2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane

Summary of extracted biomedical information

Associated references with human 9

Reference title with link to reference page	Journal	Year	Authors & PubMed Link
Glass bottle sampling solid phase microextraction gas chromatography mass spectrometry for breath analysis of drug metabolites.	J Chromatogr A	2017	Y. Lu, W. Niu, X. Zou, C. Shen, L. Xia, C. Huang, H. Wang, H. Jiang, Y. Chu J Chromatogr A 2017 May;1496:20-24. PubMed:28365077
Effect of 1.8-Cineole in Dermatophagoides pteronyssinus-Stimulated Bronchial Epithelial Cells and Mouse Model of Asthma.	Biol. Pharm. Bull.	2016	HS. Lee, DE. Park, WJ. Song, HW. Park, HR. Kang, SH. Cho, SW. Sohn Biol. Pharm. Bull. 2016 ;39(6):946-52. PubMed:27251496
Phytochemical screening, anticancer and antioxidant activities of Origanum vulgare L. ssp. viride (Boiss.) Hayek, a plant of traditional usage.	J. Sci. Food Agric.	2015	S. Koldaş, I. Demirtas, T. Ozen, MA. Demirci, L. Behçet J. Sci. Food Agric. 2015 Mar;95(4):786-98. PubMed:25200133
A review of the volatiles from the healthy human body.	J Breath Res	2014	B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Ion mobility spectrometry for pharmacokinetic studies--exemplary application.	J Breath Res	2013	V. Ruzsanyi J Breath Res 2013 Dec;7(4):046008. PubMed:24287589
Time-dependent aroma changes in breast milk after oral intake of a pharmacological preparation containing 1,8-cineole.	Clin Nutr	2012	F. Kirsch, J. Beauchamp, A. Buettner Clin Nutr 2012 Oct;31(5):682-92. PubMed:22405404
Real-time breath gas analysis for pharmacokinetics: monitoring exhaled breath by on-line proton-transfer-reaction mass spectrometry after ingestion of eucalyptol-containing capsules.	J Breath Res	2010	J. Beauchamp, F. Kirsch, A. Buettner J Breath Res 2010 Jun;4(2):026006. PubMed:21383474
Flavor release and perception in hard candy: influence of flavor compound-flavor solvent interactions.	J. Agric. Food Chem.	2004	AL. Schober, DG. Peterson J. Agric. Food Chem. 2004 May;52(9):2628-31. PubMed:15113169
Flavor release and perception in hard candy: influence of flavor compound-compound interactions.	J. Agric. Food Chem.	2004	AL. Schober, DG. Peterson J. Agric. Food Chem. 2004 May;52(9):2623-7. PubMed:15113168

Associated curated diseases 3

Download diseases

Associated disease mapping

Mapping of all associated diseases to 2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Chronic Obstructive Pulmonary Disease (Copd)	MeSH: Pulmonary Disease, Chronic Obstructive A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002 Link to MeSH Database: D029424	31
Asthma	MeSH: Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Link to MeSH Database: D001249	91
Bronchiectasis	MeSH: Bronchiectasis Persistent abnormal dilatation of the bronchi. Link to MeSH Database: D001987	3

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 9 associated references with 2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 9 associated references with 2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 9 associated references with 2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 9 associated references with 2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₁₀H₁₈O
Mass	154.253
Synonyms	Eucalyptol cineole 1,8-Cineole 1,8-Cineol Cajeputol 470-82-6 1,8-Epoxy-p-menthane Eucalyptole Zineol Eucapur Terpan p-Cineole 1,8-Oxido-p-menthane 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane Eukalyptol CINEOL Cucalyptol Eukalyptol [Czech] Soledum Eucalyptol (natural) Zedoary oil p-Menthane, 1,8-epoxy- Cineole (VAN) EUCALYPTUS OIL 2-Oxabicyclo[2.2.2]octane, 1,3,3-trimethyl- Eucalyptol [USAN] NCI-C56575 UNII-RV6J6604TK FEMA No. 2465 NSC 6171 1,3,3-Trimethyl-2-oxabicyclo(2.2.2)octane 2-Oxa-1,3,3-trimethylbicyclo(2.2.2)octane Eucalyptol (USAN) 2-Oxabicyclo(2.2.2)octane, 1,3,3-trimethyl- CCRIS 3727 HSDB 991 Cineole (Eucalyptol) NSC6171 2,2,4-trimethyl-3-oxabicyclo[2.2.2]octane 2-Oxa-1,3,3-trimethylbicyclo[2.2.2]octane EINECS 207-431-5 eucaliptol eucalytol Cineolum BIDD:ER0481 AI3-00578 RV6J6604TK CNL 4,7,7-trimethyl-8-oxabicyclo[2.2.2]octane CHEBI:27961 WEEGYLXZBRQIMU-UHFFFAOYSA-N 8000-48-4 NCGC00091666-01 NCGC00091666-04 WLN: T66 A B AOTJ B1 B1 F1 DSSTox_CID_616 DSSTox_RID_75692 DSSTox_GSID_20616 W-106080 CAS-470-82-6 SMR000471853 Eucalyptol [USAN:USP] (1s,4s)-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane Eucalyptol,(S) 1.8-cineole Eucalyptol, 99% Eucalyptol, Ph Helv p-Menthane,8-epoxy- 1,8-Cineol AC1L1EEE Spectrum2_000221 Spectrum3_000683 Spectrum4_001747 Spectrum5_000704 1,8-cineol (eucalyptol) bmse000523 D05YAR EC 207-431-5 Casella-med brand of cineole SCHEMBL19622 SCHEMBL41020 BSPBio_002405 KBioGR_002194 MLS001050089 MLS001066338 DivK1c_000333 SPECTRUM1500294 SPBio_000261 Eucalyptol, analytical standard CHEMBL485259 GTPL2464 CHEMBL1231862 CHEMBL1397305 DTXSID4020616 SCHEMBL13554591 SCHEMBL17836873 CTK6B3326 HMS501A15 KBio1_000333 KBio3_001625 MolPort-039-339-173 NINDS_000333 HMS2271P04 Pharmakon1600-01500294 ZINC967566 p-Menthane, 1,8-epoxy- (VAN) HY-N0066 NSC-6171 Tox21_111161 Tox21_202090 Tox21_302902 5750AF CCG-36080 LS-128 MFCD00167977 NSC760388 SBB057535 Acylated oxime isatin derivative, 19 AKOS015903223 AKOS016034339 Tox21_111161_1 CS-8146 DB03852 FCH1679459 LMPR0102090019 NSC-760388 IDI1_000333 Eucalyptol, tested according to Ph.Eur. NCGC00091666-02 NCGC00091666-03 NCGC00091666-05 NCGC00095774-01 NCGC00178671-01 NCGC00256479-01 NCGC00259639-01 AC-20234 AN-23469 Eucalyptol, natural, >=99%, FCC, FG KB-51836 NCI60_005108 SC-47256 ST096004 1,3-Trimethyl-2-oxabicyclo[2.2.2]octane 2-Oxa-1,3-trimethylbicyclo[2.2.2]octane TR-017465 2-Oxabicyclo[2.2.2]octane,3,3-trimethyl- FT-0607033 FT-0626369 1,3,3-Trimethyl-2-oxabicyclo[2,2,2]octan 1,3,3-trimethyl-2-oxabicyclo[2,2,2]octane 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan A19469 C09844 D04115 {1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane} {2-Oxa-1,3,3-trimethylbicyclo[2.2.2]octane} AB01563262_01 SR-01000763816 {2-Oxabicyclo[2.2.2]octane,} 1,3,3-trimethyl- SR-01000763816-2 1,8-Cineole, primary pharmaceutical reference standard I14-18994 Cineole, European Pharmacopoeia (EP) Reference Standard Eucalyptol, certified reference material, TraceCERT(R) F0001-1260 Eucalyptol Solution, 1000 mg/L, (RM, ISO GUIDE 34) 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane (ACD/Name 4.0) Eucalyptol, United States Pharmacopeia (USP) Reference Standard Eucalyptol (cineole), Pharmaceutical Secondary Standard Certified Reference Material InChI=1/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H 10458-11-4 8024-52-0 8024-53-1 855347-23-8
PubChem CID	2758