Ethanol

Description

Description of ethanol with associated disease summary

Ethanol is an important compound in glycolysis and gluconeogenesis pathway. To detect and quantify ethanol, NMR method is applied. In one study about smoking-related diseases including chronic obstructive pulmonary disease (COPD) and pulmonary Langerhans cell histiocytosis (PLCH), the concentrations of ethanol, methanol and 2-propanol in COPD and PLCH patients are higher than healthy smokers (J Proteome Res. (2013)). However, the ethanol and methanol increase in both COPD and PLCH patients cannot be linked to the reduction of acetone by liver alcohol dehydrogenase due to no acetone variation is detected (J Proteome Res. (2013)). More studies has to be performed to explain the relation between alcohols and smoking-related diseases. The ethanol concentration difference also observed between cystic fibrosis and healthy control using NMF detection method (Thorax. (2012)). Ethanol concentration in CF patients is also higher than the healthy control. The increase of ethanol may be related to the reduced ability of Pseudomonas aeruginosa to oxidize ethanol to acetate. Description of disease(s) related to ethanol:

Chronic obstructive pulmonary disease (COPD)

The concentration of EBC ethanol is increased in COPD patients (J Proteome Res. (2013)) . However, the ethanol and methanol increase in both COPD and PLCH patients cannot be linked to the reduction of acetone by liver alcohol dehydrogenase or other pathways (J Proteome Res. (2013)). More studies has to be performed to explain the relation between alcohols and smoking-related diseases.

Pulmonary Langerhans cell histiocytosis (PLCH)

The concentration of EBC ethanol is increased in COPD patients (J Proteome Res. (2013)). However, the ethanol and methanol increase in both COPD and PLCH patients cannot be linked to the reduction of acetone by liver alcohol dehydrogenase or other pathways (J Proteome Res. (2013)). More studies has to be performed to explain the relation between alcohols and smoking-related diseases.

Cystic fibrosis

The concentration of EBC ethanol is increased in CF patients (Thorax. (2012)). The increase of ethanol may be related to the reduced ability of Pseudomonas aeruginosa to oxidize ethanol to acetate.

Summary of extracted biomedical information

Imgsrv

Associated references with human 3

Download references
Reference title

with link to reference page

Journal Year Authors & PubMed Link
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate. J. Proteome Res. 2013 G. de Laurentiis, D. Paris, D. Melck, P. Montuschi, M. Maniscalco, A. Bianco, M. Sofia, A. Motta
J. Proteome Res. 2013 Mar;12(3):1502-11. PubMed:23360153
NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis. Thorax. 2012 P. Montuschi, D. Paris, D. Melck, V. Lucidi, G. Ciabattoni, V. Raia, C. Calabrese, A. Bush, PJ. Barnes, A. Motta
Thorax. 2012 Mar;67(3):222-8. doi: 10.1136/thoraxjnl-2011-200072. Epub 2011 Nov 21. PubMed:22106016

Associated curated diseases 3

Download diseases

Associated disease mapping

Mapping of all associated diseases to ethanol is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Cystic Fibrosis MeSH: Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967
Link to MeSH Database: D003550
20
Pulmonary Langerhans Cell Histiocytosis MeSH: Histiocytosis, Langerhans-Cell
A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder. Year introduced: 1990(1975)
Link to MeSH Database: D006646
1
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 3 associated references with ethanol. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 3 associated references with ethanol. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 3 associated references with ethanol. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 3 associated references with ethanol. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C2H6O
Mass 46.069
Synonyms ethanol
ethyl alcohol
alcohol
Methylcarbinol
grain alcohol
Ethyl hydroxide
Ethyl hydrate
64-17-5
Algrain
Alkohol
Anhydrol
Tecsol
EtOH
Denatured alcohol
Hydroxyethane
Jaysol S
Potato alcohol
Cologne Spirit
Absolute ethanol
Alcool ethylique
PubChem CID 702