Thionitrous acid

Description

Description of Thionitrous acid with associated disease summary

Nitrosothiols (RS-NOs) are formed by interaction of thiols with nitric oxide (NO) and NO metabolites. This formation serve to stabilize NO into a non-cytotoxic form. RS-NOs are biologically active as vasodilators and bronchodilators. Inflammation or immune activation may be important stimulants of RSNOs generation.. RS-NOs levels in EBC are reported to be elevated in severe asthma, COPD, CF subjects and in smokers. A correlation is shown between EBC RS-NOs values and smoking history. However, there is no difference in RS-NOs concentrations in patients with mild asthma and healthy control (Am J Respir Crit Care Med. (2001)). RS-NOs are detected using a colorimetric assay kit. The assay is based upon the classic reaction of Saville and Griess. The analysis of EBC RS-NOS may have clinical relevance as a noninvasive biomarker of airway nitrosative stress. It is suggested that RS-NOs may be a better index of NO biologic pathway than NO2 in classifying asthma severity. Description of disease(s) related to Nitrosothiols (RS-NOs):

Disease summary

Asthma

Concentrations of EBC RS-NOs increase in severe asthma subjects. RS-NOs levels in mild asthma subjects are not different from one in health control.

Cystic fibrosis (CF)

High levels of RS-NOs in EBC are found in patients with CF.

Chronic obstructive pulmonary disease (COPD)

EBC RS-NOs values are shown to be increased in patients with COPD.

Summary of extracted biomedical information

The involved biomedical functions are known as Exhalation, Respiratory physiology, Recurrent inflammation and Inflammation.

Associated references with human 2

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Reference title

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Journal Year Authors & PubMed Link
S-nitrosothiols regulate cell-surface pH buffering by airway epithelial cells during the human immune response to rhinovirus. Am. J. Physiol. Lung Cell Mol. Physiol. 2006 S. Carraro, J. Doherty, K. Zaman, I. Gainov, R. Turner, J. Vaughan, JF. Hunt, J. Márquez, B. Gaston
Am. J. Physiol. Lung Cell Mol. Physiol. 2006 May;290(5):L827-32. PubMed:16603595
Nitric oxide metabolites are not reduced in exhaled breath condensate of patients with primary ciliary dyskinesia. Chest 2003 Z. Csoma, A. Bush, NM. Wilson, L. Donnelly, B. Balint, PJ. Barnes, SA. Kharitonov
Chest 2003 Aug;124(2):633-8. PubMed:12907553

Associated curated diseases 3

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Associated disease mapping

Mapping of all associated diseases to Thionitrous acid is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249 		91
Cystic Fibrosis MeSH: Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967
Link to MeSH Database: D003550 		20
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424 		31

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 2 associated references with Thionitrous acid. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 2 associated references with Thionitrous acid. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 2 associated references with Thionitrous acid. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 2 associated references with Thionitrous acid. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula HNOS
Mass 63.074
Synonyms Thionitrous acid
UNII-852497M0QB
29335-37-3
S-Nitrosothiol
Thionitrous acid (hnos)
nitrososulfane
nitrosothiol
Nitrososulfur
nitrosomercaptan
HSNO
HSN=O
(hydridosulfanido)oxidonitrogen
CHEBI:65308
DTXSID90183573
852497M0QB
FT-0673401
PubChem CID 11389353