Palmitic acid

Description

Description of palmitic acid with associated disease summary

Palmitic acid (hexadecanoic acid) is a saturated fatty acid. Phospholipid esters of palmitic acid compose more than 60% lung surfactant therefore palmitic acid become the majority non-volatile lipid detected in EBC. In addition, the concentration of palmitic acid does not depend on gender, age or smoking. It becomes a reasonable standard for compensating the dilution factor (J Chromatogr B Analyt Technol Biomed Life Sci. (2010)). However, two studies show that the concentration levels of EBC palmitic acid in asthma patients is significantly lower than the concentrations in healthy controls (J Allergy Clin Immunol. (2011), J Allergy Clin Immunol. (2010)). Description of disease(s) related to Palmitic acid:

Disease summary

Asthma

Although the concentration level of EBC palmitic acid is assumed normally distributed among all samples, two studies show that the concentration levels of EBC palmitic acid in asthma patients is significantly lower than the concentrations in healthy controls (J Allergy Clin Immunol. (2011), J Allergy Clin Immunol. (2010)).

Summary of extracted biomedical information

Palmitic acid is associated with abnormalities such as gamma-Chain Disease. The involved biomedical functions are known as Oxidation, fatty acid oxidation, Isoprenylation, palmitoylation and Ingestion. The associated genes/proteins with palmitic acid are EPO gene. Palmitic acid is associated with decanaldehyde, Naphthalene, Tritium, Isotopes and Deuterium.
Imgsrv

Associated references with human 19

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Reference title

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Journal Year Authors & PubMed Link
Targeted eicosanoids lipidomics of exhaled breath condensate in healthy subjects. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2010 M. Sanak, A. Gielicz, K. Nagraba, M. Kaszuba, J. Kumik, A. Szczeklik
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2010 Jul;878(21):1796-800. PubMed:20627827
Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation? Am. J. Physiol. Endocrinol. Metab. 2010 L. Hodson, SE. McQuaid, SM. Humphreys, R. Milne, BA. Fielding, KN. Frayn, F. Karpe
Am. J. Physiol. Endocrinol. Metab. 2010 Oct;299(4):E584-92. PubMed:20628024
Reduced tricarboxylic acid cycle flux in type 2 diabetes mellitus? Diabetologia 2008 P. Schrauwen, MK. Hesselink
Diabetologia 2008 Sep;51(9):1694-7. PubMed:18587560
Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART. Am. J. Physiol. Endocrinol. Metab. 2007 WT. Cade, DN. Reeds, B. Mittendorfer, BW. Patterson, WG. Powderly, S. Klein, KE. Yarasheski
Am. J. Physiol. Endocrinol. Metab. 2007 Mar;292(3):E812-9. PubMed:17106066
The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes. Diabet. Med. 2006 MG. Masding, AJ. Stears, GC. Burdge, SA. Wootton, DD. Sandeman
Diabet. Med. 2006 Jul;23(7):768-74. PubMed:16842482
Pulmonary surfactant in patients with Pneumocystis pneumonia and acquired immunodeficiency syndrome. Crit. Care Med. 2006 R. Schmidt, P. Markart, C. Ruppert, B. Temmesfeld, R. Nass, J. Lohmeyer, W. Seeger, A. Günther
Crit. Care Med. 2006 Sep;34(9):2370-6. PubMed:16849999
Absorption and transport of dietary long-chain fatty acids in cirrhosis: a stable-isotope-tracing study. Am. J. Clin. Nutr. 2005 E. Cabré, JM. Hernández-Pérez, L. Fluvià, C. Pastor, A. Corominas, MA. Gassull
Am. J. Clin. Nutr. 2005 Mar;81(3):692-701. PubMed:15755841
Validation of deuterium-labeled fatty acids for the measurement of dietary fat oxidation during physical activity. J. Lipid Res. 2004 A. Raman, S. Blanc, A. Adams, DA. Schoeller
J. Lipid Res. 2004 Dec;45(12):2339-44. PubMed:15342677
Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. Prostaglandins Leukot. Essent. Fatty Acids 2003 GC. Burdge, SA. Wootton
Prostaglandins Leukot. Essent. Fatty Acids 2003 Oct;69(4):283-90. PubMed:12907139
Palmitoylation and processing of the lipopeptide surfactant protein C. Biochim. Biophys. Acta 2002 A. ten Brinke, LM. van Golde, JJ. Batenburg
Biochim. Biophys. Acta 2002 Aug;1583(3):253-65. PubMed:12176392
Effects of obesity on substrate utilization during exercise. Obes. Res. 2002 BH. Goodpaster, RR. Wolfe, DE. Kelley
Obes. Res. 2002 Jul;10(7):575-84. PubMed:12105277
Kinetics of intramuscular triglyceride fatty acids in exercising humans. J. Appl. Physiol. 2000 Z. Guo, B. Burguera, MD. Jensen
J. Appl. Physiol. 2000 Nov;89(5):2057-64. PubMed:11053362
Differential oxidation of individual dietary fatty acids in humans. Am. J. Clin. Nutr. 2000 JP. DeLany, MM. Windhauser, CM. Champagne, GA. Bray
Am. J. Clin. Nutr. 2000 Oct;72(4):905-11. PubMed:11010930
Lipolysis and lipid oxidation in weight-losing cancer patients and healthy subjects. Metab. Clin. Exp. 2000 SD. Zuijdgeest-van Leeuwen, JW. van den Berg, JL. Wattimena, A. van der Gaast, GR. Swart, JH. Wilson, PC. Dagnelie
Metab. Clin. Exp. 2000 Jul;49(7):931-6. PubMed:10910006
Eicosapentaenoic acid ethyl ester supplementation in cachectic cancer patients and healthy subjects: effects on lipolysis and lipid oxidation. Clin Nutr 2000 SD. Zuijdgeest-Van Leeuwen, PC. Dagnelie, JL. Wattimena, JW. Van den Berg, A. Van der Gaast, GR. Swart, JH. Wilson
Clin Nutr 2000 Dec;19(6):417-23. PubMed:11104593
Effect of fatty acid chain length and saturation on the gastrointestinal handling and metabolic disposal of dietary fatty acids in women. Br. J. Nutr. 1999 AE. Jones, M. Stolinski, RD. Smith, JL. Murphy, SA. Wootton
Br. J. Nutr. 1999 Jan;81(1):37-43. PubMed:10341674
The gastrointestinal handling and metabolism of [1-13C]palmitic acid in healthy women. Lipids 1995 JL. Murphy, A. Jones, S. Brookes, SA. Wootton
Lipids 1995 Apr;30(4):291-8. PubMed:7609595
Multicenter trial of single-dose modified bovine surfactant extract (Survanta) for prevention of respiratory distress syndrome. Ross Collaborative Surfactant Prevention Study Group. Pediatrics 1990 RF. Soll, RE. Hoekstra, JJ. Fangman, AJ. Corbet, JM. Adams, LS. James, K. Schulze, W. Oh, JD. Roberts, JP. Dorst
Pediatrics 1990 Jun;85(6):1092-102. PubMed:2187176
Chain shortening of palmitic acid in human subjects. Am. J. Clin. Nutr. 1988 MT. Clandinin, S. Khetarpal, ES. Kielo, MA. French, B. Tokarska, YK. Goh
Am. J. Clin. Nutr. 1988 Sep;48(3):587-91. PubMed:3414572

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to palmitic acid is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
91
Aspirin Sensitive Asthma MeSH: Asthma, Aspirin-Induced
Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use. Year introduced: 2010
Link to MeSH Database: D055963
2

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 19 associated references with palmitic acid. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 6

Concept Name External ID Definition Weighted Score Hits References
Isotopes 854.0 1
  1. Validation of deuterium-labeled fatty acids for the measurement of dietary fat oxidation during physical activity.
    A. Raman, S. Blanc, A. Adams, DA. Schoeller (2004) J. Lipid Res.
Deuterium 925.0 1
  1. Validation of deuterium-labeled fatty acids for the measurement of dietary fat oxidation during physical activity.
    A. Raman, S. Blanc, A. Adams, DA. Schoeller (2004) J. Lipid Res.
Esters CHEBI:35701 944.0 1
  1. Targeted eicosanoids lipidomics of exhaled breath condensate in healthy subjects.
    M. Sanak, A. Gielicz, K. Nagraba, M. Kaszuba, J. Kumik, A. Szczeklik (2010) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
decanaldehyde 769.23 1
  1. Volatile organics off-gassed among tobacco-exposed clothing fabrics.
    YC. Chien, CP. Chang, ZZ. Liu (2011) J. Hazard. Mater.
Naphthalene CHEBI:16482 1000.0 1
  1. Volatile organics off-gassed among tobacco-exposed clothing fabrics.
    YC. Chien, CP. Chang, ZZ. Liu (2011) J. Hazard. Mater.
Phenols CHEBI:33853 928.57 1
  1. Volatile organics off-gassed among tobacco-exposed clothing fabrics.
    YC. Chien, CP. Chang, ZZ. Liu (2011) J. Hazard. Mater.

Associated functions 3

Concept Name External ID Definition Weighted Score Hits References
palmitoylation 1000.0 1
  1. Palmitoylation and processing of the lipopeptide surfactant protein C.
    A. ten Brinke, LM. van Golde, JJ. Batenburg (2002) Biochim. Biophys. Acta
Ingestion 825.94 1
  1. Validation of deuterium-labeled fatty acids for the measurement of dietary fat oxidation during physical activity.
    A. Raman, S. Blanc, A. Adams, DA. Schoeller (2004) J. Lipid Res.
Ion Transport 873.58 1
  1. Volatile organics off-gassed among tobacco-exposed clothing fabrics.
    YC. Chien, CP. Chang, ZZ. Liu (2011) J. Hazard. Mater.

Associated genes 1

Concept Name External ID Definition Weighted Score Hits References
EPO gene EntrezGene:2056 694.0 1
  1. Volatile organics off-gassed among tobacco-exposed clothing fabrics.
    YC. Chien, CP. Chang, ZZ. Liu (2011) J. Hazard. Mater.

Chemical Information

Formula C16H32O2
Mass 256.43
Synonyms palmitic acid
Hexadecanoic acid
Cetylic acid
palmitate
n-Hexadecanoic acid
57-10-3
Hexadecylic acid
Hydrofol
n-Hexadecoic acid
1-Pentadecanecarboxylic acid
Palmitinic acid
Pentadecanecarboxylic acid
C16 fatty acid
hexaectylic acid
Industrene 4516
Emersol 140
Emersol 143
Hystrene 8016
Hystrene 9016
1-Hexyldecanoic Acid
PubChem CID 985