1-methylimidazole

Description

Description of 1-methylimidazole with associated disease summary

Nuclear magnetic resonance (NMR)-based metabolomics has the ability to separate exhaled breath condensate (EBC) profiles of patients affected by pulmonary diseases from those of healthy subjects. In a study, 50 duplicated EBC samples from smokers (without COPD, with COPD, or with pulmonary Langerhans cell histiocytosis (PLCH)) were analyzed by means of NMR spectroscopy followed by principal component analysis (PCA) and projection to latent structures discriminant analysis (PLSDA). The result shows clusterization of EBC spectra was disease-specific; COPD and PLCH samples present a profile different from that of HS (smokes without COPD), showing 1-methylimidazole reduction. The concentration of 1-methylimidazole is drastically reduced in COPD and in PLCH. The ratio of 1-methylimidazole concentration in HS:COPD:PLCH is 1:0.05:0.28 respectively ( J Proteome Res. (2013) ). EBC-NMR investigation offers a powerful tool for assessing the evolution of airway diseases even in the presence of a strong common factor: smoking. ( J Proteome Res. (2013) ) Description of disease(s) related to 1-methylimidazole:

Disease summary

Pulmonary Langerhans cell histiocytosis (PLCH)

The concentration of 1-methylimidazole is drastically reduced in COPD and in PLCH ( J Proteome Res. (2013) ).

Chronic obstructive pulmonary disease (COPD)

The concentration of 1-methylimidazole is drastically reduced in COPD and in PLCH ( J Proteome Res. (2013) ).

Summary of extracted biomedical information

Associated references with human 2

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link
A review of the volatiles from the healthy human body.	J Breath Res	2014	B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate.	J. Proteome Res.	2013	G. de Laurentiis, D. Paris, D. Melck, P. Montuschi, M. Maniscalco, A. Bianco, M. Sofia, A. Motta J. Proteome Res. 2013 Mar;12(3):1502-11. PubMed:23360153

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to 1-methylimidazole is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Pulmonary Langerhans Cell Histiocytosis	MeSH: Histiocytosis, Langerhans-Cell A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder. Year introduced: 1990(1975) Link to MeSH Database: D006646	1
Chronic Obstructive Pulmonary Disease (Copd)	MeSH: Pulmonary Disease, Chronic Obstructive A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002 Link to MeSH Database: D029424	31

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 2 associated references with 1-methylimidazole. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 2 associated references with 1-methylimidazole. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 2 associated references with 1-methylimidazole. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 2 associated references with 1-methylimidazole. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₄H₆N₂
Mass	82.106
Synonyms	1-methylimidazole N-Methylimidazole 1-Methyl-1H-imidazole 616-47-7 1H-Imidazole, 1-methyl- IMIDAZOLE, 1-METHYL- methylimidazole n-methyl imidazole 1-methyl-imidazole EINECS 210-484-7 NSC 88064 CHEBI:113454 MCTWTZJPVLRJOU-UHFFFAOYSA-N MFCD00005292 AK105901 1-Methylimidazole-d3 Q-200126 UNII-P4617QS63Y N-methylimidazol 1-methylimidazol
PubChem CID	1390