Hexaldehyde

Description

Description of Hexaldehyde with associated disease summary

Individual aldehydes resulting from lipid peroxidation can be measured in exhaled breath condensate (EBC). Whether the levels of aldehydes could be used for comparison between patients with stable/moderate to severe/chronic obstructive pulmonary diseases with those of smoking/nonsmoking control subjects was investigated. Hexanal is a known breakdown product of oxidized linoleic and arachidonic, palmitoleic, and oleic acid, respectively. Hexanal could be measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Hexanal increased in patients with COPD as compared with nonsmoking control subjects (p=0.004) but not compared with smoking control subjects (p=0.1). Literature suggests different aldehydes can be identified and measured in EBC of humans; these aldehydes may be envisaged as potential biomarkers for monitoring diseases and response to therapy; of which hexanal is one of these aldehydes ( Am J Respir Crit Care Med. (2003) ). Description of disease(s) related to Hexanal:

Disease summary

Chronic obstructive pulmonary disease (COPD)

Hexanal increased in patients with COPD as compared with nonsmoking control subjects (p=0.004) but not compared with smoking control subjects (p=0.1) ( Am J Respir Crit Care Med. (2003) ).

Summary of extracted biomedical information

The involved biomedical functions are known as peroxidation and Lipid Peroxidation. Hexaldehyde is associated with n-hexanal, Aldehydes, pentanal, Complex Mixtures and Schiff Bases.
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Associated references with human 8

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Journal Year Authors & PubMed Link
Volatile organic compounds associated with Plasmodium falciparum infection in vitro. Parasit Vectors 2017 R. Correa, LM. Coronado, AC. Garrido, AA. Durant-Archibold, C. Spadafora
Parasit Vectors 2017 May;10(1):215. PubMed:28464853
MicroRNA response of inhalation exposure to hexanal in lung tissues from Fischer 344 rats. Environ. Toxicol. 2016 Y. Cho, MK. Song, SC. Jeong, K. Lee, Y. Heo, TS. Kim, JC. Ryu
Environ. Toxicol. 2016 Dec;31(12):1909-1921. PubMed:26403475
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Detection of multiple sclerosis from exhaled breath using bilayers of polycyclic aromatic hydrocarbons and single-wall carbon nanotubes. ACS Chem Neurosci 2011 R. Ionescu, Y. Broza, H. Shaltieli, D. Sadeh, Y. Zilberman, X. Feng, L. Glass-Marmor, I. Lejbkowicz, K. Müllen, A. Miller, H. Haick
ACS Chem Neurosci 2011 Dec;2(12):687-93. PubMed:22860162
Comparison of metabolomic profiles obtained using chemical ionization and electron ionization MS in exhaled breath. Bioanalysis 2011 MA. Turner, C. Guallar-Hoyas, AL. Kent, ID. Wilson, CL. Thomas
PubMed:22185273
Phase-resolved real-time breath analysis during exercise by means of smart processing of PTR-MS data. Anal Bioanal Chem 2011 H. Schwoebel, R. Schubert, M. Sklorz, S. Kischkel, R. Zimmermann, JK. Schubert, W. Miekisch
Anal Bioanal Chem 2011 Oct;401(7):2079-91. PubMed:21706328
Chemosensory irritations and pulmonary effects of acute exposure to emissions from oriented strand board. Hum Exp Toxicol 2011 R. Gminski, R. Marutzky, S. Kevekordes, F. Fuhrmann, W. Bürger, D. Hauschke, W. Ebner, V. Mersch-Sundermann
Hum Exp Toxicol 2011 Sep;30(9):1204-21. PubMed:21071553
Differences in source emission rates of volatile organic compounds in inner-city residences of New York City and Los Angeles. J Expo Anal Environ Epidemiol 2004 SN. Sax, DH. Bennett, SN. Chillrud, PL. Kinney, JD. Spengler
J Expo Anal Environ Epidemiol 2004 ;14 Suppl 1:S95-109. PubMed:15118751

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to Hexaldehyde is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 8 associated references with Hexaldehyde. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 8 associated references with Hexaldehyde. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 8 associated references with Hexaldehyde. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 8 associated references with Hexaldehyde. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C6H12O
Mass 100.161
Synonyms HEXANAL
Caproaldehyde
Hexaldehyde
66-25-1
Caproic aldehyde
1-Hexanal
Capronaldehyde
n-Hexanal
Hexanaldehyde
n-Caproaldehyde
Hexylaldehyde
Aldehyde C-6
Hexyl aldehyde
n-Caproylaldehyde
Hexoic aldehyde
n-Hexaldehyde
n-Capronaldehyde
C6 aldehyde
n-Caproic aldehyde
Kapronaldehyd
PubChem CID 6184