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Volatile Organic Compounds in Exhaled Breath of Idiopathic Pulmonary Fibrosis for Discrimination from Healthy Subjects.
YI. Yamada, G. Yamada, M. Otsuka, H. Nishikiori, K. Ikeda, Y. Umeda, H. Ohnishi, K. Kuronuma, H. Chiba, JI. Baumbach, H. Takahashi
Lung 2017 04;195(2):247-254.
PubMed: 28247041
Abstract
Purpose Human breath analysis is proposed with increasing frequency as a useful tool in clinical application. We performed this study to find the characteristic volatile organic compounds (VOCs) in the exhaled breath of patients with idiopathic pulmonary fibrosis (IPF) for discrimination from healthy subjects. Methods VOCs in the exhaled breath of 40 IPF patients and 55 healthy controls were measured using a multi-capillary column and ion mobility spectrometer. The patients were examined by pulmonary function tests, blood gas analysis, and serum biomarkers of interstitial pneumonia. Results We detected 85 VOC peaks in the exhaled breath of IPF patients and controls. IPF patients showed 5 significant VOC peaks; p-cymene, acetoin, isoprene, ethylbenzene, and an unknown compound. The VOC peak of p-cymene was significantly lower (p
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
1-methyl-4-propan-2-ylbenzene | 19 |