Adenosine 5'-monophosphate

Description

Description of adenosine 5'-monophosphate with associated disease summary

Adenosine monophosphate (AMP) mediates multiple inflammatory cell responses. AMP has been demonstrated to be a potential biomarker of neutrophilic airway inflammation in older children/adults with cystic fibrosis (CF). Although the correlations between purines and airway bronchitis in older children/adults are known, the feasibility and utility of AMP as exhaled breath condensate (EBC) biomarker in young children has not been established. Previous studies have demonstrated that LC-MS/MS method is suitable for quantitative analysis of AMP in the EBC of older population. The EBC samples collected from children <3 years old with CF or other lung diseases during clinically indicated infant pulmonary function tests (iPFTs) were analyzed using the same method. It was demonstrated that EBC from young children undergoing iPFTs can be safely collected. The feasibility of analyzing EBC biomarker AMP was also demonstrated. While promising, additional investigations are needed to validate the association of AMP and lung functions or diseases in infants and preschoolers ( Pediatr Pulmonol. (2013) ). Description of disease(s) related to Adenosine monophosphate (AMP):

Cystic Fibrosis

No significant difference of AMP/adenosine ratio between CF and non-CF groups (P = 0.769) ( Pediatr Pulmonol. (2013) ).

Summary of extracted biomedical information

Adenosine 5'-monophosphate is associated with abnormalities such as Pneumonia, Hyperostosis Frontalis Interna and Intestinal Diseases. The involved biomedical functions are known as inhibitors, adenylate cyclase activity, reverse transcription polymerase chain reaction, adenylate kinase activity and Exocytosis. The associated genes/proteins with adenosine 5'-monophosphate are MAPK3 gene, ADCY6 gene, ADCY9 gene, ADCY5 gene and GLI3 gene. Adenosine 5'-monophosphate is associated with Amines, quinoxaline, 3-methylquercetin, Chlorides and kaempferol.
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Associated references with human 73

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Journal Year Authors & PubMed Link
Effects of low- versus high-dose fluticasone propionate/formoterol fumarate combination therapy on AMP challenge in asthmatic patients: A double-blind, randomised clinical trial. Pulm Pharmacol Ther 2016 F. Kanniess, Z. Diamant, M. Lomax
Pulm Pharmacol Ther 2016 04;37:65-72. PubMed:26912209
Effects of cigarette smoke on methacholine- and AMP-induced air trapping in asthmatics. J Asthma 2015 L. Prieto, J. Palop, R. Llusar, S. Herrera, C. Perez-Frances, A. Lanuza, D. Aguilar
J Asthma 2015 Feb;52(1):26-33. PubMed:25019351
Metabolomic Endotype of Asthma. J. Immunol. 2015 SA. Comhair, J. McDunn, C. Bennett, J. Fettig, SC. Erzurum, SC. Kalhan
J. Immunol. 2015 Jul;195(2):643-50. PubMed:26048149
Exhaled Nitric Oxide and Airway Hyperresponsiveness to Adenosine 5'-monophosphate and Methacholine in Children with Asthma. Int. Arch. Allergy Immunol. 2015 MS. Perzanowski, Y. Yoo
Int. Arch. Allergy Immunol. 2015 ;166(2):107-13. PubMed:25792296
Can exhaled nitric oxide be a surrogate marker of bronchial hyperresponsiveness to adenosine 5'-monophosphate in steroid-naive asthmatic children? Clin. Exp. Allergy 2015 M. Arga, A. Bakirtas, E. Topal, I. Turktas
Clin. Exp. Allergy 2015 Apr;45(4):758-66. PubMed:25378028
Adenosine dry powder inhalation for bronchial challenge testing, part 2: proof of concept in asthmatic subjects. Eur J Pharm Biopharm 2014 AJ. Lexmond, E. van der Wiel, P. Hagedoorn, W. Bult, HW. Frijlink, NH. ten Hacken, AH. de Boer
Eur J Pharm Biopharm 2014 Sep;88(1):148-52. PubMed:24780441
Challenging the two-minute tidal breathing challenge test. J Aerosol Med Pulm Drug Deliv 2013 AJ. Lexmond, P. Hagedoorn, HW. Frijlink, AH. de Boer
J Aerosol Med Pulm Drug Deliv 2013 Dec;26(6):380-6. PubMed:23509936
Axial distribution of nitric oxide airway production in asthma patients. Respir Physiol Neurobiol 2013 A. Van Muylem, Y. Kerckx, A. Michils
Respir Physiol Neurobiol 2013 Jan;185(2):313-8. PubMed:23059373
Is low dose inhaled corticosteroid therapy as effective for inflammation and remodeling in asthma? A randomized, parallel group study. Respir. Res. 2012 M. Baraket, BG. Oliver, JK. Burgess, S. Lim, GG. King, JL. Black
Respir. Res. 2012 Feb;13:11. PubMed:22300506
Natural pollen exposure increases the response plateau to adenosine 5'-monophosphate and bronchial but not alveolar nitric oxide in sensitized subjects. Respiration 2012 V. Lopez, L. Prieto, C. Perez-Frances, D. Barato, J. Marin
Respiration 2012 ;83(3):225-32. PubMed:21778692
Adenosine A₂a receptors and O₂ sensing in development. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011 BJ. Koos
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Adenosine 5'-monophosphate challenge elicits a more peripheral airway response than methacholine challenge. J. Appl. Physiol. 2011 A. Michils, Y. Elkrim, A. Haccuria, A. Van Muylem
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Proof of concept study to evaluate step-down therapy with inhaled corticosteroid alone or additive therapy on surrogate inflammatory markers in asthma. Br J Clin Pharmacol 2011 L. McKinlay, PA. Williamson, PM. Short, TC. Fardon, BJ. Lipworth
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Particle size matters: diagnostics and treatment of small airways involvement in asthma. Eur. Respir. J. 2011 J. Cohen, DS. Postma, WR. Douma, JM. Vonk, AH. De Boer, NH. ten Hacken
Eur. Respir. J. 2011 Mar;37(3):532-40. PubMed:20595155
Prolonged protection of the new inhaled corticosteroid fluticasone furoate against AMP hyperresponsiveness in patients with asthma. Allergy 2010 M. van den Berge, B. Luijk, P. Bareille, N. Dallow, DS. Postma, JW. Lammers
Allergy 2010 Dec;65(12):1531-5. PubMed:20560909
The role of PACAP in central cardiorespiratory regulation. Respir Physiol Neurobiol 2010 MM. Farnham, PM. Pilowsky
Respir Physiol Neurobiol 2010 Nov;174(1-2):65-75. PubMed:20470908
Maximal response plateau to adenosine 5'-monophosphate in asthma. Relationship with the response to methacholine, exhaled nitric oxide, and exhaled breath condensate pH. Chest 2009 L. Prieto, S. Esnal, V. Lopez, D. Barato, R. Rojas, J. Marín
Chest 2009 Jun;135(6):1521-1526. PubMed:19225062
Exhaled nitric oxide measurement is not useful for predicting the response to inhaled corticosteroids in subjects with chronic cough. Chest 2009 L. Prieto, A. Ferrer, S. Ponce, J. Palop, J. Marín
Chest 2009 Sep;136(3):816-822. PubMed:19411296
The use of bronchial challenge to diagnose asthma in preschool children. Prim Care Respir J 2009 S. Godfrey
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Adenosine and adenosine receptors in the pathomechanism and treatment of respiratory diseases. Curr. Med. Chem. 2008 G. Vass, I. Horváth
Curr. Med. Chem. 2008 ;15(9):917-22. PubMed:18473799
Physiology of the small airways: A gender difference? Respir Med 2008 J. Cohen, WR. Douma, NH. Ten Hacken, M. Oudkerk, DS. Postma
Respir Med 2008 Sep;102(9):1264-71. PubMed:18617383
Pituitary adenylate cyclase-activating polypeptide is vital for neonatal survival and the neuronal control of breathing. Respir Physiol Neurobiol 2008 RJ. Wilson, KJ. Cumming
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Similarities and differences in the autonomic control of airway and urinary bladder smooth muscle. Naunyn Schmiedebergs Arch. Pharmacol. 2008 MC. Michel, S. Parra
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Rapid effect of inhaled ciclesonide in asthma: a randomized, placebo-controlled study. Chest 2008 EM. Erin, AS. Zacharasiewicz, GC. Nicholson, AJ. Tan, H. Neighbour, R. Engelstätter, M. Hellwig, OM. Kon, PJ. Barnes, TT. Hansel
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Ciclesonide improves measures of small airway involvement in asthma. Eur. Respir. J. 2008 J. Cohen, WR. Douma, NH. ten Hacken, JM. Vonk, M. Oudkerk, DS. Postma
Eur. Respir. J. 2008 Jun;31(6):1213-20. PubMed:18287130
Effects of montelukast on subjective and objective outcome measures in preschool asthmatic children. Pediatr. Pulmonol. 2008 A. Moeller, A. Lehmann, N. Knauer, M. Albisetti, M. Rochat, W. Johannes
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Arthropod D2 receptors positively couple with cAMP through the Gi/o protein family. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 2007 MC. Clark, DJ. Baro
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Adenosine in the airways: implications and applications. Eur. J. Pharmacol. 2006 L. Spicuzza, G. Di Maria, R. Polosa
Eur. J. Pharmacol. 2006 Mar;533(1-3):77-88. PubMed:16458886
The effect of challenge method on sensitivity and reactivity to adenosine 5'-monophosphate in subjects with suspected asthma. Chest 2006 L. Prieto, I. Reig, R. Rojas, A. Ferrer, J. Domenech
Chest 2006 Nov;130(5):1448-53. PubMed:17099023
AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil. Eur. J. Clin. Invest. 2006 CT. Bruce, D. Zhao, DH. Yates, PS. Thomas
Eur. J. Clin. Invest. 2006 Dec;36(12):899-905. PubMed:17087785
Markers of exacerbation severity in chronic obstructive pulmonary disease. Respir. Res. 2006 LG. Franciosi, CP. Page, BR. Celli, M. Cazzola, MJ. Walker, M. Danhof, KF. Rabe, OE. Della Pasqua
Respir. Res. 2006 May;7:74. PubMed:16686949
Anti-inflammatory effects of once daily low dose inhaled ciclesonide in mild to moderate asthmatic patients. Allergy 2006 AM. Wilson, M. Duong, B. Pratt, M. Dolovich, PM. O'Byrne
Allergy 2006 May;61(5):537-42. PubMed:16629781
Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice. Respir. Res. 2006 R. Ten Broeke, R. De Crom, R. Van Haperen, V. Verweij, T. Leusink-Muis, I. Van Ark, F. De Clerck, FP. Nijkamp, G. Folkerts
Respir. Res. 2006 Apr;7:58. PubMed:16597326
Early rise in exhaled nitric oxide and mast cell activation in repeated low-dose allergen challenge. Eur. Respir. J. 2006 E. Ihre, P. Gyllfors, LE. Gustafsson, M. Kumlin, B. Dahlén
Eur. Respir. J. 2006 Jun;27(6):1152-9. PubMed:16510451
Effect of fluticasone propionate-salmeterol therapy on seasonal changes in airway responsiveness and exhaled nitric oxide levels in patients with pollen-induced asthma. Ann. Allergy Asthma Immunol. 2005 L. Prieto, V. Gutiérrez, C. Pérez-Francés, C. Badiola, A. Lanuza, L. Bruno, A. Ferrer
Ann. Allergy Asthma Immunol. 2005 Nov;95(5):452-61. PubMed:16312168
Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge. Ann. Allergy Asthma Immunol. 2005 BJ. Lipworth, EJ. Sims, SK. Das, H. Buck, M. Paterson
Ann. Allergy Asthma Immunol. 2005 Jun;94(6):675-81. PubMed:15984601
Benefit from anti-inflammatory treatment during clinical remission of atopic asthma. Respir Med 2005 LM. van den Toorn, JB. Prins, JC. de Jongste, K. Leman, PG. Mulder, HC. Hoogsteden, SE. Overbeek
Respir Med 2005 Jun;99(6):779-87. PubMed:15878496
Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests. Thorax 2005 N. Berkman, A. Avital, R. Breuer, E. Bardach, C. Springer, S. Godfrey
Thorax 2005 May;60(5):383-8. PubMed:15860713
Timing and nature of wheezing at the endpoint of a bronchial challenge in preschool children. Pediatr. Pulmonol. 2005 S. Godfrey, S. Cohen, A. Avital, C. Springer
Pediatr. Pulmonol. 2005 Mar;39(3):262-7. PubMed:15668938
Adenosine 5'-monophosphate increases levels of leukotrienes in breath condensate in asthma. Respir Med 2004 E. Bucchioni, Z. Csoma, L. Allegra, KF. Chung, PJ. Barnes, SA. Kharitonov
Respir Med 2004 Jul;98(7):651-5. PubMed:15250231
Exhaled nitric oxide levels and airway responsiveness to adenosine 5'-monophosphate in subjects with nasal polyposis. Int. Arch. Allergy Immunol. 2004 L. Prieto, T. Seijas, V. Gutiérrez, S. Uixera, L. Bruno, R. López
Int. Arch. Allergy Immunol. 2004 Aug;134(4):303-9. PubMed:15205562
Duration of effect of single-dose inhaled fluticasone propionate on AMP-induced bronchoconstriction. Eur. Respir. J. 2004 B. Luijk, RD. Kempsford, AM. Wright, P. Zanen, JW. Lammers
Eur. Respir. J. 2004 Apr;23(4):559-64. PubMed:15083754
Repeated dosing effects of mediator antagonists in inhaled corticosteroid-treated atopic asthmatic patients. Chest 2004 DK. Lee, CM. Jackson, K. Haggart, BJ. Lipworth
Chest 2004 Apr;125(4):1372-7. PubMed:15078748
Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids. Clin. Exp. Allergy 2004 DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth
Clin. Exp. Allergy 2004 Jan;34(1):110-4. PubMed:14720270
A synthetic VIP peptide analogue inhibits neutrophil recruitment in rat airways in vivo. Regul. Pept. 2004 S. Sergejeva, H. Hoshino, S. Yoshihara, K. Kashimoto, J. Lötvall, A. Lindén
Regul. Pept. 2004 Feb;117(2):149-54. PubMed:14700751
The effect of montelukast on bronchial provocation tests and exhaled nitric oxide levels in asthmatic patients. Isr. Med. Assoc. J. 2003 N. Berkman, A. Avital, E. Bardach, C. Springer, R. Breuer, S. Godfrey
Isr. Med. Assoc. J. 2003 Nov;5(11):778-81. PubMed:14650101
Airway responsiveness to adenosine 5'-monophosphate and exhaled nitric oxide measurements: predictive value as markers for reducing the dose of inhaled corticosteroids in asthmatic subjects. Chest 2003 L. Prieto, L. Bruno, V. Gutiérrez, S. Uixera, C. Pérez-Francés, A. Lanuza, A. Ferrer
Chest 2003 Oct;124(4):1325-33. PubMed:14555562
Exhaled nitric oxide is age-dependent in asthma. Pediatr. Pulmonol. 2003 A. Avital, K. Uwyyed, N. Berkman, E. Bar-Yishay, S. Godfrey, C. Springer
Pediatr. Pulmonol. 2003 Nov;36(5):433-8. PubMed:14520727
[New techniques in the study of asthma]. An Sist Sanit Navar 2003 JM. Olaguíbel, MJ. Alvarez, P. Uribe, BE. García, AI. Tabar
An Sist Sanit Navar 2003 ;26 Suppl 2:57-63. PubMed:13679964
Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma. Br J Clin Pharmacol 2003 GP. Currie, JJ. Lima, JE. Sylvester, DK. Lee, WJ. Cockburn, BJ. Lipworth
Br J Clin Pharmacol 2003 Oct;56(4):422-6. PubMed:12968987
Effects of fluticasone plus salmeterol versus twice the dose of fluticasone in asthmatic patients. Eur. J. Clin. Pharmacol. 2003 GP. Currie, CE. Bates, DK. Lee, CM. Jackson, BJ. Lipworth
Eur. J. Clin. Pharmacol. 2003 May;59(1):11-5. PubMed:12743669
The skin vasoconstrictor assay does not correlate significantly to airway or systemic responsiveness to inhaled budesonide in asthmatic patients. Eur. J. Clin. Pharmacol. 2003 AM. Wilson, WJ. Coutie, EJ. Sims, BJ. Lipworth
Eur. J. Clin. Pharmacol. 2003 Feb;58(10):643-7. PubMed:12610738
Effects of montelukast on surrogate inflammatory markers in corticosteroid-treated patients with asthma. Am. J. Respir. Crit. Care Med. 2003 GP. Currie, DK. Lee, K. Haggart, CE. Bates, BJ. Lipworth
Am. J. Respir. Crit. Care Med. 2003 May;167(9):1232-8. PubMed:12456382
Concentrations of exhaled nitric oxide in asthmatics and subjects with allergic rhinitis sensitized to the same pollen allergen. Clin. Exp. Allergy 2002 L. Prieto, V. Gutiérrez, S. Uixera, L. Bruno
Clin. Exp. Allergy 2002 Dec;32(12):1728-33. PubMed:12653163
Modifications of airway responsiveness to adenosine 5'-monophosphate and exhaled nitric oxide concentrations after the pollen season in subjects with pollen-induced rhinitis. Chest 2002 L. Prieto, S. Uixera, V. Gutiérrez, L. Bruno
Chest 2002 Sep;122(3):940-7. PubMed:12226036
Effect of salmeterol on seasonal changes in airway responsiveness and exhaled nitric oxide in pollen-sensitive asthmatic subjects. Chest 2002 L. Prieto, V. Gutiérrez, V. Torres, S. Uixera, J. Marín
Chest 2002 Sep;122(3):798-805. PubMed:12226016
Exhaled nitric oxide and bronchial responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis. Chest 2002 L. Prieto, V. Gutiérrez, S. Uixera
Chest 2002 Jun;121(6):1853-9. PubMed:12065349
Airway inflammation is present during clinical remission of atopic asthma. Am. J. Respir. Crit. Care Med. 2001 LM. van den Toorn, SE. Overbeek, JC. de Jongste, K. Leman, HC. Hoogsteden, JB. Prins
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Am. J. Physiol. Endocrinol. Metab. 2001 Dec;281(6):E1144-50. PubMed:11701427
Corticosteroid-induced improvement in the PC20 of adenosine monophosphate is more closely associated with reduction in airway inflammation than improvement in the PC20 of methacholine. Am. J. Respir. Crit. Care Med. 2001 M. van den Berge, HA. Kerstjens, RJ. Meijer, DM. de Reus, GH. Koëter, HF. Kauffman, DS. Postma
Am. J. Respir. Crit. Care Med. 2001 Oct;164(7):1127-32. PubMed:11673197
PC(20) adenosine 5'-monophosphate is more closely associated with airway inflammation in asthma than PC(20) methacholine. Am. J. Respir. Crit. Care Med. 2001 M. Van Den Berge, RJ. Meijer, HA. Kerstjens, DM. de Reus, GH. Koëter, HF. Kauffman, DS. Postma
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Clin. Exp. Allergy 2001 Apr;31(4):616-24. PubMed:11359431
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Chest 2001 Apr;119(4):1021-6. PubMed:11296164
Effect of inhaled ciclesonide on airway responsiveness to inhaled AMP, the composition of induced sputum and exhaled nitric oxide in patients with mild asthma. Pulm Pharmacol Ther 2001 F. Kanniess, K. Richter, S. Böhme, RA. Jörres, H. Magnussen
Pulm Pharmacol Ther 2001 ;14(2):141-7. PubMed:11273796
Effects of once-daily formoterol and budesonide given alone or in combination on surrogate inflammatory markers in asthmatic adults. Chest 2000 I. Aziz, AM. Wilson, BJ. Lipworth
Chest 2000 Oct;118(4):1049-58. PubMed:11035676
Adolescents in clinical remission of atopic asthma have elevated exhaled nitric oxide levels and bronchial hyperresponsiveness. Am. J. Respir. Crit. Care Med. 2000 LM. van Den Toorn, JB. Prins, SE. Overbeek, HC. Hoogsteden, JC. de Jongste
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Mometasone furoate antagonizes AMP-induced bronchoconstriction in patients with mild asthma. J. Allergy Clin. Immunol. 2000 ST. Holgate, H. Arshad, P. Stryszak, JE. Harrison
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Associated curated diseases 0

No curated diseases are identified in current reference collection.

Associated abnormalities 3

Concept Name External ID Weighted Score Hits References
Pneumonia 986.06 1
  1. Effect of inhaled ciclesonide on airway responsiveness to inhaled AMP, the composition of induced sputum and exhaled nitric oxide in patients with mild asthma.
    F. Kanniess, K. Richter, S. Böhme, RA. Jörres, H. Magnussen (2001) Pulm Pharmacol Ther
Hyperostosis Frontalis Interna 508.83 1
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
Intestinal Diseases 733.47 1
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy

Associated chemicals 7

Concept Name External ID Definition Weighted Score Hits References
Amines CHEBI:32952 812.17 2
  1. Exhaled nitric oxide and bronchial responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.
    L. Prieto, V. Gutiérrez, S. Uixera (2002) Chest
quinoxaline 855.55 2
  1. Exhaled nitric oxide and bronchial responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.
    L. Prieto, V. Gutiérrez, S. Uixera (2002) Chest
3-methylquercetin 815.69 2
  1. Exhaled nitric oxide and bronchial responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.
    L. Prieto, V. Gutiérrez, S. Uixera (2002) Chest
Chlorides 875.94 2
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
kaempferol CHEBI:28499 1000.0 1
  1. Exhaled nitric oxide and bronchial responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.
    L. Prieto, V. Gutiérrez, S. Uixera (2002) Chest
Flavonoids CHEBI:63326 875.5 1
  1. Exhaled nitric oxide and bronchial responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.
    L. Prieto, V. Gutiérrez, S. Uixera (2002) Chest
KT 5720 928.57 1
  1. Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge.
    BJ. Lipworth, EJ. Sims, SK. Das, H. Buck, M. Paterson (2005) Ann. Allergy Asthma Immunol.

Associated functions 23

Concept Name External ID Definition Weighted Score Hits References
inhibitors 838.08 6
  1. Exhaled nitric oxide and bronchial responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.
    L. Prieto, V. Gutiérrez, S. Uixera (2002) Chest
  2. Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge.
    BJ. Lipworth, EJ. Sims, SK. Das, H. Buck, M. Paterson (2005) Ann. Allergy Asthma Immunol.
  3. The use of bronchial challenge to diagnose asthma in preschool children.
    S. Godfrey (2009) Prim Care Respir J
adenylate cyclase activity 991.95 5
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
  2. Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge.
    BJ. Lipworth, EJ. Sims, SK. Das, H. Buck, M. Paterson (2005) Ann. Allergy Asthma Immunol.
reverse transcription polymerase chain reaction 1000.0 3
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
adenylate kinase activity 980.2 3
  1. The use of bronchial challenge to diagnose asthma in preschool children.
    S. Godfrey (2009) Prim Care Respir J
Exocytosis GO:0006887 878.22 3
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
Vasodilation 925.5 2
  1. Exhaled nitric oxide and bronchial responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.
    L. Prieto, V. Gutiérrez, S. Uixera (2002) Chest
Immunoreactivity 944.0 2
  1. Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells.
    K. Morita, A. Sakakibara, S. Kitayama, K. Kumagai, K. Tanne, T. Dohi (2002) J. Pharmacol. Exp. Ther.
  2. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
Phosphorylation 979.0 2
  1. Can exhaled nitric oxide be a surrogate marker of bronchial hyperresponsiveness to adenosine 5'-monophosphate in steroid-naive asthmatic children?
    M. Arga, A. Bakirtas, E. Topal, I. Turktas (2015) Clin. Exp. Allergy
Calmodulin Pathway 950.5 2
  1. Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells.
    K. Morita, A. Sakakibara, S. Kitayama, K. Kumagai, K. Tanne, T. Dohi (2002) J. Pharmacol. Exp. Ther.
Gene Expression 1000.0 2
  1. Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells.
    K. Morita, A. Sakakibara, S. Kitayama, K. Kumagai, K. Tanne, T. Dohi (2002) J. Pharmacol. Exp. Ther.
Signal Transduction GO:0007165 673.5 2
  1. [New techniques in the study of asthma].
    JM. Olaguíbel, MJ. Alvarez, P. Uribe, BE. García, AI. Tabar (2003) An Sist Sanit Navar
  2. Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge.
    BJ. Lipworth, EJ. Sims, SK. Das, H. Buck, M. Paterson (2005) Ann. Allergy Asthma Immunol.
Platelet aggregation 950.5 1
  1. Can exhaled nitric oxide be a surrogate marker of bronchial hyperresponsiveness to adenosine 5'-monophosphate in steroid-naive asthmatic children?
    M. Arga, A. Bakirtas, E. Topal, I. Turktas (2015) Clin. Exp. Allergy
Intestinal chloride secretion 1000.0 1
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
mRNA Expression 906.5 1
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
Functional disorder 683.97 1
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
Reverse Transcription 950.5 1
  1. Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge.
    BJ. Lipworth, EJ. Sims, SK. Das, H. Buck, M. Paterson (2005) Ann. Allergy Asthma Immunol.
antagonists 1000.0 1
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
Baresthesia 794.14 1
  1. Exhaled nitric oxide and bronchial responsiveness to adenosine 5'-monophosphate in subjects with allergic rhinitis.
    L. Prieto, V. Gutiérrez, S. Uixera (2002) Chest
Regulation 1000.0 1
  1. Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge.
    BJ. Lipworth, EJ. Sims, SK. Das, H. Buck, M. Paterson (2005) Ann. Allergy Asthma Immunol.
depolarization 1000.0 1
  1. Dose-response comparison of budesonide dry powder inhalers using adenosine monophosphate bronchial challenge.
    BJ. Lipworth, EJ. Sims, SK. Das, H. Buck, M. Paterson (2005) Ann. Allergy Asthma Immunol.
Cell physiology 1000.0 1
  1. Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells.
    K. Morita, A. Sakakibara, S. Kitayama, K. Kumagai, K. Tanne, T. Dohi (2002) J. Pharmacol. Exp. Ther.
Hypoxia 944.0 1
  1. Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells.
    K. Morita, A. Sakakibara, S. Kitayama, K. Kumagai, K. Tanne, T. Dohi (2002) J. Pharmacol. Exp. Ther.
Stimulus 937.5 1
  1. Can exhaled nitric oxide be a surrogate marker of bronchial hyperresponsiveness to adenosine 5'-monophosphate in steroid-naive asthmatic children?
    M. Arga, A. Bakirtas, E. Topal, I. Turktas (2015) Clin. Exp. Allergy

Associated genes 6

Concept Name External ID Definition Weighted Score Hits References
MAPK3 gene EntrezGene:5595 700.0 2
  1. Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells.
    K. Morita, A. Sakakibara, S. Kitayama, K. Kumagai, K. Tanne, T. Dohi (2002) J. Pharmacol. Exp. Ther.
ADCY6 gene EntrezGene:112 1000.0 1
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
ADCY9 gene EntrezGene:115 1000.0 1
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
ADCY5 gene EntrezGene:111 1000.0 1
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
GLI3 gene EntrezGene:2737 722.22 1
  1. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids.
    DK. Lee, K. Haggart, FM. Robb, BJ. Lipworth (2004) Clin. Exp. Allergy
MAPK1 gene EntrezGene:5594 644.0 1
  1. Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells.
    K. Morita, A. Sakakibara, S. Kitayama, K. Kumagai, K. Tanne, T. Dohi (2002) J. Pharmacol. Exp. Ther.

Chemical Information

Formula C10H14N5O7P
Mass 347.224
Synonyms adenosine 5'-monophosphate
5'-adenylic acid
adenylic acid
Adenosine monophosphate
adenosine phosphate
61-19-8
adenosine 5'-phosphate
Phosphaden
5'-AMP
adenylate
Phosphentaside
Adenovite
Phosaden
Cardiomone
Lycedan
My-B-Den
Vitamin B8
Myoston
5'-adenosine monophosphate
Ergadenylic acid
PubChem CID 6083