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Axial distribution of nitric oxide airway production in asthma patients.
A. Van Muylem, Y. Kerckx, A. Michils
Respir Physiol Neurobiol 2013 Jan;185(2):313-8.
PubMed: 23059373
Abstract
In healthy subjects, axial distribution of nitric oxide (NO) airway production is likely heterogeneous: notably a distal peak of production in terminal bronchioles and a quasi-nil NO production in the most of the conducting airways. In asthma, few information exists about the contributions of the proximal and distal airways to NO overproduction. In 18 asthma patients, sites of constriction after methacholine and adenosine 5'-monophosphate (AMP) challenges were assessed by ventilation distribution tests with He and SF(6). The resulting decreases in fractional exhaled NO (FENO) were measured. Changes in He and SF(6) slopes indicated a pre-acinar bronchoconstriction due to AMP and a more proximal action for methacholine. FENO decreased by 38.7% and 20.2% (p<0.001) after AMP and methacholine challenges, respectively. Significant FENO decreases after AMP and methacholine implies substantial pre-acinar but also, contrary to healthy subjects, more proximal airway production. In conclusion, nitric oxide overproduction in asthma patients appears to involve the most part of the conducting airways.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Adenosine 5'-monophosphate | 92 |