Description of 12-HETE with associated disease summary
AsthmaConcentration of EBC 12-HETE increases in asthma subjects.
Aspirin-induced asthmaEBC 12-HETE increases in aspirin-induced asthma subjects. There is no significance difference in the level of 12-HETE between asthma and aspirin-induced asthma subjects.
Chronic obstructive pulmonary disease (COPD)EBC 12-HETE level decreases in COPD subjects. However, 12-HETE level is reported to be dysregulated in COPD subjects.
Churg-Strauss syndrome (CSS)A significant elevation of 12-HETE EBC is observed in CSS subjects in contrast to healthy controls, asthma and HES. The increase in 12-HETE is independent of the activity of CSS.
Summary of extracted biomedical information
Associated references with human 2Download references
with link to reference page
|Journal||Year||Authors & PubMed Link|
|Distinct eicosanoid profile in exhaled breath condensates from granulomatosis with polyangiitis (Wegener's) patients.||Clin. Rheumatol.||2013||
W. Szczeklik, M. Sanak, B. Sokołowska, B. Jakieła, J. Sznajd, A. Gielicz, M. Kaszuba, A. Sawina, J. Musiał
Clin. Rheumatol. 2013 Oct;32(10):1549-52. PubMed:23728497
|Eicosanoids in sickle cell disease: potential relevance of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid to the pathophysiology of vaso-occlusion.||J. Lab. Clin. Med.||1998||
BN. Setty, D. Chen, P. O'Neal, JB. Littrell, MH. Grossman, MJ. Stuart
J. Lab. Clin. Med. 1998 Apr;131(4):344-53. PubMed:9579388
Associated curated diseases 4Download diseases
Associated disease mapping
Mapping of all associated diseases to 12-HETE is displayed in red.
with link to disease page
Description of MeSH term
with link to MeSH Database
|Number of references|
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Link to MeSH Database: D001249
|Churg Strauss Syndrome||
Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA. Year introduced: 1989Link to MeSH Database: D015267
|Chronic Obstructive Pulmonary Disease (Copd)||
Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002Link to MeSH Database: D029424
|Aspirin Sensitive Asthma||
Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use. Year introduced: 2010Link to MeSH Database: D055963
Associated abnormalities 0
No associated abnormalities are detected in current reference collection.
There are 2 associated references with 12-HETE. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.
Associated chemicals 0
No associated chemicals are detected in current reference collection.
There are 2 associated references with 12-HETE. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.
Associated functions 0
No associated functions are detected in current reference collection.
There are 2 associated references with 12-HETE. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.
Associated genes 0
No associated genes are detected in current reference collection.
There are 2 associated references with 12-HETE. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
NCBI Entrez Crosslinks
5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (E,Z,Z,Z)-