Formate

Description

Description of formate with associated disease summary

Formate is the anion derived from formic acid which is the simplest carboxylic acid. Formate is an intermediate in normal metabolism and it typically produced as a byproduct in the production of acetate. Recently, Formate was used to separate the patients with smoking-related diseases using NMR-based metabolomics of exhaled breath condensate (EBC) (J Proteome Res. (2013)). Description of disease(s) related to Formate:

Disease summary

Pulmonary Langerhans Cell Histiocytosis (PLCH)

The increase in the level of formate was found in subjects with PLCH, compared to COPD subjects.

Chronic Obstructive Pulmonary Disease (COPD)

The decrease in the level of formate was found in subjects with COPD, compared to normal and PLCH subjects.

Summary of extracted biomedical information

The involved biomedical functions are known as Adjudication, Analyte and Ingestion. formate is associated with Glycolates, Oxalates, Fumarates, Organic acid and Sulfuric Acid Esters.
Imgsrv

Associated references with human 3

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Reference title

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Journal Year Authors & PubMed Link
Separation of oxalate, formate and glycolate in human body fluid samples by capillary electrophoresis with contactless conductometric detection. J Chromatogr A 2014 P. Kubáň, P. Ďurč, M. Bittová, F. Foret
J Chromatogr A 2014 Jan;1325:241-6. PubMed:24388242
Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate. J. Proteome Res. 2013 G. de Laurentiis, D. Paris, D. Melck, P. Montuschi, M. Maniscalco, A. Bianco, M. Sofia, A. Motta
J. Proteome Res. 2013 Mar;12(3):1502-11. PubMed:23360153
Effects of sample processing, time and storage condition on cysteinyl leukotrienes in exhaled breath condensate. J Breath Res 2010 AS. Ohanian, J. Zimmerman, JS. Debley
J Breath Res 2010 Dec;4(4):046002. PubMed:21383485

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to formate is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 3 associated references with formate. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 3 associated references with formate. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 3 associated references with formate. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 3 associated references with formate. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula CHO2
Mass 45.017
Synonyms formate
Formic acid, ion(1-)
HCO2 anion
71-47-6
aminate
formylate
methanoate
hydrogen carboxylate
Ammonium tetraformate
CHEMBL183491
formiate
Formate ion
Sodium
formate
a carboxyl group
Hydrogencarboxylic acid
HCOO-
AC1L18W4
GTPL4540
CHEBI:15740
CTK5I5292
PubChem CID 283