Back
Hydrogen cyanide in the headspace of oral fluid and in mouth-exhaled breath.
W. Chen, M. Metsälä, O. Vaittinen, L. Halonen
J Breath Res 2014 Jun;8(2):027108.
PubMed: 24844251
Abstract
Mouth-exhaled hydrogen cyanide (HCN) concentrations have previously been reported to originate from the oral cavity. However, a direct correlation between the HCN concentration in oral fluid and in mouth-exhaled breath has not been explicitly shown. In this study, we set up a new methodology to simultaneously measure HCN in the headspace of oral fluid and in mouth-exhaled breath. Our results show that there is a statistically significant correlation between stimulated oral fluid HCN and mouth-exhaled HCN (rs = 0.76, p < 0.001). This confirms that oral fluid is the main contributor to mouth-exhaled HCN. Furthermore, we observe that after the application of an oral disinfectant, both the stimulated oral fluid and mouth-exhaled HCN concentrations decrease. This implies that HCN production in the oral cavity is related to the bacterial and/or enzymatic activity.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Formonitrile | 26 |