Isopropanol

Description

Description of isopropanol with associated disease summary

2-propanol is a potential marker of chronic obstructive pulmonary disease (COPD), pulmonary Langerhans cell histiocytosis (PLCH) and Cystic fibrosis. To detect and quantify acetate, NMR method is applied. In one study about smoking-related diseases including COPD and PLCH, the concentrations of 2-propanol in COPD and PLCH patients are higher than healthy smokers (J Proteome Res. (2013)). 2-propanol can be formed from reduction of acetone by alcohol dehydrogenase in liver. However, no acetone variation were detected. (J Proteome Res. (2013)). More studies has to be performed to explain the relation between alcohols and smoking-related diseases. The 2-propanol concentration difference also observed between cystic fibrosis and healthy control using NMF detection method (Thorax. (2012)). As in COPD and PLCH patients, 2-propanol concentration in CF patients is higher than the healthy control. The increase of 2-propanol may be due to metabolism in bacteria and/or increased lipid degradation and lipid peroxidation. Description of disease(s) related to 2-propanol:

Chronic obstructive pulmonary disease (COPD)

The concentration of EBC 2-propanol is increased in COPD patients (J Proteome Res. (2013)) . Although 2-propanol can be formed from reduction of acetone by alcohol dehydrogenase in liver, no acetone variation were detected. (J Proteome Res. (2013)). More studies has to be performed to explain the relation between alcohols and smoking-related diseases.

Pulmonary Langerhans cell histiocytosis (PLCH)

The concentration of EBC 2-propanol is increased in PLCH patients (J Proteome Res. (2013)) . Although 2-propanol can be formed from reduction of acetone by alcohol dehydrogenase in liver, no acetone variation were detected. (J Proteome Res. (2013)). More studies has to be performed to explain the relation between alcohols and smoking-related diseases.

Disease summary

Cystic fibrosis (CF)

The concentration of EBC 2-propanol is increased in CF patients (Thorax. (2012)). The increase of 2-propanol may be due to metabolism in bacteria and/or increased lipid degradation and lipid peroxidation.

Summary of extracted biomedical information

The involved biomedical functions are known as Skin Absorption, Biochemical Reaction and Disinfectants. Isopropanol is associated with acetonitrile and Propylene Glycols.
Imgsrv

Associated references with human 27

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Reference title

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Journal Year Authors & PubMed Link
Bio-sniffer (gas-phase biosensor) with secondary alcohol dehydrogenase (S-ADH) for determination of isopropanol in exhaled air as a potential volatile biomarker. Biosens Bioelectron 2017 PJ. Chien, T. Suzuki, M. Tsujii, M. Ye, K. Toma, T. Arakawa, Y. Iwasaki, K. Mitsubayashi
Biosens Bioelectron 2017 May;91:341-346. PubMed:28043076
Breath gas concentrations mirror exposure to sevoflurane and isopropyl alcohol in hospital environments in non-occupational conditions. J Breath Res 2016 M. Castellanos, G. Xifra, JM. Fernández-Real, JM. Sánchez
J Breath Res 2016 Jan;10(1):016001. PubMed:26824193
Alcohol increases bonding between the tracheal tube and the tracheal tube connector. A A Case Rep 2015 P. Mullick, A. Kumar, S. Prakash
A A Case Rep 2015 May;4(9):114-6. PubMed:25909775
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate. J. Proteome Res. 2013 G. de Laurentiis, D. Paris, D. Melck, P. Montuschi, M. Maniscalco, A. Bianco, M. Sofia, A. Motta
J. Proteome Res. 2013 Mar;12(3):1502-11. PubMed:23360153
NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis. Thorax. 2012 P. Montuschi, D. Paris, D. Melck, V. Lucidi, G. Ciabattoni, V. Raia, C. Calabrese, A. Bush, PJ. Barnes, A. Motta
Thorax. 2012 Mar;67(3):222-8. doi: 10.1136/thoraxjnl-2011-200072. Epub 2011 Nov 21. PubMed:22106016
Exhaled aerosol transmission of pandemic and seasonal H1N1 influenza viruses in the ferret. PLoS ONE 2012 F. Koster, K. Gouveia, Y. Zhou, K. Lowery, R. Russell, H. MacInnes, Z. Pollock, RC. Layton, J. Cromwell, D. Toleno, J. Pyle, M. Zubelewicz, K. Harrod, R. Sampath, S. Hofstadler, P. Gao, Y. Liu, YS. Cheng
PLoS ONE 2012 ;7(4):e33118. PubMed:22509254
Assessment of exposure to alcohol vapor from alcohol-based hand rubs. Int J Environ Res Public Health 2012 V. Bessonneau, O. Thomas
Int J Environ Res Public Health 2012 03;9(3):868-79. PubMed:22690169
Demonstration that methadone is being present in the exhaled breath aerosol fraction. J Pharm Biomed Anal 2011 O. Beck, S. Sandqvist, J. Franck
J Pharm Biomed Anal 2011 Dec;56(5):1024-8. PubMed:21873017
Eurasian-origin gene segments contribute to the transmissibility, aerosol release, and morphology of the 2009 pandemic H1N1 influenza virus. PLoS Pathog. 2011 SS. Lakdawala, EW. Lamirande, AL. Suguitan, W. Wang, CP. Santos, L. Vogel, Y. Matsuoka, WG. Lindsley, H. Jin, K. Subbarao
PLoS Pathog. 2011 Dec;7(12):e1002443. PubMed:22241979
Biomarkers of recent drinking, retrograde extrapolation of blood-alcohol concentration and plasma-to-blood distribution ratio in a case of driving under the influence of alcohol. J Forensic Leg Med 2011 AW. Jones
J Forensic Leg Med 2011 Jul;18(5):213-6. PubMed:21663869
Quantitative assessment of airborne exposures generated during common cleaning tasks: a pilot study. Environ Health 2010 A. Bello, MM. Quinn, MJ. Perry, DK. Milton
Environ Health 2010 Nov;9:76. PubMed:21118559
Subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution: an intervention study. Environ Health 2010 L. Jacobs, TS. Nawrot, B. de Geus, R. Meeusen, B. Degraeuwe, A. Bernard, M. Sughis, B. Nemery, LI. Panis
Environ Health 2010 Oct;9:64. PubMed:20973949
Characterization of occupational exposures to cleaning products used for common cleaning tasks--a pilot study of hospital cleaners. Environ Health 2009 A. Bello, MM. Quinn, MJ. Perry, DK. Milton
Environ Health 2009 Mar;8:11. PubMed:19327131
Ethanol-based cleanser versus isopropyl alcohol to decontaminate stethoscopes. Am J Infect Control 2009 P. Lecat, E. Cropp, G. McCord, NA. Haller
Am J Infect Control 2009 Apr;37(3):241-3. PubMed:19185394
Dissolved VOC concentrations and salt contents affecting air-sweat equilibrium partition of hydrophilic and hydrophobic VOCs. J Environ Sci Health A Tox Hazard Subst Environ Eng 2008 WH. Cheng
J Environ Sci Health A Tox Hazard Subst Environ Eng 2008 Jan;43(1):98-104. PubMed:18161563
An adaptive breath sampler for use with human subjects with an impaired respiratory function. Analyst 2007 M. Basanta, T. Koimtzis, D. Singh, I. Wilson, CL. Thomas
Analyst 2007 Feb;132(2):153-63. PubMed:17260076
Can alcohol-based hand-rub solutions cause you to lose your driver's license? Comparative cutaneous absorption of various alcohols. Antimicrob. Agents Chemother. 2007 TL. Brown, S. Gamon, P. Tester, R. Martin, K. Hosking, GC. Bowkett, D. Gerostamoulos, ML. Grayson
Antimicrob. Agents Chemother. 2007 Mar;51(3):1107-8. PubMed:17194820
The analysis of 1-propanol and 2-propanol in humid air samples using selected ion flow tube mass spectrometry. Rapid Commun. Mass Spectrom. 2006 T. Wang, W. Carroll, W. Lenny, P. Boit, D. Smith
Rapid Commun. Mass Spectrom. 2006 ;20(2):125-30. PubMed:16331744
Gas chromatography-mass spectroscopy analysis of emissions from cement when using ultrasonically driven tools. Acta Orthop 2005 SB. Shewale, RD. Briggs
Acta Orthop 2005 Oct;76(5):647-50. PubMed:16263610
Personal exposure to ultrafine particles and oxidative DNA damage. Environ. Health Perspect. 2005 PS. Vinzents, P. Møller, M. Sørensen, LE. Knudsen, O. Hertel, FP. Jensen, B. Schibye, S. Loft
Environ. Health Perspect. 2005 Nov;113(11):1485-90. PubMed:16263500
Grand rounds: latex-induced occupational asthma in a surgical pathologist. Environ. Health Perspect. 2005 J. Green-McKenzie, D. Hudes
Environ. Health Perspect. 2005 Jul;113(7):888-93. PubMed:16002378
Urinary sevoflurane and hexafluoro-isopropanol as biomarkers of low-level occupational exposure to sevoflurane. Int Arch Occup Environ Health 2005 A. Accorsi, B. Morrone, I. Domenichini, S. Valenti, GB. Raffi, FS. Violante
Int Arch Occup Environ Health 2005 Jun;78(5):369-78. PubMed:15864632
Breathing and heart rate during experimental solvent exposure of young adults with self-reported multiple chemical sensitivity (sMCS). Neurotoxicology 2003 K. Haumann, E. Kiesswetter, C. van Thriel, M. Blaszkewicz, K. Golka, A. Seeber
Neurotoxicology 2003 Mar;24(2):179-86. PubMed:12606290
Comparison of models for the estimation of biological partition coefficients. J. Toxicol. Environ. Health Part A 2002 MP. Payne, LC. Kenny
J. Toxicol. Environ. Health Part A 2002 Jul;65(13):897-931. PubMed:12133236
Acute sensory irritation from exposure to isopropanol (2-propanol) at TLV in workers and controls: objective versus subjective effects. Ann Occup Hyg 2002 MA. Smeets, C. Mauté, PH. Dalton
Ann Occup Hyg 2002 Jun;46(4):359-73. PubMed:12176705
Analysis of 2-propanol in exhaled breath using in situ enrichment and cataluminescence detection. Luminescence Y. Wu, F. Wen, D. Liu, H. Kong, C. Zhang, S. Zhang
Luminescence 2011 Mar-Apr;26(2):125-9. PubMed:20155729

Associated curated diseases 3

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Associated disease mapping

Mapping of all associated diseases to isopropanol is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

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Number of references
Cystic Fibrosis MeSH: Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967
Link to MeSH Database: D003550
20
Pulmonary Langerhans Cell Histiocytosis MeSH: Histiocytosis, Langerhans-Cell
A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder. Year introduced: 1990(1975)
Link to MeSH Database: D006646
1
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 27 associated references with isopropanol. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 27 associated references with isopropanol. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 27 associated references with isopropanol. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 27 associated references with isopropanol. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C3H8O
Mass 60.096
Synonyms isopropanol
2-Propanol
Isopropyl alcohol
Propan-2-ol
67-63-0
2-Hydroxypropane
Alcojel
Alkolave
Avantine
Hartosol
Dimethylcarbinol
sec-Propyl alcohol
Petrohol
Takineocol
Avantin
i-Propanol
1-Methylethanol
2-Propyl alcohol
Alcolo
Isohol
PubChem CID 3776