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Design and synthesis of 3,3'-biscoumarin-based c-Met inhibitors.
J. Xu, J. Ai, S. Liu, X. Peng, L. Yu, M. Geng, F. Nan
Org. Biomol. Chem. 2014 Jun;12(22):3721-34.
PubMed: 24781551
Abstract
A library of biscoumarin-based c-Met inhibitors was synthesized, based on optimization of 3,3'-biscoumarin hit 3, which was identified as a non-ATP competitive inhibitor of c-Met from a diverse library of coumarin derivatives. Among these compounds, 38 and 40 not only showed potent enzyme activities with IC50 values of 107 nM and 30 nM, respectively, but also inhibited c-Met phosphorylation in BaF3/TPR-Met and EBC-1 cells.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Adenosine triphosphate | 134 |