2002 |
L. Prieto, S. Uixera, V. Gutiérrez, L. Bruno
Chest 2002 Sep;122(3):940-7. PubMed:12226036 |
| Effect of salmeterol on seasonal changes in airway responsiveness and exhaled nitric oxide in pollen-sensitive asthmatic subjects. | Chest | 2002 |
L. Prieto, V. Gutiérrez, V. Torres, S. Uixera, J. Marín
Chest 2002 Sep;122(3):798-805. PubMed:12226016 |
| Exhaled nitric oxide and bronchial responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis. | Chest | 2002 |
L. Prieto, V. Gutiérrez, S. Uixera
Chest 2002 Jun;121(6):1853-9. PubMed:12065349 |
| Airway inflammation is present during clinical remission of atopic asthma. | Am. J. Respir. Crit. Care Med. | 2001 |
LM. van den Toorn, SE. Overbeek, JC. de Jongste, K. Leman, HC. Hoogsteden, JB. Prins
Am. J. Respir. Crit. Care Med. 2001 Dec;164(11):2107-13. PubMed:11739143 |
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MK. Evans, I. Savasi, GJ. Heigenhauser, LL. Spriet
Am. J. Physiol. Endocrinol. Metab. 2001 Dec;281(6):E1144-50. PubMed:11701427 |
| Corticosteroid-induced improvement in the PC20 of adenosine monophosphate is more closely associated with reduction in airway inflammation than improvement in the PC20 of methacholine. | Am. J. Respir. Crit. Care Med. | 2001 |
M. van den Berge, HA. Kerstjens, RJ. Meijer, DM. de Reus, GH. Koëter, HF. Kauffman, DS. Postma
Am. J. Respir. Crit. Care Med. 2001 Oct;164(7):1127-32. PubMed:11673197 |
| PC(20) adenosine 5'-monophosphate is more closely associated with airway inflammation in asthma than PC(20) methacholine. | Am. J. Respir. Crit. Care Med. | 2001 |
M. Van Den Berge, RJ. Meijer, HA. Kerstjens, DM. de Reus, GH. Koëter, HF. Kauffman, DS. Postma
Am. J. Respir. Crit. Care Med. 2001 Jun;163(7):1546-50. PubMed:11401871 |
| A comparison of topical budesonide and oral montelukast in seasonal allergic rhinitis and asthma. | Clin. Exp. Allergy | 2001 |
AM. Wilson, OJ. Dempsey, EJ. Sims, BJ. Lipworth
Clin. Exp. Allergy 2001 Apr;31(4):616-24. PubMed:11359431 |
| Evaluation of salmeterol or montelukast as second-line therapy for asthma not controlled with inhaled corticosteroids. | Chest | 2001 |
AM. Wilson, OJ. Dempsey, EJ. Sims, BJ. Lipworth
Chest 2001 Apr;119(4):1021-6. PubMed:11296164 |
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F. Kanniess, K. Richter, S. Böhme, RA. Jörres, H. Magnussen
Pulm Pharmacol Ther 2001 ;14(2):141-7. PubMed:11273796 |
| Effects of once-daily formoterol and budesonide given alone or in combination on surrogate inflammatory markers in asthmatic adults. | Chest | 2000 |
I. Aziz, AM. Wilson, BJ. Lipworth
Chest 2000 Oct;118(4):1049-58. PubMed:11035676 |
| Adolescents in clinical remission of atopic asthma have elevated exhaled nitric oxide levels and bronchial hyperresponsiveness. | Am. J. Respir. Crit. Care Med. | 2000 |
LM. van Den Toorn, JB. Prins, SE. Overbeek, HC. Hoogsteden, JC. de Jongste
Am. J. Respir. Crit. Care Med. 2000 Sep;162(3 Pt 1):953-7. PubMed:10988112 |
| Mometasone furoate antagonizes AMP-induced bronchoconstriction in patients with mild asthma. | J. Allergy Clin. Immunol. | 2000 |
ST. Holgate, H. Arshad, P. Stryszak, JE. Harrison
J. Allergy Clin. Immunol. 2000 May;105(5):906-11. PubMed:10808170 |
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M. Sue-Chu, AH. Henriksen, L. Bjermer
Respir Med 1999 Oct;93(10):719-25. PubMed:10581661 |
| Effect of endogenous nitric oxide inhibition on airway responsiveness to histamine and adenosine-5'-monophosphate in asthma. | Thorax | 1998 |
DA. Taylor, JL. McGrath, LM. Orr, PJ. Barnes, BJ. O'Connor
Thorax 1998 Jun;53(6):483-9. PubMed:9713448 |
| Respiratory sensation during bronchial challenge testing with methacholine, sodium metabisulphite, and adenosine monophosphate. | Thorax | 1996 |
GB. Marks, DH. Yates, M. Sist, B. Ceyhan, M. De Campos, DM. Scott, PJ. Barnes
Thorax 1996 Aug;51(8):793-8. PubMed:8795666 |
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A. Avital, C. Springer, E. Bar-Yishay, S. Godfrey
Thorax 1995 May;50(5):511-6. PubMed:7597663 |
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LP. Boulet, H. Turcott, S. Plante, J. Chakir
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|
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Associated curated diseases 0
No curated diseases are identified in current reference collection.
Associated abnormalities 3
| Concept Name | External ID | Weighted Score | Hits | References | |
| Pneumonia | 986.06 | 1 |
|
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| Hyperostosis Frontalis Interna | 508.83 | 1 |
|
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| Intestinal Diseases | 733.47 | 1 |
|
Associated chemicals 7
Associated functions 23
Associated genes 6
NCBI Entrez Crosslinks
Chemical Information
| Formula | C10H14N5O7P |
| Mass | 347.224 |
| Synonyms | adenosine 5'-monophosphate 5'-adenylic acid adenylic acid Adenosine monophosphate adenosine phosphate 61-19-8 adenosine 5'-phosphate Phosphaden 5'-AMP adenylate Phosphentaside Adenovite Phosaden Cardiomone Lycedan My-B-Den Vitamin B8 Myoston 5'-adenosine monophosphate Ergadenylic acid |
| PubChem CID | 6083 |